Intelligent freeform manufacturing of complex organs.

abstract：:A microcapsule suspension, a substitute for animal blood in hemolysis tests, has been developed for evaluation of the absolute hemolytic properties of circulatory artificial organs. The microcapsule suspension was made by dispersing microcapsule slurry into an ethylene glycol sodium chloride solution. The microcapsule...

journal_title：Artificial organs

authors： Maruyama O,Yamane T,Tsunemoto N,Nishida M,Tsutsui T,Jikuya T

更新日期：1999-03-01 00:00:00

abstract：:In this study two aspects of hybrid functional electrical stimulation (FES) orthoses were investigated: joint motion constraints and FES control strategies. First, the effects of joint motion constraints on the gait of normal subjects were investigated using modern motion analysis systems, including electromyogram (EM...

journal_title：Artificial organs

authors： Yang L,Granat MH,Paul JP,Condie DN,Rowley DI

更新日期：1997-03-01 00:00:00

abstract：:The BiVACOR is a novel rotary Biventricular Assist Device (BiVAD) undergoing development to treat global end-stage heart failure. The design includes left and right vanes positioned on a shared rotating hub to form a double-sided magnetically and hydrodynamically suspended centrifugal impeller. The performance of the ...

journal_title：Artificial organs

authors： Timms D,Fraser J,Hayne M,Dunning J,McNeil K,Pearcy M

更新日期：2008-10-01 00:00:00

abstract：:Pyridoxalated-hemoglobin-polyoxyethylene conjugate (PHP), which is made from out-dated human red blood cells by two major chemical modifications, namely pyridoxalation and conjugation with polyoxyethylene (POE), is currently under development as a physiological oxygen carrier. This study assessed the effects of PHP-88...

journal_title：Artificial organs

authors： Takahashi T,Iwasaki K,Malchesky PS,Harasaki H,Matsushita M,Nosé Y,Rolin H 3rd,Hall PM

更新日期：1993-03-01 00:00:00

abstract：:Artificial cells are prepared in the laboratory for medical and biotechnological applications. Encapsulated cells are being studied for the treatment of diabetes, liver failure, and other conditions. More recently, there have been extensive studies into the use of encapsulated genetically engineered cells for gene the...

journal_title：Artificial organs

authors： Chang TM

更新日期：1998-11-01 00:00:00

abstract：:Although it is now understood that trained skeletal muscle can generate enough steady-state power to provide significant circulatory support, there are currently no means by which to tap this endogenous energy source to aid the failing heart. To that end, an implantable muscle energy converter (MEC) has been construct...

journal_title：Artificial organs

authors： Trumble DR,Melvin DB,Byrne MT,Magovern JA

更新日期：2005-09-01 00:00:00

abstract：:Medial opening-wedge has gained popularity in comparison to other techniques of high tibial osteotomy. This technique involves the creation of a gap in the tibia. Filling the gap with autologous iliac bone graft was recommended in the classic description, to prevent complications such as correction loss or delayed bon...

journal_title：Artificial organs

authors： Zorzi AR,da Silva HG,Muszkat C,Marques LC,Cliquet A Jr,de Miranda JB

更新日期：2011-03-01 00:00:00

abstract：:The purpose of this study was the investigation of the usability and ergonomics of ventricular assist devices (VADs) in everyday usage. Patients with four different VAD types were observed. After implantation, instruction, and discharge from the hospital, the patients returned on a regular basis to the outpatient clin...

journal_title：Artificial organs

authors： Geidl L,Zrunek P,Deckert Z,Zimpfer D,Sandner S,Wieselthaler G,Schima H

更新日期：2009-09-01 00:00:00

abstract：:Characteristics of morphology, cardiac function, and cardiac reserve at late state were evaluated at rest, by changing the pacing rates, and after exercise in patients with ventricular pacemakers for isolated congenital complete atrioventricular block. Heart size was reduced statistically after pacemaker implantation,...

journal_title：Artificial organs

authors： Nawa S,Kioka Y,Shimizu A,Tsuji H,Miyachi Y,Ebara K,Kino K,Shigenobu M,Murakami T,Senoo Y

更新日期：1987-06-01 00:00:00

abstract：:The compliance problem represents a major obstacle in the development of implantable blood pumps. The motor-driven pumps are enclosed in an airtight casing with gas in the motor space. The trapped gas in the motor space either increases the load on the motor during systole or impedes blood sac filling. Potential solut...

journal_title：Artificial organs

authors： Lee S,Rosenberg G,Donachy JH,Wisman CB,Pierce WS

更新日期：1984-02-01 00:00:00

abstract：:In a controlled European multicenter study, clinical tolerance of subcutaneously administered recombinant human erythropoietin (rh-EPO) therapy and its influence on the course of illness in 362 hemodialyzed patients (162 males, 200 females) from 16 European dialysis centers was studied. Of these, 181 patients served a...

journal_title：Artificial organs

authors： Klinkmann H,Wieczorek L,Scigalla P

更新日期：1993-04-01 00:00:00

abstract：:Planar particle image velocimetry was used to explore the flow behavior of the newly designed 12-cc Penn State pneumatic pediatric assist pump. Wall shear maps complemented the velocity data. Bjork-Shiley Monostrut 17-mm mechanical heart valves were used in the inlet and outlet ports. In comparison with larger Penn St...

journal_title：Artificial organs

authors： Manning KB,Wivholm BD,Yang N,Fontaine AA,Deutsch S

更新日期：2008-06-01 00:00:00

abstract：:We have made an eccentric roller type total artificial heart (ERTAH). The ERTAH is a positive-displacement device comparable to a DeBakey roller pump. Its left and right outputs are determined by the size of its blood chambers, and the ratio of its left and right output is almost constant. We focused on an interatrial...

journal_title：Artificial organs

authors： Wada H,Fukunaga S,Watari M,Sakai H,Sugawara Y,Ochikubo H,Imai K,Shibamura H,Orihashi K,Sueda T,Matsuura Y

更新日期：1999-08-01 00:00:00

abstract：:It has previously been shown that the mixture of bicarbonate and calcium in the solutions used for continuous renal replacement therapy led to crystallization and significant changes in calcium concentration and pH. The aim of this study was to investigate the impact of bicarbonate/calcium and lactate/calcium solution...

journal_title：Artificial organs

authors： Maccariello E,Dalboni MA,Draibe SA,Rocha E,Pavão dos Santos OF,Santos B,Cendoroglo M

更新日期：2004-06-01 00:00:00

abstract：:We compared in vitro rates of hemolysis for a recently developed centrifugal pump with a conventional roller pump (10-10-00; Stöckert, Munich, Germany). Flow rates of 0.3 L/min and 1 L/min and a pressure of 200 mm Hg were chosen to simulate conditions during neonatal extracorporeal membrane oxygenation (ECMO). There w...

journal_title：Artificial organs

authors： Moon YS,Ohtsubo S,Gomez MR,Moon JK,Nosé Y

更新日期：1996-06-01 00:00:00

abstract：:We designed a 24-field array and an on-line control box that selects which and how many of 24 fields will conduct electrical charge during functional electrical stimulation. The array was made using a conductive microfiber textile, silver two-component adhesive, and the conductive ink imprint on the polycarbonate. The...

journal_title：Artificial organs

authors： Popović-Bijelić A,Bijelić G,Jorgovanović N,Bojanić D,Popović MB,Popović DB

更新日期：2005-06-01 00:00:00

abstract：:The aim of this study was to compare patients with severe biventricular heart failure who underwent Berlin Heart Excor implantation with (cardiogenic shock [CS] status) or without the need for preoperative extracorporeal life support (ECLS) as a bridge to long-term device. A total of 40 consecutive patients with sever...

journal_title：Artificial organs

authors： Weymann A,Farag M,Sabashnikov A,Fatullayev J,Zeriouh M,Schmack B,Arif R,Müller F,Alt C,Raake P,Prakash Patil N,Popov AF,Rüdiger Simon A,Karck M,Ruhparwar A,Heidelberg-Cologne-Harefield Cardiothoracic Transplantation & Mecha

更新日期：2017-06-01 00:00:00

abstract：:The implementation of simultaneous mechanical cavopulmonary assistance having blood pumps located in both of the vena cavae is investigated as an approach to treating patients with an ailing Fontan physiology. Identical intravascular blood pumps are employed to model the hemodynamic support of a patient-specific Fonta...

journal_title：Artificial organs

authors： Throckmorton AL,Lopez-Isaza S,Moskowitz W

更新日期：2013-06-01 00:00:00

abstract：:To analyze the autonomic nervous system during left heart bypass with a vibrating flow pump (VFP), fluctuations in hemodynamic derivatives were evaluated by the spectral analysis method using fast fourier transform methodology. After the left pleural cavity was opened through the fourth intercostal space under general...

journal_title：Artificial organs

authors： Yambe T,Kobayashi S,Nanka S,Naganuma S,Nitta S,Matsuki H,Abe K,Yoshizawa M,Fukuju T,Tabayashi K,Takeda H,Hashimoto H

更新日期：1996-06-01 00:00:00

abstract：:To date, single-needle (SN) hemodialysis (HD) requires a dialysis machine equipped with two blood pumps-one controlling arterial blood flow (Qb) and one controlling venous Qb. B. Braun has developed an innovative single-pump SN HD system. Therefore, usability is improved by reducing complexity. The aim of this study w...

journal_title：Artificial organs

authors： Bieser W,Welsch M,Jakob M,Meibaum J,Rodriguez DA,Wolff H,Marcelli D,Barth C

更新日期：2018-08-01 00:00:00

abstract：:This study explores a quantitative evaluation of blood damage that occurs in a continuous flow left ventricular assist device due to fluid stress. Computational fluid dynamics (CFD) analysis is used to track the shear stress history of 388 particle streaklines. The accumulation of shear and exposure time is integrated...

journal_title：Artificial organs

authors： Song X,Throckmorton AL,Wood HG,Antaki JF,Olsen DB

更新日期：2003-10-01 00:00:00

abstract：:Tissue-cultured bovine aortic endothelial cells were subjected to flow in an in vitro circulatory loop designed to simulate the flow and pressure conditions in the aorta. The cells were cultured under stationary conditions on tubes of fibronectin-coated Silastic or of Dacron velour. The tubes were then added to the fl...

journal_title：Artificial organs

authors： Eskin SG,Navarro LT,O'Bannon W,DeBakey ME

更新日期：1983-02-01 00:00:00

abstract：:The accurate representation of rotary blood pumps in a numerical environment is important for meaningful investigation of pump-cardiovascular system interactions. Although numerous models for ventricular assist devices (VADs) have been developed, modeling methods for rotary total artificial hearts (rTAHs) are still re...

journal_title：Artificial organs

authors： Nestler F,Bradley AP,Wilson SJ,Timms DL

更新日期：2014-03-01 00:00:00

abstract：:Cardiopulmonary bypass (CPB), an integral part of valve surgery, is known to cause hemodilution, which can lead to a need for blood transfusion as well as a systemic inflammatory reaction. Our aim was to evaluate a reduced priming (RP) system for CPB with regard to clinical outcomes in patients undergoing valve surger...

journal_title：Artificial organs

authors： Sato K,Namura O,Sogawa M,Shimada K,Tosaka Y,Hayashi J

更新日期：2006-08-01 00:00:00

abstract：:In a preliminary experiment, 38% of the spent dialysis fluid water was reclaimed by a forward osmosis process through a cellulose triacetate membrane. The simplicity of forward osmosis and its minimal external energy requirements may allow the construction of a small bulk device that can reclaim a considerable portion...

journal_title：Artificial organs

authors： Talaat KM

更新日期：2009-12-01 00:00:00

abstract：:This article presents the first in vivo experiments with a new type of valveless ventricular assist device, a wave-generating pump. Our goal was to evaluate the hemodynamic performance of the pump by comparing it with the Biomedicus BP-80 centrifugal pump and by sustaining a 3 h long left ventricular assistance. We co...

journal_title：Artificial organs

authors： Feier H,Mekkaoui C,Drevet JB,Sérée Y,Richomme C,Rolland PH,Mesana TG

更新日期：2002-12-01 00:00:00

abstract：:The principle of a patient-specific immunoadsorber (PsIA) is demonstrated. Studies with model systems (HSA/anti-HSA) on immobilization, stability, and leakage form the basis for the presented fast-performance liquid chromatography (FPLC) and batch experiments, which were conducted using two different protein A adsorbe...

journal_title：Artificial organs

authors： Kunkel S,Holtz M,Grossjohann B,Schuett W,Klinkmann H,Kong D,Yamada R,Kimura H,Matic GB,Ramlow W,Boeden HF

更新日期：2002-02-01 00:00:00

abstract：:This paper presents an overview of the U.S. Food and Drug Administration's regulatory requirements for introducing medical device and diagnostic products into commercial distribution in the United States. For any specific product, the requirements vary depending upon the product's associated risks, classification, and...

journal_title：Artificial organs

authors： Morton WA

更新日期：1982-11-01 00:00:00

abstract：:A small and light direct-drive centrifugal pump has been developed for cardiopulmonary bypass. In the development process, blood compatibility studies including a hemolysis study, an in vitro fluid dynamic performance study, and in vivo durability and feasibility studies were performed. The centrifugal pump with a 50 ...

journal_title：Artificial organs

authors： Jikuya T,Sasaki T,Aizawa T,Shiono M,Glueck JA,Smith CP,Feldman L,Sakuma I,Sekela ME,Noda T

更新日期：1992-12-01 00:00:00

abstract：:We assessed the relationship of certain clinical variables (including bradykinin [BK] release and dialysis membrane) to initial mean arterial pressure (MAP) reduction in 47 patients requiring continuous renal replacement therapy (CRRT) in an intensive care unit. The pretreatment MAP was 84 +/- 14 mm Hg for the group a...

journal_title：Artificial organs

authors： Stoves J,Goode NP,Visvanathan R,Jones CH,Shires M,Will EJ,Davison AM

更新日期：2001-12-01 00:00:00