abstract：:In this proof of principle study, we investigated the effectiveness and safety of hemodynamic support with the Intra-Ventricular Membrane Pump (IVMP). The IVMP was implanted into the apex of the left ventricle. Hemodynamic assessment was performed in six ex vivo beating porcine hearts (PhysioHeart platform). The cardi...

journal_title：Artificial organs

authors： van Dort DIM,Thannhauser J,Gommans FDH,Ten Cate TJ,Duncker DJ,Suryapranata H,Morshuis WJ,Geuzebroek GSC

更新日期：2020-12-01 00:00:00

abstract：:In a healthy human cardiac system, a large asymmetric clockwise vortex present in the left ventricle (LV) efficiently diverts the filling jet from the mitral annulus to the left ventricular outflow track. However, prior clinical studies have shown that artificial mitral valve replacement can affect the formation of ph...

journal_title：Artificial organs

authors： Tan SG,Hon JKF,Nguyen YN,Kim S,Leo HL

更新日期：2020-12-01 00:00:00

abstract：:Tubular polymer scaffolds based on tissue engineering techniques have been studied as potential alternatives for vascular regeneration implants. The blood vessels of the cardiovascular system are mainly fibrous, composed of collagen (Col) and elastin (El), and its inner layer consists of endothelial cells. In this wor...

journal_title：Artificial organs

authors： Rodrigues ICP,Pereira KD,Woigt LF,Jardini AL,Luchessi AD,Lopes ÉSN,Webster TJ,Gabriel LP

更新日期：2020-11-10 00:00:00

abstract：:Extracorporeal life support (ECLS) has been increasingly utilized to manage cardiac and pulmonary dysfunction. The impact of obesity on outcomes of ECLS is poorly defined. The purpose of the study was to compare in-hospital mortality, resource use, complications, and readmissions in obese versus non-obese patients rec...

journal_title：Artificial organs

authors： Christian-Miller N,Hadaya J,Nakhla M,Sanaiha Y,Madrigal J,Emami S,Cale M,Sareh S,Benharash P

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:The use of ventricular assist devices (VAD) as a bridge to heart transplant (HT) is increasing, while HT volume remains stagnant. This may portend longer waiting times and an otherwise more competitive environment for all patients on the HT waiting list. METHODS:A retrospective analysis of patients who were...

journal_title：Artificial organs

authors： Han JJ,Elzayn H,Duda MM,Iyengar A,Acker AM,Patrick WL,Helmers M,Birati EY,Atluri P

更新日期：2020-10-01 00:00:00

abstract：:Replacing the renal excretion of low molecular weight proteins (LMWP) by extracorporeal dialysis (dialysis) treatment poses technological challenges. Hemodialyzers with sieving coefficients for LMWP that match or even exceed those of the glomerular membrane barrier are commercially available; however, the associated l...

journal_title：Artificial organs

authors： Glancey G

更新日期：2020-10-01 00:00:00

abstract：:Tissue engineering utilizes an interdisciplinary approach to generate constructs for the treatment and repair of diseased organs. Generation of small vessels as vascular grafts or as envisioned central vessel for vascularized constructs is still a challenge. Here, the decellularization of porcine vessels by a non-dete...

journal_title：Artificial organs

authors： Eyre K,Samper E,Haverich A,Hilfiker A,Andrée B

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:Lung infection (LI) often occurs in patients with liver transplantation (LT). This meta-analysis was conducted to determine the risk factors associated with LI after LT. METHODS:We retrieved relevant research published as of February 2020 from 8 electronic databases. The studieswere reviewed against the incl...

journal_title：Artificial organs

authors： Zhang J,He Q,Du L,Ji R,Yuan L,Zhang H,Yuan X,Shen L,Li Y

更新日期：2020-09-26 00:00:00

abstract：:We have studied the cardiac beat synchronization (CBS) control for a rotary blood pump (RBP) and revealed that it can promote pulsatility and reduce cardiac load. Besides, patients with LVAD support sometimes suffer from aortic and mitral regurgitation (AR and MR). A control method for the RBP should be validated in w...

journal_title：Artificial organs

authors： Ogawa D,Kobayashi S,Yamazaki K,Motomura T,Nishimura T,Shimamura J,Tsukiya T,Mizuno T,Takewa Y,Tatsumi E,Nishinaka T

更新日期：2020-08-19 00:00:00

abstract：:Our objective was to assess the effect of nitric oxide added to the sweep gas of the oxygenator during cardiopulmonary bypass (CPB) in infants on platelet count, platelet function, clinical outcomes, and safety. A randomized, double-blinded, placebo-controlled clinical trial in infants less than a year of age undergoi...

journal_title：Artificial organs

authors： Niebler RA,Chiang-Ching H,Daley K,Janecke R,Jobe SM,Mitchell ME,Varner C,Woods K,Scott JP

更新日期：2020-08-01 00:00:00

abstract：:This work introduces a new Lagrangian strain-based model to predict the shear-induced hemolysis in biomedical devices. Current computational models for device-induced hemolysis usually utilize empirical fitting of the released free hemoglobin (Hb) in plasma from damaged red blood cells (RBCs). These empirical correlat...

journal_title：Artificial organs

authors： Nikfar M,Razizadeh M,Zhang J,Paul R,Wu ZJ,Liu Y

更新日期：2020-08-01 00:00:00

abstract：:The polymer poly(ε-caprolactone) (PCL) has been used in the biomaterial field for its relatively inexpensive price and suitability for modification. Also, its chemical and biological properties are desirable for biomedical applications. The electrospinning process has been used for producing polymer fibers of PCL due ...

journal_title：Artificial organs

authors： Capellato P,Silva G,Popat K,Simon-Walker R,Alves Claro AP,Zavaglia C

更新日期：2020-08-01 00:00:00

abstract：:The outcome predictors of intra-aortic balloon pump (IABP) in patients who undergo mitral valve surgery remain unknown. This study aimed to retrospectively review valvular surgery in patients who received an IABP to identify the predictors of failure of IABP support and anticipate the necessary therapy. This retrospec...

journal_title：Artificial organs

authors： Liang M,Wang C,Feng K,Chen G,Wang K,Wu Z

更新日期：2020-08-01 00:00:00

abstract：:Roller pumps have been widely used in the ventricular assist field for many years, while the significant hemolysis caused by its mechanical stress is still a fundamental problem. Although the usual under-occlusion setting was considered as an effective method to reduce the hemolysis rate, its nonocclusive condition of...

journal_title：Artificial organs

authors： Zhou Y,Sun B,Chen M,Cui C

更新日期：2020-07-31 00:00:00

abstract：:Patients with kidney failure can only survive with some form of kidney replacement (transplant or dialysis). Unfortunately, innovations in kidney replacement therapy lag behind many other medical fields. This study compiles expert opinions on candidate technologies for future kidney replacement therapies. A worldwide ...

journal_title：Artificial organs

authors： Pereira Cabral B,Bonventre JV,Wieringa F,Mota FB

更新日期：2020-07-22 00:00:00

abstract：:Dual chamber (DC) peritoneal dialysis (PD) dialysates contain fewer glucose degradation products (GDPs), so potentially reducing advanced glycosylation end products (AGEs), which have been reported to increase inflammation and cardiovascular risk. We wished to determine whether use of DC dialysates resulted in demonst...

journal_title：Artificial organs

authors： Vareesangthip K,Vongsanim S,Fan S,Davenport A

更新日期：2020-07-09 00:00:00

abstract：:Only a small number of English hospitals provide postcardiotomy venoarterial extracorporeal membrane oxygenation (VA-ECMO) and there are doubts about its efficacy and safety. The aim of this service evaluation was to determine local survival rates and report on patient demographics. This was a retrospective service ev...

journal_title：Artificial organs

authors： Charlesworth M,Garcia M,Head L,Barker JM,Ashworth AD,Barnard JB,Feddy L,Venkateswaran RV

更新日期：2020-07-01 00:00:00

abstract：:Transcatheter aortic valve (TAV) replacement has become a viable alternative to surgery for high and intermediate risk patients with severe aortic stenosis. This technology may extend to the younger and lower risk patients. In this population, long-term durability of the TAV is key. Increased leaflet mechanical stress...

journal_title：Artificial organs

authors： Stanová V,Zenses AS,Thollon L,Kadem L,Barragan P,Rieu R,Pibarot P

更新日期：2020-07-01 00:00:00

abstract：:With the incidence of end-stage heart failure steadily increasing, the need for a practical total artificial heart (TAH) has never been greater. Continuous flow TAHs (CFTAH) are being developed using rotary blood pumps (RBPs), leveraging their small size, mechanical simplicity, and excellent durability. To completely ...

journal_title：Artificial organs

authors： Nestler F,Timms DL,Stevens M,Bradley AP,Wilson SJ,Kleinheyer M,Lovell N,Frazier OH,Cohn WE

更新日期：2020-06-01 00:00:00

abstract：:The use of extracorporeal membrane oxygenator instead of standard cardiopulmonary bypass during lung transplantation is debatable. Moreover, recently, the concept of prolonged postoperative extracorporeal membrane oxygenator (ECMO) support has been introduced in many transplant centers to prevent primary graft dysfunc...

journal_title：Artificial organs

authors： Dell'Amore A,Campisi A,Congiu S,Mazzarra S,Pastore S,Dolci G,Baiocchi M,Frascaroli G

更新日期：2020-06-01 00:00:00

abstract：:Controlled and repeatable in vitro evaluation of cardiovascular devices using a mock circulation loop (MCL) is essential prior to in vivo or clinical trials. MCLs often consist of only a systemic circulation with no autoregulatory responses and limited validation. This study aimed to develop, and validate against huma...

journal_title：Artificial organs

authors： Gregory SD,Pauls JP,Wu EL,Stephens A,Steinseifer U,Tansley G,Fraser JF

更新日期：2020-06-01 00:00:00

abstract：:Extracorporeal membrane oxygenation (ECMO) is gaining importance in the perioperative management of lung transplant patients. To date, the ideal substance for anticoagulation of ECMO patients is still a matter of debate. In this study, we describe our experience with the use of low molecular weight heparin (LMWH) in c...

journal_title：Artificial organs

authors： Gratz J,Pausch A,Schaden E,Baierl A,Jaksch P,Erhart F,Hoetzenecker K,Wiegele M

更新日期：2020-06-01 00:00:00

abstract：:Mechanical circulatory support (MCS) devices continue to be hampered by thrombotic adverse events (AEs), a consequence of device-imparted supraphysiologic shear stresses, leading to shear-mediated platelet activation (SMPA). In advancing MCS devices from design to clinical use, in vitro circulatory loops containing th...

journal_title：Artificial organs

authors： Li M,Walk R,Roka-Moiia Y,Sheriff J,Bluestein D,Barth EJ,Slepian MJ

更新日期：2020-06-01 00:00:00

abstract：:Right ventricular failure is one of the most common complications encountered after left ventricular assist device implantation and heart transplantation. It has been reported to have an incidence up to 30%. It increases morbidity and short-term mortality. Impella RP is a small pump that can provide up to 4L/min of fl...

journal_title：Artificial organs

authors： Monteagudo-Vela M,Simon A,Panoulas V

更新日期：2020-05-01 00:00:00

abstract：:Continuous-flow left ventricular assist devices (LVADs) reduce peak systolic flow, increase diastolic flow, and eliminate pulsatility of circulation. Altered blood flow may lead to a change in end-organ perfusion. Analysis of the flow dynamics of the arteries of end organs, such as the brain, may indicate whether an o...

journal_title：Artificial organs

authors： Karahan M,Kocabeyoglu SS,Kervan U,Sert DE,Aygun E,Tola M,Demirkan B,Mungan S,Kursun O,Catav Z,Pac M

更新日期：2020-05-01 00:00:00

abstract：:Ventricular assist devices (VADs) are considered the standard of care for end-stage heart failure (HF) patients. Despite increasing confidence in the technology, evidence data, endorsement by scientific societies and guidelines, the number of implants reached a steady state and is not increasing at the expected pace. ...

journal_title：Artificial organs

authors： Barbone A,Pagliaro B,Basciu A,Iaccarino A,Droandi G,Romano G,Citterio E,Fumero A,Torracca L,Pini D

更新日期：2020-04-23 00:00:00

abstract：:Cardiopulmonary bypass (CPB) requirement in infants presents a unique challenge because of the large prime volume-to-blood volume ratio. Packed red blood cells (PRBCs) tend to deteriorate with long-term storage owing to their unphysiological composition and osmolality. Given that blood priming is inevitable in neonate...

journal_title：Artificial organs

authors： Gholampour Dehaki M,Niknam S,Bakhshandeh H,Azarfarin R

更新日期：2020-03-01 00:00:00

abstract：:EXTEND (EXTra-uterine Environment for Neonatal Development) is a novel system for supporting extremely premature infants that replicates in utero conditions by maintaining a sterile fluid environment and providing gas exchange via a pumpless arteriovenous oxygenator circuit connected to the umbilical vessels. Target g...

journal_title：Artificial organs

authors： Hornick MA,Mejaddam AY,McGovern PE,Hwang G,Han J,Peranteau WH,Partridge EA,Davey MG,Flake AW

更新日期：2019-12-01 00:00:00

abstract：:Spiral/helical forms of blood flow have been observed in large arteries of the cardiovascular system, but their benefits remain underappreciated. Spiral flow has been postulated to improve near-wall washout, promoting anti-atherothrombotic conditions. This research aims to study the washout characteristics of spiral f...

journal_title：Artificial organs

authors： Huang Zhang P,Tkatch C,Newman R,Grimme W,Vainchtein D,Kresh JY

更新日期：2019-12-01 00:00:00

abstract：:Mechanical circulatory support (MCS) devices for pediatric patients continue to lag in development behind those for adults. There is no heart pump with the design innovation to support dysfunctional states of heart failure and the anatomic heterogeneity of cardiac defects in pediatric patients. To address this unmet n...

journal_title：Artificial organs

authors： Fox C,Sarkisyan H,Stevens R,Arabia F,Fischer W,Rossano J,Throckmorton A

更新日期：2019-11-01 00:00:00

abstract：:The new Advanced ventricular assist device (Advanced VAD) has many features such as improving pulsatility and preventing regurgitant flow during pump stoppage. The purpose of this study was to evaluate the effects of design modifications of the Advanced VAD on these features in vitro. Bench testing of four versions of...

journal_title：Artificial organs

authors： Miyamoto T,Byram N,Karimov JH,Adams J,Dessoffy R,Kuban BD,Gao S,Horvath DJ,Fukamachi K

更新日期：2019-10-01 00:00:00

abstract：:Transcatheter aortic valve implantation (TAVI) has gained considerable acceptance in the past decade due to its lower risks than conventional open-heart surgery. However, the deformation and delamination of the leaflets during the crimping procedure have raised questions about the durability and long-term serviceabili...

journal_title：Artificial organs

authors： Mao J,Rassoli A,Tong Y,Rouse EN,Le-Bel G,How D,Germain L,Fatouraee N,Zhang Z,Reed RR,Guidoin R

更新日期：2019-10-01 00:00:00

abstract：:In a typical open-heart surgery, the blood flow through the aortic cannula is a critical element of the cardiopulmonary bypass (CPB) procedure. Especially for the neonatal and pediatric CPB flow conditions, the need for small hydraulic diameter and large blood flow results confined turbulent jet flow regimes that exac...

journal_title：Artificial organs

authors： Rasooli R,Pekkan K

更新日期：2019-10-01 00:00:00

abstract：:The PI3K/Akt signaling pathway has been implicated in playing an important role in platelet activation during hemostasis and thrombosis involving platelet-matrix interaction and platelet aggregation. Its role in non-physiological shear stress (NPSS)-induced platelet activation relevant to high-shear blood contacting m...

journal_title：Artificial organs

authors： Chen Z,Li T,Kareem K,Tran D,Griffith BP,Wu ZJ

更新日期：2019-09-01 00:00:00

abstract：:We developed a novel miniaturized extracorporeal centrifugal pump "BIOFLOAT NCVC (Nipro Corporation Osaka, Japan) as a ventricular assist device (VAD) and performed a preclinical study that is part of the process for its approval as a bridge to decision by the pharmaceutical and medical device agencies. The aim of thi...

journal_title：Artificial organs

authors： Shimamura J,Mizuno T,Takewa Y,Tsukiya T,Naito N,Akiyama D,Iizuka K,Katagiri N,Nishimura T,Ono M,Tatsumi E

更新日期：2019-09-01 00:00:00

abstract：:No standardized treatment algorithm exists for the management of continuous-flow left ventricular assist device (CF-LVAD)-specific infections. The aim of this systematic review and meta-analysis was to compare the outcomes of CF-LVAD-specific infections as managed by device exchange to other treatment modalities not i...

journal_title：Artificial organs

authors： Bauer TM,Choi JH,Luc JGY,Weber MP,Moncho Escrivá E,Patel S,Maynes EJ,Boyle AJ,Samuels LE,Entwistle JW,Morris RJ,Massey HT,Tchantchaleishvili V

更新日期：2019-05-01 00:00:00

abstract：:Robotic surgery for intracardiac pathologies in children is relatively uncommon. This study presents our initial experience with robotic-assisted cardiac surgery in children. We also present the feasibility and safety of robotic surgery in children. From May 2013 to June 2018, 30 children underwent totally endoscopic ...

journal_title：Artificial organs

authors： Onan B,Aydin U,Kadirogullari E,Onan IS,Sen O

更新日期：2019-04-01 00:00:00

abstract：:Left ventricle (LV) unloading caused by a left ventricular assist device (LVAD) has been shown to enhance reverse LV remodeling in end-stage cardiomyopathy. Several reports consistently suggest that a pulsatile-flow LVAD has more profound effects compared to continuous-flow LVAD, though the responsible mechanisms are ...

journal_title：Artificial organs

authors： Saito T,Miyagawa S,Toda K,Yoshikawa Y,Fukushima S,Saito S,Yoshioka D,Sakata Y,Daimon T,Sawa Y

更新日期：2019-04-01 00:00:00

abstract：:We aim to evaluate clinical outcomes of emergent extracorporeal membrane oxygenation (ECMO) implantation in newborns with life-threatening meconium aspiration syndrome (MAS) in peripheral hospitals with Hub and Spoke (HandS) setting. We retrospectively reviewed all neonates presenting with MAS, with no other comorbidi...

journal_title：Artificial organs

authors： Fichera D,Zanella F,Fabozzo A,Doglioni N,Trevisanuto D,Lolli E,Vida V,Ceccherini E,Ebraico A,Stellin G,Padalino M

更新日期：2019-01-01 00:00:00

abstract：:Our aim was to study the feasibility of implanting the Infant Jarvik 2015 in patients weighing less than 8 kg. The Infant Jarvik 2015 left ventricular assist device (LVAD) was tested in a hybrid simulator of the cardiovascular system reproducing specific patients' hemodynamics for different patient weights (2-7 kg). F...

journal_title：Artificial organs

authors： Di Molfetta A,Zielinski K,Ferrari G,Kozarski M,Okrzeja P,Iacobelli R,Filippelli S,Perri G,Darowski M,Massetti M,Jarvik R,Amodeo A

更新日期：2019-01-01 00:00:00