Abstract:
:Neurologic complications during neonatal extracorporeal life support (ECLS) are associated with significant morbidity and mortality. Gaseous microemboli (GME) in the ECLS circuit may be a possible cause. Advances in neonatal circuitry may improve hemodynamic performance and GME handling leading to reduction in patient complications. This study compared hemodynamic performance and GME handling using two centrifugal pumps (Maquet RotaFlow and Medos Deltastream DP3) and polymethylpentene oxygenators (Maquet Quadrox-iD and Medos Hilite 800LT) in a neonatal ECLS circuit model. The experimental circuit was primed with Lactated Ringer's solution and packed human red blood cells (hematocrit 40%) and arranged in parallel with the RotaFlow and DP3 pump, Quadrox-iD and Hilite oxygenator, and Better-Bladder. Hemodynamic trials evaluating pressure drops and total hemodynamic energy (THE) were conducted at 300 and 500 mL/min at 36°C. GME handling was measured after 0.5 mL of air was injected into the venous line using the Emboli Detection and Classification Quantifier System with unique pump, oxygenator, and Better-Bladder combinations. The RotaFlow pump and Quadrox oxygenator arrangement had lower pressure drops and THE loss at both flow rates compared to the DP3 pump and Hilite oxygenator (P < 0.01). Total GME volume and counts decreased with Better-Bladder at both flow rates with all combinations (P < 0.01). Hemodynamic performance and energy loss were similar in all of the circuit combinations. The Better-Bladder significantly decreased GME. All four combinations of pumps and oxygenators also performed similarly in terms of GME handling.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Glass K,Trivedi P,Wang S,Woitas K,Kunselman AR,Ündar Adoi
10.1111/aor.12908subject
Has Abstractpub_date
2017-04-01 00:00:00pages
392-400issue
4eissn
0160-564Xissn
1525-1594journal_volume
41pub_type
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journal_title:Artificial organs
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journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章,评审
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更新日期:2015-10-01 00:00:00
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journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1046/j.1525-1594.1998.06127.x
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journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1992.tb00537.x
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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