Artificial liver: present and future.

abstract：:A small and light direct-drive centrifugal pump has been developed for cardiopulmonary bypass. In the development process, blood compatibility studies including a hemolysis study, an in vitro fluid dynamic performance study, and in vivo durability and feasibility studies were performed. The centrifugal pump with a 50 ...

journal_title：Artificial organs

authors： Jikuya T,Sasaki T,Aizawa T,Shiono M,Glueck JA,Smith CP,Feldman L,Sakuma I,Sekela ME,Noda T

更新日期：1992-12-01 00:00:00

abstract：:Most bioartificial liver support systems are based on hollow fiber capillaries within modified dialysis cartridges or more sophisticated bioreactor constructions. Due to their design microscopic follow-up of reorganization and growth of tissue between the hollow fibers is not possible. The SlideReactor is a simple hol...

journal_title：Artificial organs

authors： Sauer IM,Schwartlander R,Schmid J,Efimova E,Vondran FW,Kehr D,Pless G,Spinelli A,Brandenburg B,Hildt E,Neuhaus P

更新日期：2005-03-01 00:00:00

abstract：:This article reports preliminary results of pilot studies of a new implantable two channel drop foot stimulator. The stimulator consists of an externally worn transmitter inductively coupled to an implanted receiver unit located in the lower leg, lateral and distal to the knee. The receiver is connected to electrodes ...

journal_title：Artificial organs

authors： Kenney L,Bultstra G,Buschman R,Taylor P,Mann G,Hermens H,Holsheimer J,Nene A,Tenniglo M,van der Aa H,Hobby J

更新日期：2002-03-01 00:00:00

abstract：:Protein adsorption and platelet adhesion are two important biological processes arising at the blood prosthetic interface. The effect of certain antibiotics, namely, neomycin, gentamicin, ampicillin, penicillin-G, and streptomycin to modulate the albumin polycarbonate surface interaction was investigated using 125I al...

journal_title：Artificial organs

authors： Chandy T,Sharma CP

更新日期：1988-04-01 00:00:00

abstract：:We compared in vitro rates of hemolysis for a recently developed centrifugal pump with a conventional roller pump (10-10-00; Stöckert, Munich, Germany). Flow rates of 0.3 L/min and 1 L/min and a pressure of 200 mm Hg were chosen to simulate conditions during neonatal extracorporeal membrane oxygenation (ECMO). There w...

journal_title：Artificial organs

authors： Moon YS,Ohtsubo S,Gomez MR,Moon JK,Nose Y

更新日期：1996-05-01 00:00:00

abstract：:A comparative assessment has been made regarding efficacy and safety of the double filtration plasmapheresis (DFPP), thermofiltration (TFPP), and low-density lipoprotein (LDL) adsorptive (PA) methods by making a crossover test on heterozygous familial hypercholesterolemia patients. Treatments by DFPP, TFPP (secondary ...

journal_title：Artificial organs

authors： Suzuki M,Yamane S,Matsugane T,Nobuto T,Azuma N,Nishide T,Shinomiya M,Saito K,Sasaki N,Nosé Y

更新日期：1996-04-01 00:00:00

abstract：:The developments in apheresis techniques and their clinical applications world-wide are technologically driven. In the past, apheresis survey statistics have high-lighted both the differences by region in clinical practice and in the types of technologies utilized. Such differences have provided a basis for the scient...

journal_title：Artificial organs

authors： Malchesky PS,Bambauer R,Horiuchi T,Kaplan A,Sakurada Y,Samuelsson G

更新日期：1995-04-01 00:00:00

abstract：:Transcatheter aortic valve (TAV) replacement has become a viable alternative to surgery for high and intermediate risk patients with severe aortic stenosis. This technology may extend to the younger and lower risk patients. In this population, long-term durability of the TAV is key. Increased leaflet mechanical stress...

journal_title：Artificial organs

authors： Stanová V,Zenses AS,Thollon L,Kadem L,Barragan P,Rieu R,Pibarot P

更新日期：2020-07-01 00:00:00

abstract：:Different methods are used, clinically and experimentally, to assist severely impaired heart function by means of skeletal muscle. The efficiency of these methods is restricted by skeletal muscle losing strength after transpositioning and during conditioning and not being sufficiently resistant to fatigue. This is mai...

journal_title：Artificial organs

authors： Lanmüller H,Sauermann S,Unger E,Schnetz G,Mayr W,Bijak M,Girsch W

更新日期：1999-04-01 00:00:00

abstract：:We reviewed the role of the BioMedicus pump in the reduction of neurologic complications following the repair of Type 1 and Type 2 thoracoabdominal aortic aneurysms. Since 1991, we have used several different methods for the repair of thoracoabdominal aortic aneurysms including simple cross-clamping, selective use of ...

journal_title：Artificial organs

authors： Safi HJ

更新日期：1996-06-01 00:00:00

abstract：:To save priming time and perform more rapid initiation of emergency cardiopulmonary bypass for acute cardiopulmonary failure, an extracorporeal circuit with a hollow-fiber oxygenator (EL-2000 for pediatric use; Kurary Co. Ltd., Osaka, Japan) was preprimed, and the gas-exchange function was evaluated after 1 year of st...

journal_title：Artificial organs

authors： Otsu T,Terasaki H,Choi H,Tajiri A,Okamoto T,Matsuyama K,Morioka T

更新日期：1992-10-01 00:00:00

abstract：:In this study, a detection algorithm for suction and regurgitation of the centrifugal pump during left heart bypass without relying on external flow or pressure sensors was developed and evaluated in acute studies using adult goats. The detection scheme relies on power spectral density (PSD) analysis of the motor curr...

journal_title：Artificial organs

authors： Yuhki A,Hatoh E,Nogawa M,Miura M,Shimazaki Y,Takatani S

更新日期：1999-06-01 00:00:00

abstract：:Our aim was to study the feasibility of implanting the Infant Jarvik 2015 in patients weighing less than 8 kg. The Infant Jarvik 2015 left ventricular assist device (LVAD) was tested in a hybrid simulator of the cardiovascular system reproducing specific patients' hemodynamics for different patient weights (2-7 kg). F...

journal_title：Artificial organs

authors： Di Molfetta A,Zielinski K,Ferrari G,Kozarski M,Okrzeja P,Iacobelli R,Filippelli S,Perri G,Darowski M,Massetti M,Jarvik R,Amodeo A

更新日期：2019-01-01 00:00:00

abstract：:A totally implantable centrifugal artificial heart has been developed in which a pivot bearing supported centrifugal pump is used as a blood pump. The following have been adopted as blood contacting materials in our pump: titanium alloy (Ti-6A1-4V) for the housing and impeller, alumina ceramic (Al2O3) for the male piv...

journal_title：Artificial organs

authors： Takami Y,Yamane S,Makinouchi K,Niimi Y,Sueoka A,Nosé Y

更新日期：1998-09-01 00:00:00

abstract：:The BiVACOR is a novel rotary Biventricular Assist Device (BiVAD) undergoing development to treat global end-stage heart failure. The design includes left and right vanes positioned on a shared rotating hub to form a double-sided magnetically and hydrodynamically suspended centrifugal impeller. The performance of the ...

journal_title：Artificial organs

authors： Timms D,Fraser J,Hayne M,Dunning J,McNeil K,Pearcy M

更新日期：2008-10-01 00:00:00

abstract：:The use of Berlin Heart EXCOR VAD (BH) is a validated therapy to bridge pediatric patients to heart transplant. Serial echocardiographic (ECHO) assessment of VAD patients is necessary to support patients' management. This work aims at developing an innovative strategy to evaluate the BH device functioning by ECHO and ...

journal_title：Artificial organs

authors： Di Molfetta A,Iacobelli R,Ferrari G,Filippelli S,Perri G,Toscano A,Adorisio R,Guccione P,Amodeo A

更新日期：2018-04-01 00:00:00

abstract：:Existing peritoneal dialysis (PD) solutions were formulated for the maintenance of fluid and electrolyte balance, correction of metabolic acidosis, and the removal of metabolic waste products. Solutions currently in development are designed to improve biocompatibility by neutralizing pH and reducing glucose degradatio...

journal_title：Artificial organs

authors： Martis L,Chen C,Moberly JB

更新日期：1998-01-01 00:00:00

abstract：:There are presently no short-term in vitro fatigue tests available that can predict long-term in vivo performance of elastomers in physiological environments. Thus, the introduction of new and better elastomers for cardiovascular applications is hampered in the development stage by lack of data about which materials s...

journal_title：Artificial organs

authors： McMillin CR

更新日期：1983-02-01 00:00:00

abstract：:Activated clotting time (ACT) is the most commonly used laboratory test to control the heparin effect during extracorporeal techniques. The study was undertaken in order to test in vitro the influence of heparin, platelet count, hematocrit, platelet fragmentation, and platelet activation on ACT. Blood was drawn from v...

journal_title：Artificial organs

authors： Girardi L,Sudi K,Muntean W

更新日期：2000-07-01 00:00:00

abstract：:The treatment of rheumatoid arthritis remains difficult and often controversial. Plasma exchange has been advocated in some cases. In the present study 71 sessions of double filtration plasmapheresis (DFPP) were performed in 21 patients with rheumatoid arthritis in an average of 3.7 +/- 1.1 sessions per patient within...

journal_title：Artificial organs

authors： Liu JD,Zhang C,Li WS,Lun LD

更新日期：1997-02-01 00:00:00

abstract：:This work describes the preparation and characterization of anionic collagen composites with rhamsan and vinylidene fluoride-trifluorethylene with improved rheological and dielectric properties without loss of collagen secondary structure with an interaction occurring between both macromolecules of the composites. On ...

journal_title：Artificial organs

authors： Goissis G,Piccirili L,Goes JC,de Guzzi Plepis AM,Das-Gupta DK

更新日期：1998-03-01 00:00:00

abstract：:Cardiac monitoring of ventricular assist devices (VADs) is important for detecting heart failure risks, such as critical arrhythmia and ventricular fibrillation, and for supplying data that are useful for hemodynamic control. Specifically, impedance cardiograms (ICGs) are especially beneficial because they have no eff...

journal_title：Artificial organs

authors： Choi SW,Park SM

更新日期：2012-05-01 00:00:00

abstract：:Percutaneous femoral venoarterial (VA) or jugular venovenous (VV) extracorporeal membrane oxygenation (ECMO) can result in delivery of hypoxic blood to the brain, coronaries, and upper extremities. Additionally, VA-ECMO by percutaneous femoral artery cannulation may compromise perfusion to the lower limbs. Use of near...

journal_title：Artificial organs

authors： Wong JK,Smith TN,Pitcher HT,Hirose H,Cavarocchi NC

更新日期：2012-08-01 00:00:00

abstract：:The cochlea is an end organ, which is metabolically dependent on a nutrient and oxygen supply to maintain its normal physiological function. Cochlear ischemia and reperfusion (IR) injury is considered one of the most important causes of human idiopathic sudden sensorineural hearing loss. The aim of the present study w...

journal_title：Artificial organs

authors： Onal M,Elsurer C,Selimoglu N,Yilmaz M,Erdogan E,Bengi Celik J,Kal O,Onal O

更新日期：2017-08-01 00:00:00

abstract：:Visual prostheses are the focus of intensive research efforts to restore some measure of useful vision to blind or near-blind patients. The development of such technology is being guided to an extent by tools that simulate prosthesis behavior for healthy sighted subjects in order to assess system requirements and conf...

journal_title：Artificial organs

authors： Obeid I,Veraart C,Delbeke J

更新日期：2010-05-01 00:00:00

abstract：:Growth factors and morphogens secreted by bone marrow mesenchymal stem cells (BMSCs) of bone marrow fluid may promote tooth regeneration. Accordingly, a tissue engineering approach was utilized to develop an economical strategy for obtaining the growth factors and morphogens from BMSCs. Unerupted second molar tooth bu...

journal_title：Artificial organs

authors： Kuo TF,Lin HC,Yang KC,Lin FH,Chen MH,Wu CC,Chang HH

更新日期：2011-02-01 00:00:00

abstract：:Widespread use of heart transplantation is limited by the scarcity of donor organs. Total artificial heart (TAH) development has been pursued to address this shortage, especially to treat patients who require biventricular support. We have developed a novel TAH that utilizes a continuously spinning rotor that shuttles...

journal_title：Artificial organs

authors： Glynn J,Song H,Hull B,Withers S,Gelow J,Mudd J,Starr A,Wampler R

更新日期：2017-10-01 00:00:00

abstract：:Patients with end-stage renal disease have a very high prevalence and extent of arterial calcification. A number of studies suggest that similar pathophysiologic mechanisms are responsible for development and progression of calcification of atherosclerotic plaque and bone formation. Fetuin-A is a potent calcification ...

journal_title：Artificial organs

authors： Kirkpantur A,Altun B,Hazirolan T,Akata D,Arici M,Kirazli S,Turgan C

更新日期：2009-10-01 00:00:00

abstract：:In 1993, the development began of a small axial flow blood pump, the DeBakey ventricular assist device (VAD). The material was recently converted to a titanium alloy, and a waterproof pump package was incorporated for long-term intracorporeal circulation. Thirteen intrathoracic implantations in calves were achieved. N...

journal_title：Artificial organs

authors： Tayama E,Olsen DB,Ohashi Y,Benkowski R,Morley D,Noon GP,Nosé Y,Debakey ME

更新日期：1999-12-01 00:00:00

abstract：:Extracorporeal membrane oxygenation (ECMO) is gaining importance in the perioperative management of lung transplant patients. To date, the ideal substance for anticoagulation of ECMO patients is still a matter of debate. In this study, we describe our experience with the use of low molecular weight heparin (LMWH) in c...

journal_title：Artificial organs

authors： Gratz J,Pausch A,Schaden E,Baierl A,Jaksch P,Erhart F,Hoetzenecker K,Wiegele M

更新日期：2020-06-01 00:00:00