Abstract：
:Implantation of left ventricular assist devices typically requires cardiopulmonary bypass support, which is associated with postoperative complications. A novel suture-less inflow cannula, which can be implanted without bypass, uses mild myocardial compression to seal the interface, however, this may lead to necrosis of the myocardium. To circumvent this issue, a bilayered scaffold has been developed to promote tissue growth at the interface between cannula and myocardium. The bilayered scaffold consists of a silicone base layer, which mimics the seal, and a melt electrospun polycaprolactone scaffold to serve as a tissue integration layer. Biocompatibility of the bilayered scaffolds was assessed by analyzing cell viability, morphology, and metabolic activity of human foreskin fibroblasts cultured on the scaffolds for up to 14 days. There was no evidence of cytotoxicity and the cells adhered readily to the bilayered scaffolds, revealing a cell morphology characteristic of fibroblasts, in contrast to the low cell adhesion observed on flat silicone sheets. The rate of cell proliferation on the bilayered scaffolds rose over the 14-day period and was significantly greater than cells seeded on the silicone sheets. This study suggests that melt electrospun bilayered scaffolds have the potential to support tissue integration of a suture-less inflow cannula for cardiovascular applications. Furthermore, the method of fabrication described here and the application of bilayered scaffolds could also have potential uses in a diverse range of biomedical applications.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Liao S,Theodoropoulos C,Blackwood KA,Woodruff MA,Gregory SDdoi
10.1111/aor.13018subject
Has Abstractpub_date
2018-05-01 00:00:00pages
E43-E54issue
5eissn
0160-564Xissn
1525-1594journal_volume
42pub_type
杂志文章abstract：:A pseudo-one compartment model has been proposed to describe phosphorus kinetics during hemodialysis and the immediate post-dialysis period. This model assumes that phosphorus mobilization from tissues is proportional to the difference between the pre-dialysis serum concentration (a constant) and the instantaneous ser...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12897
更新日期：2017-11-01 00:00:00
abstract：:Methods to predict and control cardiac output (CO) accurately in total artificial heart (TAH) recipients have varied significantly in the last few decades. Early models exhibited minimal control mechanisms and involved fixed pumping parameters. Elaborate electromechanical systems that have recently evolved require int...
journal_title：Artificial organs
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:This study assessed the efficacy of multiarterial bypass in coronary artery bypass grafting (CABG) in dialysis patients. Eighty dialysis patients who underwent CABG were divided into 2 groups. Group A consisted of 38 patients in whom the left internal thoracic artery and additional saphenous vein graft (SVG) had been ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:Few instruments are currently available to test mitral valve function in an ex vivo state due to the technical difficulties involved. To investigate the native ex vivo mitral valve or prosthetic mitral valve with chordae, we developed a mitral valve adapter with an annulus suturing portion and 2 papillary muscle sutur...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.1999.06293.x
更新日期：1999-10-01 00:00:00
abstract：:Changing financial incentives have strongly influenced dosing patterns of recombinant human erythropoietin (rHuEPO) since its introduction in 1989. Although guidelines for prescribing rHuEPO exist, the extent to which they are adhered to is unknown. Using a retrospective cohort observational study design, the factors ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.2000.06495.x
更新日期：2000-02-01 00:00:00
abstract：:This article reviews the clinical, biological, radiological, and pathological procedures and their respective indications for the practical diagnosis of the following various histological patterns of renal osteodystrophy: osteitis fibrosa due to parathyroid hormone (PTH) hypersecretion: osteomalacia or rickets due to ...
journal_title：Artificial organs
pub_type： 杂志文章,评审
doi：10.1046/j.1525-1594.1998.06198.x
更新日期：1998-07-01 00:00:00
abstract：:Five typical mechanical heart valves (Starr-Edwards, Björk-Shiley convexo-concave (c-c), Björk-Shiley monostrut, Bicer-Val, and St. Jude Medical) were tested in the mitral position under the pulsatile flow condition. The test program included measurements of velocity and turbulent stresses at 5 downstream locations. T...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1997.tb00451.x
更新日期：1997-10-01 00:00:00
abstract：:With the goal of investigating artificial proprioception elicited by electrical stimulation, we have developed a tactile phi phenomenon-based stimulator. This two-channel microprocessed pulse amplitude modulation system generates two different envelope waveforms (triangular and elliptical) and allows programming and v...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1995.tb02318.x
更新日期：1995-03-01 00:00:00
abstract：:This paper presents an overview of the U.S. Food and Drug Administration's regulatory requirements for introducing medical device and diagnostic products into commercial distribution in the United States. For any specific product, the requirements vary depending upon the product's associated risks, classification, and...
journal_title：Artificial organs
pub_type： 临床试验,杂志文章
doi：10.1111/j.1525-1594.1982.tb04146.x
更新日期：1982-11-01 00:00:00
abstract：:This is a revision of the IDE Application Form, "How to Comply with the Food and Drug Administration's New 'Investigational Device Exemption (IDE)' Regulations, Including an Application Form" originally published in Artificial Organs, Volume 4, Number 4, November 1980. This publication updates the IDE application form...
journal_title：Artificial organs
pub_type： 杂志文章
doi：
更新日期：1982-02-01 00:00:00
abstract：:The use of recombinant human erythropoietin (rHuEpo) has revolutionized anemia management of early and late stages of chronic kidney disease. Darbopoietin is also now available for the treatment of anemia of chronic kidney disease. In addition, rHuEpo has been used for the treatment of anemia observed in critical illn...
journal_title：Artificial organs
pub_type： 杂志文章,评审
doi：10.1046/j.1525-1594.2003.07287.x
更新日期：2003-09-01 00:00:00
abstract：:Stem cells transplanted to an injured heart affect the host myocardium indirectly. The cytokine hepatocyte growth factor (HGF) may play a key role in this paracrine activity. We hypothesized that HGF-overexpressing stem cells would restore cardiac function after myocardial infarction (MI). Because there is a high rate...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2011.01328.x
更新日期：2012-03-01 00:00:00
abstract：:The aim of this study is to evaluate the effect of temperature on cerebral oxygen metabolism at total body flow bypass and antegrade cerebral perfusion (ACP). Neonatal piglets were put on cardiopulmonary bypass (CPB) with the initial flow rate of 200mL/kg/min. After cooling to 18°C (n=6) or 25°C (n=7), flow was reduce...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2010.01131.x
更新日期：2010-11-01 00:00:00
abstract：:Cell exclusion is the phenomenon whereby the hematocrit and viscosity of blood decrease in areas of high stress. While this is well known in naturally occurring Poiseuille flow in the human body, it has never previously been shown in Couette flow, which occurs in implantable devices including blood pumps. The high-she...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2012.01561.x
更新日期：2013-03-01 00:00:00
abstract：:We developed a new left ventricular (LV) assist catheter (transaortic valve from LV to femoral artery) that is implemented percutaneously and exerted as a synchronous pulsatile partial LV flow support with conventional intraaortic balloon pump (IABP) driving system and centrifugal pump system. We investigated whether ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1992.tb00311.x
更新日期：1992-06-01 00:00:00
abstract：:The presence in rat serum of three novel immunosuppressive proteins is associated with induction of tolerance after liver grafting. One of these, KX-5 (40 kilodalton molecular weight) is present 40-100 days after grafting of DA liver into PVG, a combination in which liver grafts are not rejected; two others, KX-2 (87 ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1996.tb00646.x
更新日期：1996-10-01 00:00:00
abstract：PURPOSE:We were led to the premise that with retrograde oxygenated blood perfusion, it would be possible to perform operations on the beating heart. METHODS:The experiment consisted of two stages: procedure 1 and 2. In procedure 1, six pigs were used. Retrograde perfusion flow was controlled to be in the range of 5.0-...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2004.47279.x
更新日期：2004-03-01 00:00:00
abstract：:Hemodynamic control of left ventricular assist devices (LVADs) is generally a complicated problem due to diverse operating environments and the variability of the patients: both the changes in the circulatory and metabolic parameters as well as disturbances that require adjustment to the operating point. This challeng...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2007.00350.x
更新日期：2007-02-01 00:00:00
abstract：:From January 1980 through December 1990, implantation of a permanent pacemaker was performed in 34 patients following open heart surgery. The patients were divided into two groups according to the clinical indications for implantation of permanent pacemakers. Group 1 (9 patients) had surgical atrioventricular block, a...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1993.tb00591.x
更新日期：1993-05-01 00:00:00
abstract：:We aimed to investigate whether acellular endocardium can be used as a useful biomaterial for the intima of engineered small-caliber vascular grafts. Fresh endocardium was harvested from the swine left atrium and was decellularized by digestion with the decellularization solution of Triton X-100 and SDS containing DNa...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12814
更新日期：2016-12-01 00:00:00
abstract：:Present-day computational fluid dynamics (CFD) techniques can be used to analyze the behavior of fluid flow in a variety of pumps. CFD can be a powerful tool during the design stage for rapid virtual prototyping of different designs, analyzing performance parameters, and making design improvements. Computational flow ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：:Infusion into rats of the polycation hexadimethrine (HDM) leads to onset of massive proteinuria, which recovers when the infusion is stopped. Several lines of evidence indicate that the proteinuria results from binding of HDM to polyanions of the glomerular filter, with neutralization of shielding of their charges. To...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1987.tb02712.x
更新日期：1987-12-01 00:00:00
abstract：:Insufficient unloading of the left ventricle with blood stagnation is a main cause of unsuccessful left ventricular (LV) recovery during percutaneous cardiopulmonary support (PCPS). The purpose of this investigation was to evaluate the effectiveness of transaortic catheter venting (TACV) for LV unloading. Six adult mo...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1997.tb03744.x
更新日期：1997-07-01 00:00:00
abstract：:Our aim was to study the aging effects on the in vitro biological properties of bone marrow-derived mesenchymal stem cells (BMSCs) for construction of tissue-engineered heart valves. BMSCs were taken from teenagers with congenital heart diseases, and middle-aged and elderly patients with valvular diseases. Proliferati...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2009.00824.x
更新日期：2010-03-01 00:00:00
abstract：:Cardiopulmonary bypass (CPB) has a risk of cerebral injury, with an important role of gaseous micro-emboli (GME) coming from the CPB circuit. Pulsatile perfusion is supposed to perform specific conditions for supplementary GME activity. We aimed to determine whether pulsatile CPB augments production and delivery of GM...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12000
更新日期：2013-04-01 00:00:00
abstract：:The existence of acquired von Willebrand syndrome (AVWS) in patients with continuous flow left ventricular assist devices (LVADs) is well documented and has been verified by numerous investigators. AVWS has not been observed to occur in pulsatile devices such as the SynCardia total artificial heart (TAH), the HeartMat...
journal_title：Artificial organs
pub_type： 杂志文章,评审
doi：10.1111/aor.13291
更新日期：2018-12-01 00:00:00
abstract：:For introduction of a left atrial (LA) cannula by the transseptal puncture technique, we examined the feasibility of using biplane transesophageal echocardiography (B-TEE). A transseptal puncture was performed on 15 patients (3 male; 12 female; mean age, 48.9 +/- 11.2 years) by B-TEE guide during percutaneous transven...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1992.tb00537.x
更新日期：1992-08-01 00:00:00
abstract：:The thrombogenicity of membrane oxygenators as well as clotting parameters profiles, using standard human clotting tests, was analyzed in calves and pigs during 6 h perfusion. Three calves and 3 pigs were connected to extracorporeal circulation with standard heparinization. Blood samples were taken for coagulation var...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.2001.025007579.x
更新日期：2001-07-01 00:00:00
abstract：:For the last few years we have attempted to separate and isolate from biological fluids the uremic Middle Molecules (MM). The first step in the treatment of plasma is an ultrafiltration through AN69 membrane. The samples are fractionated by Sephadex G-15 chromatography into 9 peaks "a" to "i' under precise conditions ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Molecular biology has been moving swiftly toward clarifying the entire genome of organisms, including human. The human genome efforts that promote this transaction are characterized by the large-scale, high throughput production of data about the structure of the genome of the molecular level and its computer-assisted...
journal_title：Artificial organs
pub_type： 杂志文章,评审
doi：10.1111/j.1525-1594.1996.tb04553.x
更新日期：1996-08-01 00:00:00
