The BiVACOR rotary biventricular assist device: concept and in vitro investigation.


:The BiVACOR is a novel rotary Biventricular Assist Device (BiVAD) undergoing development to treat global end-stage heart failure. The design includes left and right vanes positioned on a shared rotating hub to form a double-sided magnetically and hydrodynamically suspended centrifugal impeller. The performance of the device was assessed in a pulsatile mock circulation loop replicating end-stage biventricular heart failure, and was shown to restore flow from pathological (2 L/min) to normal levels (5 L/min). A novel technique to balance the left/right outflow of the BiVAD was also investigated, for which a maximum relative left to right outflow differential of 1.8 L/min was achieved at normal physiologic afterloads. The in vitro results encourage device progression to in vivo animal studies. Successful development of this BiVAD will provide a suitably miniature device for patients who require biventricular assistance.


Artif Organs


Artificial organs


Timms D,Fraser J,Hayne M,Dunning J,McNeil K,Pearcy M




Has Abstract


2008-10-01 00:00:00














  • Influence of antihypertensive drugs and steroid hormones on protein adsorption/desorption on polycarbonate.

    abstract::To develop artificial materials for prolonged use in the vascular system, the complicated process of surface-induced thrombosis needs to be better understood. It is documented that certain antihypertensive drugs can inhibit platelet adhesion to an artificial surface; on the other hand, steroid drugs increase platelet ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Chandy T,Sharma CP

    更新日期:1991-06-01 00:00:00

  • Effect of hemodialysis on T lymphocyte subsets, con-A-activated suppressor cell activity, and interleukin-2 receptor expression on lymphocytes in chronic uremic patients.

    abstract::Effect of hemodialysis (HD) on some indices of immune response was studied in nine chronic uremics. Total lymphocyte, OKT4+, and OKT8+ cell numbers significantly decreased during the first 20 min of HD, and they were decreased till the third hour of the procedure, whereas the OKT4+/OKT8+ cell number ratio did not chan...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Tchórzewski H,Luciak M,Trznadel K,Majewska E,Pokoca L

    更新日期:1989-06-01 00:00:00

  • Effects of hemodynamic conditions and valve sizing on leaflet bending stress in self-expanding transcatheter aortic valve: An in vitro study.

    abstract::Transcatheter aortic valve (TAV) replacement has become a viable alternative to surgery for high and intermediate risk patients with severe aortic stenosis. This technology may extend to the younger and lower risk patients. In this population, long-term durability of the TAV is key. Increased leaflet mechanical stress...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Stanová V,Zenses AS,Thollon L,Kadem L,Barragan P,Rieu R,Pibarot P

    更新日期:2020-07-01 00:00:00

  • Testosterone and hemoglobin in hemodialysis male and female patients.

    abstract::It has been speculated that testosterone stimulates erythropoiesis. We hypothesized that hemoglobin levels in hemodialysis (HD) patients are associated with serum testosterone concentrations. Testosterone, hemoglobin, and other biochemical parameters were measured in a representative sample of 98 chronic HD patients (...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Ekart R,Taskovska M,Hojs N,Bevc S,Hojs R

    更新日期:2014-07-01 00:00:00

  • Changes in Spirometry After Left Ventricular Assist Device Implantation.

    abstract::Left ventricular assist devices (LVADs) are increasingly being used as life-saving therapy in patients with end-stage heart failure. The changes in spirometry following LVAD implantation and subsequent unloading of the left ventricle and pulmonary circulation are unknown. In this study, we explored long-term changes i...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Mohamedali B,Bhat G,Yost G,Tatooles A

    更新日期:2015-12-01 00:00:00

  • Building a Better Neonatal Extracorporeal Life Support Circuit: Comparison of Hemodynamic Performance and Gaseous Microemboli Handling in Different Pump and Oxygenator Technologies.

    abstract::Neurologic complications during neonatal extracorporeal life support (ECLS) are associated with significant morbidity and mortality. Gaseous microemboli (GME) in the ECLS circuit may be a possible cause. Advances in neonatal circuitry may improve hemodynamic performance and GME handling leading to reduction in patient...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Glass K,Trivedi P,Wang S,Woitas K,Kunselman AR,Ündar A

    更新日期:2017-04-01 00:00:00

  • Magnetic suspension of the rotor of a ventricular assist device of mixed flow type.

    abstract::This work presents results of preliminary studies concerning application of magnetic bearing in a ventricular assist device (VAD) being developed by Dante Pazzanese Institute of Cardiology-IDPC (São Paulo, Brazil). The VAD-IDPC has a novel architecture that distinguishes from other known VADs. In this, the rotor has a...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Horikawa O,de Andrade AJ,da Silva I,Bock EG

    更新日期:2008-04-01 00:00:00

  • Surface modification of silicone rubber membrane by plasma induced graft copolymerization as artificial cornea.

    abstract::In this study a highly biocompatible polymer membrane was prepared by surface modification. An artificial cornea was also developed for clinical applications. Silicone rubber (SR) membrane was grafted with hydrophilic monomers such as 2-hydroxyethyl methacrylate (HEMA) and acrylic acid by plasma induced grafted polyme...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Hsiue GH,Lee SD,Chang PC

    更新日期:1996-11-01 00:00:00

  • Clinical validation of a predictive modeling equation for sodium.

    abstract::Changes in plasma sodium (Na) concentration during hemodialysis were predicted by changes in Na concentration of the dialysate at equilibrium with the plasma, according to the formula C't = CD - (CD - C'0) [(V0 - QFt)/V0]A/QF, where C'0 and C't are the Na concentration of the dialysate at equilibrium with the plasma a...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Man NK,Petitclerc T,Tien NQ,Jehenne G,Funck-Brentano JL

    更新日期:1985-05-01 00:00:00

  • Investigation of parameter estimator and adaptive controller for assist pump by computer simulation.

    abstract::The multi-output adaptive controller of a left ventricular assist device (LVAD) was studied by computer simulation. The controller regulated two outputs--mean aortic pressure (mAoP) and mean atrial pressure (mLAP)--by regulating vacuum pressure (input). The autoregressive models were used to describe the circulatory s...

    journal_title:Artificial organs

    pub_type: 杂志文章


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    更新日期:1991-04-01 00:00:00

  • Intelligent freeform manufacturing of complex organs.

    abstract::Different from the existing tissue engineering strategies, rapid prototyping (RP) techniques aim to automatically produce complex organs directly from computer-aided design freeform models with high resolution and sophistication. Analogous to building a nuclear power plant, cell biology (especially, renewable stem cel...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审


    authors: Wang X

    更新日期:2012-11-01 00:00:00

  • Feasibility of extracorporeal on-line large-scale plasma adsorptions on protein A-sepharose columns in cancer patients.

    abstract::The feasibility of extracorporeal adsorption of 1.5-3 L plasma on protein A-Sepharose was investigated in six patients with advanced cancer. Anticoagulation with heparin was associated with respiratory distress syndrome in two patients, most likely caused by complement activation as indicated by a transient leukopenia...

    journal_title:Artificial organs

    pub_type: 杂志文章


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    更新日期:1984-02-01 00:00:00

  • A novel in vitro assessment of tissue valve calcification by a continuous flow type method.

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    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Park JC,Hwang YS,Han DW,Suh H

    更新日期:2000-02-01 00:00:00

  • Improved mechanism for capturing muscle power for circulatory support.

    abstract::Although it is now understood that trained skeletal muscle can generate enough steady-state power to provide significant circulatory support, there are currently no means by which to tap this endogenous energy source to aid the failing heart. To that end, an implantable muscle energy converter (MEC) has been construct...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审


    authors: Trumble DR,Melvin DB,Byrne MT,Magovern JA

    更新日期:2005-09-01 00:00:00

  • Analysis of left ventricular impedance in comparison with ultrasound images.

    abstract::Cardiac monitoring of ventricular assist devices (VADs) is important for detecting heart failure risks, such as critical arrhythmia and ventricular fibrillation, and for supplying data that are useful for hemodynamic control. Specifically, impedance cardiograms (ICGs) are especially beneficial because they have no eff...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Choi SW,Park SM

    更新日期:2012-05-01 00:00:00

  • Re-endothelialization of non-detergent decellularized porcine vessels.

    abstract::Tissue engineering utilizes an interdisciplinary approach to generate constructs for the treatment and repair of diseased organs. Generation of small vessels as vascular grafts or as envisioned central vessel for vascularized constructs is still a challenge. Here, the decellularization of porcine vessels by a non-dete...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Eyre K,Samper E,Haverich A,Hilfiker A,Andrée B

    更新日期:2020-10-01 00:00:00

  • Chaotic dynamics in circulation with Tohoku University vibrating flow pump.

    abstract::For the development of a totally implantable ventricular assist system (VAS), we have been developing the vibrating flow pump (VFP), which can generate oscillated blood flow with a relative high frequency (10-50 Hz) for a totally implantable system. In this study, the effects of left ventricular assistance with this u...

    journal_title:Artificial organs

    pub_type: 杂志文章


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    更新日期:1999-01-01 00:00:00

  • Reciprocal influences between ambulatorial peritoneal dialysis and pulmonary function.

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    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Marmanillo CG,Pecoits-Filho RF,Romão JE Jr,Kakehashi ET,Sabbaga E,Marcondes M,Abensur H

    更新日期:2001-11-01 00:00:00

  • A novel, valveless ventricular assist device: the FishTail pump. First experimental in vivo studies.

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    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Feier H,Mekkaoui C,Drevet JB,Sérée Y,Richomme C,Rolland PH,Mesana TG

    更新日期:2002-12-01 00:00:00

  • A novel method to evaluate thromboresistance of drip chambers with filter used in extracorporeal blood circuits for hemodialysis.

    abstract::We have developed a novel method to simultaneously evaluate thromboresistance of two different types of drip chambers with a filter used in extracorporeal blood circuits for hemodialysis using canine arteriovenous shunt models. Bilateral bypasses between the femoral artery and vein on both sides of the animal were for...

    journal_title:Artificial organs

    pub_type: 杂志文章


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    更新日期:1997-02-01 00:00:00

  • Multicenter Experience With Mechanical Circulatory Support Using a New Diagonal Pump in 233 Children.

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    journal_title:Artificial organs

    pub_type: 杂志文章,多中心研究


    authors: Stiller B,Houmes RJ,Rüffer A,Kumpf M,Müller A,Kipfmüller F,Köditz H,Herber Jonat S,Schmoor C,Benk C,Tibboel D,Fleck T

    更新日期:2018-04-01 00:00:00

  • From wooden limbs to biomaterial organs: the ethics of organ replacement and artificial organs.

    abstract::This paper discussed issues of ethical assessment and moral concern associated with organ replacement and physical enhancement: research, allocation, organ donation, artificial organs, xenografts, biomaterials, and neuromaterials. While emphasizing the medical and moral benefits over associated risks, it calls for a b...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Kielstein R,Sass HM

    更新日期:1995-05-01 00:00:00

  • Artificial cells with emphasis on cell encapsulation of genetically engineered cells.

    abstract::Artificial cells are prepared in the laboratory for medical and biotechnological applications. Encapsulated cells are being studied for the treatment of diabetes, liver failure, and other conditions. More recently, there have been extensive studies into the use of encapsulated genetically engineered cells for gene the...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Chang TM

    更新日期:1998-11-01 00:00:00

  • Oxidative Stress Increases Erythrocyte Sensitivity to Shear-Mediated Damage.

    abstract::Patients receiving mechanical circulatory support often present with heightened inflammation and free radical production associated with pre-existing conditions in addition to that which is due to blood interactions with nonbiological surfaces. The aim of this experimental laboratory study was to assess the deformabil...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: McNamee AP,Horobin JT,Tansley GD,Simmonds MJ

    更新日期:2018-02-01 00:00:00

  • The impact of polyethylene glycol conjugation on bovine hemoglobin's circulatory half-life and renal effects in a rabbit top-loaded transfusion model.

    abstract::This study compares the effects of polyethylene glycol (PEG) modified bovine hemoglobin on vascular half-life and renal function in rabbits to those of unmodified bovine hemoglobin. Renal function was assessed by the measurement of the glomerular filtration rate, urinalysis, blood chemistries, hemoglobin (Hb) excretio...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Conover CD,Gilbert CW,Shum KL,Shorr RG

    更新日期:1997-08-01 00:00:00

  • Morphological characteristics and proliferation of keratocytes cultured under simulated microgravity.

    abstract::This study probed the changes of keratocytes cultured under simulated microgravity. Keratocytes were isolated from rabbit corneas using collagenase digestion method. Cells were seeded in a 55-mL capacity high-aspect-ratio vessel (HARV) of rotary cell culture system (RCCS) at a density of 1 x 10(4) cells/mL. Dehydrated...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Chen J,Chen R,Gao S

    更新日期:2007-09-01 00:00:00

  • Computational fluid dynamics prediction of blood damage in a centrifugal pump.

    abstract::This study explores a quantitative evaluation of blood damage that occurs in a continuous flow left ventricular assist device due to fluid stress. Computational fluid dynamics (CFD) analysis is used to track the shear stress history of 388 particle streaklines. The accumulation of shear and exposure time is integrated...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Song X,Throckmorton AL,Wood HG,Antaki JF,Olsen DB

    更新日期:2003-10-01 00:00:00

  • Regenerative medicine for cardiovascular disorders-new milestones: adult stem cells.

    abstract::Cardiovascular disorders are the leading causes of mortality and morbidity in the developed world. Cell-based modalities have received considerable scientific attention over the last decade for their potential use in this clinical arena. This review was intended as a brief overview on the subject of therapeutic potent...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审


    authors: Akar AR,Durdu S,Corapcioglu T,Ozyurda U

    更新日期:2006-04-01 00:00:00

  • Evidence of absence of porcine endogenous retrovirus (PERV) infection in patients treated with a bioartificial liver support system.

    abstract::Porcine endogenous retrovirus (PERV) genomes are present in all pig cells. In this retrospective study, we assessed PERV infectivity in 28 patients treated with an extracorporeal bioartificial liver (HepatAssist system) that includes a membrane device containing porcine hepatocytes. All patients tested negative for PE...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Pitkin Z,Mullon C

    更新日期:1999-09-01 00:00:00

  • Constraint stress, microstructural characteristics, and enhanced mechanical properties of a special fibroblast-embedded collagen construct.

    abstract::Cell-contracted collagen gels could provide rejection-free biomaterials for tissue engineering, but their application is limited by relatively low mechanical strength. We developed a special type I collagen construct (based on embedded fibroblasts) that was formed into a gel thread by using two anchors to constrain ge...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Feng Z,Ishibashi M,Nomura Y,Kitajima T,Nakamura T

    更新日期:2006-11-01 00:00:00