Prolonged left ventricular dysfunction induced by sequential multifocal ischemic infarcts in dogs.

Abstract:

:A method of creating multifocal ischemia in animals leading to left ventricular (LV) functional impairment is described. In a series of 10 mongrel dogs, electrodes were implanted in multiple branches of the coronary arteries. Subsequently, in seven animals, an 800-microA anodal current was applied for 3 h repeatedly over a span of 4-9 weeks. After current application, serum creatine kinase cardiac isoenzyme increased by 12.2 +/- 4.6 U/L (p less than 0.01) and ischemic electrocardiographic changes were consistently present. After an average of 10.7 current applications, all animals were tachypneic on mild exertion. Repeated measurement of LV function demonstrated a substantial reduction in cardiac reserve. No significant changes in three control animals were observed. The animals were sacrificed 80 days (range 49-108 days) after the initial current application. Presacrifice cineangiography and postmortem examination disclosed coronary artery occlusions, stenoses, recanalizations, and collateralization in the distributions expected on the basis of the time elapsed since electrode activation. In all cases, the myocardium exhibited diffuse fibrosis. This method reliably brings about multifocal myocardial ischemic changes in dogs and may provide a chronic LV failure model particularly suitable for the evaluation of LV assist systems.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Polanski J,Mandell G,Wasfie T,Freed PS,Yoshizu H,Stein PD,Sabbah HN,Kantrowitz A

doi

10.1111/j.1525-1594.1984.tb04321.x

subject

Has Abstract

pub_date

1984-11-01 00:00:00

pages

445-57

issue

4

eissn

0160-564X

issn

1525-1594

journal_volume

8

pub_type

杂志文章
  • Measurement of the closing behavior of the björk-shiley monoleaflet mechanical heart valve with an electrohydraulic total artificial heart.

    abstract::When cavitation occurs near a material surface of a mechanical heart valve (MHV), pits on the surface of the MHV and hemolysis are caused. Therefore, it is very important to investigate the possibility of the occurrence of cavitation in an MHV. To study the possibility of cavitation occurrence in a 25 mm Björk-Shiley ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2003.06981.x

    authors: Lee H,Tsukiya T,Homma A,Taenaka Y,Tatsumi E,Takano H

    更新日期:2003-08-01 00:00:00

  • A compact highly efficient and low hemolytic centrifugal blood pump with a magnetically levitated impeller.

    abstract::A magnetically levitated (maglev) centrifugal blood pump (CBP), intended for use as a ventricular assist device, needs to be highly durable and reliable for long-term use without any mechanical failure. Furthermore, maglev CBPs should be small enough to be implanted into patients of various size and weight. We have de...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2006.00202.x

    authors: Asama J,Shinshi T,Hoshi H,Takatani S,Shimokohbe A

    更新日期:2006-03-01 00:00:00

  • A new technique to increase coronary flow. Preliminary report.

    abstract::This study was planned to investigate whether part of the energy produced by cardiac contraction to propel blood toward the systemic circulation can be used to increase the coronary flow in systole. Ten devices (I-X) designed to divert laterally part of a flow column (without substantially increasing resistance to flo...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1979.tb01080.x

    authors: Moulopoulos S,Stamatelopoulos S,Boufas D,Yannopoulos C,Marousis G,Kouvaras G

    更新日期:1979-11-01 00:00:00

  • Pretreatment With Inactivated Bacillus Calmette-Guerin Increases CD4+CD25+ Regulatory T Cell Function and Decreases Functional and Structural Effects of Asthma Induction in a Rat Asthma Model.

    abstract::Bacillus Calmette-Guerin (BCG) has been shown to have therapeutic effects on asthma through CD4+CD25+ regulatory T cells (Tregs). We sought to assess pretreatment with inactivated BCG on CD4+CD25+ Tregs and its functional and structural effects in rat asthma model. The rat asthma model was established using ovalbumin ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12566

    authors: Gong P,Li Y,Tan YP,Li H

    更新日期:2016-04-01 00:00:00

  • Ductular cholestasis, an unusual form of intrahepatic cholestasis, associated with cardiogenic shock and ventricular assist device.

    abstract::Ventricular assist devices have been shown to be effective in advanced heart failure selected patients. They often have borderline end-organ function, what facilitates organ dysfunction. Liver failure is difficult to manage and leads to increased morbidity and mortality. We report a case of ductular cholestasis, an un...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00760.x

    authors: Mohedano-Gómez A,Pérez-Vela JL,Renes-Carreño E,De-Andrés CI,Corres-Peiretti MA,Arribas-López P,Gutierrez-Rodriguez J,Perales-Rodríguez-De-Viguri N

    更新日期:2010-02-01 00:00:00

  • Physiologic control of cardiac assist devices.

    abstract::Total artificial hearts (TAHs) and biventricular assist devices (BVADs) have varying levels of acceptance and reliability, and the research on both focuses on their control mechanisms. Efforts generally aim to achieve a response to physiologic demand and left/right output balance, and beneficial cardiac output (CO) an...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1996.tb04438.x

    authors: Hall AW,Soykan O,Harken AH

    更新日期:1996-03-01 00:00:00

  • Research into the development of a wearable bioartificial kidney with a continuous hemofilter and a bioartificial tubule device using tubular epithelial cells.

    abstract::Current hemodialysis treatment is insufficient because of intermittent treatment and loss of tubular function. In order to overcome the loss of tubular function, a bioartificial kidney has been developed consisting of continuous hemofiltration (CHF) with 10 L/day of filtrate and a bioartificial tubule device using pro...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.2004.07323.x

    authors: Saito A

    更新日期:2004-01-01 00:00:00

  • Internal jugular vein cannulation with two silicone rubber catheters: a new and safe temporary vascular access for hemodialysis. Thirty months' experience.

    abstract::Temporary and immediately usable vascular access is a vital need in treating uremic patients. Subclavian vein cannulation, although a major progress, has been associated with significant morbidity and mortality. Accordingly, for the last 2.5 years the authors have been developing an alternative technique consisting of...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1986.tb02587.x

    authors: Canaud B,Beraud JJ,Joyeux H,Mion C

    更新日期:1986-10-01 00:00:00

  • Bacterial and fungal infection in neonates undergoing venoarterial extracorporeal membrane oxygenation: an analysis of the registry data of the extracorporeal life support organization.

    abstract::A review and analysis of 5,001 neonatal venoarterial (VA) extracorporeal membrane oxygenation (ECMO) cases showed that bacterial and fungal infection occurred in 147 (2.9%) and 26 (0.6%) patients, respectively, with an overall incidence of 3.5%. Bivariate analysis was used to compare infected infants with controls, ba...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1996.tb04428.x

    authors: Douglass BH,Keenan AL,Purohit DM

    更新日期:1996-03-01 00:00:00

  • Influence of reuse and of reuse sterilants on the first-use syndrome.

    abstract::Over a 4 year period, five of 98 patients at our dialysis unit developed signs and symptoms consistent with first-use syndrome (FUS). Marked improvement was noted after subjecting new dialyzers to automated processing using either formaldehyde or peracetic acid. No episodes of FUS occurred in patients being treated wi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1987.tb02645.x

    authors: Vanholder R,Ringoir S

    更新日期:1987-04-01 00:00:00

  • Quantification of Shear-Induced Platelet Activation: High Shear Stresses for Short Exposure Time.

    abstract::Thrombosis and thromboembolism are the life-threatening clinical complications for patients supported or treated with prosthetic cardiovascular devices. The high mechanical shear stress within these devices is believed to be the major contributing factor to cause platelet activation (PA) and function alteration, leadi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12438

    authors: Ding J,Chen Z,Niu S,Zhang J,Mondal NK,Griffith BP,Wu ZJ

    更新日期:2015-07-01 00:00:00

  • Fluid-Structure Interactions Analysis of Shear-Induced Modulation of a Mesenchymal Stem Cell: An Image-Based Study.

    abstract::Although effects of biochemical modulation of stem cells have been widely investigated, only recent advances have been made in the identification of mechanical conditioning on cell signaling pathways. Experimental investigations quantifying the micromechanical environment of mesenchymal stem cells (MSCs) are challengi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12547

    authors: Ghaemi RV,Vahidi B,Sabour MH,Haghighipour N,Alihemmati Z

    更新日期:2016-03-01 00:00:00

  • Temporary right heart assist: a minimally invasive approach.

    abstract::A surgical method for the implantation of a mechanical right ventricular assist device which avoids resternotomy/thoracotomy and related complications at the time of explantation is presented. In order to support the failing right heart, a Dacron vascular graft was sewn to the pulmonary artery. For venous drainage, a ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2012.01520.x

    authors: Schopka S,Haneya A,Rupprecht L,Camboni D,Schmid C,Hilker M

    更新日期:2012-08-01 00:00:00

  • The effect of electrode placement and interphase interval on force production during stimulation of the dorsiflexor muscles.

    abstract::The aims of this study were to investigate whether introducing an interphase interval (IPI) to biphasic pulses during stimulation of the dorsiflexor muscles would affect force production and to determine whether the IPI effect is dependent on electrode position. Twelve healthy volunteers participated in the study. Eac...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12346

    authors: Springer S,Braun-Benyamin O,Abraham-Shitreet C,Becher M,Laufer Y

    更新日期:2014-11-01 00:00:00

  • Pump Speed Waveform Analysis to Detect Aortic Valve Opening in Patients on Ventricular Assist Device Support.

    abstract::As the aortic valve (AV) opens, the pump pressure head remains constant, which is reflected as a "notch/plateau" in pump pressure and flow signals. However, instantaneous flow estimation may be influenced by friction and is particularly difficult in axial pumps. Therefore, a new method to determine the duration of AV ...

    journal_title:Artificial organs

    pub_type: 杂志文章,多中心研究

    doi:10.1111/aor.12570

    authors: Hayward C,Lim CP,Schima H,Macdonald P,Moscato F,Muthiah K,Granegger M

    更新日期:2015-08-01 00:00:00

  • A percutaneously accessible pulsatile left ventricular assist device: modified assist device type 5.

    abstract::To provide percutaneous access, a new circulatory assist system was developed. We call this newly developed system the modified assist device (MAD). The system is composed of a sac-type blood pump and cannula. Inflow and outflow valves are mounted in the apex and at the side wall 10 cm from the apex of the cannula, re...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1996.tb00718.x

    authors: Imanishi K,Imachi K,Yoshito H,Isoyama T,Abe Y,Chinzei T,Mabuchi K,Kanda K,Tsutsui N,Suma K,Fujimasa I

    更新日期:1996-02-01 00:00:00

  • Potential mechanisms for muscle-powered cardiac support.

    abstract::Biomechanical actuation of an implanted ventricular assist device (VAD) is an attractive means of providing long-term circulatory support. Studies show that energy from electrically stimulated skeletal muscle can, in principle, be used to provide tether-free cardiac assistance without the need for percutaneous driveli...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2010.01170.x

    authors: Trumble DR

    更新日期:2011-07-01 00:00:00

  • Hemolysis Related to Turbulent Eddy Size Distributions Using Comparisons of Experiments to Computations.

    abstract::Turbulent blood flow in medical devices contributes to blood trauma, yet the exact mechanism(s) have not been fully elucidated. Local turbulent stresses, viscous stresses, and the rate of dissipation of the turbulent kinetic energy have been proffered as hypotheses to describe and predict blood damage. In this work, s...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12572

    authors: Ozturk M,O'Rear EA,Papavassiliou DV

    更新日期:2015-12-01 00:00:00

  • Prediction of postdialysis serum sodium concentration and transcellular fluid shift without measuring body fluid volumes.

    abstract::The postdialysis levels of serum sodium concentration, urea concentration, and osmolality, as well as the magnitude of both transcellular fluid shifts and sodium removal, were predicted based on computer modeling without measuring body fluid volumes. A 4-h hemodialysis was performed in five patients at a constant ultr...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1983.tb04219.x

    authors: Kimura G,Van Stone JC,Bauer JH

    更新日期:1983-11-01 00:00:00

  • Arterial pressure: its role in perfusion and as a criterion of extracorporeal circulation adequacy.

    abstract::Thirty-five patients undergoing open-heart surgery are reported. Cardiac index, mean arterial pressure, oxygen consumption, lactate, pyruvate, and lactate excess in the blood were measured. An inverse correlation of arterial pressure with oxygen consumption and lactate excess was found during perfusion. Comparison of ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1982.tb01675.x

    authors: Osipov VP,Khodas MJ,Dementjeva II,Pjatnitskaja GKh

    更新日期:1982-08-01 00:00:00

  • (13) C Breath Tests Are Feasible in Patients With Extracorporeal Membrane Oxygenation Devices.

    abstract::Temporary extracorporeal membrane oxygenation (ECMO) has been established as an essential part of therapy in patients with pulmonary or cardiac failure. As physiological gaseous exchange is artificially altered in this patient group, it is debatable whether a (13) C-breath test can be carried out. In this proof of tec...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12634

    authors: Bednarsch J,Menk M,Malinowski M,Weber-Carstens S,Pratschke J,Stockmann M

    更新日期:2016-07-01 00:00:00

  • Plasma middle molecules in asymptomatic and "sick" uremic patients.

    abstract::By using high speed gel filtration combined with ion exchange gradient elution chromatography, the concentrations of plasma (p) middle molecules (MM) were determined in 126 samples from 90 non-dialyzed azotemic patients and in 210 pre-dialysis samples from 53 regular hemodialysis and 24 intermittent peritoneal dialysi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:

    authors: Asaba H,Bergström J,Fürst P,Johnson C,Yahiel V

    更新日期:1981-01-01 00:00:00

  • Intraarterial perfusion of the hindlimb with pyridoxalated hemoglobin polyoxyethylene conjugate solution in anesthetized dogs.

    abstract::To evaluate the potential clinical usefulness of a modified hemoglobin, pyridoxalated hemoglobin polyoxyethylene conjugate (PHP), the hindlimb vascular bed was perfused with PHP solution while monitoring tissue oxygen tension (PtO2) in anesthetized dogs. The hindlimb region was perfused through the external iliac arte...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1995.tb02371.x

    authors: Kida Y,Yamakawa T,Iwasaki S,Furusho N,Kadowaki Y,Iwata S,Iwashita Y,Nishi K

    更新日期:1995-06-01 00:00:00

  • Biological evaluation of liposome-encapsulated hemoglobin surface-modified with a novel PEGylated nonphospholipid amphiphile.

    abstract::Traumatic injury is often associated with hemorrhagic shock. Liposome-encapsulated hemoglobin (LEH) is being developed as an artificial oxygen carrier to address post-hemorrhage oxygen and volume deficit. Here, we report a new composition of LEH based on the use of polyethylene glycol (PEG2K ) conjugated with nonphosp...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12304

    authors: Yadav VR,Nag O,Awasthi V

    更新日期:2014-08-01 00:00:00

  • Effect of cyclosporine therapy with low doses of corticosteroids on idiopathic nephrotic syndrome.

    abstract::Cyclosporine (CyA) has an immunosuppressive effect that might suggest a therapeutic role in idiopathic glomerular conditions. We focused on the optimization of CyA treatment control in patients with idiopathic nephrotic syndrome by using trough-level CyA measurements (C0) and the 2-h postdose levels (C2). Twenty-two p...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00838.x

    authors: Griveas I,Visvardis G,Papadopoulou D,Nakopolou L,Karanikas E,Gogos K,Stavianoudakis G

    更新日期:2010-03-01 00:00:00

  • Improved retention of endothelial cells seeded on polyurethane small-diameter vascular grafts modified by a recombinant RGD-containing protein.

    abstract::Sponge-type small-diameter vascular grafts were fabricated from a medical-grade polyurethane, Pellethane 2363-80A, by utilization of a salt casting technique. The grafts were compliance matched with a storage modulus of 0.53 +/- 0.08 MPa. The luminal surface of grafts was modified with a thin layer ( approximately 40 ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2003.07141.x

    authors: Hsu SH,Sun SH,Chen DC

    更新日期:2003-12-01 00:00:00

  • Formation of Blood Foam in the Air Trap During Hemodialysis Due to Insufficient Automatic Priming of Dialyzers.

    abstract::We were encouraged to investigate the reasons for large amounts of foam observed in bloodlines during hemodialysis (HD). Foam was visible in the venous air trap within the Artis Gambro dialysis device. Estimates of the extent of foam were graded (0-no foam, 10-extensive foam) by two persons that were blind to the type...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13070

    authors: Jonsson P,Lindmark L,Axelsson J,Karlsson L,Lundberg L,Stegmayr B

    更新日期:2018-05-01 00:00:00

  • Use of hemoperfusion in experimental intoxication with nerve agents.

    abstract::The aim of this study was to evaluate the efficiency of hemoperfusion (HP) through coated resin adsorbent Synachrom E-5 in animal intoxications with organophosphate inhibitors of cholinesterases type of nerve agents. Five anesthetized dogs were intoxicated with 2 to 6 LD50 of VX substance and another 4 with 2 to 3 LD5...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1994.tb03317.x

    authors: Monhart V,Fusek J,Brndiar M,Tlustakova M

    更新日期:1994-10-01 00:00:00

  • Effects of inhaled nitric oxide on postoperative pulmonary circulation in patients with congenital heart disease.

    abstract::We studied 22 patients with residual pulmonary hypertension or symptoms of postoperative pulmonary hypertensive crisis. They received low-dose inhalation (10 ppm) of nitric oxide (NO), a selective pulmonary vasodilator, after total correction for congenital heart anomalies. Fifteen minutes of NO inhalation improved th...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1997.tb00692.x

    authors: Matsui J,Yahagi N,Kumon K,Hayashi H,Watanabe Y,Haruna M,Tanigami H,Yagihara T,Takamoto S,Kamiya T

    更新日期:1997-01-01 00:00:00

  • Electrical pulse train and single pulse stimulation of the small intestine: acute and chronic studies in the dog.

    abstract::In vitro tests have shown that electric currents may lead either to relaxation or contraction of the bowel wall. Because voluntary changes of the intestinal motility could be useful in the treatment of intestinal disorders, we investigated the reactions elicited by electrostimulation of the small intestine in the inta...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1989.tb02846.x

    authors: Moritz A,Grundfest-Broniatowski S,Ilyes L,Kasick J,Jacobs G,Olsen E,Nosé Y

    更新日期:1989-04-01 00:00:00