Oral treatment for jaundice using immobilized bilirubin oxidase.

Abstract:

:Jaundice is characterized by an excessive accumulation of bilirubin in the blood and tissues. A novel approach to reduce plasma levels of bilirubin by blocking its enterohepatic circulation was investigated. The treatment consisted of oral administration of immobilized bilirubin oxidase, which could oxidize bilirubin in the intestine to less toxic and more water-soluble products. In vivo administration of 0.1 to 2.0 mg/day of immobilized enzyme over a four-day period to chronically jaundiced Gunn rats effectively lowered plasma bilirubin levels, but only when the molar ratio of total serum bilirubin to rat serum albumin (B/RSA) was larger than 0.35. Plasma bilirubin concentration decreased in that group from an initial value of 11.3 to 6.3 mg/dl (-40%, n = 5) after eight days. This decrease was statistically significant (p < 0.05 by Student's t test). However, administration of bilirubin oxidase to rats with a B/RSA ratio less than 0.35 (n = 10) resulted in no statistically significant change in plasma bilirubin concentration.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Soltys PJ,Mullon C,Langer R

doi

10.1111/j.1525-1594.1992.tb00527.x

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

331-5

issue

4

eissn

0160-564X

issn

1525-1594

journal_volume

16

pub_type

杂志文章
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    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1988.tb01529.x

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  • Physiologic control of cardiac assist devices.

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    doi:10.1111/j.1525-1594.1996.tb04438.x

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    journal_title:Artificial organs

    pub_type: 杂志文章

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    更新日期:2013-08-01 00:00:00

  • Significant left ventricular unloading with transaortic catheter venting during venoarterial bypass.

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    pub_type: 杂志文章

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    更新日期:1997-07-01 00:00:00

  • Demand for and use of functional electrical stimulation systems and conventional orthoses in the spinal lesioned community of the UK.

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    pub_type: 杂志文章

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  • Anionic collagen: polymer composites with improved dielectric and rheological properties.

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    pub_type: 杂志文章

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    更新日期:1998-03-01 00:00:00

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    pub_type: 杂志文章

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  • Artificial cells with emphasis on cell encapsulation of genetically engineered cells.

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    pub_type: 杂志文章

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    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12814

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    更新日期:2016-12-01 00:00:00

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    pub_type: 杂志文章

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  • Optimal continuous retrograde coronary perfusion flow rate with beating heart in normal temperature.

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    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2004.47279.x

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    更新日期:2004-03-01 00:00:00

  • Comparison of rapid in situ, regular in situ, and ex vivo flushing on hepatic function.

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    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1988.tb02760.x

    authors: Castellanos J,Toledo-Pereyra LH,Finkelstein I,Kestenberg W,Chapman M,Choudhury S

    更新日期:1988-06-01 00:00:00

  • Results of the European clinical trial of Arrow CorAide left ventricular assist system.

    abstract::The aim of this study was to evaluate the safety and performance of the Arrow CorAide left ventricular assist system (LVAS) (Arrow International, Reading, PA, USA), a continuous-flow left ventricular assist device, as bridge to transplantation or recovery as well as destination therapy in patients with New York Heart ...

    journal_title:Artificial organs

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1525-1594.2012.01539.x

    authors: Saeed D,Arusoglu L,Gazzoli F,Hetzer R,Morshius M,Alloni A,Viganò M,Koerfer R,Golding LA,El Banayosy A

    更新日期:2013-02-01 00:00:00

  • Evaluation of membrane oxygenators and reservoirs in terms of capturing gaseous microemboli and pressure drops.

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    pub_type: 杂志文章

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    authors: Guan Y,Palanzo D,Kunselman A,Undar A

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  • Experimental high-volume hemofiltration with predilutional tris-hydroxymethylaminomethane for correction of low tidal volume ventilation-induced acidosis.

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    pub_type: 杂志文章

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    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2006.00202.x

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  • Hybrid assembly of metal head and femoral stem from different manufacturers during isolated acetabular revision.

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    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2010.01015.x

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    更新日期:2010-08-01 00:00:00

  • Utilization of activated carbon hemoperfusion to assist recovery of ischemically damaged canine liver allografts.

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    pub_type: 杂志文章

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  • Acetate-free biofiltration: a viable alternative to bicarbonate dialysis.

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    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1989.tb01561.x

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    pub_type: 杂志文章

    doi:10.1111/aor.12955

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    pub_type: 杂志文章,meta分析

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    pub_type: 临床试验,杂志文章

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    更新日期:2001-05-01 00:00:00