A New 2D Echocardiographic Approach to Evaluate the Membrane and Valve Movement of the Berlin Heart EXCOR VAD Chamber in Pediatric VAD Patients.

Abstract:

:The use of Berlin Heart EXCOR VAD (BH) is a validated therapy to bridge pediatric patients to heart transplant. Serial echocardiographic (ECHO) assessment of VAD patients is necessary to support patients' management. This work aims at developing an innovative strategy to evaluate the BH device functioning by ECHO and its interaction with the native heart in a pediatric population. ECHO evaluation of BH membrane movement, and inflow and outflow valves was performed in 2D, 2D-color Doppler, M-mode, and M-mode color Doppler to assess the functioning of the device by direct positioning of the ECHO probe on the BH cannulas and membranes. Forty Berlin Heart EXCOR VAD were analyzed in 18 patients. Seven BH were placed as RVAD and 33 as LVAD. Results evidenced that 14 (21) inflow (outflow) valves presented a mild regurgitation, while 5 inflow (3 outflow) valves presented a moderate regurgitation. In three cases, we observed severe valve regurgitation with back flow in the left ventricle/right atrium. In both cases, the BH chambers were substituted, but we observed that in one case the regurgitation was due to cannulas compression, while in the other case it was due to valve malfunctioning. The M-mode and the ECHO of the membranes and valves permitted to appreciate the beat phenomenon to assess if the native heart and the BH are working in opposite or in the same phase. The membrane ECHO permits evaluation of minimal changes in membrane movement to assure the completely empty-completely fully work modality. Systematic ECHO assessment of BH chamber might support the BH programming and the detection of anomalous VAD-heart interaction.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Di Molfetta A,Iacobelli R,Ferrari G,Filippelli S,Perri G,Toscano A,Adorisio R,Guccione P,Amodeo A

doi

10.1111/aor.13122

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

451-456

issue

4

eissn

0160-564X

issn

1525-1594

journal_volume

42

pub_type

杂志文章
  • Evaluation of membrane oxygenators and reservoirs in terms of capturing gaseous microemboli and pressure drops.

    abstract::An increasing amount of evidence points to cerebral embolization during cardiopulmonary bypass (CPB) as the principal etiologic factor of neurologic complications. In this study, the capability of capturing and classification of gaseous emboli and pressure drop of three different membrane oxygenators (Sorin Apex, Teru...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00955.x

    authors: Guan Y,Palanzo D,Kunselman A,Undar A

    更新日期:2009-11-01 00:00:00

  • Flow pattern analysis of the Baylor total artificial heart.

    abstract::To obtain an optimal design of the left blood chamber of the total artificial heart (TAH), flow visualization studies were performed. Information on velocities in critical areas of the left chamber was gathered using sectional pulsed laser light. The flow patterns on the entire pumping duration were photographed frame...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1994.tb03345.x

    authors: Meier D,Wernicke JT,Orime Y,Takatani S,Tasai K,Damm G,Naito K,Mizuguchi K,Makinouchi K,Glueck J

    更新日期:1994-12-01 00:00:00

  • (13) C Breath Tests Are Feasible in Patients With Extracorporeal Membrane Oxygenation Devices.

    abstract::Temporary extracorporeal membrane oxygenation (ECMO) has been established as an essential part of therapy in patients with pulmonary or cardiac failure. As physiological gaseous exchange is artificially altered in this patient group, it is debatable whether a (13) C-breath test can be carried out. In this proof of tec...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12634

    authors: Bednarsch J,Menk M,Malinowski M,Weber-Carstens S,Pratschke J,Stockmann M

    更新日期:2016-07-01 00:00:00

  • Long-term performance of homograft and autograft valves.

    abstract::Five hundred and eighty homograft valves have been inserted into the aortic position as isolated valve replacements, and followed up for 7--14 years. After ten years 90% of frozen homografts, 80% of autografts and 70% of freeze-dried homografts were free of valve-related death. There was only one embolism reported giv...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1980.tb03894.x

    authors: Bodnar E,Wain WH,Martelli V,Ross DN

    更新日期:1980-02-01 00:00:00

  • Transcutaneous monitoring of blood gas tensions in patients on intermittent peritoneal dialysis.

    abstract::A relative contraindication to intermittent peritoneal dialysis (IPD) is chronic lung disease. To evaluate whether the instillation of 2 L of fluid into the peritoneal cavity affects respiratory function, five IPD patients were studied in the supine position during the first 4 h of a routine IPD session. Blood gas ten...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1988.tb02768.x

    authors: Korzets Z,Pomeranz A,Shachor Y,Bernheim J

    更新日期:1988-06-01 00:00:00

  • Anterior chest wall axillary artery to contralateral axillary vein graft for vascular access in hemodialysis.

    abstract::Patients with end-stage renal failure and peripheral vascular disease pose a difficult management problem in establishing long-term angioaccess for hemodialysis. In 4 patients with access problems, we created axillary artery to contralateral axillary vein Goretex grafts. The grafts were cannulated regularly for period...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1995.tb02291.x

    authors: Ono K,Muto Y,Yano K,Yukizane T

    更新日期:1995-12-01 00:00:00

  • The accurate control of ultrafiltration.

    abstract::An apparatus has been contructed to regulate ultrafiltration accurately during dialysis. The principle of the apparatus is that, per unit of time, exactly the same amount of dialysate is introduced into the dialyzer as is discharged from it. The apparatus consists of two isovolumetric pumps connected in line. The four...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1978.tb03442.x

    authors: Flendrig JG,Carpay WM,Dekkers WT

    更新日期:1978-05-01 00:00:00

  • Minimally invasive access for central extracorporeal life support: how we do it.

    abstract::Central extracorporeal life support (ECLS) is an effective treatment method of cardiogenic shock patients with or without lung failure. However, complications like infection and bleeding are common. The classical implantation approach requires full sternotomy, mobilization of the heart, with the well-known risks of bl...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12344

    authors: Weymann A,Sabashnikov A,Patil NP,Mohite PN,Zych B,Garcia Saez D,Popov AF,Simon AR

    更新日期:2015-02-01 00:00:00

  • Binding of antithrombin to immobilized heparin under varying flow conditions.

    abstract::Rheologic factors are likely to influence the balance between thrombotic and antithrombotic forces at the level of the vascular wall. In this study, the effects of flow-velocity/wall shear stress on the interaction of antithrombin (AT) with surface-immobilized heparin were investigated. The binding of AT to low-affini...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:

    authors: Pasche B,Elgue G,Olsson P,Riesenfeld J,Rasmuson A

    更新日期:1991-12-01 00:00:00

  • Effects of pK variability on bicarbonate balance evaluation in dialysis patients.

    abstract::Bicarbonate balance is usually calculated from the Henderson-Hasselbalch equation under the assumption that pK is constant. To evaluate the pK variability and its effects on bicarbonate computed with autoanalyzers in dialysis patients, we studied 44 patients on maintenance hemodialysis. The pH, PCO2, total CO2, and pK...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1987.tb02715.x

    authors: Santoro A,Ferrari G,Spongano M,Cavalli F,Zucchelli P

    更新日期:1987-12-01 00:00:00

  • A newly designed adapter for testing an ex vivo mitral valve apparatus.

    abstract::Few instruments are currently available to test mitral valve function in an ex vivo state due to the technical difficulties involved. To investigate the native ex vivo mitral valve or prosthetic mitral valve with chordae, we developed a mitral valve adapter with an annulus suturing portion and 2 papillary muscle sutur...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1999.06293.x

    authors: Katoh T,Ikeda N,Nishi K,Gohra H,Hamano K,Noda H,Fujimura Y,Esato K

    更新日期:1999-10-01 00:00:00

  • Biomechanical properties of decellularized porcine pulmonary valve conduits.

    abstract::Tissue-engineered heart valves constructed from a xenogeneic or allogeneic decellularized matrix might overcome the disadvantages of current heart valve substitutes. One major necessity besides effective decellularization is to preserve the biomechanical properties of the valve. Native and decellularized porcine pulmo...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2007.00452.x

    authors: Seebacher G,Grasl C,Stoiber M,Rieder E,Kasimir MT,Dunkler D,Simon P,Weigel G,Schima H

    更新日期:2008-01-01 00:00:00

  • Experimental setup to evaluate the performance of percutaneous pulmonary valved stent in different outflow tract morphologies.

    abstract::Percutaneous pulmonary valve implantation is a potential treatment for right ventricular outflow tract (RVOT) dysfunction. However, RVOT implantation site varies among subjects and the success of the procedure depends on RVOT morphology selection. The aim of this study was to use in vitro testing to establish percutan...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2008.00673.x

    authors: Vismara R,Laganà K,Migliavacca F,Schievano S,Coats L,Taylor A,Bonhoeffer P

    更新日期:2009-01-01 00:00:00

  • Prolonged left ventricular dysfunction induced by sequential multifocal ischemic infarcts in dogs.

    abstract::A method of creating multifocal ischemia in animals leading to left ventricular (LV) functional impairment is described. In a series of 10 mongrel dogs, electrodes were implanted in multiple branches of the coronary arteries. Subsequently, in seven animals, an 800-microA anodal current was applied for 3 h repeatedly o...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1984.tb04321.x

    authors: Polanski J,Mandell G,Wasfie T,Freed PS,Yoshizu H,Stein PD,Sabbah HN,Kantrowitz A

    更新日期:1984-11-01 00:00:00

  • Acellular Endocardium as a Novel Biomaterial for the Intima of Tissue-Engineered Small-Caliber Vascular Grafts.

    abstract::We aimed to investigate whether acellular endocardium can be used as a useful biomaterial for the intima of engineered small-caliber vascular grafts. Fresh endocardium was harvested from the swine left atrium and was decellularized by digestion with the decellularization solution of Triton X-100 and SDS containing DNa...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12814

    authors: Wang F,Guan X,Wu T,Qiao J,Han Z,Wu J,Yu X,You Q

    更新日期:2016-12-01 00:00:00

  • Experimental study of a new method for early detection of vascular access stenoses: pulse pressure analysis at hemodialysis needle.

    abstract::Hemodialysis vascular access (VA) stenosis remains a frequent complication. However, early detection is challenging and costly. The aim of this in vitro study was to assess a new detection method based on pulse pressure analysis at the hemodialysis needle. A silicon model of a radiocephalic arteriovenous fistula was b...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00772.x

    authors: Van Canneyt K,Planken RN,Eloot S,Segers P,Verdonck P

    更新日期:2010-02-01 00:00:00

  • Superior mesenteric artery mycotic aneurysm in patients with left ventricular assist device support and intravenous drug abuse.

    abstract::Mycotic aneurysm of the superior mesenteric artery (SMA) is one of the complications associated with infective endocarditis. However, there are no previous case reports in the literature describing mycotic SMA aneurysm after left ventricular assist device (LVAD) implantation. We describe the case of a 31-year-old male...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2011.01250.x

    authors: Motomura T,Bruckner B,Leon-Becerril J,Anaya-Ayala JE,de Rienzo-Madero B,Bismuth J,Bunge R,Irwin S,Loebe M

    更新日期:2011-07-01 00:00:00

  • Dual-pump support in the inferior and superior vena cavae of a patient-specific fontan physiology.

    abstract::The implementation of simultaneous mechanical cavopulmonary assistance having blood pumps located in both of the vena cavae is investigated as an approach to treating patients with an ailing Fontan physiology. Identical intravascular blood pumps are employed to model the hemodynamic support of a patient-specific Fonta...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12039

    authors: Throckmorton AL,Lopez-Isaza S,Moskowitz W

    更新日期:2013-06-01 00:00:00

  • Cooling device for bradycardia based on Peltier element for accurate anastomosis of off-pump coronary artery bypass grafting.

    abstract::Upon introducing off-pump coronary artery bypass grafting (CABG), the indications for CABG were expanded to include patients who previously had no operative indications. For accurate anastomosis, various devices and methods have been developed. Bradycardia is easily induced by drug administration. However, this method...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2002.07087.x

    authors: Kuniyoshi Y,Koja K,Miyagi K,Shimoji M,Uezu T,Arakaki K,Yamashiro S,Mabuni K,Senaha S

    更新日期:2002-10-01 00:00:00

  • Judicious usage of estrogen/progesterone for angiodysplasia.

    abstract::We recently experienced a case of a female hemodialysis patient with multiple intestinal angiodysplasias. In 2001, she complained of melena, and angiographic embolization halted bleeding from ileum angiodysplasia. In 2002, she again complained of black stool. Abdominal angiography found jejunum angiodysplasia, and pha...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2004.29003.x

    authors: Takenaka T,Kanno Y,Suzuki H

    更新日期:2005-01-01 00:00:00

  • Nonsymmetric leaflet motion of St. Jude Medical mitral valves simulated with a computer-controlled hydraulic mock circulator.

    abstract::Since the introduction of high-performance prosthetic heart valves, particularly bileaflet valves and monoleaflet valves with larger opening angles, we have observed in vivo complex leaflet motion which has not been experimentally confirmed yet. We developed a computer-controlled hydraulic mock circulator to study the...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb00373.x

    authors: Ohta Y,Okamoto K,Sonderegger M,Dohi T,Matsumoto H,Horiuchi T

    更新日期:1997-04-01 00:00:00

  • Simple evaluation method of biocompatibility of artificial oxygenator hollow fiber.

    abstract::We made miniature modules filled with artificial oxygenator hollow fibers and conducted a simple experiment to study the effect of different membrane structures on the blood. Three types of modules were made: one filled with polyolefin, one filled with polypropylene, and a blank module. The 3 modules were connected th...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1996.tb00677.x

    authors: Nishida H,Shibuya M,Endo M,Koyanagi H

    更新日期:1996-12-01 00:00:00

  • Physical testing of elastomers for cardiovascular applications.

    abstract::There are presently no short-term in vitro fatigue tests available that can predict long-term in vivo performance of elastomers in physiological environments. Thus, the introduction of new and better elastomers for cardiovascular applications is hampered in the development stage by lack of data about which materials s...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1983.tb04162.x

    authors: McMillin CR

    更新日期:1983-02-01 00:00:00

  • Plasma exchange and immunoadsorption for removal of antibodies prior to ABO incompatible bone marrow transplant.

    abstract::ABO incompatible allogeneic bone marrow transplants can be performed successfully to treat patients with leukemia or aplastic anemia. These transplants carry no great risk of rejection or graft-versus-host disease, however, some method must be used to avoid acute hemolysis at the time of infusion of ABO incompatible m...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1981.tb03998.x

    authors: Bensinger WI

    更新日期:1981-08-01 00:00:00

  • Adsorption of microorganism components by lixelle beads.

    abstract::We reported previously that Lixelle, which was used for beta-2 microglobulin (BMG) adsorption columns, could adsorb not only BMG but also inflammatory cytokines. We then were interested in the application of Lixelle to patients with systemic inflammatory response syndrome (SIRS) and tried to find out its ability to ad...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2000.06502-2.x

    authors: Tsuchida K,Takemoto Y,Nakatani T,Nakamura T,Sugimura K,Yamamoto K

    更新日期:2000-07-01 00:00:00

  • Testosterone and hemoglobin in hemodialysis male and female patients.

    abstract::It has been speculated that testosterone stimulates erythropoiesis. We hypothesized that hemoglobin levels in hemodialysis (HD) patients are associated with serum testosterone concentrations. Testosterone, hemoglobin, and other biochemical parameters were measured in a representative sample of 98 chronic HD patients (...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12218

    authors: Ekart R,Taskovska M,Hojs N,Bevc S,Hojs R

    更新日期:2014-07-01 00:00:00

  • Cytotoxicity and genotoxicity of bovine pericardium preserved in glycerol.

    abstract::Bovine pericardium is a widely utilized biomaterial. Usually, after harvesting, it is advantageous that the pericardium be immersed in glycerol to improve its shelf life. This can induce some degree of toxicity in the material. The studies were performed in compliance with the rules of ISO 10993 and OECD 487, in the b...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2008.00542.x

    authors: Rodas AC,Maizato MJ,Leirner AA,Pitombo RN,Polakiewicz B,Beppu MM,Higa OZ

    更新日期:2008-04-01 00:00:00

  • A comparative study between flow visualization and computational fluid dynamic analysis for the sun medical centrifugal blood pump.

    abstract::Flow visualization experiments and computational fluid dynamic (CFD) analyses were performed and the results were compared to clarify the detailed fluid dynamic characteristics for the prototype design of a centrifugal pump, namely, an implantable ventricular assist system from Sun Medical, whose hemocompatibility was...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2004.07161.x

    authors: Yamane T,Miyamoto Y,Tajima K,Yamazaki K

    更新日期:2004-05-01 00:00:00

  • The effect of electrode placement and interphase interval on force production during stimulation of the dorsiflexor muscles.

    abstract::The aims of this study were to investigate whether introducing an interphase interval (IPI) to biphasic pulses during stimulation of the dorsiflexor muscles would affect force production and to determine whether the IPI effect is dependent on electrode position. Twelve healthy volunteers participated in the study. Eac...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12346

    authors: Springer S,Braun-Benyamin O,Abraham-Shitreet C,Becher M,Laufer Y

    更新日期:2014-11-01 00:00:00

  • Intravenous prostacyclin mitigates inhaled nitric oxide rebound effect: A case control study.

    abstract::Although extracorporeal membrane oxygenation (ECMO) improves oxygenation, pulmonary vascular resistance may be increased due to endothelial function impairment. Inhaled nitric oxide (iNO) is increasingly used for treatment of pulmonary hypertension after surgical repair of congenital heart defects, with or without ECM...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1999.06448.x

    authors: Hermon M,Golej J,Burda G,Marx M,Trittenwein G,Pollak A

    更新日期:1999-11-01 00:00:00