Abstract:
:The aim of this study is to evaluate the effect of temperature on cerebral oxygen metabolism at total body flow bypass and antegrade cerebral perfusion (ACP). Neonatal piglets were put on cardiopulmonary bypass (CPB) with the initial flow rate of 200mL/kg/min. After cooling to 18°C (n=6) or 25°C (n=7), flow was reduced to 100mL/kg/min (half-flow, HF) for 15min and ACP was initiated at 40mL/kg/min for 45min. Following rewarming, animals were weaned from bypass and survived for 4h. At baseline, HF, ACP, and 4 h post-CPB, cerebral blood flow (CBF) was measured using fluorescent microspheres. Cerebral oxygen extraction (CEO(2) ) and cerebral metabolic rate of oxygen (CMRO(2) ) were monitored. Regional cranial oxygen saturation (rSO(2) ) was continuously recorded throughout the procedure using near-infrared spectroscopy. At 18°C, CBF trended lower at HF and ACP and matched baseline after CPB. CEO(2) trended lower at HF and ACP, and trended higher after CPB compared with baseline. CMRO(2) at ACP matched that at HF. Cranial rSO(2) was significantly greater at HF and ACP (P<0.001, P<0.001) and matched baseline after CPB. At 25°C, CBF trended lower at HF, rebounded and trended higher at ACP, and matched baseline after CPB. CEO(2) was equal at HF and ACP and trended higher after CPB compared with baseline. CMRO(2) at ACP was greater than that at HF (P=0.001). Cranial rSO(2) was significantly greater at HF (P=0.01), equal at ACP, and lower after CPB (P=0.03). Lactate was significantly higher at all time points (P=0.036, P<0.001, and P<0.001). ACP provided sufficient oxygen to the brain at a total body flow rate of 100mL/kg/min at deep hypothermia. Although ACP provided minimum oxygenation to the brain which met the oxygen requirement, oxygen metabolism was altered during ACP at moderate hypothermia. ACP strategy at moderate hypothermia needs further investigation.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Sasaki T,Boni L,Riemer RK,Yeung JT,Ramamoorthy C,Beckman R,Gisner C,Shuttleworth P,Hanley FL,Reddy VMdoi
10.1111/j.1525-1594.2010.01131.xsubject
Has Abstractpub_date
2010-11-01 00:00:00pages
980-6issue
11eissn
0160-564Xissn
1525-1594journal_volume
34pub_type
杂志文章abstract::A galactosamine-induced fulminant hepatic failure (FHF) rat model was used to study the effects of homologous cross-circulation and in situ liver perfusion. Cross-circulation with homologous donors did not significantly improve the survival time or recovery rate of grade II hepatic coma rats. Homologous in situ liver ...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1980.tb03929.x
更新日期:1980-08-01 00:00:00
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journal_title:Artificial organs
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doi:10.1111/j.1525-1594.1988.tb02747.x
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1979.tb03800.x
更新日期:1979-02-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1996.tb04418.x
更新日期:1996-01-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1983.tb04187.x
更新日期:1983-05-01 00:00:00
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更新日期:1998-07-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1046/j.1525-1594.1998.06127.x
更新日期:1998-05-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.12682
更新日期:2016-08-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1046/j.1525-1594.1998.05087.x
更新日期:1998-04-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:2005-04-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.13713
更新日期:2020-08-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1996.tb04428.x
更新日期:1996-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-04-01 00:00:00
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doi:10.1046/j.1525-1594.2003.07132.x
更新日期:2003-07-01 00:00:00
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journal_title:Artificial organs
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更新日期:1994-07-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1985.tb04366.x
更新日期:1985-05-01 00:00:00
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journal_title:Artificial organs
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journal_title:Artificial organs
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更新日期:1983-11-01 00:00:00
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