Biomechanical properties of decellularized porcine pulmonary valve conduits.


:Tissue-engineered heart valves constructed from a xenogeneic or allogeneic decellularized matrix might overcome the disadvantages of current heart valve substitutes. One major necessity besides effective decellularization is to preserve the biomechanical properties of the valve. Native and decellularized porcine pulmonary heart valve conduits (PPVCs) (with [n = 10] or without [n = 10] cryopreservation) were compared to cryopreserved human pulmonary valve conduits (n = 7). Samples of the conduit were measured for wall thickness and underwent tensile tests. Elongation measurement was performed with a video extensometer. Decellularized PPVC showed a higher failure force both in longitudinal (+73%; P < 0.01) and transverse (+66%; P < 0.001) direction compared to human homografts. Failure force of the tissue after cryopreservation was still higher in the porcine group (longitudinal: +106%, P < 0.01; transverse: +58%, P < 0.001). In comparison to human homografts, both decellularized and decellularized cryopreserved porcine conduits showed a higher extensibility in longitudinal (decellularized: +61%, P < 0.001; decellularized + cryopreserved: +51%, P < 0.01) and transverse (decellularized: +126%, P < 0.001; decellularized + cryopreserved: +118%, P < 0.001) direction. Again, cryopreservation did not influence the biomechanical properties of the decellularized porcine matrix.


Artif Organs


Artificial organs


Seebacher G,Grasl C,Stoiber M,Rieder E,Kasimir MT,Dunkler D,Simon P,Weigel G,Schima H




Has Abstract


2008-01-01 00:00:00














  • Partial artificial heart (ALVAD) use with subsequent cardiac and renal allografting in a patient with stone heart syndrome.

    abstract::The abdominal left ventricular assist device (ALVAD) is an order of magnitude more effective than conventional intra-aortic balloon pumping (IABP) in unloading and providing circulatory support to the failing left ventricle. This is a report of a unique case which demonstrates that in the absence of pulmonary vascular...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Norman JC,Dacso CC,Reul GJ,Massin EK,Klima T,Kahan BD,Keiser JT,Cooley DA

    更新日期:1978-11-01 00:00:00

  • The role of PI3K/Akt signaling pathway in non-physiological shear stress-induced platelet activation.

    abstract::The PI3K/Akt signaling pathway has been implicated in playing an important role in platelet activation during hemostasis and thrombosis involving platelet-matrix interaction and platelet aggregation. Its role in non-physiological shear stress (NPSS)-induced platelet activation relevant to high-shear blood contacting m...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Chen Z,Li T,Kareem K,Tran D,Griffith BP,Wu ZJ

    更新日期:2019-09-01 00:00:00

  • The application of immobilized enzymes in an artificial liver support system.

    abstract::A novel method of extracorporeal support for fulminant liver failure is reported whereby the most important detoxification processes of the liver are reproduced in an enzyme reactor. Most of the endogenous toxins involved in hepatic coma can be deactivated directly by conjugation with a hydrophilic residue such as glu...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Brunner G,Holloway CJ,Lösgen H

    更新日期:1979-02-01 00:00:00

  • Feasibility of extracorporeal on-line large-scale plasma adsorptions on protein A-sepharose columns in cancer patients.

    abstract::The feasibility of extracorporeal adsorption of 1.5-3 L plasma on protein A-Sepharose was investigated in six patients with advanced cancer. Anticoagulation with heparin was associated with respiratory distress syndrome in two patients, most likely caused by complement activation as indicated by a transient leukopenia...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Wallmark A,Grubb A,Freiburghaus C,Flodgren P,Husberg B,Lindholm T,Lindström C,Thysell H,Sjögren HO

    更新日期:1984-02-01 00:00:00

  • Rate of thrombus accumulation on intravenacaval IVOX devices explanted from human clinical trial patients with acute respiratory failure.

    abstract::The weight gain of IVOX devices removed from the first 49 human clinical trials patients after from 1 to 29 days of implantation into the venae caval blood stream has been assessed. Each patient had received sufficient systemic heparin to maintain activated clotting times between 150 and 200 s while the IVOX device wa...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Imai H,Schaap RN,Mortensen JD

    更新日期:1994-11-01 00:00:00

  • Flow behavior within the 12-cc Penn State pulsatile pediatric ventricular assist device: an experimental study of the initial design.

    abstract::Planar particle image velocimetry was used to explore the flow behavior of the newly designed 12-cc Penn State pneumatic pediatric assist pump. Wall shear maps complemented the velocity data. Bjork-Shiley Monostrut 17-mm mechanical heart valves were used in the inlet and outlet ports. In comparison with larger Penn St...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Manning KB,Wivholm BD,Yang N,Fontaine AA,Deutsch S

    更新日期:2008-06-01 00:00:00

  • Application of computational fluid dynamics techniques to blood pumps.

    abstract::Present-day computational fluid dynamics (CFD) techniques can be used to analyze the behavior of fluid flow in a variety of pumps. CFD can be a powerful tool during the design stage for rapid virtual prototyping of different designs, analyzing performance parameters, and making design improvements. Computational flow ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Sukumar R,Athavale MM,Makhijani VB,Przekwas AJ

    更新日期:1996-06-01 00:00:00

  • Development of a DNA immunoadsorbent: coupling DNA on sepharose 4FF by an efficient activation method.

    abstract::To remove anti-DNA antibodies from a patient's plasma with systemic lupus erythematosus (SLE), a DNA immunoadsorbent was developed by covalently coupling calf thymus DNA on activated Sepharose 4FF. Sepharose 4FF was activated with 5-norbornene-2,3-dicarboximido carbonochloridate (Cl-CO-ONB), which was proven to be a v...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Kong DL,Schuett W,Boeden HF,Kunkel S,Holtz M,Matic G,Yamada R,Yu YT,Klinkmann H

    更新日期:2000-11-01 00:00:00

  • Short hemodialysis: long-term mortality and morbidity.

    abstract::Individualized short hemodialysis treatment schedules, approximately three 3-h treatments per week, were introduced in a nephrology unit in 1976. In May 1985, 259 patients had been treated, which corresponds to approximately 60 new patients per million inhabitants per year. Ages at start of therapy ranged between 17 a...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Wauters JP,Bercini-Pansiot S,Gilliard N,Stauffer JC

    更新日期:1986-06-01 00:00:00

  • Oral treatment for jaundice using immobilized bilirubin oxidase.

    abstract::Jaundice is characterized by an excessive accumulation of bilirubin in the blood and tissues. A novel approach to reduce plasma levels of bilirubin by blocking its enterohepatic circulation was investigated. The treatment consisted of oral administration of immobilized bilirubin oxidase, which could oxidize bilirubin ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Soltys PJ,Mullon C,Langer R

    更新日期:1992-08-01 00:00:00

  • Noninvasive average flow estimation for an implantable rotary blood pump: a new algorithm incorporating the role of blood viscosity.

    abstract::The effect of blood hematocrit (HCT) on a noninvasive flow estimation algorithm was examined in a centrifugal implantable rotary blood pump (iRBP) used for ventricular assistance. An average flow estimator, based on three parameters, input electrical power, pump speed, and HCT, was developed. Data were collected in a ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Malagutti N,Karantonis DM,Cloherty SL,Ayre PJ,Mason DG,Salamonsen RF,Lovell NH

    更新日期:2007-01-01 00:00:00

  • Cell exclusion in couette flow: evaluation through flow visualization and mechanical forces.

    abstract::Cell exclusion is the phenomenon whereby the hematocrit and viscosity of blood decrease in areas of high stress. While this is well known in naturally occurring Poiseuille flow in the human body, it has never previously been shown in Couette flow, which occurs in implantable devices including blood pumps. The high-she...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Leslie LJ,Marshall LJ,Devitt A,Hilton A,Tansley GD

    更新日期:2013-03-01 00:00:00

  • Estimation of maximum ventricular elastance under assistance with a rotary blood pump.

    abstract::The maximum ventricular elastance is a reliable index for assessing the cardiac function from changes in its pressure-volume relationship. The advantage of this index is that it can represent the contractility of either unassisted hearts or native hearts assisted with rotary blood pumps. However, there are situations ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Sugai TK,Tanaka A,Yoshizawa M,Shiraishi Y,Yambe T,Nitta S,Baba A

    更新日期:2010-05-01 00:00:00

  • Heart valve inspired and multi-stream aortic cannula: Novel designs for cardiopulmonary bypass improvement in neonates.

    abstract::In a typical open-heart surgery, the blood flow through the aortic cannula is a critical element of the cardiopulmonary bypass (CPB) procedure. Especially for the neonatal and pediatric CPB flow conditions, the need for small hydraulic diameter and large blood flow results confined turbulent jet flow regimes that exac...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Rasooli R,Pekkan K

    更新日期:2019-10-01 00:00:00

  • Effects of customized bicarbonate buffered solutions for continuous renal replacement therapies on polymorphonuclear leukocytes function and viability.

    abstract::It has previously been shown that the mixture of bicarbonate and calcium in the solutions used for continuous renal replacement therapy led to crystallization and significant changes in calcium concentration and pH. The aim of this study was to investigate the impact of bicarbonate/calcium and lactate/calcium solution...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Maccariello E,Dalboni MA,Draibe SA,Rocha E,Pavão dos Santos OF,Santos B,Cendoroglo M

    更新日期:2004-06-01 00:00:00

  • Miniaturized centrifugal ventricular assist device for bridge to decision: Preclinical chronic study in a bovine model.

    abstract::We developed a novel miniaturized extracorporeal centrifugal pump "BIOFLOAT NCVC (Nipro Corporation Osaka, Japan) as a ventricular assist device (VAD) and performed a preclinical study that is part of the process for its approval as a bridge to decision by the pharmaceutical and medical device agencies. The aim of thi...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Shimamura J,Mizuno T,Takewa Y,Tsukiya T,Naito N,Akiyama D,Iizuka K,Katagiri N,Nishimura T,Ono M,Tatsumi E

    更新日期:2019-09-01 00:00:00

  • Estimation of theophylline clearance during continuous arteriovenous hemofiltration.

    abstract::Pharmacologic agents and other non-protein-bound compounds smaller than 5,000 daltons have the potential to be removed by continuous arteriovenous hemofiltration (CAVH). A proposed method for estimating drug clearance by CAVH (ClCAVH) equates ultrafiltrate clearance to the product of the sieving coefficient and the av...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Horton MW,Godley PJ,Moore ES,Fineg J,Gillespie WR

    更新日期:1990-12-01 00:00:00

  • In vitro generation of atrioventricular heart valve neoscaffolds.

    abstract::Tissue engineering of cardiovascular structures represents a novel approach to improve clinical strategies in heart valve disease treatment. The aim of this study was to engineer decellularized atrioventricular heart valve neoscaffolds with an intact ultrastructure and to reseed them with umbilical cord-derived endoth...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Weymann A,Radovits T,Schmack B,Li S,Korkmaz S,Soós P,Istók R,Veres G,Chaimow N,Karck M,Szabó G

    更新日期:2014-07-01 00:00:00

  • Comparison of Centrifugal and Roller Pump Hemolysis Rates at Low Flow.

    abstract::We compared in vitro rates of hemolysis for a recently developed centrifugal pump with a conventional roller pump (10-10-00; Stöckert, Munich, Germany). Flow rates of 0.3 L/min and 1 L/min and a pressure of 200 mm Hg were chosen to simulate conditions during neonatal extracorporeal membrane oxygenation (ECMO). There w...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Moon YS,Ohtsubo S,Gomez MR,Moon JK,Nose Y

    更新日期:1996-05-01 00:00:00

  • Liposome encapsulated hemoglobin as a resuscitation fluid for hemorrhagic shock.

    abstract::The effectiveness of the blood substitute neo red cells (NRC) on hemorrhagic shock was evaluated in dogs. Shock was induced by bloodletting, and NRC was infused immediately until the dogs recovered from shock; the process was repeated 3 times (mild shock), or NRC was infused after shock was maintained for 30 min, and ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Usuba A,Osuka F,Kimura T,Sato R,Fujita Y,Yamashita M,Hoshino C

    更新日期:1998-02-01 00:00:00

  • Assessment of total hip arthroplasty by means of computed tomography 3D models and fracture risk evaluation.

    abstract::Total hip arthroplasty (THA) can be achieved by using a cemented or noncemented prosthesis. Besides patient's age, weight, and other clinical signs, the evaluation of the quality of the bones is a crucial parameter on which orthopedic surgeons base the choice between cemented and noncemented THA. Although bone density...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Gargiulo P,Pétursson T,Magnússon B,Bifulco P,Cesarelli M,Izzo GM,Magnúsdóttir G,Halldórsson G,Ludvigsdóttir GK,Tribel J,Jónsson H Jr

    更新日期:2013-06-01 00:00:00

  • Prediction of mechanical hemolysis in medical devices via a Lagrangian strain-based multiscale model.

    abstract::This work introduces a new Lagrangian strain-based model to predict the shear-induced hemolysis in biomedical devices. Current computational models for device-induced hemolysis usually utilize empirical fitting of the released free hemoglobin (Hb) in plasma from damaged red blood cells (RBCs). These empirical correlat...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Nikfar M,Razizadeh M,Zhang J,Paul R,Wu ZJ,Liu Y

    更新日期:2020-08-01 00:00:00

  • Quantification of the secondary flow in a radial coupled centrifugal blood pump based on particle tracking velocimetry.

    abstract::Secondary flow in the centrifugal blood pump helps to enhance the washout effect and to minimize thrombus formation. On the other hand, it has an adverse effect on pump efficiency. Excessive secondary flow may induce hemolytic effects. Understanding the secondary flow is thus important to the design of a compact, effi...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Watanabe N,Masuda T,Iida T,Kataoka H,Fujimoto T,Takatani S

    更新日期:2005-01-01 00:00:00

  • Is serum albumin a marker of nutritional status in hemodialysis patients without evidence of inflammation?

    abstract::Hypoalbuminemia, a strong predictor of morbidity and mortality in hemodialysis patients, can be a consequence of a combination of malnutrition and inflammatory reactions. The purpose of this study was to analyze serum albumin as a marker of nutritional status in maintenance hemodialysis patients with no signs of infla...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Santos NS,Draibe SA,Kamimura MA,Canziani ME,Cendoroglo M,Júnior AG,Cuppari L

    更新日期:2003-08-01 00:00:00

  • Comparison of rapid in situ, regular in situ, and ex vivo flushing on hepatic function.

    abstract::The efficacy of three flushing techniques on subsequent liver function was assessed using the in vivo isolated liver perfusion model (ILPM). Livers from brain-dead mongrel dogs were flushed with cold Euro-Collins as follows: Group I, rapid in situ flushing (10 min); Group II, regular in situ flushing (45 min); Group I...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Castellanos J,Toledo-Pereyra LH,Finkelstein I,Kestenberg W,Chapman M,Choudhury S

    更新日期:1988-06-01 00:00:00

  • A Meta-Analysis of Renal Function After Adult Cardiac Surgery With Pulsatile Perfusion.

    abstract::The aim of this meta-analysis was to determine whether pulsatile perfusion during cardiac surgery has a lesser effect on renal dysfunction than nonpulsatile perfusion after cardiac surgery in randomized controlled trials. MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were used to identify ava...

    journal_title:Artificial organs

    pub_type: 杂志文章,meta分析


    authors: Nam MJ,Lim CH,Kim HJ,Kim YH,Choi H,Son HS,Lim HJ,Sun K

    更新日期:2015-09-01 00:00:00

  • Melt Electrospun Bilayered Scaffolds for Tissue Integration of a Suture-Less Inflow Cannula for Rotary Blood Pumps.

    abstract::Implantation of left ventricular assist devices typically requires cardiopulmonary bypass support, which is associated with postoperative complications. A novel suture-less inflow cannula, which can be implanted without bypass, uses mild myocardial compression to seal the interface, however, this may lead to necrosis ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Liao S,Theodoropoulos C,Blackwood KA,Woodruff MA,Gregory SD

    更新日期:2018-05-01 00:00:00

  • Computational simulation of a non-newtonian model of the blood separation process.

    abstract::The aim of this work is to construct a computational fluid dynamics model capable of simulating the transient non-Newtonian process of apheresis. A Lagrangian-Eulerian model has been developed which tracks the blood particles within a two-dimensional flow configuration. Within the Eulerian method, the fluid mass and m...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: De Gruttola S,Boomsma K,Poulikakos D

    更新日期:2005-12-01 00:00:00

  • Development of cellulose-DNA immunoadsorbent.

    abstract::The aim of this study was to prepare a DNA immunoadsorbent for the specific, extracorporeal removal of anti-DNA antibodies from the blood of patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Two kinds of cellulose beads were applied as a carrier. Calf thymus DNA was covalently coupled to ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Kong D,Schuett W,Dai J,Kunkel S,Holtz M,Yamada R,Yu Y,Klinkmann H

    更新日期:2002-02-01 00:00:00

  • Development of a composite degradable/nondegradable tissue-engineered vascular graft.

    abstract::The present study aimed to determine the feasibility of constructing a reinforced autologous vascular graft by combining the advantages of fibrin gel as an autologous cell carrier material with the inherent mechanical strength of an integrated mesh structure. It was hypothesized that the mesh and dynamic culture condi...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Tschoeke B,Flanagan TC,Cornelissen A,Koch S,Roehl A,Sriharwoko M,Sachweh JS,Gries T,Schmitz-Rode T,Jockenhoevel S

    更新日期:2008-10-01 00:00:00