Effect of variation in systemic blood flow on plasma TNF-alpha in a pig model with left ventricular assist device.

abstract：:The implementation of simultaneous mechanical cavopulmonary assistance having blood pumps located in both of the vena cavae is investigated as an approach to treating patients with an ailing Fontan physiology. Identical intravascular blood pumps are employed to model the hemodynamic support of a patient-specific Fonta...

journal_title：Artificial organs

authors： Throckmorton AL,Lopez-Isaza S,Moskowitz W

更新日期：2013-06-01 00:00:00

abstract：:Transcatheter aortic valve implantation (TAVI) has gained considerable acceptance in the past decade due to its lower risks than conventional open-heart surgery. However, the deformation and delamination of the leaflets during the crimping procedure have raised questions about the durability and long-term serviceabili...

journal_title：Artificial organs

authors： Mao J,Rassoli A,Tong Y,Rouse EN,Le-Bel G,How D,Germain L,Fatouraee N,Zhang Z,Reed RR,Guidoin R

更新日期：2019-10-01 00:00:00

abstract：:To perform the first experimental tests for validation of a new gear unit concept, the pump chamber, diaphragm, and pusher plate design of an orthotopic electromechanical total artificial heart (TAH) (Helmholtz Labtype) was manufactured. In its early stage of development, it provides some of the most important feature...

journal_title：Artificial organs

authors： Kaufmann R,Reul H,Rau G

更新日期：1994-07-01 00:00:00

abstract：:As a preliminary investigation to establish a cryopreservation method suited for bioartificial livers (BALs), three-dimensional (3-D) cryopreservation experiments with fibroblasts were performed, in which the cells were firstly seeded into a porous scaffold, and the scaffold containing the cells was then cryopreserved...

journal_title：Artificial organs

authors： Miyoshi H,Ehashi T,Ohshima N,Jagawa A

更新日期：2010-07-01 00:00:00

abstract：:The polymer poly(ε-caprolactone) (PCL) has been used in the biomaterial field for its relatively inexpensive price and suitability for modification. Also, its chemical and biological properties are desirable for biomedical applications. The electrospinning process has been used for producing polymer fibers of PCL due ...

journal_title：Artificial organs

authors： Capellato P,Silva G,Popat K,Simon-Walker R,Alves Claro AP,Zavaglia C

更新日期：2020-08-01 00:00:00

abstract：:We designed a 24-field array and an on-line control box that selects which and how many of 24 fields will conduct electrical charge during functional electrical stimulation. The array was made using a conductive microfiber textile, silver two-component adhesive, and the conductive ink imprint on the polycarbonate. The...

journal_title：Artificial organs

authors： Popović-Bijelić A,Bijelić G,Jorgovanović N,Bojanić D,Popović MB,Popović DB

更新日期：2005-06-01 00:00:00

abstract：:While pediatric HeartWare HVAD application has increased, determining candidacy and timing for initiation of pediatric VAD support has remained a challenge. We present our experience with a systematic approach to HVAD implantation as a bridge to pediatric heart transplantation. We performed a retrospective, single cen...

journal_title：Artificial organs

authors： Nelson McMillan K,Hibino N,Brown EE,Wadia R,Hunt EA,Marshall C,Alvarez-Machado M,Alejo D,Coulson JD,Ravekes W,Vricella LA

更新日期：2019-01-01 00:00:00

abstract：:A method of creating multifocal ischemia in animals leading to left ventricular (LV) functional impairment is described. In a series of 10 mongrel dogs, electrodes were implanted in multiple branches of the coronary arteries. Subsequently, in seven animals, an 800-microA anodal current was applied for 3 h repeatedly o...

journal_title：Artificial organs

authors： Polanski J,Mandell G,Wasfie T,Freed PS,Yoshizu H,Stein PD,Sabbah HN,Kantrowitz A

更新日期：1984-11-01 00:00:00

abstract：:A comparative study of the thrombogenicity of several microporous membranes was performed using an ex vivo system simulating the conditions in an artificial lung. A study of platelet adhesion and adsorbed protein layer indicated that the membranes separated into three groups. Copolyurethane membranes adsorbed very few...

journal_title：Artificial organs

authors： Knight PM,Lyman DJ

更新日期：1985-02-01 00:00:00

abstract：:Stents are small, usually metallic tubes that are intended to prop open arteries blocked with atherosclerotic plaques. While stents have been used successfully in recent years, they still suffer from failure due to development of new tissue in stented segment (restenosis). Variations in the failure rates associated wi...

journal_title：Artificial organs

authors： Frank AO,Walsh PW,Moore JE Jr

更新日期：2002-07-01 00:00:00

abstract：:Hypoalbuminemia, a strong predictor of morbidity and mortality in hemodialysis patients, can be a consequence of a combination of malnutrition and inflammatory reactions. The purpose of this study was to analyze serum albumin as a marker of nutritional status in maintenance hemodialysis patients with no signs of infla...

journal_title：Artificial organs

authors： Santos NS,Draibe SA,Kamimura MA,Canziani ME,Cendoroglo M,Júnior AG,Cuppari L

更新日期：2003-08-01 00:00:00

abstract：:Extracorporeal life support (ECLS) has been increasingly utilized to manage cardiac and pulmonary dysfunction. The impact of obesity on outcomes of ECLS is poorly defined. The purpose of the study was to compare in-hospital mortality, resource use, complications, and readmissions in obese versus non-obese patients rec...

journal_title：Artificial organs

authors： Christian-Miller N,Hadaya J,Nakhla M,Sanaiha Y,Madrigal J,Emami S,Cale M,Sareh S,Benharash P

更新日期：2020-11-01 00:00:00

abstract：:The aim of this study was to develop procedures for the diagnosis and nonsurgical management of decreased insulin flow in an implantable programmable pump for long-term intraperitoneal or intravenous insulin delivery featuring a sideport. Patency of the catheter lumen was tested by measuring the time needed for sidepo...

journal_title：Artificial organs

authors： Scavini M,Reich S,Eaton RP,Charles MA,Dunn FL

更新日期：1996-09-01 00:00:00

abstract：:The compliance problem represents a major obstacle in the development of implantable blood pumps. The motor-driven pumps are enclosed in an airtight casing with gas in the motor space. The trapped gas in the motor space either increases the load on the motor during systole or impedes blood sac filling. Potential solut...

journal_title：Artificial organs

authors： Lee S,Rosenberg G,Donachy JH,Wisman CB,Pierce WS

更新日期：1984-02-01 00:00:00

abstract：:We have been developing a new type of centrifugal pump for long-term use. The magnetically suspended centrifugal pump (MSCP) contains no shaft and seal so that long life expectancy is predicted. Paracorporeal left ventricular (LV) assist circulation between the left atrium and the descending aorta was instituted using...

journal_title：Artificial organs

authors： Yamada T,Nishimura K,Park CH,Kono S,Yuasa S,Tsukiya T,Akamatsu T,Matsuda K,Ban T

更新日期：1997-07-01 00:00:00

abstract：:Mechanical circulatory support (MCS) devices for pediatric patients continue to lag in development behind those for adults. There is no heart pump with the design innovation to support dysfunctional states of heart failure and the anatomic heterogeneity of cardiac defects in pediatric patients. To address this unmet n...

journal_title：Artificial organs

authors： Fox C,Sarkisyan H,Stevens R,Arabia F,Fischer W,Rossano J,Throckmorton A

更新日期：2019-11-01 00:00:00

abstract：:Stem cells transplanted to an injured heart affect the host myocardium indirectly. The cytokine hepatocyte growth factor (HGF) may play a key role in this paracrine activity. We hypothesized that HGF-overexpressing stem cells would restore cardiac function after myocardial infarction (MI). Because there is a high rate...

journal_title：Artificial organs

authors： Poppe A,Golsong P,Blumenthal B,von Wattenwyl R,Blanke P,Beyersdorf F,Schlensak C,Siepe M

更新日期：2012-03-01 00:00:00

abstract：:Since the introduction of high-performance prosthetic heart valves, particularly bileaflet valves and monoleaflet valves with larger opening angles, we have observed in vivo complex leaflet motion which has not been experimentally confirmed yet. We developed a computer-controlled hydraulic mock circulator to study the...

journal_title：Artificial organs

authors： Ohta Y,Okamoto K,Sonderegger M,Dohi T,Matsumoto H,Horiuchi T

更新日期：1997-04-01 00:00:00

abstract：:A physiological controller is a key component to optimize the performance of left ventricular assist devices (LVADs) from short term to long term (10-20 years). The difficulties of its design lie in the inaccurate modeling of any particular human cardiovascular system because of limited knowledge, the large fluctuatio...

journal_title：Artificial organs

authors： Wu Y,Allaire PE,Tao G,Adams M,Liu Y,Wood H,Olsen DB

更新日期：2004-10-01 00:00:00

abstract：:An apparatus has been contructed to regulate ultrafiltration accurately during dialysis. The principle of the apparatus is that, per unit of time, exactly the same amount of dialysate is introduced into the dialyzer as is discharged from it. The apparatus consists of two isovolumetric pumps connected in line. The four...

journal_title：Artificial organs

authors： Flendrig JG,Carpay WM,Dekkers WT

更新日期：1978-05-01 00:00:00

abstract：:Planar particle image velocimetry was used to explore the flow behavior of the newly designed 12-cc Penn State pneumatic pediatric assist pump. Wall shear maps complemented the velocity data. Bjork-Shiley Monostrut 17-mm mechanical heart valves were used in the inlet and outlet ports. In comparison with larger Penn St...

journal_title：Artificial organs

authors： Manning KB,Wivholm BD,Yang N,Fontaine AA,Deutsch S

更新日期：2008-06-01 00:00:00

abstract：:Following implantation of a left ventricular assist device (LVAD), acceptable functional performance is now being achieved; however, peak VO2 and peak work load (watts) remain considerably limited. Maximum physical capacity is essentially dependent on generated cardiac output (CO) and arteriovenous oxygen difference (...

journal_title：Artificial organs

authors： Schmidt T,Bjarnason-Wehrens B,Mommertz S,Hannig M,Schulte-Eistrup S,Willemsen D,Reiss N

更新日期：2018-07-01 00:00:00

abstract：:This article describes a new powering system for implantable medical devices that could significantly increase their lifetime. The idea is based on the substitution of the usual implantable device battery for an electric accumulator (rechargeable battery), which is fed by the electric power generated by a photovoltaic...

journal_title：Artificial organs

authors： Algora C,Peña R

更新日期：2009-10-01 00:00:00

abstract：:Porous polyurethane (nonwoven) was used for the development of tracheal prosthesis, which--in a special testing design--was adapted to shape and biomechanic properties of the natural organ. This prosthesis was implanted into 19 beagle dogs using inverted, everted, and end-to-end anastomosis. Insufficiency of the anast...

journal_title：Artificial organs

authors： Schauwecker HH,Gerlach J,Planck H,Bücherl ES

更新日期：1989-06-01 00:00:00

abstract：:Thousands of ventricular assist devices (VADs) currently provide circulatory support to patients worldwide, and dozens of heart pump designs for adults and pediatric patients are under various stages of development in preparation for translation to clinical use. The successful bench-to-bedside development of a VAD inv...

journal_title：Artificial organs

authors： Throckmorton AL,Patel-Raman SM,Fox CS,Bass EJ

更新日期：2016-06-01 00:00:00

abstract：:Replacing the renal excretion of low molecular weight proteins (LMWP) by extracorporeal dialysis (dialysis) treatment poses technological challenges. Hemodialyzers with sieving coefficients for LMWP that match or even exceed those of the glomerular membrane barrier are commercially available; however, the associated l...

journal_title：Artificial organs

authors： Glancey G

更新日期：2020-10-01 00:00:00

abstract：:For some time now researchers have argued the efficacy of pulsatile versus nonpulsatile hemodynamic support. Pulsatile systems, while providing a more physiological pumping source, are burdened with a multiparametric output function that can greatly affect the utility of such ventricular assist device (VAD) support. A...

journal_title：Artificial organs

authors： Mills TC,Ott RA

更新日期：1992-04-01 00:00:00

abstract：:This paper describes a new miniaturized implantable bladder controller that is composed of 4 main parts: a volume monitoring device based on the tomography approach, a fully programmable miniaturized central processor and stimulator, a bidirectional data and power link, and an external controller. The proposed system ...

journal_title：Artificial organs

authors： Sawan M,Arabi K,Provost B

更新日期：1997-03-01 00:00:00

abstract：:This article reports preliminary results of pilot studies of a new implantable two channel drop foot stimulator. The stimulator consists of an externally worn transmitter inductively coupled to an implanted receiver unit located in the lower leg, lateral and distal to the knee. The receiver is connected to electrodes ...

journal_title：Artificial organs

authors： Kenney L,Bultstra G,Buschman R,Taylor P,Mann G,Hermens H,Holsheimer J,Nene A,Tenniglo M,van der Aa H,Hobby J

更新日期：2002-03-01 00:00:00

abstract：:To evaluate the potential clinical usefulness of a modified hemoglobin, pyridoxalated hemoglobin polyoxyethylene conjugate (PHP), the hindlimb vascular bed was perfused with PHP solution while monitoring tissue oxygen tension (PtO2) in anesthetized dogs. The hindlimb region was perfused through the external iliac arte...

journal_title：Artificial organs

authors： Kida Y,Yamakawa T,Iwasaki S,Furusho N,Kadowaki Y,Iwata S,Iwashita Y,Nishi K

更新日期：1995-06-01 00:00:00