Abstract：
:Widespread use of heart transplantation is limited by the scarcity of donor organs. Total artificial heart (TAH) development has been pursued to address this shortage, especially to treat patients who require biventricular support. We have developed a novel TAH that utilizes a continuously spinning rotor that shuttles between two positions to provide pulsatile, alternating blood flow to the systemic and pulmonary circulations without artificial valves. Flow rates and pressures generated by the TAH are controlled by adjusting rotor speed, cycle frequency, and the proportion of each cycle spent pumping to either circulation. To validate the design, a TAH prototype was placed in a mock circulatory loop that simulates vascular resistance, pressure, and compliance in normal and pathophysiologic conditions. At a systemic blood pressure of 120/80 mm Hg, nominal TAH output was 7.4 L/min with instantaneous flows reaching 17 L/min. Pulmonary artery, and left and right atrial pressures were all maintained within normal ranges. To simulate implant into a patient with severe pulmonary hypertension, the pulmonary vascular resistance of the mock loop was increased to 7.5 Wood units. By increasing pump speed to the pulmonary circulation, cardiac output could be maintained at 7.4 L/min as mean pulmonary artery pressure increased to 56 mm Hg while systemic blood pressures remained normal. This in vitro testing of a novel, shuttling TAH demonstrated that cardiac output could be maintained across a range of pathophysiologic conditions including pulmonary hypertension. These experiments serve as a proof-of-concept for the design, which has proceeded to in vivo testing.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Glynn J,Song H,Hull B,Withers S,Gelow J,Mudd J,Starr A,Wampler Rdoi
10.1111/aor.12959subject
Has Abstractpub_date
2017-10-01 00:00:00pages
904-910issue
10eissn
0160-564Xissn
1525-1594journal_volume
41pub_type
杂志文章abstract：:Mycotic aneurysm of the superior mesenteric artery (SMA) is one of the complications associated with infective endocarditis. However, there are no previous case reports in the literature describing mycotic SMA aneurysm after left ventricular assist device (LVAD) implantation. We describe the case of a 31-year-old male...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2011.01250.x
更新日期：2011-07-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章,评审
doi：10.1111/j.1525-1594.2005.29108.x
更新日期：2005-09-01 00:00:00
abstract：:Sponge-type small-diameter vascular grafts were fabricated from a medical-grade polyurethane, Pellethane 2363-80A, by utilization of a salt casting technique. The grafts were compliance matched with a storage modulus of 0.53 +/- 0.08 MPa. The luminal surface of grafts was modified with a thin layer ( approximately 40 ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2003.07141.x
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2005.29022.x
更新日期：2005-02-01 00:00:00
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journal_title：Artificial organs
pub_type： 临床试验,杂志文章
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更新日期：1999-12-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2009.00924.x
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journal_title：Artificial organs
pub_type： 杂志文章
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12359
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.13757
更新日期：2020-12-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.13281
更新日期：2018-12-01 00:00:00
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journal_title：Artificial organs
pub_type： 临床试验,杂志文章
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更新日期：1996-04-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12655
更新日期：2016-09-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2004.47349.x
更新日期：2004-04-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12268
更新日期：2014-11-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12955
更新日期：2018-01-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2006.00261.x
更新日期：2006-07-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1993.tb00617.x
更新日期：1993-08-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2011.01233.x
更新日期：2011-07-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.2002.06931_4.x
更新日期：2002-08-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：
更新日期：1981-02-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1995.tb02409.x
更新日期：1995-07-01 00:00:00
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更新日期：2009-07-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
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更新日期：2000-06-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
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更新日期：1997-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-06-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1991.tb00745.x
更新日期：1991-10-01 00:00:00
abstract：:This article presents results from the field calculation in a model of biological tissue taking into account the electroporation process. The electroporation model used in this study was proposed and experimentally verified by Glaser et al. for planar membranes. The numerical method for field calculation is based on a...
journal_title：Artificial organs
pub_type： 杂志文章
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更新日期：2005-06-01 00:00:00
abstract：:The aim of this study was to verify if dialysis solution volumes used in patients on continuous ambulatory peritoneal dialysis (CAPD) interfere with pulmonary function and if the pulmonary volumes interfere with the lymphatic absorption of the peritoneal cavity. We submitted 10 CAPD patients with a mean age of 48 +/- ...
journal_title：Artificial organs
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doi：10.1046/j.1525-1594.2001.06904.x
更新日期：2001-11-01 00:00:00
