Probing expert opinions on the future of kidney replacement therapies.

abstract：:Most bioartificial liver support systems are based on hollow fiber capillaries within modified dialysis cartridges or more sophisticated bioreactor constructions. Due to their design microscopic follow-up of reorganization and growth of tissue between the hollow fibers is not possible. The SlideReactor is a simple hol...

journal_title：Artificial organs

authors： Sauer IM,Schwartlander R,Schmid J,Efimova E,Vondran FW,Kehr D,Pless G,Spinelli A,Brandenburg B,Hildt E,Neuhaus P

更新日期：2005-03-01 00:00:00

abstract：:Medial opening-wedge has gained popularity in comparison to other techniques of high tibial osteotomy. This technique involves the creation of a gap in the tibia. Filling the gap with autologous iliac bone graft was recommended in the classic description, to prevent complications such as correction loss or delayed bon...

journal_title：Artificial organs

authors： Zorzi AR,da Silva HG,Muszkat C,Marques LC,Cliquet A Jr,de Miranda JB

更新日期：2011-03-01 00:00:00

abstract：:A 68-year-old woman with fulminant hepatic failure of unknown etiology was treated with a bioartificial liver assist device. Prior to treatment, she had a number of clinical and laboratory features that suggested a hopeless outcome. Treatment was associated with a dramatic change in her mental status, and her clinical...

journal_title：Artificial organs

authors： Sussman NL,Kelly JH

更新日期：1993-01-01 00:00:00

abstract：:The ventricular assist device inflow cannulation site is the primary interface between the device and the patient. Connecting these cannulae to either atria or ventricles induces major changes in flow dynamics; however, there are little data available on precise quantification of these changes. The objective of this i...

journal_title：Artificial organs

authors： Timms D,Gregory S,Hsu PL,Thomson B,Pearcy M,McNeil K,Fraser J,Steinseifer U

更新日期：2010-09-01 00:00:00

abstract：:In an effort to improve and automate the fluid dynamic design of rotary blood pumps, a coupled computational fluid dynamics (CFD) shape optimization methodology has been developed and implemented. This program couples a finite element flow simulation with a gradient-based optimization routine to modify automatically t...

journal_title：Artificial organs

authors： Antaki JF,Ghattas O,Burgreen GW,He B

更新日期：1995-07-01 00:00:00

abstract：:The characteristic depressed hemodynamic state and gradually declining circulatory function in Fontan patients necessitates alternative postoperative management strategies incorporating a system level approach. In this study, the single-ventricle Fontan circulation is modeled by constructing a practical in vitro bench...

journal_title：Artificial organs

authors： Dur O,Lara M,Arnold D,Vandenberghe S,Keller BB,DeGroff C,Pekkan K

更新日期：2009-11-01 00:00:00

abstract：:The development of a ventricular assist device is depicted. The seven subprograms that make up the project are described briefly. Results obtained during the clinical assay showed that the new design of the input cannula working as a false auricle provides better efficiency, as well as a certain level of autoregulatio...

journal_title：Artificial organs

authors： del Cañizo JF,Antoranz JC,Desco MM,Alvarez-Valdivielso JM,Fernandez-Caleya D,López M,Garcia-Barreno P,Duarte J

更新日期：1994-07-01 00:00:00

abstract：:In clinical application of rotary blood pumps, flow obstruction as a result of suction of the inflow cannula, kinking of tubing, or thrombus formation occurs quite frequently. Early detection of such problems is essential to avoid hemolysis, tissue degradation, or release of thrombi to the patient. A program was devel...

journal_title：Artificial organs

authors： Holzer S,Scherer R,Schmidt C,Schwendenwein I,Wieselthaler G,Noisser R,Schima H

更新日期：1995-07-01 00:00:00

abstract：:This study demonstrates in a novel way how volume and shape are restored to denervated degenerated muscles due to a special pattern of electrical stimulation. To this purpose, Spiral Computer Tomography (CT) and special image processing tools were used to develop a method to isolate the rectus femoris from other muscl...

journal_title：Artificial organs

authors： Gargiulo P,Vatnsdal B,Ingvarsson P,Knútsdóttir S,Gudmundsdóttir V,Yngvason S,Helgason T

更新日期：2008-08-01 00:00:00

abstract：:In vitro cardiovascular device performance evaluation in a mock circulation loop (MCL) is a necessary step prior to in vivo testing. A MCL that accurately represents the physiology of the cardiovascular system accelerates the assessment of the device's ability to treat pathological conditions. To serve this purpose, a...

journal_title：Artificial organs

authors： Timms DL,Gregory SD,Greatrex NA,Pearcy MJ,Fraser JF,Steinseifer U

更新日期：2011-04-01 00:00:00

abstract：:Five hundred and eighty homograft valves have been inserted into the aortic position as isolated valve replacements, and followed up for 7--14 years. After ten years 90% of frozen homografts, 80% of autografts and 70% of freeze-dried homografts were free of valve-related death. There was only one embolism reported giv...

journal_title：Artificial organs

authors： Bodnar E,Wain WH,Martelli V,Ross DN

更新日期：1980-02-01 00:00:00

abstract：:Implantable ventricular assist devices have proven efficacious as a bridge to transplantation and as a bridge to recovery. Although current indications for use of assist devices are somewhat limited, they are likely to expand in the upcoming years, including their use as destination therapy for end-stage heart failure...

journal_title：Artificial organs

authors： Hampton CR,Verrier ED

更新日期：2002-11-01 00:00:00

abstract：:Thyrotoxic crisis (thyroid storm) is a life-threatening condition. Standard therapy is based on thiamazole, prednisolone, and nonselective beta-blockers. Extracorporeal plasmapheresis is an additional tool for removing circulating thyroxine in patients who do not respond quickly to conventional standard therapy. As th...

journal_title：Artificial organs

authors： Koball S,Hickstein H,Gloger M,Hinz M,Henschel J,Stange J,Mitzner S

更新日期：2010-02-01 00:00:00

abstract：:The sensitivity of liver allografts to even minimal periods of ischemia currently limits the duration of hepatic preservation prior to liver transplantation. This study evaluates the role of activated carbon hemoperfusion (ACH) for assisting the recovery of canine livers ischemically damaged by a 20-min occlusion of t...

journal_title：Artificial organs

authors： Toledo-Pereyra LH

更新日期：1985-08-01 00:00:00

abstract：:Sponge-type small-diameter vascular grafts were fabricated from a medical-grade polyurethane, Pellethane 2363-80A, by utilization of a salt casting technique. The grafts were compliance matched with a storage modulus of 0.53 +/- 0.08 MPa. The luminal surface of grafts was modified with a thin layer ( approximately 40 ...

journal_title：Artificial organs

authors： Hsu SH,Sun SH,Chen DC

更新日期：2003-12-01 00:00:00

abstract：:This article describes two ongoing numerical studies of fluid-structure interaction in the cardiovascular system: an idealized pulsatile ventricular assist device (VAD), consisting of two fluid chambers separated by a flexible diaphragm; and blood flow and heart wall motion during passive filling of a canine heart. Si...

journal_title：Artificial organs

authors： Doyle MG,Vergniaud JB,Tavoularis S,Bourgault Y

更新日期：2008-11-01 00:00:00

abstract：:Pump power loss is defined as input power that is not used for the output work of the pump. Less pump power loss means a higher pump efficiency. A common opinion is that the pump power loss is closely related to heat generation of the pump, which may affect not only the endurance of pump materials, but also blood dama...

journal_title：Artificial organs

authors： Takami Y,Nakazawa T,Makinouchi K,Glueck J,Ohara Y,Benkowski RJ,Nosé Y

更新日期：1996-07-01 00:00:00

abstract：:Small-caliber decellularized xenografts with surface heparin coating are known to reduce in vivo thrombogenicity. This study was performed to examine whether heparin coating on the small-caliber decellularized xenografts would reduce macrophage infiltration and intimal hyperplasia. In a rabbit model of bilateral carot...

journal_title：Artificial organs

authors： Cai WW,Gu YJ,Wang XN,Chen CZ

更新日期：2009-06-01 00:00:00

abstract：:Only a small number of English hospitals provide postcardiotomy venoarterial extracorporeal membrane oxygenation (VA-ECMO) and there are doubts about its efficacy and safety. The aim of this service evaluation was to determine local survival rates and report on patient demographics. This was a retrospective service ev...

journal_title：Artificial organs

authors： Charlesworth M,Garcia M,Head L,Barker JM,Ashworth AD,Barnard JB,Feddy L,Venkateswaran RV

更新日期：2020-07-01 00:00:00

abstract：:As the aortic valve (AV) opens, the pump pressure head remains constant, which is reflected as a "notch/plateau" in pump pressure and flow signals. However, instantaneous flow estimation may be influenced by friction and is particularly difficult in axial pumps. Therefore, a new method to determine the duration of AV ...

journal_title：Artificial organs

authors： Hayward C,Lim CP,Schima H,Macdonald P,Moscato F,Muthiah K,Granegger M

更新日期：2015-08-01 00:00:00

abstract：:Oxidative stress is crucial in red blood cell (RBC) damage induced by activated neutrophils in in vitro experiments. The aim of the study was to evaluate whether the bioincompatibility phenomena occurring during hemodialysis (HD) (where neutrophil activation with increased free radical production is well documented) m...

journal_title：Artificial organs

authors： Lucchi L,Bergamini S,Botti B,Rapanà R,Ciuffreda A,Ruggiero P,Ballestri M,Tomasi A,Albertazzi A

更新日期：2000-01-01 00:00:00

abstract：:The majority of cases involving the surgical treatment of congenital heart disease require implementation of cardiopulmonary bypass (CPB). However, neonates and infants are particularly prone to serious complications associated with CPB as a result of capillary leak due to cardiovascular failure. These complications a...

journal_title：Artificial organs

authors： Schnoering H,Arens J,Detering SM,Sachweh JS,Goetzenich A,Schmitz-Rode T,Steinseifer U,Vazquez-Jimenez JF

更新日期：2013-06-01 00:00:00

abstract：:We have developed a novel method to simultaneously evaluate thromboresistance of two different types of drip chambers with a filter used in extracorporeal blood circuits for hemodialysis using canine arteriovenous shunt models. Bilateral bypasses between the femoral artery and vein on both sides of the animal were for...

journal_title：Artificial organs

authors： Yamazaki M,Kobayashi K,Mori Y,Satoh T,Kubota S

更新日期：1997-02-01 00:00:00

abstract：:The developments in apheresis techniques and their clinical applications world-wide are technologically driven. In the past, apheresis survey statistics have high-lighted both the differences by region in clinical practice and in the types of technologies utilized. Such differences have provided a basis for the scient...

journal_title：Artificial organs

authors： Malchesky PS,Bambauer R,Horiuchi T,Kaplan A,Sakurada Y,Samuelsson G

更新日期：1995-04-01 00:00:00

abstract：:An investigation has been made into whether charcoal hemoperfusion stimulates a hyperplastic response in the liver of the normal rat. Animals underwent hemoperfusion over Norit RBX1 (Strathclyde, Glasgow, U.K.) charcoal granules using a technique which allowed perfusion in the unrestrained and conscious state. Control...

journal_title：Artificial organs

authors： Ryan CJ,Courtney JM,Wood CB,Blumgart LH

更新日期：1982-05-01 00:00:00

abstract：:The new Advanced ventricular assist device (Advanced VAD) has many features such as improving pulsatility and preventing regurgitant flow during pump stoppage. The purpose of this study was to evaluate the effects of design modifications of the Advanced VAD on these features in vitro. Bench testing of four versions of...

journal_title：Artificial organs

authors： Miyamoto T,Byram N,Karimov JH,Adams J,Dessoffy R,Kuban BD,Gao S,Horvath DJ,Fukamachi K

更新日期：2019-10-01 00:00:00

abstract：:The most common method of controlling acidemia during lung-protective ventilation is CO₂ removal with an extracorporeal lung assist (ECLA) system. Another possibility to prevent acidemia is based on intravenous (i.v.) application of tris-hydroxymethyl-aminomethane (3 mol/L, THAM) buffer, which can bind hydrogen proton...

journal_title：Artificial organs

authors： Russ M,Deja M,Ott S,Bedarf J,Keckel T,Hiebl B,Wagner JJ,Unger JK

更新日期：2011-06-01 00:00:00

abstract：:The heparin-conjugated fibrin (HCF) system has been developed to deliver bone morphogenetic proteins (BMPs) for a long-term period and thus enhance bone regeneration. In the present study, we tested the effectiveness of the delivery system for spinal fusion with a very low dose of BMP-2. A total of 15 rabbits underwen...

journal_title：Artificial organs

authors： Koo KH,Lee JM,Ahn JM,Kim BS,La WG,Kim CS,Im GI

更新日期：2013-05-01 00:00:00

abstract：:The kinetic features of ultrafiltration of cellulose dialysis membrane stored under various humidity and temperature conditions were studied to obtain basic information of shelf-life characteristics of dialyzers. The ultrafiltration rate (UFR) decreased with time and the UFR-time curve suggested that the UFR would app...

journal_title：Artificial organs

authors： Sato H,Kidaka T

更新日期：1981-08-01 00:00:00

abstract：:A surgical method for the implantation of a mechanical right ventricular assist device which avoids resternotomy/thoracotomy and related complications at the time of explantation is presented. In order to support the failing right heart, a Dacron vascular graft was sewn to the pulmonary artery. For venous drainage, a ...

journal_title：Artificial organs

authors： Schopka S,Haneya A,Rupprecht L,Camboni D,Schmid C,Hilker M

更新日期：2012-08-01 00:00:00