Development of an atraumatic small centrifugal pump for second-generation cardiopulmonary bypass.

abstract：:This study compares the effects of polyethylene glycol (PEG) modified bovine hemoglobin on vascular half-life and renal function in rabbits to those of unmodified bovine hemoglobin. Renal function was assessed by the measurement of the glomerular filtration rate, urinalysis, blood chemistries, hemoglobin (Hb) excretio...

journal_title：Artificial organs

authors： Conover CD,Gilbert CW,Shum KL,Shorr RG

更新日期：1997-08-01 00:00:00

abstract：:Filtration through membranes with different nominal cut-off was used for isolation of middle molecule fractions from uremic serum. Comparison was made with test substances which in gel filtration did not show a regular relationship between molecular weight and partition coefficient. The XM50 membrane (cut-off 50,000 D...

journal_title：Artificial organs

authors： Buzio C,Montagna G,Calderini C,Manari A,Migone L

更新日期：1981-01-01 00:00:00

abstract：:Total artificial hearts (TAHs) and biventricular assist devices (BVADs) have varying levels of acceptance and reliability, and the research on both focuses on their control mechanisms. Efforts generally aim to achieve a response to physiologic demand and left/right output balance, and beneficial cardiac output (CO) an...

journal_title：Artificial organs

authors： Hall AW,Soykan O,Harken AH

更新日期：1996-03-01 00:00:00

abstract：:This study was planned to investigate whether part of the energy produced by cardiac contraction to propel blood toward the systemic circulation can be used to increase the coronary flow in systole. Ten devices (I-X) designed to divert laterally part of a flow column (without substantially increasing resistance to flo...

journal_title：Artificial organs

authors： Moulopoulos S,Stamatelopoulos S,Boufas D,Yannopoulos C,Marousis G,Kouvaras G

更新日期：1979-11-01 00:00:00

abstract：:Cardiac surgery with cardiopulmonary bypass is associated with a systemic inflammatory response syndrome. The major clinical features of this include a reduction of pulmonary compliance and increased extracellular fluids, with increased pulmonary shunt fraction similar to acute respiratory distress syndrome, thus resu...

journal_title：Artificial organs

authors： Luciani R,Goracci M,Simon C,Principe F,Fazzari L,Punzo G,Menè P

更新日期：2009-08-01 00:00:00

abstract：:The purpose of this study was to characterize changes in hepatic venous pressures in patients with chronic hepatitis C. The histology and laboratory data from patients with chronic hepatitis C who underwent a transjugular liver biopsy (TJLB) and hepatic venous pressure gradient measurement were analyzed. Portal hypert...

journal_title：Artificial organs

authors： Khurana S,Simcox T,Twaddell W,Drachenberg C,Flasar M

更新日期：2010-07-01 00:00:00

abstract：:In bioartificial pancreatic systems, isolated islets of Langerhans are protected against immune rejection by an artificial membrane, permeable to glucose and insulin, but not to immunoglobulins and lymphocytes. Some of these devices, referred to as vascular systems, are set up to be connected to a vascular site in the...

journal_title：Artificial organs

authors： Lepeintre J,Briandet H,Moussy F,Chicheportiche D,Darquy S,Rouchette J,Imbaud P,Duron JJ,Reach G

更新日期：1990-02-01 00:00:00

abstract：:A belt worn controller and lithium-ion battery pack have been developed for use with the initial clinical trials of the Jarvik 2000 heart. Patient interface considerations, safety, and simplicity were major design inputs for the system. The controller was developed using all analog technology to avoid difficulties wit...

journal_title：Artificial organs

authors： Jarvik R,Scott V,Morrow M,Takecuhi E

更新日期：1999-06-01 00:00:00

abstract：:A comparative study of the thrombogenicity of several microporous membranes was performed using an ex vivo system simulating the conditions in an artificial lung. A study of platelet adhesion and adsorbed protein layer indicated that the membranes separated into three groups. Copolyurethane membranes adsorbed very few...

journal_title：Artificial organs

authors： Knight PM,Lyman DJ

更新日期：1985-02-01 00:00:00

abstract：:The effect of blood hematocrit (HCT) on a noninvasive flow estimation algorithm was examined in a centrifugal implantable rotary blood pump (iRBP) used for ventricular assistance. An average flow estimator, based on three parameters, input electrical power, pump speed, and HCT, was developed. Data were collected in a ...

journal_title：Artificial organs

authors： Malagutti N,Karantonis DM,Cloherty SL,Ayre PJ,Mason DG,Salamonsen RF,Lovell NH

更新日期：2007-01-01 00:00:00

abstract：:The flow of blood as a viscous, Newtonian, incompressible liquid in an expanding spherical cavity with a ball-type inlet valve was examined. This type of flow can serve as a model of the phase of ventricular diastole in a sac-type artificial heart. The critical values of Reynolds numbers at which flow interruption beh...

journal_title：Artificial organs

authors： Starobin IM,Zaĭko VM

更新日期：1983-02-01 00:00:00

abstract：:Cell-contracted collagen gels could provide rejection-free biomaterials for tissue engineering, but their application is limited by relatively low mechanical strength. We developed a special type I collagen construct (based on embedded fibroblasts) that was formed into a gel thread by using two anchors to constrain ge...

journal_title：Artificial organs

authors： Feng Z,Ishibashi M,Nomura Y,Kitajima T,Nakamura T

更新日期：2006-11-01 00:00:00

abstract：:This article presents results from the field calculation in a model of biological tissue taking into account the electroporation process. The electroporation model used in this study was proposed and experimentally verified by Glaser et al. for planar membranes. The numerical method for field calculation is based on a...

journal_title：Artificial organs

authors： Ramos A

更新日期：2005-06-01 00:00:00

abstract：:The BiVACOR is a novel rotary Biventricular Assist Device (BiVAD) undergoing development to treat global end-stage heart failure. The design includes left and right vanes positioned on a shared rotating hub to form a double-sided magnetically and hydrodynamically suspended centrifugal impeller. The performance of the ...

journal_title：Artificial organs

authors： Timms D,Fraser J,Hayne M,Dunning J,McNeil K,Pearcy M

更新日期：2008-10-01 00:00:00

abstract：:A computer simulation was carried out to investigate the influence of nonpulsatile left ventricular assistance on hemodynamics. A simulation circuit was constructed to represent the circulatory system. A source of current was added to denote the nonpulsatile blood pump. The left and right ventricles were replaced by v...

journal_title：Artificial organs

authors： Mitsui N,Fukunaga S,Koura Y,Morita S,Hotei H,Sueshiro M,Sueda T,Matsuura Y

更新日期：1996-05-01 00:00:00

abstract：:Insufficient unloading of the left ventricle with blood stagnation is a main cause of unsuccessful left ventricular (LV) recovery during percutaneous cardiopulmonary support (PCPS). The purpose of this investigation was to evaluate the effectiveness of transaortic catheter venting (TACV) for LV unloading. Six adult mo...

journal_title：Artificial organs

authors： Shibuya M,Kitamura M,Kurihara H,Kikuchi C,Endo M,Koyanagi H

更新日期：1997-07-01 00:00:00

abstract：:Biofilms are communities of bacteria that can cause infections which are resistant to the immune system and antimicrobial treatments, posing a significant threat for patients with implantable and indwelling medical devices. The purpose of our research was to determine if utilizing specific parameters for electric curr...

journal_title：Artificial organs

authors： Haddad PA,Mah TF,Mussivand T

更新日期：2016-08-01 00:00:00

abstract：:Robotic surgery for intracardiac pathologies in children is relatively uncommon. This study presents our initial experience with robotic-assisted cardiac surgery in children. We also present the feasibility and safety of robotic surgery in children. From May 2013 to June 2018, 30 children underwent totally endoscopic ...

journal_title：Artificial organs

authors： Onan B,Aydin U,Kadirogullari E,Onan IS,Sen O

更新日期：2019-04-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are regarded as a potential autologous source for cartilage repair, because they can differentiate into chondrocytes by transforming growth factor-beta (TGF-beta) treatment under the 3-dimensional (3-D) culture condition. However, more efficient and versatile methods for chondrogenic diff...

journal_title：Artificial organs

authors： Lee HJ,Choi BH,Min BH,Son YS,Park SR

更新日期：2006-09-01 00:00:00

abstract：:When cavitation occurs near a material surface of a mechanical heart valve (MHV), pits on the surface of the MHV and hemolysis are caused. Therefore, it is very important to investigate the possibility of the occurrence of cavitation in an MHV. To study the possibility of cavitation occurrence in a 25 mm Björk-Shiley ...

journal_title：Artificial organs

authors： Lee H,Tsukiya T,Homma A,Taenaka Y,Tatsumi E,Takano H

更新日期：2003-08-01 00:00:00

abstract：:Continuous-flow left ventricular assist devices (LVADs) reduce peak systolic flow, increase diastolic flow, and eliminate pulsatility of circulation. Altered blood flow may lead to a change in end-organ perfusion. Analysis of the flow dynamics of the arteries of end organs, such as the brain, may indicate whether an o...

journal_title：Artificial organs

authors： Karahan M,Kocabeyoglu SS,Kervan U,Sert DE,Aygun E,Tola M,Demirkan B,Mungan S,Kursun O,Catav Z,Pac M

更新日期：2020-05-01 00:00:00

abstract：:Although the debate still continues over the effectiveness of pulsatile versus nonpulsatile perfusion, it has been clearly proven that there are several significant physiological benefits of pulsatile perfusion during cardiopulmonary bypass (CPB) compared to nonpulsatile perfusion. However, the components of the extra...

journal_title：Artificial organs

authors： Undar A,Lodge AJ,Daggett CW,Runge TM,Ungerleider RM,Calhoon JH

更新日期：1998-08-01 00:00:00

abstract：:Experiments have been successfully performed culminating in functional, vascularized, three-dimensional cardiac muscle tissue. Past experience in tissue engineering has led us to the understanding that cell seeding density plays a critical role in the formation and function of both in vitro and in vivo engineered tiss...

journal_title：Artificial organs

authors： Birla R,Dhawan V,Huang YC,Lytle I,Tiranathanagul K,Brown D

更新日期：2008-09-01 00:00:00

abstract：:Secondary flow in the centrifugal blood pump helps to enhance the washout effect and to minimize thrombus formation. On the other hand, it has an adverse effect on pump efficiency. Excessive secondary flow may induce hemolytic effects. Understanding the secondary flow is thus important to the design of a compact, effi...

journal_title：Artificial organs

authors： Watanabe N,Masuda T,Iida T,Kataoka H,Fujimoto T,Takatani S

更新日期：2005-01-01 00:00:00

abstract：:Jaundice is characterized by an excessive accumulation of bilirubin in the blood and tissues. A novel approach to reduce plasma levels of bilirubin by blocking its enterohepatic circulation was investigated. The treatment consisted of oral administration of immobilized bilirubin oxidase, which could oxidize bilirubin ...

journal_title：Artificial organs

authors： Soltys PJ,Mullon C,Langer R

更新日期：1992-08-01 00:00:00

abstract：:The objectives of this study were: (i) to evaluate the effects of perfusion modes (pulsatile vs. nonpulsatile) on vital organs recovery and (ii) to investigate the influences of two different perfusion modes on the homeostasis of thyroid hormones in pediatric patients undergoing cardiopulmonary bypass (CPB) procedures...

journal_title：Artificial organs

authors： Akçevin A,Alkan-Bozkaya T,Qiu F,Undar A

更新日期：2010-11-01 00:00:00

abstract：:The rotary blood pump will be an implantable left ventricular assist device (LVAD) in the near future. However, the best control method and the interrelationship between the rotary blood pump and native heart functions are unclear. An estimation was made of the native heart cardiac output from the change of an LVAD's ...

journal_title：Artificial organs

authors： Nakata K,Ohashi Y,Tayama E,Ohtsuka G,Takami Y,Mueller J,Glueck J,Nosé Y

更新日期：1998-05-01 00:00:00

abstract：:There is increasing evidence showing that adult stem cells are useful for tissue regeneration. Bone marrow mesenchymal stem cells (MSCs) are self-renewing and are potent in differentiating into multiple cells and tissues. To investigate the practicability of repairing burn wounds with tissue-engineered (TE) skin combi...

journal_title：Artificial organs

authors： Liu P,Deng Z,Han S,Liu T,Wen N,Lu W,Geng X,Huang S,Jin Y

更新日期：2008-12-01 00:00:00

abstract：:Success of total artificial heart (TAH) implantation as a temporary measure depends on three factors: proper patient selection, adequate surgical technique, and safe cardiac prostheses. From 1986 until March 1990, 237 patients with stagnant heart failure were examined. Sixty-one patients (27%) were put on a waiting li...

journal_title：Artificial organs

authors： Shumakov V,Zimin N,Kazakov E,Kormer A,Vorontsov S,Nikolaenko E,Kozlov I,Drobyshev A

更新日期：1991-10-01 00:00:00

abstract：:Pharmacologic agents and other non-protein-bound compounds smaller than 5,000 daltons have the potential to be removed by continuous arteriovenous hemofiltration (CAVH). A proposed method for estimating drug clearance by CAVH (ClCAVH) equates ultrafiltrate clearance to the product of the sieving coefficient and the av...

journal_title：Artificial organs

authors： Horton MW,Godley PJ,Moore ES,Fineg J,Gillespie WR

更新日期：1990-12-01 00:00:00