Abstract:
:The implementation of simultaneous mechanical cavopulmonary assistance having blood pumps located in both of the vena cavae is investigated as an approach to treating patients with an ailing Fontan physiology. Identical intravascular blood pumps are employed to model the hemodynamic support of a patient-specific Fontan. Pressure flow characteristics, energy gain calculations, and blood damage analyses are assessed for each model. The performance of the dual-support scenario is compared to conditions of mechanical support in the inferior vena cava only and to a nonsupported cavopulmonary circuit. The blood pump in the superior vena cava generates pressures ranging from 1 to 22 mm Hg for flow rates of 1-4 L/min at operating speeds of 1250-2500 rpm. The blood pump in the inferior vena cava produces pressures at levels approximately 20% lower. The blood pumps positively augment the hydraulic energy in the total cavopulmonary connection circuit as a function of flow rate and rotational speed. Scalar stress levels and fluid residence times are at acceptable levels. Damage indices for the dual-support case, however, are elevated slightly above 3.5%. These results suggest that concurrent, mechanical assistance of the inferior vena cava and superior vena cava in Fontan patients has the potential to be beneficial, but additional studies are needed to further explore this approach.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Throckmorton AL,Lopez-Isaza S,Moskowitz Wdoi
10.1111/aor.12039subject
Has Abstractpub_date
2013-06-01 00:00:00pages
513-22issue
6eissn
0160-564Xissn
1525-1594journal_volume
37pub_type
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journal_title:Artificial organs
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journal_title:Artificial organs
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pub_type: 杂志文章,多中心研究
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journal_title:Artificial organs
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