Abstract：
:Following implantation of a left ventricular assist device (LVAD), acceptable functional performance is now being achieved; however, peak VO2 and peak work load (watts) remain considerably limited. Maximum physical capacity is essentially dependent on generated cardiac output (CO) and arteriovenous oxygen difference (avDO2 ). We investigated the changes in CO and avDO2 during exercise in LVAD patients with an HVAD pump (HeartWare Inc., Framingham, MA, USA). Approximately 6 weeks after implantation, 20 patients (100% male, 60.8 ± 7.3 years old, BMI 25.7 ± 3.3) underwent a six-minute walk test (6MWT), a cardiopulmonary exercise test (CPET), and noninvasive hemodynamic measurement. The mean six-minute walking distance (6MWD) was 403 m (68% of predicted), and mean peak VO2 was 10.9 mL/kg/min (39% of predicted). Mean total CO improved from 3.8 L at rest to 7.0 L at maximum exercise. The mean avDO2 increased from 7.4 mL/dL (44% of oxygen content) at rest to 13.2 mL/dL (75% of oxygen content) at maximum exercise. There was a significant increase in both total CO (P < 0.01) and avDO2 (P < 0.05) between rest and sub-maximum exercise. As exercise levels increased, however, no further significant changes were achieved. Long-term studies, especially in combination with exercise programs, would be desirable in order to observe the development of these parameters.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Schmidt T,Bjarnason-Wehrens B,Mommertz S,Hannig M,Schulte-Eistrup S,Willemsen D,Reiss Ndoi
10.1111/aor.13102subject
Has Abstractpub_date
2018-07-01 00:00:00pages
686-694issue
7eissn
0160-564Xissn
1525-1594journal_volume
42pub_type
杂志文章abstract：:In patients undergoing exchange-transfusion with hemoglobin (Hb)-based oxygen (O₂) carriers (HBOC), native Hb coexists with newly transfused Hb. The two Hb types share the same arterial and venous PO₂, but their affinities for O₂ vary. A simple spreadsheet model is described aiming at evaluating the contribution of ea...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2011.01296.x
更新日期：2012-02-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.1999.06448.x
更新日期：1999-11-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2008.00700.x
更新日期：2009-02-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.13524
更新日期：2019-12-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1994.tb03317.x
更新日期：1994-10-01 00:00:00
abstract：:Cardiopulmonary bypass (CPB) requirement in infants presents a unique challenge because of the large prime volume-to-blood volume ratio. Packed red blood cells (PRBCs) tend to deteriorate with long-term storage owing to their unphysiological composition and osmolality. Given that blood priming is inevitable in neonate...
journal_title：Artificial organs
pub_type： 杂志文章,随机对照试验
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更新日期：2020-03-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1984.tb04275.x
更新日期：1984-05-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2009.00760.x
更新日期：2010-02-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1995.tb02371.x
更新日期：1995-06-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2010.01088.x
更新日期：2011-04-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1997.tb00489.x
更新日期：1997-12-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1996.tb00718.x
更新日期：1996-02-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1978.tb03465.x
更新日期：1978-08-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12959
更新日期：2017-10-01 00:00:00
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journal_title：Artificial organs
pub_type： 临床试验,杂志文章
doi：10.1111/j.1525-1594.1996.tb04586.x
更新日期：1996-09-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.2000.06482-2.x
更新日期：2000-02-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.1999.06361.x
更新日期：1999-05-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.13835
更新日期：2020-10-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.13647
更新日期：2020-07-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.2001.06703.x
更新日期：2001-12-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12390
更新日期：2015-04-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1997.tb03724.x
更新日期：1997-07-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2012.01520.x
更新日期：2012-08-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.2002.07067.x
更新日期：2002-09-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1995.tb02362.x
更新日期：1995-05-01 00:00:00
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journal_title：Artificial organs
pub_type： 临床试验,杂志文章
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更新日期：1997-03-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章,随机对照试验
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更新日期：2010-11-01 00:00:00
abstract：:Renal Solutions Allient Sorbent Hemodialysis System utilizes a two-chambered pneumatic pump (Pulsar Blood Pump, Renal Solutions, Inc., Warrendale, PA, USA) to avoid limitations associated with peristaltic pumping systems. Single-needle access is enabled by counter-pulsing the two pump chambers, thereby obviating compl...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2009.00724.x
更新日期：2009-04-01 00:00:00
abstract：:The rotary blood pump will be an implantable left ventricular assist device (LVAD) in the near future. However, the best control method and the interrelationship between the rotary blood pump and native heart functions are unclear. An estimation was made of the native heart cardiac output from the change of an LVAD's ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.1998.06127.x
更新日期：1998-05-01 00:00:00
