The compliance problem: a major obstacle in the development of implantable blood pumps.

abstract：:Hypoalbuminemia, a strong predictor of morbidity and mortality in hemodialysis patients, can be a consequence of a combination of malnutrition and inflammatory reactions. The purpose of this study was to analyze serum albumin as a marker of nutritional status in maintenance hemodialysis patients with no signs of infla...

journal_title：Artificial organs

authors： Santos NS,Draibe SA,Kamimura MA,Canziani ME,Cendoroglo M,Júnior AG,Cuppari L

更新日期：2003-08-01 00:00:00

abstract：:The heparin-conjugated fibrin (HCF) system has been developed to deliver bone morphogenetic proteins (BMPs) for a long-term period and thus enhance bone regeneration. In the present study, we tested the effectiveness of the delivery system for spinal fusion with a very low dose of BMP-2. A total of 15 rabbits underwen...

journal_title：Artificial organs

authors： Koo KH,Lee JM,Ahn JM,Kim BS,La WG,Kim CS,Im GI

更新日期：2013-05-01 00:00:00

abstract：:To evaluate their toxicity at the cellular level, middle molecules from uremic serum were incubated with erythrocytes from healthy subjects and the activity of the enzyme Delta-aminolevulinic acid dehydrase (D-ALA-D) and peroxidative hemolysis were investigated. Uremic middle molecules caused a significant decrease of...

journal_title：Artificial organs

authors： Leber HW,Spiegelhalter R,Ulm A,Goubeaud G,Rawer P

更新日期：1978-11-01 00:00:00

abstract：:In 1993, the development began of a small axial flow blood pump, the DeBakey ventricular assist device (VAD). The material was recently converted to a titanium alloy, and a waterproof pump package was incorporated for long-term intracorporeal circulation. Thirteen intrathoracic implantations in calves were achieved. N...

journal_title：Artificial organs

authors： Tayama E,Olsen DB,Ohashi Y,Benkowski R,Morley D,Noon GP,Nosé Y,Debakey ME

更新日期：1999-12-01 00:00:00

abstract：:Using an ex vivo model, the effects of membrane composition and surface area on both the complement system (as reflected by plasma C3a levels) and platelets [as indicated by plasma concentrations of thromboxane B2 (TXB2) and platelet factor 4 (PF4)] were studied. In this model, polyacrylonitrile (PAN) was associated w...

journal_title：Artificial organs

authors： Mahiout A,Meinhold H,Kessel M,Schulze H,Baurmeister U

更新日期：1987-04-01 00:00:00

abstract：:This article presents results from the field calculation in a model of biological tissue taking into account the electroporation process. The electroporation model used in this study was proposed and experimentally verified by Glaser et al. for planar membranes. The numerical method for field calculation is based on a...

journal_title：Artificial organs

authors： Ramos A

更新日期：2005-06-01 00:00:00

abstract：:An investigation has been made into whether charcoal hemoperfusion stimulates a hyperplastic response in the liver of the normal rat. Animals underwent hemoperfusion over Norit RBX1 (Strathclyde, Glasgow, U.K.) charcoal granules using a technique which allowed perfusion in the unrestrained and conscious state. Control...

journal_title：Artificial organs

authors： Ryan CJ,Courtney JM,Wood CB,Blumgart LH

更新日期：1982-05-01 00:00:00

abstract：:Changing financial incentives have strongly influenced dosing patterns of recombinant human erythropoietin (rHuEPO) since its introduction in 1989. Although guidelines for prescribing rHuEPO exist, the extent to which they are adhered to is unknown. Using a retrospective cohort observational study design, the factors ...

journal_title：Artificial organs

authors： Thamer M,Richard CM,Klinkmann J,Ivanovich P,Lang G,Cotter DJ

更新日期：2000-02-01 00:00:00

abstract：:Present-day computational fluid dynamics (CFD) techniques can be used to analyze the behavior of fluid flow in a variety of pumps. CFD can be a powerful tool during the design stage for rapid virtual prototyping of different designs, analyzing performance parameters, and making design improvements. Computational flow ...

journal_title：Artificial organs

authors： Sukumar R,Athavale MM,Makhijani VB,Przekwas AJ

更新日期：1996-06-01 00:00:00

abstract：:Magnevad II is an improved version of Magnevad I and both are fourth-generation axial flow left ventricular assist devices. A major simplification has been implemented and tested. Magnevad I used a magnetically suspended rotor requiring active axial control. Magnevad II is completely passive but otherwise similar. A s...

journal_title：Artificial organs

authors： Goldowsky M,Lafaro R,Reed G

更新日期：2005-10-01 00:00:00

abstract：:One of the most important factors that seems to be involved in total hip replacement is periprosthetic osteolysis. As it is well documented that several interleukins (ILs) are triggered in periprosthetic osteolysis, this article investigates the role of five ILs in primary and replacement total hip arthroplasty, under...

journal_title：Artificial organs

authors： Beraudi A,Stea S,Cremonini S,Visentin M,Toni A

更新日期：2009-07-01 00:00:00

abstract：:Medial opening-wedge has gained popularity in comparison to other techniques of high tibial osteotomy. This technique involves the creation of a gap in the tibia. Filling the gap with autologous iliac bone graft was recommended in the classic description, to prevent complications such as correction loss or delayed bon...

journal_title：Artificial organs

authors： Zorzi AR,da Silva HG,Muszkat C,Marques LC,Cliquet A Jr,de Miranda JB

更新日期：2011-03-01 00:00:00

abstract：:Existing peritoneal dialysis (PD) solutions were formulated for the maintenance of fluid and electrolyte balance, correction of metabolic acidosis, and the removal of metabolic waste products. Solutions currently in development are designed to improve biocompatibility by neutralizing pH and reducing glucose degradatio...

journal_title：Artificial organs

authors： Martis L,Chen C,Moberly JB

更新日期：1998-01-01 00:00:00

abstract：:We aimed to investigate whether acellular endocardium can be used as a useful biomaterial for the intima of engineered small-caliber vascular grafts. Fresh endocardium was harvested from the swine left atrium and was decellularized by digestion with the decellularization solution of Triton X-100 and SDS containing DNa...

journal_title：Artificial organs

authors： Wang F,Guan X,Wu T,Qiao J,Han Z,Wu J,Yu X,You Q

更新日期：2016-12-01 00:00:00

abstract：:The development of a ventricular assist device is depicted. The seven subprograms that make up the project are described briefly. Results obtained during the clinical assay showed that the new design of the input cannula working as a false auricle provides better efficiency, as well as a certain level of autoregulatio...

journal_title：Artificial organs

authors： del Cañizo JF,Antoranz JC,Desco MM,Alvarez-Valdivielso JM,Fernandez-Caleya D,López M,Garcia-Barreno P,Duarte J

更新日期：1994-07-01 00:00:00

abstract：:To assess the influence of hydration state on plasma volume (PV) changes during ultrafiltration, 11 clinically normhydrated patients on maintenance hemodialysis were studied intraindividually during 2 hydration states differing by 2-15% of lean body mass (LBM). Plasma volume was measured continually during a 15-min ul...

journal_title：Artificial organs

authors： Wizemann V,Leibinger A,Mueller K,Nilson A

更新日期：1995-05-01 00:00:00

abstract：:The characteristic depressed hemodynamic state and gradually declining circulatory function in Fontan patients necessitates alternative postoperative management strategies incorporating a system level approach. In this study, the single-ventricle Fontan circulation is modeled by constructing a practical in vitro bench...

journal_title：Artificial organs

authors： Dur O,Lara M,Arnold D,Vandenberghe S,Keller BB,DeGroff C,Pekkan K

更新日期：2009-11-01 00:00:00

abstract：:The clearance characteristics of two sizes of hemodialyzers (0.9 m2 and 1.5 m2) from the same range of products have been studied over the dialysate flow range of 500-3,000 ml/min to establish the device's overall mass transfer resistance characteristics. The results obtained demonstrate a difference in the overall ma...

journal_title：Artificial organs

authors： Allen R,Frost TH,Hoenich NA

更新日期：1995-11-01 00:00:00

abstract：:The Genius is a convenient single-pass batch hemodialysis system. Dialysate is heated during the preparation phase. Once the container is filled at one of the three available starting temperatures, dialysate cools spontaneously. As dialysate temperature plays an important role in hemodynamic stability, knowledge of th...

journal_title：Artificial organs

authors： Dhondt A,Eloot S,Verbeke F,Vanholder R

更新日期：2010-12-01 00:00:00

abstract：:Giant cerebral aneurysms may be untreatable by conventional neurosurgical techniques. Early attempts to use circulatory assistance and deep hypothermia were abandoned due to hemorrhagic complications. More recently, interest in circulatory support for complex neurosurgical procedures has been renewed. A consecutive se...

journal_title：Artificial organs

authors： Mesana T,Collart F,Caus T,Pomane C,Graziani N,Bruder N,Dufour H,Grisoli F,Montiès JR

更新日期：2000-06-01 00:00:00

abstract：:The generation of anaphylatoxins, particularly C5a, is important in extracorporeal circulation therapies such as granulocyte/monocyte apheresis, which activates the complement system and elevates C5a levels. However, no side effects of granulocyte/monocyte apheresis using cellulose acetate beads have been reported. To...

journal_title：Artificial organs

authors： Takeda Y,Ohba M,Ueno M,Saniabadi AR,Wakabayashi I

更新日期：2010-12-01 00:00:00

abstract：:In patients with reduced respiratory function, lung resection is associated with high risk because separate ventilation is generally needed for safe management. For patients with end-stage emphysema, intraoperative respiratory management is important and particularly difficult because neither incomplete oxygenation no...

journal_title：Artificial organs

authors： Tsunezuka Y,Sato H,Tsubota M,Seki M

更新日期：2000-01-01 00:00:00

abstract：:Cardiopulmonary bypass (CPB), an integral part of valve surgery, is known to cause hemodilution, which can lead to a need for blood transfusion as well as a systemic inflammatory reaction. Our aim was to evaluate a reduced priming (RP) system for CPB with regard to clinical outcomes in patients undergoing valve surger...

journal_title：Artificial organs

authors： Sato K,Namura O,Sogawa M,Shimada K,Tosaka Y,Hayashi J

更新日期：2006-08-01 00:00:00

abstract：:The efficacy of three flushing techniques on subsequent liver function was assessed using the in vivo isolated liver perfusion model (ILPM). Livers from brain-dead mongrel dogs were flushed with cold Euro-Collins as follows: Group I, rapid in situ flushing (10 min); Group II, regular in situ flushing (45 min); Group I...

journal_title：Artificial organs

authors： Castellanos J,Toledo-Pereyra LH,Finkelstein I,Kestenberg W,Chapman M,Choudhury S

更新日期：1988-06-01 00:00:00

abstract：:Few instruments are currently available to test mitral valve function in an ex vivo state due to the technical difficulties involved. To investigate the native ex vivo mitral valve or prosthetic mitral valve with chordae, we developed a mitral valve adapter with an annulus suturing portion and 2 papillary muscle sutur...

journal_title：Artificial organs

authors： Katoh T,Ikeda N,Nishi K,Gohra H,Hamano K,Noda H,Fujimura Y,Esato K

更新日期：1999-10-01 00:00:00

abstract：:A comparative assessment has been made regarding efficacy and safety of the double filtration plasmapheresis (DFPP), thermofiltration (TFPP), and low-density lipoprotein (LDL) adsorptive (PA) methods by making a crossover test on heterozygous familial hypercholesterolemia patients. Treatments by DFPP, TFPP (secondary ...

journal_title：Artificial organs

authors： Suzuki M,Yamane S,Matsugane T,Nobuto T,Azuma N,Nishide T,Shinomiya M,Saito K,Sasaki N,Nosé Y

更新日期：1996-04-01 00:00:00

abstract：:The present study aimed to determine the feasibility of constructing a reinforced autologous vascular graft by combining the advantages of fibrin gel as an autologous cell carrier material with the inherent mechanical strength of an integrated mesh structure. It was hypothesized that the mesh and dynamic culture condi...

journal_title：Artificial organs

authors： Tschoeke B,Flanagan TC,Cornelissen A,Koch S,Roehl A,Sriharwoko M,Sachweh JS,Gries T,Schmitz-Rode T,Jockenhoevel S

更新日期：2008-10-01 00:00:00

abstract：:We have made an eccentric roller type total artificial heart (ERTAH). The ERTAH is a positive-displacement device comparable to a DeBakey roller pump. Its left and right outputs are determined by the size of its blood chambers, and the ratio of its left and right output is almost constant. We focused on an interatrial...

journal_title：Artificial organs

authors： Wada H,Fukunaga S,Watari M,Sakai H,Sugawara Y,Ochikubo H,Imai K,Shibamura H,Orihashi K,Sueda T,Matsuura Y

更新日期：1999-08-01 00:00:00

abstract：:Coil-type silicone membrane oxygenators can only be used with roller blood pumps due to the resistance from the high blood flow. Therefore, during extracorporeal membrane oxygenation (ECMO) treatment, the combination of a roller pump and an oxygenator with a high blood flow resistance will induce severe hemolysis, whi...

journal_title：Artificial organs

authors： Motomura T,Maeda T,Kawahito S,Matsui T,Ichikawa S,Ishitoya H,Kawamura M,Nishimura I,Shinohara T,Oestmann D,Glueck J,Kawaguchi Y,Sato K,Nosé Y

更新日期：2002-11-01 00:00:00

abstract：:The aim of this work is the evaluation of four different heat exchangers used for myocardium during cardioplegic system in cardiac surgeries. Four types of shell and tube heat exchangers made of different exchange elements were constructed, as follows: stainless steel tubes, aluminium tubes, polypropylene hollow fiber...

journal_title：Artificial organs

authors： Drummond M,Novello WP,de Arruda AC,Braile DM

更新日期：2003-05-01 00:00:00