Abstract:
:Changing financial incentives have strongly influenced dosing patterns of recombinant human erythropoietin (rHuEPO) since its introduction in 1989. Although guidelines for prescribing rHuEPO exist, the extent to which they are adhered to is unknown. Using a retrospective cohort observational study design, the factors influencing the initial dosing of rHuEPO prescribed to 413 hemodialysis patients in 1994 were examined. Patient weight, the only recommended guideline, was not found to be a significant predictor of dosing of rHuEPO after controlling for selected patient demographic and clinical characteristics. The strongest predictor for initial rHuEPO dosing was hematocrit followed by White race (p < 0.05). Finally, each subsequent month was associated with a significantly larger initial rHuEPO dose, reflecting the general trend in increasing dose since 1991 (p < 0.001). In conclusion, despite the recent DOQI guidelines for treatment of anemia among persons with chronic renal failure, providers are not using patient weight as an independent criterion for determining dosing of rHuEPO.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Thamer M,Richard CM,Klinkmann J,Ivanovich P,Lang G,Cotter DJdoi
10.1046/j.1525-1594.2000.06495.xsubject
Has Abstractpub_date
2000-02-01 00:00:00pages
91-4issue
2eissn
0160-564Xissn
1525-1594pii
aor6495journal_volume
24pub_type
杂志文章abstract::We have made an eccentric roller type total artificial heart (ERTAH). The ERTAH is a positive-displacement device comparable to a DeBakey roller pump. Its left and right outputs are determined by the size of its blood chambers, and the ratio of its left and right output is almost constant. We focused on an interatrial...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1046/j.1525-1594.1999.06414.x
更新日期:1999-08-01 00:00:00
abstract::Infusion into rats of the polycation hexadimethrine (HDM) leads to onset of massive proteinuria, which recovers when the infusion is stopped. Several lines of evidence indicate that the proteinuria results from binding of HDM to polyanions of the glomerular filter, with neutralization of shielding of their charges. To...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1987.tb02712.x
更新日期:1987-12-01 00:00:00
abstract::Cardiovascular disorders are the leading causes of mortality and morbidity in the developed world. Cell-based modalities have received considerable scientific attention over the last decade for their potential use in this clinical arena. This review was intended as a brief overview on the subject of therapeutic potent...
journal_title:Artificial organs
pub_type: 杂志文章,评审
doi:10.1111/j.1525-1594.2006.00209.x
更新日期:2006-04-01 00:00:00
abstract::As a preliminary investigation to establish a cryopreservation method suited for bioartificial livers (BALs), three-dimensional (3-D) cryopreservation experiments with fibroblasts were performed, in which the cells were firstly seeded into a porous scaffold, and the scaffold containing the cells was then cryopreserved...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.2009.00933.x
更新日期:2010-07-01 00:00:00
abstract::Bone marrow mesenchymal stem cells (MSCs) have demonstrated their pluripotency to differentiate into different cell lineages and may be an alternative cell source for vascular tissue engineering. The objective of this study is to create small diameter vessels by seeding and culture of genetically modified MSCs onto a ...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.2006.00322.x
更新日期:2006-12-01 00:00:00
abstract::The power-law based models for predicting shear-induced hemolysis are widely used in the optimization design of blood-contacting devices. However, this category of models has fallen short of accuracy when compared with the results of the in vitro experiments. The aim of this study is to develop an alternative model fr...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.12294
更新日期:2014-12-01 00:00:00
abstract::We compared in vitro rates of hemolysis for a recently developed centrifugal pump with a conventional roller pump (10-10-00; Stöckert, Munich, Germany). Flow rates of 0.3 L/min and 1 L/min and a pressure of 200 mm Hg were chosen to simulate conditions during neonatal extracorporeal membrane oxygenation (ECMO). There w...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1996.tb04485.x
更新日期:1996-05-01 00:00:00
abstract::Two series of experiments were conducted to assess the potential of artificial ventricular bypass in restoring cardiac activity. One series evaluated use of a paracorporeal left ventricle in 17 calves; the other evaluated biventricular bypass in 11 calves. Module pumps with a seamless blood chamber of polyurethane wer...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1987.tb02622.x
更新日期:1987-02-01 00:00:00
abstract::Nonpulsatile blood pumps are mainly used in extracorporeal life support systems. Although pulsating blood flow is known to be physiological, a pulsatile pump is not commonly applied in a circuit with a membrane oxygenator because of damage to the blood cells. The hypothesis that the placement of a pressure-relieving c...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.2004.07341.x
更新日期:2004-12-01 00:00:00
abstract::Recent reports suggest a survival advantage for dialysis patients treated by postdilutional online hemodiafiltration (OL-HDF) who achieve higher volume convective exchanges. As such, the factors associated with achieving higher convective volume exchange were determined. The convective exchange volumes during the midw...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.12709
更新日期:2016-12-01 00:00:00
abstract::In this pilot study, we assessed the feasibility of using positron emission tomography (PET) imaging for in vivo measurement of skeletal muscle ventricle (SMV) tissue blood flow. In 4 dogs, with SMVs prepared from their latissimus dorsi muscle, we quantified SMV tissue blood flow by PET and related it to the tissue fl...
journal_title:Artificial organs
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract::Right ventricular failure is one of the most common complications encountered after left ventricular assist device implantation and heart transplantation. It has been reported to have an incidence up to 30%. It increases morbidity and short-term mortality. Impella RP is a small pump that can provide up to 4L/min of fl...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.13610
更新日期:2020-05-01 00:00:00
abstract::Left ventricle (LV) unloading caused by a left ventricular assist device (LVAD) has been shown to enhance reverse LV remodeling in end-stage cardiomyopathy. Several reports consistently suggest that a pulsatile-flow LVAD has more profound effects compared to continuous-flow LVAD, though the responsible mechanisms are ...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.13348
更新日期:2019-04-01 00:00:00
abstract::Four hundred and forty-two serum ferritin determinations were performed in 144 patients on chronic intermittent hemodialysis treatment with intravenous iron substitution and/or oral iron substitution. Iron substitution should be done individually according to regular serum ferritin determinations. Intravenous iron sub...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1981.tb03980.x
更新日期:1981-05-01 00:00:00
abstract::The presence in rat serum of three novel immunosuppressive proteins is associated with induction of tolerance after liver grafting. One of these, KX-5 (40 kilodalton molecular weight) is present 40-100 days after grafting of DA liver into PVG, a combination in which liver grafts are not rejected; two others, KX-2 (87 ...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1996.tb00646.x
更新日期:1996-10-01 00:00:00
abstract::This paper discussed issues of ethical assessment and moral concern associated with organ replacement and physical enhancement: research, allocation, organ donation, artificial organs, xenografts, biomaterials, and neuromaterials. While emphasizing the medical and moral benefits over associated risks, it calls for a b...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1995.tb02362.x
更新日期:1995-05-01 00:00:00
abstract::To analyze the autonomic nervous system during left heart bypass with a vibrating flow pump (VFP), fluctuations in hemodynamic derivatives were evaluated by the spectral analysis method using fast fourier transform methodology. After the left pleural cavity was opened through the fourth intercostal space under general...
journal_title:Artificial organs
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract::Cybernetics-based concepts can allow for complete independence for paralyzed individuals, including sensory motor recovery. Spinal cord injuries are responsible for a huge stress on health and a financial burden to society. This article focuses on novel procedures such as functional diagnosis for paraplegics and tetra...
journal_title:Artificial organs
pub_type: 杂志文章,评审
doi:10.1111/aor.12620
更新日期:2015-10-01 00:00:00
abstract::The rotary blood pump will be an implantable left ventricular assist device (LVAD) in the near future. However, the best control method and the interrelationship between the rotary blood pump and native heart functions are unclear. An estimation was made of the native heart cardiac output from the change of an LVAD's ...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1046/j.1525-1594.1998.06127.x
更新日期:1998-05-01 00:00:00
abstract::Neurologic complications during neonatal extracorporeal life support (ECLS) are associated with significant morbidity and mortality. Gaseous microemboli (GME) in the ECLS circuit may be a possible cause. Advances in neonatal circuitry may improve hemodynamic performance and GME handling leading to reduction in patient...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.12908
更新日期:2017-04-01 00:00:00
abstract::In clinical application of rotary blood pumps, flow obstruction as a result of suction of the inflow cannula, kinking of tubing, or thrombus formation occurs quite frequently. Early detection of such problems is essential to avoid hemolysis, tissue degradation, or release of thrombi to the patient. A program was devel...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1995.tb02409.x
更新日期:1995-07-01 00:00:00
abstract::A computational fluid dynamic model to assess the impact of flow-diverter device on intra-aneurysmal flow in complex aortic aneurysm from the viewpoint of hemodynamics is presented. The aim of this study is to investigate the hemodynamic effects of an endovascular flow-diverter technique using multiple overlapping unc...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.12993
更新日期:2018-02-01 00:00:00
abstract::Five hundred and eighty homograft valves have been inserted into the aortic position as isolated valve replacements, and followed up for 7--14 years. After ten years 90% of frozen homografts, 80% of autografts and 70% of freeze-dried homografts were free of valve-related death. There was only one embolism reported giv...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1980.tb03894.x
更新日期:1980-02-01 00:00:00
abstract::This is a revision of the IDE Application Form, "How to Comply with the Food and Drug Administration's New 'Investigational Device Exemption (IDE)' Regulations, Including an Application Form" originally published in Artificial Organs, Volume 4, Number 4, November 1980. This publication updates the IDE application form...
journal_title:Artificial organs
pub_type: 杂志文章
doi:
更新日期:1982-02-01 00:00:00
abstract::Patients with kidney failure can only survive with some form of kidney replacement (transplant or dialysis). Unfortunately, innovations in kidney replacement therapy lag behind many other medical fields. This study compiles expert opinions on candidate technologies for future kidney replacement therapies. A worldwide ...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.13784
更新日期:2020-07-22 00:00:00
abstract::For the last few years we have attempted to separate and isolate from biological fluids the uremic Middle Molecules (MM). The first step in the treatment of plasma is an ultrafiltration through AN69 membrane. The samples are fractionated by Sephadex G-15 chromatography into 9 peaks "a" to "i' under precise conditions ...
journal_title:Artificial organs
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::In this study, the hypothesis was tested that a low-resistant, high-compliant oxygenator provides better pulse conductance and less hemolysis than a high-resistant, low-compliant oxygenator during pulsatile cardiopulmonary bypass. Forty adults undergoing coronary artery bypass surgery were randomly divided into two gr...
journal_title:Artificial organs
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1525-1594.2009.00853.x
更新日期:2010-04-01 00:00:00
abstract::Porous polyurethane (nonwoven) was used for the development of tracheal prosthesis, which--in a special testing design--was adapted to shape and biomechanic properties of the natural organ. This prosthesis was implanted into 19 beagle dogs using inverted, everted, and end-to-end anastomosis. Insufficiency of the anast...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1989.tb02866.x
更新日期:1989-06-01 00:00:00
abstract::The limited success of cardiac stem cell therapy has lately generated discussion regarding its effectiveness. We hypothesized that immediate cell loss after intramyocardial injection significantly obscures the regenerative potential of stem cell therapy. Therefore, our aim was to assess the distribution and quantity o...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.12268
更新日期:2014-11-01 00:00:00
abstract::The vibrating flow pump (VFP) can generate high frequency oscillated blood flow. Because of the high frequency driving with short stroke volume, the pump system can be small. The disposable type VFP (D-VFP) was developed for use for extracorporeal circulation. The electromagnetic actuator was detached from the vibrati...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1997.tb03724.x
更新日期:1997-07-01 00:00:00