Abstract：
BACKGROUND:Vagus nerve stimulation (VNS) paired with forelimb training drives robust, specific reorganization of movement representations in the motor cortex. The mechanisms that underlie VNS-dependent enhancement of map plasticity are largely unknown. The cholinergic nucleus basalis (NB) is a critical substrate in cortical plasticity, and several studies suggest that VNS activates cholinergic circuitry. OBJECTIVE:We examined whether the NB is required for VNS-dependent enhancement of map plasticity in the motor cortex. METHODS:Rats were trained to perform a lever pressing task and then received injections of the immunotoxin 192-IgG-saporin to selectively lesion cholinergic neurons of the NB. After lesion, rats underwent five days of motor training during which VNS was paired with successful trials. At the conclusion of behavioral training, intracortical microstimulation was used to document movement representations in motor cortex. RESULTS:VNS paired with forelimb training resulted in a substantial increase in the representation of proximal forelimb in rats with an intact NB compared to untrained controls. NB lesions prevent this VNS-dependent increase in proximal forelimb area and result in representations similar to untrained controls. Motor performance was similar between groups, suggesting that differences in forelimb function cannot account for the difference in proximal forelimb representation. CONCLUSIONS:Together, these findings indicate that the NB is required for VNS-dependent enhancement of plasticity in the motor cortex and may provide insight into the mechanisms that underlie the benefits of VNS therapy.
journal_name
Brain Stimuljournal_title
Brain stimulationauthors
Hulsey DR,Hays SA,Khodaparast N,Ruiz A,Das P,Rennaker RL 2nd,Kilgard MPdoi
10.1016/j.brs.2015.12.007subject
Has Abstractpub_date
2016-03-01 00:00:00pages
174-81issue
2eissn
1935-861Xissn
1876-4754pii
S1935-861X(16)00002-4journal_volume
9pub_type
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更新日期：2015-01-01 00:00:00
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更新日期：2013-07-01 00:00:00
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更新日期：2018-01-01 00:00:00
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journal_title：Brain stimulation
pub_type： 杂志文章,随机对照试验
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更新日期：2013-07-01 00:00:00
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更新日期：2021-01-01 00:00:00
