Biomechanical properties of decellularized porcine pulmonary valve conduits.

Abstract:

:Tissue-engineered heart valves constructed from a xenogeneic or allogeneic decellularized matrix might overcome the disadvantages of current heart valve substitutes. One major necessity besides effective decellularization is to preserve the biomechanical properties of the valve. Native and decellularized porcine pulmonary heart valve conduits (PPVCs) (with [n = 10] or without [n = 10] cryopreservation) were compared to cryopreserved human pulmonary valve conduits (n = 7). Samples of the conduit were measured for wall thickness and underwent tensile tests. Elongation measurement was performed with a video extensometer. Decellularized PPVC showed a higher failure force both in longitudinal (+73%; P < 0.01) and transverse (+66%; P < 0.001) direction compared to human homografts. Failure force of the tissue after cryopreservation was still higher in the porcine group (longitudinal: +106%, P < 0.01; transverse: +58%, P < 0.001). In comparison to human homografts, both decellularized and decellularized cryopreserved porcine conduits showed a higher extensibility in longitudinal (decellularized: +61%, P < 0.001; decellularized + cryopreserved: +51%, P < 0.01) and transverse (decellularized: +126%, P < 0.001; decellularized + cryopreserved: +118%, P < 0.001) direction. Again, cryopreservation did not influence the biomechanical properties of the decellularized porcine matrix.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Seebacher G,Grasl C,Stoiber M,Rieder E,Kasimir MT,Dunkler D,Simon P,Weigel G,Schima H

doi

10.1111/j.1525-1594.2007.00452.x

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

28-35

issue

1

eissn

0160-564X

issn

1525-1594

pii

AOR452

journal_volume

32

pub_type

杂志文章
  • Magnesium homeostasis in patients undergoing continuous ambulatory peritoneal dialysis: role of the dialysate magnesium concentration.

    abstract::We carried out this retrospective study to examine the magnesium status of our chronic ambulatory peritoneal dialysis (CAPD) patients dialyzed with 0.75 mmol/L (group I) or 0.50 mmol/L (group II) magnesium peritoneal dialysis solution. A total of 34 anuric patients on CAPD (age:31-72 years; duration of CAPD:7-74 month...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2003.07193.x

    authors: Katopodis KP,Koliousi EL,Andrikos EK,Pappas MV,Elisaf MS,Siamopoulos KC

    更新日期:2003-09-01 00:00:00

  • Effect of hemodialysis on T lymphocyte subsets, con-A-activated suppressor cell activity, and interleukin-2 receptor expression on lymphocytes in chronic uremic patients.

    abstract::Effect of hemodialysis (HD) on some indices of immune response was studied in nine chronic uremics. Total lymphocyte, OKT4+, and OKT8+ cell numbers significantly decreased during the first 20 min of HD, and they were decreased till the third hour of the procedure, whereas the OKT4+/OKT8+ cell number ratio did not chan...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1989.tb02861.x

    authors: Tchórzewski H,Luciak M,Trznadel K,Majewska E,Pokoca L

    更新日期:1989-06-01 00:00:00

  • Dialyzer reuse: interaction between dialyzer membrane, disinfectant (formalin), and blood during dialyzer reprocessing.

    abstract::The growing practice of dialyzer reuse in recent years is mainly based on medical and economic considerations. However, adverse reactions such as immunohemolytic anemia due to anti-Nform antibody associated with dialyzer reuse have been reported. In this study, scanning electron microscopy and cytologic staining were ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1996.tb04418.x

    authors: Ng YY,Yang AH,Wong KC,Lan HY,Hung TL,Kerr PG,Huang TP

    更新日期:1996-01-01 00:00:00

  • Eosinophilia in hemodialysis patients.

    abstract::Thirteen percent of 99 patients undergoing maintenance hemodialysis showed an increased predialysis peripheral blood eosinophil count (mean value of 828 cells/mm3, range 410-2,710). Patients with eosinophilia were predominantly male and evidenced more frequent elevation of total plasma IgE levels. Otherwise, no differ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1987.tb02635.x

    authors: Friedberg M,Joffe P,Nielsen B,Nielsen LP

    更新日期:1987-04-01 00:00:00

  • Complication profile of the Berlin Heart EXCOR biventricular support in children.

    abstract::In chronic cardiomyopathy, mechanical circulatory support (MCS) plays an increasingly important role for children as the shortage of suitable donor hearts increases waiting time on the transplant list. We report our experience with the paracorporal Berlin Heart EXCOR System (Berlin Heart AG, Berlin, Germany) used as a...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12062

    authors: Schweiger M,Schrempf J,Sereinigg M,Prenner G,Tscheliessnigg KH,Wasler A,Krumnikel J,Gamillschegg A,Knez I

    更新日期:2013-08-01 00:00:00

  • The Helmholtz Total Artificial Heart Labtype.

    abstract::To perform the first experimental tests for validation of a new gear unit concept, the pump chamber, diaphragm, and pusher plate design of an orthotopic electromechanical total artificial heart (TAH) (Helmholtz Labtype) was manufactured. In its early stage of development, it provides some of the most important feature...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1994.tb03374.x

    authors: Kaufmann R,Reul H,Rau G

    更新日期:1994-07-01 00:00:00

  • Multicenter Experience With Mechanical Circulatory Support Using a New Diagonal Pump in 233 Children.

    abstract::Technological innovations in pediatric extracorporeal life support circuits can reduce system-related complications and may improve patients' outcome. The Deltastream DP3 (Medos Medizintechnik AG, Stolberg, Germany) is a novel rotational pump with a diagonally streamed impeller that can be used over a broad range of f...

    journal_title:Artificial organs

    pub_type: 杂志文章,多中心研究

    doi:10.1111/aor.13016

    authors: Stiller B,Houmes RJ,Rüffer A,Kumpf M,Müller A,Kipfmüller F,Köditz H,Herber Jonat S,Schmoor C,Benk C,Tibboel D,Fleck T

    更新日期:2018-04-01 00:00:00

  • HeartWare Ventricular Assist Device Implantation for Pediatric Heart Failure-A Single Center Approach.

    abstract::While pediatric HeartWare HVAD application has increased, determining candidacy and timing for initiation of pediatric VAD support has remained a challenge. We present our experience with a systematic approach to HVAD implantation as a bridge to pediatric heart transplantation. We performed a retrospective, single cen...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13344

    authors: Nelson McMillan K,Hibino N,Brown EE,Wadia R,Hunt EA,Marshall C,Alvarez-Machado M,Alejo D,Coulson JD,Ravekes W,Vricella LA

    更新日期:2019-01-01 00:00:00

  • Permanent cardiac pacing after cardiac operations.

    abstract::From January 1980 through December 1990, implantation of a permanent pacemaker was performed in 34 patients following open heart surgery. The patients were divided into two groups according to the clinical indications for implantation of permanent pacemakers. Group 1 (9 patients) had surgical atrioventricular block, a...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1993.tb00591.x

    authors: Otaki M

    更新日期:1993-05-01 00:00:00

  • Usability and safety of ventricular assist devices: human factors and design aspects.

    abstract::The purpose of this study was the investigation of the usability and ergonomics of ventricular assist devices (VADs) in everyday usage. Patients with four different VAD types were observed. After implantation, instruction, and discharge from the hospital, the patients returned on a regular basis to the outpatient clin...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00844.x

    authors: Geidl L,Zrunek P,Deckert Z,Zimpfer D,Sandner S,Wieselthaler G,Schima H

    更新日期:2009-09-01 00:00:00

  • The application of immobilized enzymes in an artificial liver support system.

    abstract::A novel method of extracorporeal support for fulminant liver failure is reported whereby the most important detoxification processes of the liver are reproduced in an enzyme reactor. Most of the endogenous toxins involved in hepatic coma can be deactivated directly by conjugation with a hydrophilic residue such as glu...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1979.tb03801.x

    authors: Brunner G,Holloway CJ,Lösgen H

    更新日期:1979-02-01 00:00:00

  • Influence of antihypertensive drugs and steroid hormones on protein adsorption/desorption on polycarbonate.

    abstract::To develop artificial materials for prolonged use in the vascular system, the complicated process of surface-induced thrombosis needs to be better understood. It is documented that certain antihypertensive drugs can inhibit platelet adhesion to an artificial surface; on the other hand, steroid drugs increase platelet ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:

    authors: Chandy T,Sharma CP

    更新日期:1991-06-01 00:00:00

  • Treatment of severe hyperlipidemia: six years' experience with low-density lipoprotein apheresis.

    abstract::In total, 30 patients suffering from familial hypercholesterolemia, resistant to diet and lipid-lowering drugs, were treated for up to 6 years (3.6 + or - 1.6; range, 0.2-6.8 years) with low-density lipoprotein (LDL) apheresis. Three different systems were used; the dextran sulfate adsorption system (Kaneka) for 27 of...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1996.tb04455.x

    authors: Bambauer R,Schiel R,Latza R,Klinkmann J

    更新日期:1996-04-01 00:00:00

  • Clinical use of low porosity woven ultrafine polyester fiber grafts.

    abstract::A woven fabric graft made of ultrafine polyester fibers (UFPF) (Toray Graft, water porosity: 100 ml/min/cm2:120 mm Hg H2O) was clinically applied in 81 cases (28 thoracic aortic aneurysms, 6 thoracoabdominal aortic aneurysms, 42 abdominal aortic aneurysms, and 5 atherosclerotic obstructions of the peripheral arteries)...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1995.tb02245.x

    authors: Satoh S,Niu S,Kanda K,Hirai J,Nakazima S,Wada Y,Oka T,Noishiki Y

    更新日期:1995-01-01 00:00:00

  • Implantation of the total artificial heart by lateral thoracotomy.

    abstract::Progress in the techniques for surgical implantation of the artificial heart has progressed in parallel with the technology and design of the prosthesis. In the author's first experience with total artificial heart (TAH) implantation (1968) a trans-sternal split was used opening the sixth intercostal space on the righ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1977.tb00984.x

    authors: Olsen DB,Fukumasu H,Kolff J,Nakagaki M,Finch LR,Kolff WJ

    更新日期:1977-11-01 00:00:00

  • Clinical indications for the use of the "Poisk-IOM" total artificial heart: the experience of 13 implantations in humans.

    abstract::Success of total artificial heart (TAH) implantation as a temporary measure depends on three factors: proper patient selection, adequate surgical technique, and safe cardiac prostheses. From 1986 until March 1990, 237 patients with stagnant heart failure were examined. Sixty-one patients (27%) were put on a waiting li...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1991.tb00745.x

    authors: Shumakov V,Zimin N,Kazakov E,Kormer A,Vorontsov S,Nikolaenko E,Kozlov I,Drobyshev A

    更新日期:1991-10-01 00:00:00

  • Detection of suction and regurgitation of the implantable centrifugal pump based on the motor current waveform analysis and its application to optimization of pump flow.

    abstract::In this study, a detection algorithm for suction and regurgitation of the centrifugal pump during left heart bypass without relying on external flow or pressure sensors was developed and evaluated in acute studies using adult goats. The detection scheme relies on power spectral density (PSD) analysis of the motor curr...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1999.06397.x

    authors: Yuhki A,Hatoh E,Nogawa M,Miura M,Shimazaki Y,Takatani S

    更新日期:1999-06-01 00:00:00

  • Correlation between cerebral-renal near-infrared spectroscopy and ipsilateral renal perfusion parameters as clinical outcome predictors after open heart surgery in neonates and infants.

    abstract::The objective of this clinical study is to determine whether correlation exists among cerebral and renal near-infrared spectroscopy (NIRS) measurements, renal Doppler ultrasonography parameters (resistive index, peak systolic velocity), and early postoperative clinical outcomes following cardiac surgery in neonates an...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12455

    authors: Örmeci T,Alkan-Bozkaya T,Özyüksel A,Ersoy C,Ündar A,Akçevin A,Türkoğlu H

    更新日期:2015-01-01 00:00:00

  • Re-endothelialization of non-detergent decellularized porcine vessels.

    abstract::Tissue engineering utilizes an interdisciplinary approach to generate constructs for the treatment and repair of diseased organs. Generation of small vessels as vascular grafts or as envisioned central vessel for vascularized constructs is still a challenge. Here, the decellularization of porcine vessels by a non-dete...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13836

    authors: Eyre K,Samper E,Haverich A,Hilfiker A,Andrée B

    更新日期:2020-10-01 00:00:00

  • Nonsymmetric leaflet motion of St. Jude Medical mitral valves simulated with a computer-controlled hydraulic mock circulator.

    abstract::Since the introduction of high-performance prosthetic heart valves, particularly bileaflet valves and monoleaflet valves with larger opening angles, we have observed in vivo complex leaflet motion which has not been experimentally confirmed yet. We developed a computer-controlled hydraulic mock circulator to study the...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb00373.x

    authors: Ohta Y,Okamoto K,Sonderegger M,Dohi T,Matsumoto H,Horiuchi T

    更新日期:1997-04-01 00:00:00

  • Biodegradation and biocompatibility of polyorganophosphazene.

    abstract::We investigated biodegradation and biocompatibility of poly(organophosphazenes). We prepared poly(organophosphazenes) having different side chain groups. The blood compatibility of poly(organophosphazenes) containing fluorinated side groups, poly(bis[trifluoroethoxy]phosphazene) (PbFP) and poly([trifluoroethoxy][ethyl...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2002.07029.x

    authors: Kawakami H,Kanezaki S,Sudo M,Kanno M,Nagaoka S,Kubota S

    更新日期:2002-10-01 00:00:00

  • Influence of flow design on microcirculation in conditions of undulation pump-left ventricle assist device testing.

    abstract::To study the microvessels in bulbar conjunctiva, we conducted an experiment in goat with a pneumatically driven left heart bypass pump, which was replaced with an undulation pump-left ventricle assist device for 9 days. Three flow patterns were tested: complete pulsatile, continuous, and percentage of pulsatile. We st...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2006.00244.x

    authors: Dobsák P,Novakova M,Baba A,Vasku J,Isoyama T,Saito I,Abe Y,Chinzei T,Imachi K

    更新日期:2006-06-01 00:00:00

  • CD4/CD8 T-cell ratio in peritoneal dialysis effluents predicts the outcome of peritonitis in patients undergoing continuous ambulatory peritoneal dialysis.

    abstract::This study aimed to clarify the role of peritoneal T-lymphocytes in peritoneal immune defense mechanisms. This study was designed to examine the changes in T-cell subpopulations during peritonitis in patients treated with continuous ambulatory peritoneal dialysis (CAPD). Our observations were correlated to responses t...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00802.x

    authors: Griveas I,Fleva A,Karanikas E,Gogos K,Sakellariou G

    更新日期:2009-12-01 00:00:00

  • Atrial versus ventricular cannulation for a rotary ventricular assist device.

    abstract::The ventricular assist device inflow cannulation site is the primary interface between the device and the patient. Connecting these cannulae to either atria or ventricles induces major changes in flow dynamics; however, there are little data available on precise quantification of these changes. The objective of this i...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2010.01093.x

    authors: Timms D,Gregory S,Hsu PL,Thomson B,Pearcy M,McNeil K,Fraser J,Steinseifer U

    更新日期:2010-09-01 00:00:00

  • Artificial cells with emphasis on cell encapsulation of genetically engineered cells.

    abstract::Artificial cells are prepared in the laboratory for medical and biotechnological applications. Encapsulated cells are being studied for the treatment of diabetes, liver failure, and other conditions. More recently, there have been extensive studies into the use of encapsulated genetically engineered cells for gene the...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1998.06243.x

    authors: Chang TM

    更新日期:1998-11-01 00:00:00

  • Is low-intensity anticoagulant therapy possible with an open pivot valve?: analysis of its development.

    abstract::In 1976, the authors became the codevelopers of the first successful bileaflet heart valve which has become the standard in valvular surgery. However, there still remains a significant rate of thromboembolism and thrombosis which can be attributed to the inherent design of cavities in the pivot area. These cavities co...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2002.06999.x

    authors: Nicoloff DM,Friedberg HD,Villafaña MA

    更新日期:2002-05-01 00:00:00

  • The DeBakey ventricular assist device: current status in 1997.

    abstract::In 1993, the development began of a small axial flow blood pump, the DeBakey ventricular assist device (VAD). The material was recently converted to a titanium alloy, and a waterproof pump package was incorporated for long-term intracorporeal circulation. Thirteen intrathoracic implantations in calves were achieved. N...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1525-1594.1999.06300.x

    authors: Tayama E,Olsen DB,Ohashi Y,Benkowski R,Morley D,Noon GP,Nosé Y,Debakey ME

    更新日期:1999-12-01 00:00:00

  • Effects of atrial arrhytmias on the regurgitation of a monoleaflet prosthetic heart valve.

    abstract::Many patients who receive a prosthetic heart valve also have or acquire cardiac arrhythmias. However, most in vitro studies of prosthetic valves examine them under normal rhythms. In this study, a monoleaflet prosthetic heart valve was tested in vitro under conditions that simulated normal sinus rhythm, first degree a...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2005.29101.x

    authors: Zapanta CM

    更新日期:2005-08-01 00:00:00

  • The impact of pump speed and inlet cannulation site on left ventricular unloading with a rotary blood pump.

    abstract:BACKGROUND:Ventricular assist devices are gaining ground in the therapeutic treatment of chronic heart failure. These devices are sometimes used as a bridge to recovery by unloading the left ventricle (LV) and restoring its function. It is therefore important to preserve the heart muscle and apply less invasive implant...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2004.07374.x

    authors: Vandenberghe S,Nishida T,Segers P,Meyns B,Verdonck P

    更新日期:2004-07-01 00:00:00

  • Prediction of mechanical hemolysis in medical devices via a Lagrangian strain-based multiscale model.

    abstract::This work introduces a new Lagrangian strain-based model to predict the shear-induced hemolysis in biomedical devices. Current computational models for device-induced hemolysis usually utilize empirical fitting of the released free hemoglobin (Hb) in plasma from damaged red blood cells (RBCs). These empirical correlat...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13663

    authors: Nikfar M,Razizadeh M,Zhang J,Paul R,Wu ZJ,Liu Y

    更新日期:2020-08-01 00:00:00