Physical testing of elastomers for cardiovascular applications.

abstract：:Recent progress in the development of implantable rotary blood pumps realized long-term mechanical circulatory support (MCS) for bridge to transplant, bridge to recovery, or a destination therapy. Meanwhile, a short-term MCS system is becoming necessary for bridge to decision. We developed a novel inflow cannula for t...

journal_title：Artificial organs

authors： Sumikura H,Toda K,Takewa Y,Tsukiya T,Ohnuma K,Sasagawa M,Watanabe F,Ugawa J,Taenaka Y,Tatsumi E

更新日期：2011-08-01 00:00:00

abstract：:Myointimal hyperplasia (MIH) is an arterial wall smooth muscle cell (SMC) proliferative disorder. This process is responsible for a significant number of early and long-term arterial reconstructive and graft failures. Histopathologically, this process is characterized by a proliferation of SMC in the intima of traumat...

journal_title：Artificial organs

authors： Painter TA

更新日期：1991-02-01 00:00:00

abstract：:Porcine endogenous retrovirus (PERV) genomes are present in all pig cells. In this retrospective study, we assessed PERV infectivity in 28 patients treated with an extracorporeal bioartificial liver (HepatAssist system) that includes a membrane device containing porcine hepatocytes. All patients tested negative for PE...

journal_title：Artificial organs

authors： Pitkin Z,Mullon C

更新日期：1999-09-01 00:00:00

abstract：:To remove anti-DNA antibodies from a patient's plasma with systemic lupus erythematosus (SLE), a DNA immunoadsorbent was developed by covalently coupling calf thymus DNA on activated Sepharose 4FF. Sepharose 4FF was activated with 5-norbornene-2,3-dicarboximido carbonochloridate (Cl-CO-ONB), which was proven to be a v...

journal_title：Artificial organs

authors： Kong DL,Schuett W,Boeden HF,Kunkel S,Holtz M,Matic G,Yamada R,Yu YT,Klinkmann H

更新日期：2000-11-01 00:00:00

abstract：:Percutaneous femoral venoarterial (VA) or jugular venovenous (VV) extracorporeal membrane oxygenation (ECMO) can result in delivery of hypoxic blood to the brain, coronaries, and upper extremities. Additionally, VA-ECMO by percutaneous femoral artery cannulation may compromise perfusion to the lower limbs. Use of near...

journal_title：Artificial organs

authors： Wong JK,Smith TN,Pitcher HT,Hirose H,Cavarocchi NC

更新日期：2012-08-01 00:00:00

abstract：:For introduction of a left atrial (LA) cannula by the transseptal puncture technique, we examined the feasibility of using biplane transesophageal echocardiography (B-TEE). A transseptal puncture was performed on 15 patients (3 male; 12 female; mean age, 48.9 +/- 11.2 years) by B-TEE guide during percutaneous transven...

journal_title：Artificial organs

authors： Kyo S,Motoyama T,Miyamoto N,Noda H,Dohi Y,Omoto R

更新日期：1992-08-01 00:00:00

abstract：:We developed a novel miniaturized extracorporeal centrifugal pump "BIOFLOAT NCVC (Nipro Corporation Osaka, Japan) as a ventricular assist device (VAD) and performed a preclinical study that is part of the process for its approval as a bridge to decision by the pharmaceutical and medical device agencies. The aim of thi...

journal_title：Artificial organs

authors： Shimamura J,Mizuno T,Takewa Y,Tsukiya T,Naito N,Akiyama D,Iizuka K,Katagiri N,Nishimura T,Ono M,Tatsumi E

更新日期：2019-09-01 00:00:00

abstract：:In vitro tests have shown that electric currents may lead either to relaxation or contraction of the bowel wall. Because voluntary changes of the intestinal motility could be useful in the treatment of intestinal disorders, we investigated the reactions elicited by electrostimulation of the small intestine in the inta...

journal_title：Artificial organs

authors： Moritz A,Grundfest-Broniatowski S,Ilyes L,Kasick J,Jacobs G,Olsen E,Nosé Y

更新日期：1989-04-01 00:00:00

abstract：:Stents are small, usually metallic tubes that are intended to prop open arteries blocked with atherosclerotic plaques. While stents have been used successfully in recent years, they still suffer from failure due to development of new tissue in stented segment (restenosis). Variations in the failure rates associated wi...

journal_title：Artificial organs

authors： Frank AO,Walsh PW,Moore JE Jr

更新日期：2002-07-01 00:00:00

abstract：:Monoclonal antibodies for targeting cytotoxic conjugates to tumor cells are currently being evaluated together with extracorporeal affinity adsorption. The aim of the adsorption was to reduce undesired side effects in normal organs and to increase the tumor-to-normal tissue ratios. This technique is also applicable to...

journal_title：Artificial organs

authors： Mårtensson L,Nilsson R,Sjögren HO,Strand SE,Tennvall J

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Ventricular assist devices are gaining ground in the therapeutic treatment of chronic heart failure. These devices are sometimes used as a bridge to recovery by unloading the left ventricle (LV) and restoring its function. It is therefore important to preserve the heart muscle and apply less invasive implant...

journal_title：Artificial organs

authors： Vandenberghe S,Nishida T,Segers P,Meyns B,Verdonck P

更新日期：2004-07-01 00:00:00

abstract：:Using an ex vivo model, the effects of membrane composition and surface area on both the complement system (as reflected by plasma C3a levels) and platelets [as indicated by plasma concentrations of thromboxane B2 (TXB2) and platelet factor 4 (PF4)] were studied. In this model, polyacrylonitrile (PAN) was associated w...

journal_title：Artificial organs

authors： Mahiout A,Meinhold H,Kessel M,Schulze H,Baurmeister U

更新日期：1987-04-01 00:00:00

abstract：:Following implantation of a left ventricular assist device (LVAD), acceptable functional performance is now being achieved; however, peak VO2 and peak work load (watts) remain considerably limited. Maximum physical capacity is essentially dependent on generated cardiac output (CO) and arteriovenous oxygen difference (...

journal_title：Artificial organs

authors： Schmidt T,Bjarnason-Wehrens B,Mommertz S,Hannig M,Schulte-Eistrup S,Willemsen D,Reiss N

更新日期：2018-07-01 00:00:00

abstract：:Experiments have been successfully performed culminating in functional, vascularized, three-dimensional cardiac muscle tissue. Past experience in tissue engineering has led us to the understanding that cell seeding density plays a critical role in the formation and function of both in vitro and in vivo engineered tiss...

journal_title：Artificial organs

authors： Birla R,Dhawan V,Huang YC,Lytle I,Tiranathanagul K,Brown D

更新日期：2008-09-01 00:00:00

abstract：:The cochlea is an end organ, which is metabolically dependent on a nutrient and oxygen supply to maintain its normal physiological function. Cochlear ischemia and reperfusion (IR) injury is considered one of the most important causes of human idiopathic sudden sensorineural hearing loss. The aim of the present study w...

journal_title：Artificial organs

authors： Onal M,Elsurer C,Selimoglu N,Yilmaz M,Erdogan E,Bengi Celik J,Kal O,Onal O

更新日期：2017-08-01 00:00:00

abstract：:Continuous hemodiafiltration (CHDF) has been performed for the treatment of severe acute pancreatitis. Phospholipase A2 (PLA2) is one of the important mediators which exacerbate acute pancreatitis, but whether PLA2 can be removed by CHDF is unclear. In this study, the kinetics of group IB and group IIA PLA2 was examin...

journal_title：Artificial organs

authors： Suzuki M,Okahisa T,Sogabe M,Iwaki H,Okita Y,Ohnishi Y,Ito S

更新日期：2007-05-01 00:00:00

abstract：:A computer simulation was carried out to investigate the influence of nonpulsatile left ventricular assistance on hemodynamics. A simulation circuit was constructed to represent the circulatory system. A source of current was added to denote the nonpulsatile blood pump. The left and right ventricles were replaced by v...

journal_title：Artificial organs

authors： Mitsui N,Fukunaga S,Koura Y,Morita S,Hotei H,Sueshiro M,Sueda T,Matsuura Y

更新日期：1996-05-01 00:00:00

abstract：:Lipid apheresis has developed from a heroic treatment into a routine clinical therapy and currently is the major indication for performing extracorporeal plasma therapy. Whereas it was once reserved for patients with homozygous familial hypercholesterolemia, today it has a place in the secondary prevention of severe c...

journal_title：Artificial organs

authors： Bosch T

更新日期：1996-05-01 00:00:00

abstract：:For the last few years we have attempted to separate and isolate from biological fluids the uremic Middle Molecules (MM). The first step in the treatment of plasma is an ultrafiltration through AN69 membrane. The samples are fractionated by Sephadex G-15 chromatography into 9 peaks "a" to "i' under precise conditions ...

journal_title：Artificial organs

authors： Cueille G,Man NK,Sausse A,Farges JP,Funck-Brentano JL

更新日期：1981-01-01 00:00:00

abstract：:Possible routes for water and salt flow and the most likely theories that describe coupling between water and salt flow across leaky epithelia are presented. The osmotic theories seem the most likely ones. However, several of the theories have weaknesses that render them unsatisfactory, in particular because of the po...

journal_title：Artificial organs

authors： Whittembury G,Carpi-Medina P,González E,Linares H

更新日期：1987-12-01 00:00:00

abstract：:We aimed to determine the effect of elective left heart decompression at the time of initiation of central venoarterial extracorporeal membrane oxygenation (VA ECMO) on VA ECMO duration and clinical outcomes in children in a single tertiary ECMO referral center with a large pediatric population from a national referra...

journal_title：Artificial organs

authors： Hacking DF,Best D,d'Udekem Y,Brizard CP,Konstantinov IE,Millar J,Butt W

更新日期：2015-04-01 00:00:00

abstract：:A novel method of extracorporeal support for fulminant liver failure is reported whereby the most important detoxification processes of the liver are reproduced in an enzyme reactor. Most of the endogenous toxins involved in hepatic coma can be deactivated directly by conjugation with a hydrophilic residue such as glu...

journal_title：Artificial organs

authors： Brunner G,Holloway CJ,Lösgen H

更新日期：1979-02-01 00:00:00

abstract：:Dual chamber (DC) peritoneal dialysis (PD) dialysates contain fewer glucose degradation products (GDPs), so potentially reducing advanced glycosylation end products (AGEs), which have been reported to increase inflammation and cardiovascular risk. We wished to determine whether use of DC dialysates resulted in demonst...

journal_title：Artificial organs

authors： Vareesangthip K,Vongsanim S,Fan S,Davenport A

更新日期：2020-07-09 00:00:00

abstract：:Aortic wall thinness was one of the most characteristic changes observed in experimental animals under prolonged continuous flow left heart bypass. The goal of this study was to determine the roles of smooth muscle cells in the vascular remodeling process in cases demonstrating aortic wall thinness under prolonged con...

journal_title：Artificial organs

authors： Mizuno T,Nishinaka T,Ohnishi H,Tatsumi E,Tsukiya T,Oshikawa M,Shioya K,Takewa Y,Homma A,Takano H,Kitamura S,Taenaka Y

更新日期：2003-10-01 00:00:00

abstract：:In clinical application of rotary blood pumps, flow obstruction as a result of suction of the inflow cannula, kinking of tubing, or thrombus formation occurs quite frequently. Early detection of such problems is essential to avoid hemolysis, tissue degradation, or release of thrombi to the patient. A program was devel...

journal_title：Artificial organs

authors： Holzer S,Scherer R,Schmidt C,Schwendenwein I,Wieselthaler G,Noisser R,Schima H

更新日期：1995-07-01 00:00:00

abstract：:Twelve patients, 8 male and 4 female, aged from 26 to 70 years were studied. They were on hemodialysis (HD) 4 h three times weekly with cuprophan hollow fiber dialyzers (Gambro 120M) and dialysate containing 35 mEq/L of acetate. The study compares two random HD sessions on each patient. Sixty minutes prior to one rand...

journal_title：Artificial organs

authors： Grekas D,Alivanis P,Karamouzis M,Pyrpasopoulos M,Tourkantonis A

更新日期：1989-10-01 00:00:00

abstract：:The addition of human serum albumin (HSA) to peritoneal dialysate increases the clearance of bilirubin in rats suffering from obstructive jaundice. The acceptor properties of the fluid can be enhanced by using HSA that does not contain standard stabilizing additives and has been purified by further adsorption on activ...

journal_title：Artificial organs

authors： Sarnatskaya VV,Nikolaev VG,Osipova LA,Ivanov AI,Maslenny VN,Ivanyuk AA,Yushko LA

更新日期：1993-10-01 00:00:00

abstract：:As the aortic valve (AV) opens, the pump pressure head remains constant, which is reflected as a "notch/plateau" in pump pressure and flow signals. However, instantaneous flow estimation may be influenced by friction and is particularly difficult in axial pumps. Therefore, a new method to determine the duration of AV ...

journal_title：Artificial organs

authors： Hayward C,Lim CP,Schima H,Macdonald P,Moscato F,Muthiah K,Granegger M

更新日期：2015-08-01 00:00:00

abstract：:Out-of-Hospital refractory Cardiac Arrest (OHrCA) has a mortality rate between 90 and 95%. Since 2009, French medical academic societies have recommended the use of extracorporeal life support (ECLS) for OHrCA. According to these guidelines, patients were eligible for ECLS support if vital signs were still present dur...

journal_title：Artificial organs

authors： Rousse N,Robin E,Juthier F,Hysi I,Banfi C,Al Ibrahim M,Coadou H,Goldstein P,Wiel E,Vincentelli A

更新日期：2016-09-01 00:00:00

abstract：:Interest in the effects and possible mechanisms of hemodialysis on schizophrenic patients has led to a double-blind evaluation of the effects of plasmapheresis on symptoms of schizophrenia. Also, plasmapheresis was felt to be an invaluable tool for investigating the autoimmune theory of schizophrenia. Patients (n = 10...

journal_title：Artificial organs

authors： Schulz SC,van Kammen DP,Waters R,Klein HG,Balow JE,Bunney WE Jr

更新日期：1983-08-01 00:00:00