Use of hemoperfusion in experimental intoxication with nerve agents.

Abstract:

:The aim of this study was to evaluate the efficiency of hemoperfusion (HP) through coated resin adsorbent Synachrom E-5 in animal intoxications with organophosphate inhibitors of cholinesterases type of nerve agents. Five anesthetized dogs were intoxicated with 2 to 6 LD50 of VX substance and another 4 with 2 to 3 LD50 sarine. Both nerve agents were given i.m. after starting 5 h HP. The clinical and laboratory tests were monitored during each HP. HP therapy prevented the development of serious signs of intoxication provided that the administered quantity of both sarine and the VX substance was only 2 doses of LD50. Specific antidote therapy was necessary to prevent cardiorespiratory failure in animals intoxicated with a higher dose of poison. The results obtained show that HP through Synachrom E-5 in intoxication with nerve agents sarine and the VX type is only partially successful.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Monhart V,Fusek J,Brndiar M,Tlustakova M

doi

10.1111/j.1525-1594.1994.tb03317.x

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

770-2

issue

10

eissn

0160-564X

issn

1525-1594

journal_volume

18

pub_type

杂志文章
  • Utilization of activated carbon hemoperfusion to assist recovery of ischemically damaged canine liver allografts.

    abstract::The sensitivity of liver allografts to even minimal periods of ischemia currently limits the duration of hepatic preservation prior to liver transplantation. This study evaluates the role of activated carbon hemoperfusion (ACH) for assisting the recovery of canine livers ischemically damaged by a 20-min occlusion of t...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1985.tb04386.x

    authors: Toledo-Pereyra LH

    更新日期:1985-08-01 00:00:00

  • Heparin-coated cardiopulmonary bypass circuits in coronary bypass surgery.

    abstract::Cardiopulmonary bypass (CPB) is a nonphysiologic environment for an organism. The damage of blood components may also lead to organ dysfunction, some-times recognized as postperfusion syndrome. One possible way to diminish the risk of these complications would be to reduce the thorombogenicity and to improve the bioco...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1996.tb04573.x

    authors: Horimoto H,Kondo K,Asada K,Sasaki S

    更新日期:1996-08-01 00:00:00

  • Effect of variation in systemic blood flow on plasma TNF-alpha in a pig model with left ventricular assist device.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) release has been implicated in a sepsis-like syndrome following cardiopulmonary bypass (CPB). This also may be important in patients who have had a left ventricular assist device (LVAD) implanted. This report investigates the effect of reducing systemic blood flow on hemodynamic...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2001.025002146.x

    authors: Uozaki Y,Dihmis WC,Yamauchi H,Moczar M,Miyama M,Pasteau F,Tixier D,Bambang SL,Loisance DY

    更新日期:2001-02-01 00:00:00

  • Are standard human coagulation tests suitable in pigs and calves during extracorporeal circulation?

    abstract::The thrombogenicity of membrane oxygenators as well as clotting parameters profiles, using standard human clotting tests, was analyzed in calves and pigs during 6 h perfusion. Three calves and 3 pigs were connected to extracorporeal circulation with standard heparinization. Blood samples were taken for coagulation var...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2001.025007579.x

    authors: Mueller XM,Tevaearai HT,Jegger D,Tucker O,von Segesser LK

    更新日期:2001-07-01 00:00:00

  • Isoelastic polyurethane prosthesis for segmental trachea replacement in beagle dogs.

    abstract::Porous polyurethane (nonwoven) was used for the development of tracheal prosthesis, which--in a special testing design--was adapted to shape and biomechanic properties of the natural organ. This prosthesis was implanted into 19 beagle dogs using inverted, everted, and end-to-end anastomosis. Insufficiency of the anast...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1989.tb02866.x

    authors: Schauwecker HH,Gerlach J,Planck H,Bücherl ES

    更新日期:1989-06-01 00:00:00

  • Evaluation of the thrombogenicity of selected microporous oxygenator membranes.

    abstract::A comparative study of the thrombogenicity of several microporous membranes was performed using an ex vivo system simulating the conditions in an artificial lung. A study of platelet adhesion and adsorbed protein layer indicated that the membranes separated into three groups. Copolyurethane membranes adsorbed very few...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1985.tb04343.x

    authors: Knight PM,Lyman DJ

    更新日期:1985-02-01 00:00:00

  • Development of a composite degradable/nondegradable tissue-engineered vascular graft.

    abstract::The present study aimed to determine the feasibility of constructing a reinforced autologous vascular graft by combining the advantages of fibrin gel as an autologous cell carrier material with the inherent mechanical strength of an integrated mesh structure. It was hypothesized that the mesh and dynamic culture condi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2008.00601.x

    authors: Tschoeke B,Flanagan TC,Cornelissen A,Koch S,Roehl A,Sriharwoko M,Sachweh JS,Gries T,Schmitz-Rode T,Jockenhoevel S

    更新日期:2008-10-01 00:00:00

  • Development of a novel centrifugal pump: magnetic rotary pump.

    abstract::The rotational axis of the centrifugal pump has some associated problems such as blood destruction and sealing between the axis and pump housing. To improve upon these deficits we have developed a new type of blood pump, the magnetic rotary pump (MRP). The MRP has an original design with no rotational axis and no impe...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb03734.x

    authors: Naganuma S,Yambe T,Sonobe T,Kobayashi S,Nitta S

    更新日期:1997-07-01 00:00:00

  • A new technique to increase coronary flow. Preliminary report.

    abstract::This study was planned to investigate whether part of the energy produced by cardiac contraction to propel blood toward the systemic circulation can be used to increase the coronary flow in systole. Ten devices (I-X) designed to divert laterally part of a flow column (without substantially increasing resistance to flo...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1979.tb01080.x

    authors: Moulopoulos S,Stamatelopoulos S,Boufas D,Yannopoulos C,Marousis G,Kouvaras G

    更新日期:1979-11-01 00:00:00

  • Opening-wedge high tibial osteotomy with and without bone graft.

    abstract::Medial opening-wedge has gained popularity in comparison to other techniques of high tibial osteotomy. This technique involves the creation of a gap in the tibia. Filling the gap with autologous iliac bone graft was recommended in the classic description, to prevent complications such as correction loss or delayed bon...

    journal_title:Artificial organs

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1525-1594.2010.01058.x

    authors: Zorzi AR,da Silva HG,Muszkat C,Marques LC,Cliquet A Jr,de Miranda JB

    更新日期:2011-03-01 00:00:00

  • Bioengineered cartilage in a scaffold-free method by human cartilage-derived progenitor cells: a comparison with human adipose-derived mesenchymal stromal cells.

    abstract::The objective of our study was to investigate chondrogenesis potential of human adipose-derived mesenchymal stromal cells (MSCs), using as a positive control a human source of cartilage-derived progenitor cells (PCs). This source of PCs was recently described by our group and dwells on the surface of nasoseptal cartil...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12121

    authors: Baptista LS,Silva KR,Pedrosa CS,Amaral RJ,Belizário JV,Borojevic R,Granjeiro JM

    更新日期:2013-12-01 00:00:00

  • Aging adversely impacts biological properties of human bone marrow-derived mesenchymal stem cells: implications for tissue engineering heart valve construction.

    abstract::Our aim was to study the aging effects on the in vitro biological properties of bone marrow-derived mesenchymal stem cells (BMSCs) for construction of tissue-engineered heart valves. BMSCs were taken from teenagers with congenital heart diseases, and middle-aged and elderly patients with valvular diseases. Proliferati...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00824.x

    authors: Xin Y,Wang YM,Zhang H,Li J,Wang W,Wei YJ,Hu SS

    更新日期:2010-03-01 00:00:00

  • Anionic collagen: polymer composites with improved dielectric and rheological properties.

    abstract::This work describes the preparation and characterization of anionic collagen composites with rhamsan and vinylidene fluoride-trifluorethylene with improved rheological and dielectric properties without loss of collagen secondary structure with an interaction occurring between both macromolecules of the composites. On ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1998.06109.x

    authors: Goissis G,Piccirili L,Goes JC,de Guzzi Plepis AM,Das-Gupta DK

    更新日期:1998-03-01 00:00:00

  • Clinical indications for the use of the "Poisk-IOM" total artificial heart: the experience of 13 implantations in humans.

    abstract::Success of total artificial heart (TAH) implantation as a temporary measure depends on three factors: proper patient selection, adequate surgical technique, and safe cardiac prostheses. From 1986 until March 1990, 237 patients with stagnant heart failure were examined. Sixty-one patients (27%) were put on a waiting li...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1991.tb00745.x

    authors: Shumakov V,Zimin N,Kazakov E,Kormer A,Vorontsov S,Nikolaenko E,Kozlov I,Drobyshev A

    更新日期:1991-10-01 00:00:00

  • Albumin-coated Amberlite XAD-7 resin for hemoperfusion in acute liver failure. Part II: in vivo evaluation.

    abstract::Albumin-coated Amberlite XAD-7 has been previously shown to be blood compatible in in vitro hemoperfusion experiments whith human blood. In this study, the preliminary results are reported on single hemoperfusions with albumin-coated XAD-7 resin in four patients with acute liver failure. The mean platelet count was 11...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1979.tb03800.x

    authors: Hughes R,Ton HY,Langley P,Davies M,Hanid MA,Mellon P,Silk DB,Williams R

    更新日期:1979-02-01 00:00:00

  • Methodology for identification of serum middle molecules.

    abstract::Filtration through membranes with different nominal cut-off was used for isolation of middle molecule fractions from uremic serum. Comparison was made with test substances which in gel filtration did not show a regular relationship between molecular weight and partition coefficient. The XM50 membrane (cut-off 50,000 D...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:

    authors: Buzio C,Montagna G,Calderini C,Manari A,Migone L

    更新日期:1981-01-01 00:00:00

  • A reduced priming system.

    abstract::Cardiopulmonary bypass (CPB), an integral part of valve surgery, is known to cause hemodilution, which can lead to a need for blood transfusion as well as a systemic inflammatory reaction. Our aim was to evaluate a reduced priming (RP) system for CPB with regard to clinical outcomes in patients undergoing valve surger...

    journal_title:Artificial organs

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1525-1594.2006.00275.x

    authors: Sato K,Namura O,Sogawa M,Shimada K,Tosaka Y,Hayashi J

    更新日期:2006-08-01 00:00:00

  • Prediction of postdialysis serum sodium concentration and transcellular fluid shift without measuring body fluid volumes.

    abstract::The postdialysis levels of serum sodium concentration, urea concentration, and osmolality, as well as the magnitude of both transcellular fluid shifts and sodium removal, were predicted based on computer modeling without measuring body fluid volumes. A 4-h hemodialysis was performed in five patients at a constant ultr...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1983.tb04219.x

    authors: Kimura G,Van Stone JC,Bauer JH

    更新日期:1983-11-01 00:00:00

  • Cellulose acetate beads activate the complement system but inactivate the anaphylatoxins generated.

    abstract::The generation of anaphylatoxins, particularly C5a, is important in extracorporeal circulation therapies such as granulocyte/monocyte apheresis, which activates the complement system and elevates C5a levels. However, no side effects of granulocyte/monocyte apheresis using cellulose acetate beads have been reported. To...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00995.x

    authors: Takeda Y,Ohba M,Ueno M,Saniabadi AR,Wakabayashi I

    更新日期:2010-12-01 00:00:00

  • Vascular access for continuous arteriovenous hemofiltration in infants and young children.

    abstract::The blood flow through the hemofilter device is the key point for ultrafiltrate production during continuous arteriovenous hemofiltration. It mainly depends on arteriovenous pressure gradient and vascular access, which is the major problem for arteriovenous hemofiltration in infants and small children. In infants, we ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1988.tb01518.x

    authors: Zobel G,Trop M,Beitzke A,Ring E

    更新日期:1988-02-01 00:00:00

  • Double-blind evaluation of plasmapheresis in schizophrenic patients: a pilot study.

    abstract::Interest in the effects and possible mechanisms of hemodialysis on schizophrenic patients has led to a double-blind evaluation of the effects of plasmapheresis on symptoms of schizophrenia. Also, plasmapheresis was felt to be an invaluable tool for investigating the autoimmune theory of schizophrenia. Patients (n = 10...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1525-1594.1983.tb04203.x

    authors: Schulz SC,van Kammen DP,Waters R,Klein HG,Balow JE,Bunney WE Jr

    更新日期:1983-08-01 00:00:00

  • Measurement of the closing behavior of the björk-shiley monoleaflet mechanical heart valve with an electrohydraulic total artificial heart.

    abstract::When cavitation occurs near a material surface of a mechanical heart valve (MHV), pits on the surface of the MHV and hemolysis are caused. Therefore, it is very important to investigate the possibility of the occurrence of cavitation in an MHV. To study the possibility of cavitation occurrence in a 25 mm Björk-Shiley ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2003.06981.x

    authors: Lee H,Tsukiya T,Homma A,Taenaka Y,Tatsumi E,Takano H

    更新日期:2003-08-01 00:00:00

  • Double filtration plasmapheresis for the treatment of rheumatoid arthritis: a study of 21 cases.

    abstract::The treatment of rheumatoid arthritis remains difficult and often controversial. Plasma exchange has been advocated in some cases. In the present study 71 sessions of double filtration plasmapheresis (DFPP) were performed in 21 patients with rheumatoid arthritis in an average of 3.7 +/- 1.1 sessions per patient within...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb00344.x

    authors: Liu JD,Zhang C,Li WS,Lun LD

    更新日期:1997-02-01 00:00:00

  • Cerebral and lower limb near-infrared spectroscopy in adults on extracorporeal membrane oxygenation.

    abstract::Percutaneous femoral venoarterial (VA) or jugular venovenous (VV) extracorporeal membrane oxygenation (ECMO) can result in delivery of hypoxic blood to the brain, coronaries, and upper extremities. Additionally, VA-ECMO by percutaneous femoral artery cannulation may compromise perfusion to the lower limbs. Use of near...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2012.01496.x

    authors: Wong JK,Smith TN,Pitcher HT,Hirose H,Cavarocchi NC

    更新日期:2012-08-01 00:00:00

  • Serum hyaluronic acid and interleukin-6 as possible markers of carpal tunnel syndrome in chronic hemodialysis patients.

    abstract::To elucidate the precise mechanism of carpal tunnel syndrome (CTS), serum hyaluronic acid (HA), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were measured in 71 chronic hemodialysis patients with or without CTS and/or shoulder pain. Patients were divided into two gr...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1994.tb02227.x

    authors: Takasu S,Takatsu S,Kunitomo K,Kokumai Y

    更新日期:1994-06-01 00:00:00

  • The mitroflow pericardial valve. First results of a follow-up study.

    abstract::One hundred eighty-eight Mitroflow pericardial valves, implanted on 166 patients from March 1983 to December 1986, have been followed for a total of 4316 patients x months. Mortality rate in the first three postoperative months is approximately 10% related to noncardiac complications. One hundred forty-nine patients a...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1988.tb02781.x

    authors: Loisance D,Hillion ML,Cachera JP

    更新日期:1988-08-01 00:00:00

  • Extracorporeal life support during and after bilateral sequential lung transplantation in patients with pulmonary artery hypertension.

    abstract::The use of extracorporeal membrane oxygenator instead of standard cardiopulmonary bypass during lung transplantation is debatable. Moreover, recently, the concept of prolonged postoperative extracorporeal membrane oxygenator (ECMO) support has been introduced in many transplant centers to prevent primary graft dysfunc...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13628

    authors: Dell'Amore A,Campisi A,Congiu S,Mazzarra S,Pastore S,Dolci G,Baiocchi M,Frascaroli G

    更新日期:2020-06-01 00:00:00

  • Quantification of Shear-Induced Platelet Activation: High Shear Stresses for Short Exposure Time.

    abstract::Thrombosis and thromboembolism are the life-threatening clinical complications for patients supported or treated with prosthetic cardiovascular devices. The high mechanical shear stress within these devices is believed to be the major contributing factor to cause platelet activation (PA) and function alteration, leadi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12438

    authors: Ding J,Chen Z,Niu S,Zhang J,Mondal NK,Griffith BP,Wu ZJ

    更新日期:2015-07-01 00:00:00

  • A Pseudo-One Compartment Model of Phosphorus Kinetics During Hemodialysis: Further Supporting Evidence.

    abstract::A pseudo-one compartment model has been proposed to describe phosphorus kinetics during hemodialysis and the immediate post-dialysis period. This model assumes that phosphorus mobilization from tissues is proportional to the difference between the pre-dialysis serum concentration (a constant) and the instantaneous ser...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12897

    authors: Leypoldt JK,Agar BU,Cheung AK,Bernardo AA

    更新日期:2017-11-01 00:00:00

  • Clinical validation of a predictive modeling equation for sodium.

    abstract::Changes in plasma sodium (Na) concentration during hemodialysis were predicted by changes in Na concentration of the dialysate at equilibrium with the plasma, according to the formula C't = CD - (CD - C'0) [(V0 - QFt)/V0]A/QF, where C'0 and C't are the Na concentration of the dialysate at equilibrium with the plasma a...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1985.tb04365.x

    authors: Man NK,Petitclerc T,Tien NQ,Jehenne G,Funck-Brentano JL

    更新日期:1985-05-01 00:00:00