Effect of the electroporation in the field calculation in biological tissues.

Abstract:

:This article presents results from the field calculation in a model of biological tissue taking into account the electroporation process. The electroporation model used in this study was proposed and experimentally verified by Glaser et al. for planar membranes. The numerical method for field calculation is based on a two-step process: (1) a cell-scale analysis, used for obtaining the field and current in a small volume containing only one cell and its nearest neighbors; and (2) a tissue-scale analysis, based on averaged values of conductivity and permittivity (obtained from the cell-scale analysis) and used for field calculation in a large volume of the tissue. The results for a high voltage applied between two electrodes in a two-dimensional analysis show that the electric field in the porated tissue extends beyond the limits obtained when the electroporation process is not taken into account. Furthermore, due to the electroporation, the tissue conductivity increases in the space between the electrodes. These results show that the electroporation process cannot be ignored in the field calculation in biological tissues when high strength electric fields are present.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Ramos A

doi

10.1111/j.1525-1594.2005.29085.x

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

510-3

issue

6

eissn

0160-564X

issn

1525-1594

pii

AOR29085

journal_volume

29

pub_type

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