Heart valve inspired and multi-stream aortic cannula: Novel designs for cardiopulmonary bypass improvement in neonates.

Abstract:

:In a typical open-heart surgery, the blood flow through the aortic cannula is a critical element of the cardiopulmonary bypass (CPB) procedure. Especially for the neonatal and pediatric CPB flow conditions, the need for small hydraulic diameter and large blood flow results confined turbulent jet flow regimes that exacerbate blood damage and platelet activation. Simultaneously, the confined jet wake leads to complex stagnation and recirculating flows that cause considerable thrombosis, blood, and endothelial cell damage through the aorta. Thus, an ideal neonatal CPB cannula should be able to generate optimal jet expansion so that sufficient cerebral perfusion is achieved through the head-neck vessels to avoid postoperative neurological complications and developmental defects in children. To address these challenges, a formal bio-inspired design framework is conducted to reach the desired cannula function through novel analogous biological components, first-time in literature. Among the biological jet flow regimes studied, the ventricle filling-jet generated through the atrio-ventricle (AV) valves are found to be the most promising. Inspired from human AV valve shapes, 8 different novel cannula designs, considering the size constrains of neonatal and pediatric patients are built via high-accurate micro stereo-lithography. Using 2-dimensional time-resolved particle image velocimetry the turbulent jet wake characteristics are measured and compared. The proposed designs have exhibited a significant improvement as compared to standard circular cannula by around 30% reduction in maximum outflow velocity and more than 80% reduction in potential core length and spatial energy dissipation which results in a lower risk of cardiovascular and blood damage.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Rasooli R,Pekkan K

doi

10.1111/aor.13462

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

E233-E248

issue

10

eissn

0160-564X

issn

1525-1594

journal_volume

43

pub_type

杂志文章
  • Eosinophilia in hemodialysis patients.

    abstract::Thirteen percent of 99 patients undergoing maintenance hemodialysis showed an increased predialysis peripheral blood eosinophil count (mean value of 828 cells/mm3, range 410-2,710). Patients with eosinophilia were predominantly male and evidenced more frequent elevation of total plasma IgE levels. Otherwise, no differ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1987.tb02635.x

    authors: Friedberg M,Joffe P,Nielsen B,Nielsen LP

    更新日期:1987-04-01 00:00:00

  • Bone marrow combined with dental bud cells promotes tooth regeneration in miniature pig model.

    abstract::Growth factors and morphogens secreted by bone marrow mesenchymal stem cells (BMSCs) of bone marrow fluid may promote tooth regeneration. Accordingly, a tissue engineering approach was utilized to develop an economical strategy for obtaining the growth factors and morphogens from BMSCs. Unerupted second molar tooth bu...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2010.01064.x

    authors: Kuo TF,Lin HC,Yang KC,Lin FH,Chen MH,Wu CC,Chang HH

    更新日期:2011-02-01 00:00:00

  • Clinical indications for the use of the "Poisk-IOM" total artificial heart: the experience of 13 implantations in humans.

    abstract::Success of total artificial heart (TAH) implantation as a temporary measure depends on three factors: proper patient selection, adequate surgical technique, and safe cardiac prostheses. From 1986 until March 1990, 237 patients with stagnant heart failure were examined. Sixty-one patients (27%) were put on a waiting li...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1991.tb00745.x

    authors: Shumakov V,Zimin N,Kazakov E,Kormer A,Vorontsov S,Nikolaenko E,Kozlov I,Drobyshev A

    更新日期:1991-10-01 00:00:00

  • The use of an approved biodegradable polymer scaffold as a solid support system for improvement of islet engraftment.

    abstract::The aim of this study was to investigate whether the use of a medically approved biodegradable scaffold as a solid support system would enhance graft survival following transplantation into the omental pouch in a preclinical large animal model. Six beagle dogs underwent total pancreatectomy followed by islet autotrans...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2008.00688.x

    authors: Kin T,O'Neil JJ,Pawlick R,Korbutt GS,Shapiro AM,Lakey JR

    更新日期:2008-12-01 00:00:00

  • Prevention of right heart failure after left ventricular assist device implantation by phosphodiesterase 5 inhibitor.

    abstract::Right ventricular (RV) function immediately after left ventricular assist device (LVAD) implantation is a crucial prognostic factor. RV failure is linked to increased mortality and worse outcome. A phosphodiesterase 5 inhibitor, sildenafil, was shown to decrease pulmonary vascular resistance and pulmonary artery press...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12277

    authors: Hamdan R,Mansour H,Nassar P,Saab M

    更新日期:2014-11-01 00:00:00

  • Performance of baffled bubble blood oxygenators.

    abstract::Bubble blood oxygenators equipped with baffles of various types in the oxygenating column were studied. The rate of hemolysis, the volumetric coefficient for oxygen absorption into blood, and the fractional gas holdup were found to be affected mainly by the superficial gas velocity. When compared with the conventional...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1979.tb01032.x

    authors: Ohshima N,Yoshido F

    更新日期:1979-05-01 00:00:00

  • Melt Electrospun Bilayered Scaffolds for Tissue Integration of a Suture-Less Inflow Cannula for Rotary Blood Pumps.

    abstract::Implantation of left ventricular assist devices typically requires cardiopulmonary bypass support, which is associated with postoperative complications. A novel suture-less inflow cannula, which can be implanted without bypass, uses mild myocardial compression to seal the interface, however, this may lead to necrosis ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13018

    authors: Liao S,Theodoropoulos C,Blackwood KA,Woodruff MA,Gregory SD

    更新日期:2018-05-01 00:00:00

  • Ex Vivo Porcine Organ Perfusion Models as a Suitable Platform for Translational Transplant Research.

    abstract::In transplantation surgery, extending the criteria for organ donation to include organs that may have otherwise been previously discarded has provided the impetus to improve organ preservation. The traditional method of cold static storage (CS) has been tried and tested and is suitable for organs meeting standard crit...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审

    doi:10.1111/aor.12865

    authors: Kumar R,Chung WY,Dennison AR,Garcea G

    更新日期:2017-09-01 00:00:00

  • Survival of patients on chronic hemodialysis: single center experience.

    abstract::Patient survival from our hemodialysis (HD) center over the past 11 years was analyzed. Four hundred four patients, 212 female and 192 male, were treated by chronic intermittent HD. Patients were offered standard acetate-cellulosic membranes of 1.0-1.3 m2. During this period 181 patients died. One hundred three patien...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1999.06291.x

    authors: Polenakovik M,Sikole A,Stojcev N,Spasovski G,Amitov V,Nikolov V,Masin G,Klinkmann H

    更新日期:1999-01-01 00:00:00

  • Pulse push/pull hemodialysis: in vitro study on new dialysis modality with higher convective efficiency.

    abstract::Midsize molecule retention is related with renal-failure-associated mortality. Here, the authors describe a new dialysis modality, pulse push/pull hemodialysis (PPPHD), which increases convective clearance. Blood and dialysate are circulated by a pulsatile pump, but with pulsatile flow patterns that are 180 degrees ou...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2008.00561.x

    authors: Lee K,Lee SR,Mun CH,Min BG

    更新日期:2008-05-01 00:00:00

  • Differences in intravenous and subcutaneous application of recombinant human erythropoietin: a multicenter trial.

    abstract::The aims of this clinical study were to compare the maintenance doses for intravenous (i.v.) and subcutaneous (SC) administration of recombinant human erythropoietin (rhEPO) and to investigate whether there is any difference in the increase of the packed cellular volume (PCV) per week under i.v. and SC administration ...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1525-1594.1994.tb03378.x

    authors: Schaller R,Sperschneider H,Thieler H,Dutz W,Hans S,Voigt D,Marx M,Engelmann J,Schöter KH,Scigalla P

    更新日期:1994-08-01 00:00:00

  • Recharging the battery of implantable biomedical devices by light.

    abstract::This article describes a new powering system for implantable medical devices that could significantly increase their lifetime. The idea is based on the substitution of the usual implantable device battery for an electric accumulator (rechargeable battery), which is fed by the electric power generated by a photovoltaic...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00803.x

    authors: Algora C,Peña R

    更新日期:2009-10-01 00:00:00

  • Development of an atraumatic small centrifugal pump for second-generation cardiopulmonary bypass.

    abstract::A small and light direct-drive centrifugal pump has been developed for cardiopulmonary bypass. In the development process, blood compatibility studies including a hemolysis study, an in vitro fluid dynamic performance study, and in vivo durability and feasibility studies were performed. The centrifugal pump with a 50 ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1992.tb00558.x

    authors: Jikuya T,Sasaki T,Aizawa T,Shiono M,Glueck JA,Smith CP,Feldman L,Sakuma I,Sekela ME,Noda T

    更新日期:1992-12-01 00:00:00

  • Impact of hemoglobin concentration and affinity for oxygen on tissue oxygenation: the case of hemoglobin-based oxygen carriers.

    abstract::In patients undergoing exchange-transfusion with hemoglobin (Hb)-based oxygen (O₂) carriers (HBOC), native Hb coexists with newly transfused Hb. The two Hb types share the same arterial and venous PO₂, but their affinities for O₂ vary. A simple spreadsheet model is described aiming at evaluating the contribution of ea...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2011.01296.x

    authors: Samaja M,Terraneo L

    更新日期:2012-02-01 00:00:00

  • Pulsatile in vitro simulation of the pediatric univentricular circulation for evaluation of cardiopulmonary assist scenarios.

    abstract::The characteristic depressed hemodynamic state and gradually declining circulatory function in Fontan patients necessitates alternative postoperative management strategies incorporating a system level approach. In this study, the single-ventricle Fontan circulation is modeled by constructing a practical in vitro bench...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00951.x

    authors: Dur O,Lara M,Arnold D,Vandenberghe S,Keller BB,DeGroff C,Pekkan K

    更新日期:2009-11-01 00:00:00

  • A hybrid mock circulation loop for a total artificial heart.

    abstract::Rotary blood pumps are emerging as a viable technology for total artificial hearts, and the development of physiological control algorithms is accelerated with new evaluation environments. In this article, we present a novel hybrid mock circulation loop (HMCL) designed specifically for evaluation of rotary total artif...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12380

    authors: Nestler F,Bradley AP,Wilson SJ,Timms DL,Frazier OH,Cohn WE

    更新日期:2014-09-01 00:00:00

  • Intensive Home Hemodialysis: An Eye at the Past Looking for the Hemodialysis of the Future.

    abstract::Multiple observational studies along with a limited number of randomized clinical trials suggest that intensive hemodialysis (IHD) not only improves outcomes for uremic patients undergoing chronic dialysis but does so with a more favorable cost/benefit ratio compared with conventional hemodialysis. As a result of this...

    journal_title:Artificial organs

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/aor.12458

    authors: Naso A,Scaparrotta G,Naso E,Calò LA

    更新日期:2015-09-01 00:00:00

  • Research of flow dynamics and occlusion condition in roller pump systems used for ventricular assist.

    abstract::Roller pumps have been widely used in the ventricular assist field for many years, while the significant hemolysis caused by its mechanical stress is still a fundamental problem. Although the usual under-occlusion setting was considered as an effective method to reduce the hemolysis rate, its nonocclusive condition of...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13790

    authors: Zhou Y,Sun B,Chen M,Cui C

    更新日期:2020-07-31 00:00:00

  • The compliance problem: a major obstacle in the development of implantable blood pumps.

    abstract::The compliance problem represents a major obstacle in the development of implantable blood pumps. The motor-driven pumps are enclosed in an airtight casing with gas in the motor space. The trapped gas in the motor space either increases the load on the motor during systole or impedes blood sac filling. Potential solut...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1984.tb04248.x

    authors: Lee S,Rosenberg G,Donachy JH,Wisman CB,Pierce WS

    更新日期:1984-02-01 00:00:00

  • Paracorporeal assistance system for restoring cardiac activity.

    abstract::Two series of experiments were conducted to assess the potential of artificial ventricular bypass in restoring cardiac activity. One series evaluated use of a paracorporeal left ventricle in 17 calves; the other evaluated biventricular bypass in 11 calves. Module pumps with a seamless blood chamber of polyurethane wer...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1987.tb02622.x

    authors: Tolpekin VE,Koblov LF,Kuvaev AE,Gasanov EK

    更新日期:1987-02-01 00:00:00

  • Automatic Control of Veno-Venous Extracorporeal Lung Assist.

    abstract::Veno-venous extracorporeal lung assist (ECLA) can provide sufficient gas exchange even in most severe cases of acute respiratory distress syndrome. Commercially available systems are manually controlled, although an automatically controlled ECLA could allow individualized and continuous adaption to clinical requiremen...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12664

    authors: Kopp R,Bensberg R,Stollenwerk A,Arens J,Grottke O,Walter M,Rossaint R

    更新日期:2016-10-01 00:00:00

  • Magnesium homeostasis in patients undergoing continuous ambulatory peritoneal dialysis: role of the dialysate magnesium concentration.

    abstract::We carried out this retrospective study to examine the magnesium status of our chronic ambulatory peritoneal dialysis (CAPD) patients dialyzed with 0.75 mmol/L (group I) or 0.50 mmol/L (group II) magnesium peritoneal dialysis solution. A total of 34 anuric patients on CAPD (age:31-72 years; duration of CAPD:7-74 month...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2003.07193.x

    authors: Katopodis KP,Koliousi EL,Andrikos EK,Pappas MV,Elisaf MS,Siamopoulos KC

    更新日期:2003-09-01 00:00:00

  • Electrotactile stimulator for artificial proprioception.

    abstract::With the goal of investigating artificial proprioception elicited by electrical stimulation, we have developed a tactile phi phenomenon-based stimulator. This two-channel microprocessed pulse amplitude modulation system generates two different envelope waveforms (triangular and elliptical) and allows programming and v...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1995.tb02318.x

    authors: Nohama P,Lopes AV,Cliquet Júnior A

    更新日期:1995-03-01 00:00:00

  • Experiencing Functional Electrical Stimulation Roots on Education, and Clinical Developments in Paraplegia and Tetraplegia With Technological Innovation.

    abstract::Cybernetics-based concepts can allow for complete independence for paralyzed individuals, including sensory motor recovery. Spinal cord injuries are responsible for a huge stress on health and a financial burden to society. This article focuses on novel procedures such as functional diagnosis for paraplegics and tetra...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审

    doi:10.1111/aor.12620

    authors: Varoto R,Cliquet A Jr

    更新日期:2015-10-01 00:00:00

  • Effect of cyclosporine therapy with low doses of corticosteroids on idiopathic nephrotic syndrome.

    abstract::Cyclosporine (CyA) has an immunosuppressive effect that might suggest a therapeutic role in idiopathic glomerular conditions. We focused on the optimization of CyA treatment control in patients with idiopathic nephrotic syndrome by using trough-level CyA measurements (C0) and the 2-h postdose levels (C2). Twenty-two p...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00838.x

    authors: Griveas I,Visvardis G,Papadopoulou D,Nakopolou L,Karanikas E,Gogos K,Stavianoudakis G

    更新日期:2010-03-01 00:00:00

  • Effects of atrial arrhytmias on the regurgitation of a monoleaflet prosthetic heart valve.

    abstract::Many patients who receive a prosthetic heart valve also have or acquire cardiac arrhythmias. However, most in vitro studies of prosthetic valves examine them under normal rhythms. In this study, a monoleaflet prosthetic heart valve was tested in vitro under conditions that simulated normal sinus rhythm, first degree a...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2005.29101.x

    authors: Zapanta CM

    更新日期:2005-08-01 00:00:00

  • Design of a symmetry controller for cycling induced by electrical stimulation: preliminary results on post-acute stroke patients.

    abstract::This study deals with the design of a controller for cycling induced by functional electrical stimulation. The controller will be exploitable in the rehabilitation of hemiparetic patients who need to recover motor symmetry. It uses the pulse width as the control variable in the stimulation of the two legs in order to ...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.2009.00941.x

    authors: Ambrosini E,Ferrante S,Schauer T,Ferrigno G,Molteni F,Pedrocchi A

    更新日期:2010-08-01 00:00:00

  • Significant left ventricular unloading with transaortic catheter venting during venoarterial bypass.

    abstract::Insufficient unloading of the left ventricle with blood stagnation is a main cause of unsuccessful left ventricular (LV) recovery during percutaneous cardiopulmonary support (PCPS). The purpose of this investigation was to evaluate the effectiveness of transaortic catheter venting (TACV) for LV unloading. Six adult mo...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb03744.x

    authors: Shibuya M,Kitamura M,Kurihara H,Kikuchi C,Endo M,Koyanagi H

    更新日期:1997-07-01 00:00:00

  • Control systems for the electric heart.

    abstract::Methods to predict and control cardiac output (CO) accurately in total artificial heart (TAH) recipients have varied significantly in the last few decades. Early models exhibited minimal control mechanisms and involved fixed pumping parameters. Elaborate electromechanical systems that have recently evolved require int...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:

    authors: White RK,Olsen DB

    更新日期:1991-10-01 00:00:00

  • Combining novel biomolecules and stimuli-sensitive biomaterials into new recognition-response biomaterial systems.

    abstract::An important present and emerging trend in biomaterials development is the synthesis of polymers which combine capabilities of biologic recognition ("biomimetic") with sensitivity to small environmental changes ("stimuli-responsive"). This short article highlights some of the many opportunities and challenges in this ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1988.tb02813.x

    authors: Hoffman AS

    更新日期:1988-12-01 00:00:00