Abstract:
:Oxidative stress is crucial in red blood cell (RBC) damage induced by activated neutrophils in in vitro experiments. The aim of the study was to evaluate whether the bioincompatibility phenomena occurring during hemodialysis (HD) (where neutrophil activation with increased free radical production is well documented) may have detrimental effects on RBC. We evaluated RBC susceptibility to oxidative stress before and after HD in 15 patients using Cuprophan, cellulose triacetate, and polysulfone membrane. RBC were incubated with t-butyl hydroperoxide as an oxidizing agent both in the presence and in the absence of the catalase inhibitor sodium azide. The level of malonaldehyde (MDA), a product of lipid peroxidation, was measured at 0, 5, 10, 15, and 30 min of incubation. When Cuprophan membrane was used, the MDA production was significantly higher after HD, indicating an increased susceptibility to oxidative stress in comparison to pre-HD. The addition of sodium azide enhanced this phenomenon. Both cellulose triacetate and polysulfone membranes did not significantly influence RBC susceptibility to oxidative stress. Neither the level of RBC reduced glutathione nor the RBC glutathione redox ratio changed significantly during HD with any of the membranes used. The RBC susceptibility to oxidative stress was influenced in different ways according to the dialysis membrane used, being increased only when using the more bioincompatible membrane Cuprophan, where neutrophil activation with increased free radical production is well documented. The alterations found in this study might contribute to the reduced RBC longevity of HD patients where a bioincompatible membrane is used.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Lucchi L,Bergamini S,Botti B,Rapanà R,Ciuffreda A,Ruggiero P,Ballestri M,Tomasi A,Albertazzi Adoi
10.1046/j.1525-1594.2000.06432.xsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
1-6issue
1eissn
0160-564Xissn
1525-1594journal_volume
24pub_type
杂志文章abstract::Temporary extracorporeal membrane oxygenation (ECMO) has been established as an essential part of therapy in patients with pulmonary or cardiac failure. As physiological gaseous exchange is artificially altered in this patient group, it is debatable whether a (13) C-breath test can be carried out. In this proof of tec...
journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
abstract::The purpose of this study was to characterize changes in hepatic venous pressures in patients with chronic hepatitis C. The histology and laboratory data from patients with chronic hepatitis C who underwent a transjugular liver biopsy (TJLB) and hepatic venous pressure gradient measurement were analyzed. Portal hypert...
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journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.2007.00440.x
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journal_title:Artificial organs
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journal_title:Artificial organs
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doi:10.1111/j.1525-1594.2009.00814.x
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章
doi:
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journal_title:Artificial organs
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
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journal_title:Artificial organs
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更新日期:2000-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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journal_title:Artificial organs
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更新日期:2020-05-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:1993-03-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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