Abstract:
BACKGROUND:Deep brain stimulation (DBS) has emerged as a potential therapeutic strategy in the treatment of neurological disorders including epilepsy. However, the cellular mechanism responsible for the effects of DBS remains largely undefined. Therefore, using electrophysiological approach, we aimed to determine the antiepileptic effects and restorative potential of low frequency stimulation (LFS) on amygdala kindling-induced changes in electrophysiological properties of rat hippocampal CA1 pyramidal neurons. METHODS:Animals were kindled by electrical stimulation of amygdala in a rapid kindling manner (12 times per day). In one group of animals, immediately after termination of daily 12 rapid kindling stimulations, the kindling site was subjected to 4 packages of LFS at intervals of 5 min (each package contained 200 monophasic square-wave pulses, 0.1 ms pulse duration at 1 Hz). Whole cell patch clamp recording under current clamp conditions was performed on visually identified pyramidal neurons in hippocampal slice preparations obtained from amygdala-kindled rats and the rats receiving LFS. RESULTS:Kindling of the right basolateral amygdala profoundly affected spontaneous firing behavior and repetitive discharge characteristics of pyramidal neuronal electrophysiological properties. Application of LFS at the kindling site almost completely prevented the development of epilepsy and the disruptive effects of kindling on neuronal electrical activity through restoration of the normal electrophysiological characteristics. CONCLUSIONS:The results of this study implied that application of LFS during kindling acquisition prevents the kindling induced changes in functional electrical properties of CA1 pyramidal neurons, suggesting that this action may be involved in the antiepileptogenic mechanism of LFS.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Ghotbedin Z,Janahmadi M,Mirnajafi-Zadeh J,Behzadi G,Semnanian Sdoi
10.1016/j.brs.2012.11.001subject
Has Abstractpub_date
2013-07-01 00:00:00pages
515-23issue
4eissn
1935-861Xissn
1876-4754pii
S1935-861X(12)00202-1journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Dopamine agonist therapy and deep brain stimulation (DBS) of the subthalamic nucleus (STN) are antiparkinsonian treatments that act on a different part of the basal ganglia-thalamocortical motor circuitry, yet produce similar symptomatic improvements. OBJECTIVE/HYPOTHESIS:The purpose of this study was to id...
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pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:Brain stimulation
pub_type: 临床试验,杂志文章
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更新日期:2018-01-01 00:00:00
abstract::Deep brain stimulation (DBS) has evolved into a powerful clinical therapy for a range of neurological disorders, but even with impressive clinical growth, DBS technology has been relatively stagnant over its history. However, enhanced collaborations between neural engineers, neuroscientists, physicists, neurologists, ...
journal_title:Brain stimulation
pub_type: 杂志文章,评审
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abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method to induce changes in cortical neural excitability. This report presents findings from the first participant of a safety and efficacy study that examined a therapeutic rTMS protocol for persons with severe traumatic brain injury (TBI)...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2008.09.004
更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,评审
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更新日期:2015-05-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.03.003
更新日期:2018-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
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更新日期:2014-09-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2011.02.005
更新日期:2012-04-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.09.009
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) is a non-invasive method increasingly popular for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. O...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.03.012
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Direct stimulation of the vagus nerve in the neck via surgically implanted electrodes is protective in animal models of stroke. We sought to determine the safety and efficacy of a non-invasive cervical VNS (nVNS) method using surface electrodes applied to the skin overlying the vagus nerve in the neck in a m...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.11.008
更新日期:2016-03-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2011.07.008
更新日期:2012-10-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brs.2019.08.016
更新日期:2020-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.07.025
更新日期:2015-11-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2015.12.007
更新日期:2016-03-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2018.03.007
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) can provide insights into how differing cognitive contexts produce different brain states, through TMS-based measures of effective connectivity. For instance, in a recent study, the amplitude of the TMS-evoked response (TMS-ER)...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2013.11.004
更新日期:2014-03-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.04.011
更新日期:2020-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2017.04.126
更新日期:2017-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.03.004
更新日期:2020-01-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.12.001
更新日期:2015-05-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2014.01.056
更新日期:2014-05-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章,评审
doi:10.1016/j.brs.2012.08.006
更新日期:2013-05-01 00:00:00
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journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2012.03.012
更新日期:2012-04-01 00:00:00
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journal_title:Brain stimulation
pub_type: 信件,随机对照试验
doi:10.1016/j.brs.2019.10.020
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:External trigeminal nerve stimulation (ETNS) is an emergent, non-invasive neurostimulation therapy delivered bilaterally with adhesive skin electrodes. In previous studies, ETNS was associated to a decrease in seizure frequency in patients with focal drug-resistant epilepsy (DRE). OBJECTIVE:To determine the...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.06.005
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:the use of combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) for the functional evaluation of the cerebral cortex in health and disease is becoming increasingly common. However, there is still some ambiguity regarding the extent to which brain responses to auditory and somatos...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2020.10.011
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Recently, navigated transcranial magnetic stimulation (nTMS) has been suggested to be useful in preoperative functional localization of motor cortex in patients having tumors close to the somatomotor cortex. Resection of tumors in anatomically predicted eloquent areas without adverse effects have emphasized ...
journal_title:Brain stimulation
pub_type: 杂志文章
doi:10.1016/j.brs.2012.04.012
更新日期:2013-05-01 00:00:00