Effect of heparin, platelets, activated platelets, platelet fragments, and hematocrit on activated clotting time.

abstract：:Over the past several years, we have developed novel titanium-niobium-zirconium (Ti-Nb-Zr) alloys to address the long-term performance needs of orthopedic implants. The unique properties of these alloys also render them promising candidates for blood pumps. These properties include excellent biocompatibility in combin...

journal_title：Artificial organs

authors： Davidson JA,Daigle KP,Kovacs P

更新日期：1996-05-01 00:00:00

abstract：:Individualized short hemodialysis treatment schedules, approximately three 3-h treatments per week, were introduced in a nephrology unit in 1976. In May 1985, 259 patients had been treated, which corresponds to approximately 60 new patients per million inhabitants per year. Ages at start of therapy ranged between 17 a...

journal_title：Artificial organs

authors： Wauters JP,Bercini-Pansiot S,Gilliard N,Stauffer JC

更新日期：1986-06-01 00:00:00

abstract：:Veno-venous extracorporeal lung assist (ECLA) can provide sufficient gas exchange even in most severe cases of acute respiratory distress syndrome. Commercially available systems are manually controlled, although an automatically controlled ECLA could allow individualized and continuous adaption to clinical requiremen...

journal_title：Artificial organs

authors： Kopp R,Bensberg R,Stollenwerk A,Arens J,Grottke O,Walter M,Rossaint R

更新日期：2016-10-01 00:00:00

abstract：:The objective of this study is to compare the myocardium protective effect of Bretschneider's histidine-tryptophan-ketoglutarate (HTK) solution versus Modified St. Thomas' (STH) solution in pediatric cardiac surgery of Tetralogy of Fallot (TOF). Seventy-seven pediatric patients of TOF who received the total surgical r...

journal_title：Artificial organs

authors： Wang ZH,An Y,Du MC,Qin TJ,Liu YB,Xu HZ,Yang LQ

更新日期：2017-05-01 00:00:00

abstract：:In clinical settings, no method has been established to examine the fatigue of a latissimus dorsi muscle (LDM) preconditioned for cardiomyoplasty. We examined the feasibility of measuring muscle stiffness (tactile stiffness) to evaluate muscle fatigue in situ using our tactile sensor. We stimulated canine LDM with bur...

journal_title：Artificial organs

authors： Inaba H,Miyaji K,Kaneko Y,Ohtsuka T,Ezure M,Tambara K,Takamoto S,Omata S

更新日期：2000-10-01 00:00:00

abstract：:A multi-compartment capillary membrane culture model with independently perfused three-dimensionally woven capillaries was developed for immobilization of hepatocytes in bioreactors. This enables spatial restructuring of cells and enhanced mass transfer performance with more efficient oxygenation and metabolite exchan...

journal_title：Artificial organs

authors： Gerlach J,Schnoy N,Smith MD,Neuhaus P

更新日期：1994-03-01 00:00:00

abstract：:Stents are small, usually metallic tubes that are intended to prop open arteries blocked with atherosclerotic plaques. While stents have been used successfully in recent years, they still suffer from failure due to development of new tissue in stented segment (restenosis). Variations in the failure rates associated wi...

journal_title：Artificial organs

authors： Frank AO,Walsh PW,Moore JE Jr

更新日期：2002-07-01 00:00:00

abstract：:The optimal anticoagulation regimen for hemodialysis (HD) in patients with heparin-induced thrombocytopenia (HIT) has not been defined. Hemodiafiltration (HDF) adds a large convective component to HD, thereby changing the pharmacokinetics of most anticoagulants. Data on coagulation regimens for HDF are scant. We there...

journal_title：Artificial organs

authors： Mahieu E,Claes K,Jacquemin M,Evenepoel P,Op De Beek K,Bogaert AM,Kuypers D,Verhamme P,Meijers B

更新日期：2013-05-01 00:00:00

abstract：:Using an ex vivo model, the effects of membrane composition and surface area on both the complement system (as reflected by plasma C3a levels) and platelets [as indicated by plasma concentrations of thromboxane B2 (TXB2) and platelet factor 4 (PF4)] were studied. In this model, polyacrylonitrile (PAN) was associated w...

journal_title：Artificial organs

authors： Mahiout A,Meinhold H,Kessel M,Schulze H,Baurmeister U

更新日期：1987-04-01 00:00:00

abstract：:EXTEND (EXTra-uterine Environment for Neonatal Development) is a novel system for supporting extremely premature infants that replicates in utero conditions by maintaining a sterile fluid environment and providing gas exchange via a pumpless arteriovenous oxygenator circuit connected to the umbilical vessels. Target g...

journal_title：Artificial organs

authors： Hornick MA,Mejaddam AY,McGovern PE,Hwang G,Han J,Peranteau WH,Partridge EA,Davey MG,Flake AW

更新日期：2019-12-01 00:00:00

abstract：:Cybernetics-based concepts can allow for complete independence for paralyzed individuals, including sensory motor recovery. Spinal cord injuries are responsible for a huge stress on health and a financial burden to society. This article focuses on novel procedures such as functional diagnosis for paraplegics and tetra...

journal_title：Artificial organs

authors： Varoto R,Cliquet A Jr

更新日期：2015-10-01 00:00:00

abstract：:In an effort to improve and automate the fluid dynamic design of rotary blood pumps, a coupled computational fluid dynamics (CFD) shape optimization methodology has been developed and implemented. This program couples a finite element flow simulation with a gradient-based optimization routine to modify automatically t...

journal_title：Artificial organs

authors： Antaki JF,Ghattas O,Burgreen GW,He B

更新日期：1995-07-01 00:00:00

abstract：:The blood flow through the hemofilter device is the key point for ultrafiltrate production during continuous arteriovenous hemofiltration. It mainly depends on arteriovenous pressure gradient and vascular access, which is the major problem for arteriovenous hemofiltration in infants and small children. In infants, we ...

journal_title：Artificial organs

authors： Zobel G,Trop M,Beitzke A,Ring E

更新日期：1988-02-01 00:00:00

abstract：:In transplantation surgery, extending the criteria for organ donation to include organs that may have otherwise been previously discarded has provided the impetus to improve organ preservation. The traditional method of cold static storage (CS) has been tried and tested and is suitable for organs meeting standard crit...

journal_title：Artificial organs

authors： Kumar R,Chung WY,Dennison AR,Garcea G

更新日期：2017-09-01 00:00:00

abstract：:Late referral (LR) to dialysis therapy has been associated with poor outcomes in people with end-stage renal disease. This had been ascribed to the frequent use of temporary vascular catheters (TVCs) in LR patients. The effects of LR and TVC on the outcomes of an incident hemodialysis population (n = 101) were investi...

journal_title：Artificial organs

authors： Gonçalves EA,Andreoli MC,Watanabe R,Freitas MC,Pedrosa AC,Manfredi SR,Draibe SA,Cendoroglo M,Canziani ME

更新日期：2004-11-01 00:00:00

abstract：:Excessive left ventricular (LV) volume unloading can affect right ventricular (RV) function by causing a leftward shift of the interventricular septum in patients with mitral regurgitation (MR) receiving left ventricular assist device (LVAD) support. Optimal settings for the LVAD should be chosen to appropriately cont...

journal_title：Artificial organs

authors： Naito N,Nishimura T,Takewa Y,Kishimoto S,Date K,Umeki A,Ando M,Ono M,Tatsumi E

更新日期：2016-11-01 00:00:00

abstract：:Total artificial hearts (TAHs) and biventricular assist devices (BVADs) have varying levels of acceptance and reliability, and the research on both focuses on their control mechanisms. Efforts generally aim to achieve a response to physiologic demand and left/right output balance, and beneficial cardiac output (CO) an...

journal_title：Artificial organs

authors： Hall AW,Soykan O,Harken AH

更新日期：1996-03-01 00:00:00

abstract：:Cell exclusion is the phenomenon whereby the hematocrit and viscosity of blood decrease in areas of high stress. While this is well known in naturally occurring Poiseuille flow in the human body, it has never previously been shown in Couette flow, which occurs in implantable devices including blood pumps. The high-she...

journal_title：Artificial organs

authors： Leslie LJ,Marshall LJ,Devitt A,Hilton A,Tansley GD

更新日期：2013-03-01 00:00:00

abstract：:Aseptic joint loosening is a key factor that reduces the life span of arthroplasty. There are currently few effective treatments for joint loosening except surgical revision. We explored the inhibitory effects of tumor necrosis factor (TNF)-alpha-targeted small interfering RNA (siRNA) on particle-induced inflammatory ...

journal_title：Artificial organs

authors： Qin CQ,Ding Y,Huang DS,Xu J,Ma RF,Huang JB

更新日期：2011-07-01 00:00:00

abstract：:There has been increasing interest in the development of a hepatocyte bioreactor for the treatment of acute hepatic failure; however, little is known about the effect of hepatocyte byproducts on the viability of the cells in the bioreactor environment. We investigated the effects of increasing concentrations of bile o...

journal_title：Artificial organs

authors： Smirthwaite AD,Gaylor JD,Cousins RB,Grant MH

更新日期：1998-10-01 00:00:00

abstract：:Jaundice is characterized by an excessive accumulation of bilirubin in the blood and tissues. A novel approach to reduce plasma levels of bilirubin by blocking its enterohepatic circulation was investigated. The treatment consisted of oral administration of immobilized bilirubin oxidase, which could oxidize bilirubin ...

journal_title：Artificial organs

authors： Soltys PJ,Mullon C,Langer R

更新日期：1992-08-01 00:00:00

abstract：:In a healthy human cardiac system, a large asymmetric clockwise vortex present in the left ventricle (LV) efficiently diverts the filling jet from the mitral annulus to the left ventricular outflow track. However, prior clinical studies have shown that artificial mitral valve replacement can affect the formation of ph...

journal_title：Artificial organs

authors： Tan SG,Hon JKF,Nguyen YN,Kim S,Leo HL

更新日期：2020-12-01 00:00:00

abstract：:An investigation has been made into whether charcoal hemoperfusion stimulates a hyperplastic response in the liver of the normal rat. Animals underwent hemoperfusion over Norit RBX1 (Strathclyde, Glasgow, U.K.) charcoal granules using a technique which allowed perfusion in the unrestrained and conscious state. Control...

journal_title：Artificial organs

authors： Ryan CJ,Courtney JM,Wood CB,Blumgart LH

更新日期：1982-05-01 00:00:00

abstract：:Polynitroxylated pegylated hemoglobin (PNPH) as a multifunctional therapeutic takes advantage of the ability of hemoglobin (Hb) to transport oxygen, the antioxidative stress activities from the redox coupling of nitroxide and heme iron, and the hypercolloid properties of pegylation. The published preclinical data demo...

journal_title：Artificial organs

authors： Hsia CJ,Ma L

更新日期：2012-02-01 00:00:00

abstract：:Technological innovations in pediatric extracorporeal life support circuits can reduce system-related complications and may improve patients' outcome. The Deltastream DP3 (Medos Medizintechnik AG, Stolberg, Germany) is a novel rotational pump with a diagonally streamed impeller that can be used over a broad range of f...

journal_title：Artificial organs

authors： Stiller B,Houmes RJ,Rüffer A,Kumpf M,Müller A,Kipfmüller F,Köditz H,Herber Jonat S,Schmoor C,Benk C,Tibboel D,Fleck T

更新日期：2018-04-01 00:00:00

abstract：:An important present and emerging trend in biomaterials development is the synthesis of polymers which combine capabilities of biologic recognition ("biomimetic") with sensitivity to small environmental changes ("stimuli-responsive"). This short article highlights some of the many opportunities and challenges in this ...

journal_title：Artificial organs

authors： Hoffman AS

更新日期：1988-12-01 00:00:00

abstract：:Tissue engineering utilizes an interdisciplinary approach to generate constructs for the treatment and repair of diseased organs. Generation of small vessels as vascular grafts or as envisioned central vessel for vascularized constructs is still a challenge. Here, the decellularization of porcine vessels by a non-dete...

journal_title：Artificial organs

authors： Eyre K,Samper E,Haverich A,Hilfiker A,Andrée B

更新日期：2020-10-01 00:00:00

abstract：:To analyze the autonomic nervous system during left heart bypass with a vibrating flow pump (VFP), fluctuations in hemodynamic derivatives were evaluated by the spectral analysis method using fast fourier transform methodology. After the left pleural cavity was opened through the fourth intercostal space under general...

journal_title：Artificial organs

authors： Yambe T,Kobayashi S,Nanka S,Naganuma S,Nitta S,Matsuki H,Abe K,Yoshizawa M,Fukuju T,Tabayashi K,Takeda H,Hashimoto H

更新日期：1996-06-01 00:00:00

abstract：:As a preliminary investigation to establish a cryopreservation method suited for bioartificial livers (BALs), three-dimensional (3-D) cryopreservation experiments with fibroblasts were performed, in which the cells were firstly seeded into a porous scaffold, and the scaffold containing the cells was then cryopreserved...

journal_title：Artificial organs

authors： Miyoshi H,Ehashi T,Ohshima N,Jagawa A

更新日期：2010-07-01 00:00:00

abstract：:The developments in apheresis techniques and their clinical applications world-wide are technologically driven. In the past, apheresis survey statistics have high-lighted both the differences by region in clinical practice and in the types of technologies utilized. Such differences have provided a basis for the scient...

journal_title：Artificial organs

authors： Malchesky PS,Bambauer R,Horiuchi T,Kaplan A,Sakurada Y,Samuelsson G

更新日期：1995-04-01 00:00:00