Influence of flow design on microcirculation in conditions of undulation pump-left ventricle assist device testing.


:To study the microvessels in bulbar conjunctiva, we conducted an experiment in goat with a pneumatically driven left heart bypass pump, which was replaced with an undulation pump-left ventricle assist device for 9 days. Three flow patterns were tested: complete pulsatile, continuous, and percentage of pulsatile. We studied the morphology of arterioles and venules of the bulbar conjunctiva using photograph records. The setting up of continuous flow caused global vasoconstriction (significant in venules-P < 0.05). During the pumping in the pulsatile and percentage of pulsatile modes, no significant changes of microvessel morphology were observed. The findings described could point to some disturbances in the microcirculatory bed in conditions of continuous flow.


Artif Organs


Artificial organs


Dobsák P,Novakova M,Baba A,Vasku J,Isoyama T,Saito I,Abe Y,Chinzei T,Imachi K




Has Abstract


2006-06-01 00:00:00














  • Control systems for the electric heart.

    abstract::Methods to predict and control cardiac output (CO) accurately in total artificial heart (TAH) recipients have varied significantly in the last few decades. Early models exhibited minimal control mechanisms and involved fixed pumping parameters. Elaborate electromechanical systems that have recently evolved require int...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: White RK,Olsen DB

    更新日期:1991-10-01 00:00:00

  • Respiratory gas exchange through the hydrophilic membrane.

    abstract::To assess the efficiency of respiratory gas exchange in vitro through a dialysis membrane mounted inside a flat plate Kiil dialyzer, the model reactions of hydrogen peroxide reduction by a metal ion and of the carbon dioxide precipitation in the form of a carbonate in the dialysate were used. A comparison of the rates...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Zborowski M

    更新日期:1983-05-01 00:00:00

  • Preservation of human saphenous vein against reactive oxygen species-induced oxidative stress by green tea polyphenol pretreatment.

    abstract::The injurious effects of reactive oxygen species on venous tissues and the potential protective role played by green tea polyphenol (GTPP) on human saphenous veins were investigated. Oxidative stress was induced exogenously in the vein segments, either by adding 0.8 or 1.6 M of H2O2, or by using 80 or 160 U/L of xanth...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Han DW,Suh H,Park YH,Cho BK,Hyon SH,Park JC

    更新日期:2003-12-01 00:00:00

  • Standing up with denervated muscles in humans using functional electrical stimulation.

    abstract::The use of electrical stimulation for denervated muscles is still considered to be a controversial issue by many rehabilitation facilities and medical professionals because prior clinical experience has shown that treating denervated muscle tissue using exponential current over a long time period constitutes an imposs...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Kern H,Hofer C,Strohhofer M,Mayr W,Richter W,Stöhr H

    更新日期:1999-05-01 00:00:00

  • Beta-2-microglobulin and main granulocyte components in hemodialysis patients.

    abstract::Plasma levels of granulocyte elastase in complex with alpha 1-proteinase inhibitor (E-alpha 1-PI) increased during hemodialysis from 110 +/- 10 to 506 +/- 66 micrograms/L using dialyzers made of polyamide, from 95 +/- 2.2 to 211 +/- 54 micrograms/ml with hemophane and from 114 +/- 10 to 203 +/- 25 using dialyzers made...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Haag-Weber M,Schollmeyer P,Hörl WH

    更新日期:1989-04-01 00:00:00

  • Effects of atrial arrhytmias on the regurgitation of a monoleaflet prosthetic heart valve.

    abstract::Many patients who receive a prosthetic heart valve also have or acquire cardiac arrhythmias. However, most in vitro studies of prosthetic valves examine them under normal rhythms. In this study, a monoleaflet prosthetic heart valve was tested in vitro under conditions that simulated normal sinus rhythm, first degree a...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Zapanta CM

    更新日期:2005-08-01 00:00:00

  • Isoelastic polyurethane prosthesis for segmental trachea replacement in beagle dogs.

    abstract::Porous polyurethane (nonwoven) was used for the development of tracheal prosthesis, which--in a special testing design--was adapted to shape and biomechanic properties of the natural organ. This prosthesis was implanted into 19 beagle dogs using inverted, everted, and end-to-end anastomosis. Insufficiency of the anast...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Schauwecker HH,Gerlach J,Planck H,Bücherl ES

    更新日期:1989-06-01 00:00:00

  • Charged compounds of the glomerular filter and their role in normal and disordered permselectivity.

    abstract::Infusion into rats of the polycation hexadimethrine (HDM) leads to onset of massive proteinuria, which recovers when the infusion is stopped. Several lines of evidence indicate that the proteinuria results from binding of HDM to polyanions of the glomerular filter, with neutralization of shielding of their charges. To...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Hunsicker LG,Bertolatus JA

    更新日期:1987-12-01 00:00:00

  • Peritoneal dialysis for the removal of protein-bound markers of hepatic insufficiency.

    abstract::The addition of human serum albumin (HSA) to peritoneal dialysate increases the clearance of bilirubin in rats suffering from obstructive jaundice. The acceptor properties of the fluid can be enhanced by using HSA that does not contain standard stabilizing additives and has been purified by further adsorption on activ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Sarnatskaya VV,Nikolaev VG,Osipova LA,Ivanov AI,Maslenny VN,Ivanyuk AA,Yushko LA

    更新日期:1993-10-01 00:00:00

  • Intestinal tissue oxygenation and tumor necrosis factor-alpha release during systemic blood flow changes in pigs with left ventricular assist devices.

    abstract::We previously demonstrated that tumor necrosis factor-alpha (TNF-alpha) increased following a reduction in systemic blood flow to 60% or less of the original cardiac output using a left ventricular assist device (LVAD). The aim of this study was to investigate the effect of reducing systemic blood flow on tissue oxyge...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Uozaki Y,Dihmis WC,Yamauchi H,Moczar M,Miyama M,Pasteau F,Tixier D,Bambang SL,Loisance DY

    更新日期:2001-01-01 00:00:00

  • Cerebral oxygen metabolism during total body flow and antegrade cerebral perfusion at deep and moderate hypothermia.

    abstract::The aim of this study is to evaluate the effect of temperature on cerebral oxygen metabolism at total body flow bypass and antegrade cerebral perfusion (ACP). Neonatal piglets were put on cardiopulmonary bypass (CPB) with the initial flow rate of 200mL/kg/min. After cooling to 18°C (n=6) or 25°C (n=7), flow was reduce...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Sasaki T,Boni L,Riemer RK,Yeung JT,Ramamoorthy C,Beckman R,Gisner C,Shuttleworth P,Hanley FL,Reddy VM

    更新日期:2010-11-01 00:00:00

  • The microsystems based visual prosthesis for optic nerve stimulation.

    abstract::The microsystems based visual prosthesis (MiViP) visual prosthesis generates visual perceptions well below safety and stimulator saturation limits. These perceptions, called phosphenes, are of reasonably small size and are broadly distributed in the visual field. They can thus be used to convey useful visual informati...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Delbeke J,Wanet-Defalque MC,Gérard B,Troosters M,Michaux G,Veraart C

    更新日期:2002-03-01 00:00:00

  • (13) C Breath Tests Are Feasible in Patients With Extracorporeal Membrane Oxygenation Devices.

    abstract::Temporary extracorporeal membrane oxygenation (ECMO) has been established as an essential part of therapy in patients with pulmonary or cardiac failure. As physiological gaseous exchange is artificially altered in this patient group, it is debatable whether a (13) C-breath test can be carried out. In this proof of tec...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Bednarsch J,Menk M,Malinowski M,Weber-Carstens S,Pratschke J,Stockmann M

    更新日期:2016-07-01 00:00:00

  • Effects of pK variability on bicarbonate balance evaluation in dialysis patients.

    abstract::Bicarbonate balance is usually calculated from the Henderson-Hasselbalch equation under the assumption that pK is constant. To evaluate the pK variability and its effects on bicarbonate computed with autoanalyzers in dialysis patients, we studied 44 patients on maintenance hemodialysis. The pH, PCO2, total CO2, and pK...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Santoro A,Ferrari G,Spongano M,Cavalli F,Zucchelli P

    更新日期:1987-12-01 00:00:00

  • Effects of pyridoxalated hemoglobin polyoxyethylene conjugate and other hemoglobin-related substances on arterial blood pressure in anesthetized and conscious rats.

    abstract::The effects of pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) and other hemoglobin-related substances on arterial blood pressure (ABP) and heart rate (HR) were examined. Infusion of PHP and other hemoglobin-related substances elevated ABP and increased HR. The degree of the increase in ABP and HR did not dif...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Kida Y,Maeda M,Iwata S,Iwashita Y,Goto K,Nishi K

    更新日期:1995-02-01 00:00:00

  • A Pseudo-One Compartment Model of Phosphorus Kinetics During Hemodialysis: Further Supporting Evidence.

    abstract::A pseudo-one compartment model has been proposed to describe phosphorus kinetics during hemodialysis and the immediate post-dialysis period. This model assumes that phosphorus mobilization from tissues is proportional to the difference between the pre-dialysis serum concentration (a constant) and the instantaneous ser...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Leypoldt JK,Agar BU,Cheung AK,Bernardo AA

    更新日期:2017-11-01 00:00:00

  • The role of PI3K/Akt signaling pathway in non-physiological shear stress-induced platelet activation.

    abstract::The PI3K/Akt signaling pathway has been implicated in playing an important role in platelet activation during hemostasis and thrombosis involving platelet-matrix interaction and platelet aggregation. Its role in non-physiological shear stress (NPSS)-induced platelet activation relevant to high-shear blood contacting m...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Chen Z,Li T,Kareem K,Tran D,Griffith BP,Wu ZJ

    更新日期:2019-09-01 00:00:00

  • Influence of middle molecules on the anemia of uremic patients.

    abstract::To evaluate their toxicity at the cellular level, middle molecules from uremic serum were incubated with erythrocytes from healthy subjects and the activity of the enzyme Delta-aminolevulinic acid dehydrase (D-ALA-D) and peroxidative hemolysis were investigated. Uremic middle molecules caused a significant decrease of...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Leber HW,Spiegelhalter R,Ulm A,Goubeaud G,Rawer P

    更新日期:1978-11-01 00:00:00

  • Quantification of Shear-Induced Platelet Activation: High Shear Stresses for Short Exposure Time.

    abstract::Thrombosis and thromboembolism are the life-threatening clinical complications for patients supported or treated with prosthetic cardiovascular devices. The high mechanical shear stress within these devices is believed to be the major contributing factor to cause platelet activation (PA) and function alteration, leadi...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Ding J,Chen Z,Niu S,Zhang J,Mondal NK,Griffith BP,Wu ZJ

    更新日期:2015-07-01 00:00:00

  • Changes in Spirometry After Left Ventricular Assist Device Implantation.

    abstract::Left ventricular assist devices (LVADs) are increasingly being used as life-saving therapy in patients with end-stage heart failure. The changes in spirometry following LVAD implantation and subsequent unloading of the left ventricle and pulmonary circulation are unknown. In this study, we explored long-term changes i...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Mohamedali B,Bhat G,Yost G,Tatooles A

    更新日期:2015-12-01 00:00:00

  • Central Extracorporeal Life Support With Left Ventricular Decompression to Berlin Heart Excor: A Reliable "Bridge to Bridge" Strategy in Crash and Burn Patients.

    abstract::The aim of this study was to compare patients with severe biventricular heart failure who underwent Berlin Heart Excor implantation with (cardiogenic shock [CS] status) or without the need for preoperative extracorporeal life support (ECLS) as a bridge to long-term device. A total of 40 consecutive patients with sever...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Weymann A,Farag M,Sabashnikov A,Fatullayev J,Zeriouh M,Schmack B,Arif R,Müller F,Alt C,Raake P,Prakash Patil N,Popov AF,Rüdiger Simon A,Karck M,Ruhparwar A,Heidelberg-Cologne-Harefield Cardiothoracic Transplantation & Mecha

    更新日期:2017-06-01 00:00:00

  • Are the Current Doppler Echocardiography Criteria Able to Discriminate Mitral Bileaflet Mechanical Heart Valve Malfunction? An In Vitro Study.

    abstract::Malfunction of bileaflet mechanical heart valves in the mitral position could either be due to patient-prosthesis mismatch (PPM) or leaflet obstruction. The aim of this article is to investigate the validity of current echocardiographic criteria used for diagnosis of mitral prosthesis malfunction, namely maximum veloc...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Evin M,Guivier-Curien C,Pibarot P,Kadem L,Rieu R

    更新日期:2016-05-01 00:00:00

  • In Vitro Assessment of Electric Currents Increasing the Effectiveness of Vancomycin Against Staphylococcus epidermidis Biofilms.

    abstract::Biofilms are communities of bacteria that can cause infections which are resistant to the immune system and antimicrobial treatments, posing a significant threat for patients with implantable and indwelling medical devices. The purpose of our research was to determine if utilizing specific parameters for electric curr...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Haddad PA,Mah TF,Mussivand T

    更新日期:2016-08-01 00:00:00

  • A novel, valveless ventricular assist device: the FishTail pump. First experimental in vivo studies.

    abstract::This article presents the first in vivo experiments with a new type of valveless ventricular assist device, a wave-generating pump. Our goal was to evaluate the hemodynamic performance of the pump by comparing it with the Biomedicus BP-80 centrifugal pump and by sustaining a 3 h long left ventricular assistance. We co...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Feier H,Mekkaoui C,Drevet JB,Sérée Y,Richomme C,Rolland PH,Mesana TG

    更新日期:2002-12-01 00:00:00

  • Stent treatment of inferior vena cava compression in an ovine with a total artificial heart.

    abstract::Although current continuous-flow total artificial hearts (CFTAHs) are much smaller than previous models, venous kinking may still occur after device implantation, especially in smaller animals. By inserting a self-expanding stent at the site of venous narrowing in a sheep model implanted with a CFTAH, we were able to ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Tuzun E,Parnis S,Rios J,Winkler JA,Cohn WE

    更新日期:2011-07-01 00:00:00

  • Controlled delivery of low-dose bone morphogenetic protein-2 using heparin-conjugated fibrin in the posterolateral lumbar fusion of rabbits.

    abstract::The heparin-conjugated fibrin (HCF) system has been developed to deliver bone morphogenetic proteins (BMPs) for a long-term period and thus enhance bone regeneration. In the present study, we tested the effectiveness of the delivery system for spinal fusion with a very low dose of BMP-2. A total of 15 rabbits underwen...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Koo KH,Lee JM,Ahn JM,Kim BS,La WG,Kim CS,Im GI

    更新日期:2013-05-01 00:00:00

  • Modeling the transfer of low molecular weight plasma proteins during hemodialysis and online hemodiafiltration.

    abstract::Replacing the renal excretion of low molecular weight proteins (LMWP) by extracorporeal dialysis (dialysis) treatment poses technological challenges. Hemodialyzers with sieving coefficients for LMWP that match or even exceed those of the glomerular membrane barrier are commercially available; however, the associated l...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Glancey G

    更新日期:2020-10-01 00:00:00

  • Combining novel biomolecules and stimuli-sensitive biomaterials into new recognition-response biomaterial systems.

    abstract::An important present and emerging trend in biomaterials development is the synthesis of polymers which combine capabilities of biologic recognition ("biomimetic") with sensitivity to small environmental changes ("stimuli-responsive"). This short article highlights some of the many opportunities and challenges in this ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Hoffman AS

    更新日期:1988-12-01 00:00:00

  • Re-endothelialization of non-detergent decellularized porcine vessels.

    abstract::Tissue engineering utilizes an interdisciplinary approach to generate constructs for the treatment and repair of diseased organs. Generation of small vessels as vascular grafts or as envisioned central vessel for vascularized constructs is still a challenge. Here, the decellularization of porcine vessels by a non-dete...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Eyre K,Samper E,Haverich A,Hilfiker A,Andrée B

    更新日期:2020-10-01 00:00:00

  • Influence of reuse and of reuse sterilants on the first-use syndrome.

    abstract::Over a 4 year period, five of 98 patients at our dialysis unit developed signs and symptoms consistent with first-use syndrome (FUS). Marked improvement was noted after subjecting new dialyzers to automated processing using either formaldehyde or peracetic acid. No episodes of FUS occurred in patients being treated wi...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Vanholder R,Ringoir S

    更新日期:1987-04-01 00:00:00