Is the New Infant Jarvik 2015 Suitable for Patients

Abstract:

:Our aim was to study the feasibility of implanting the Infant Jarvik 2015 in patients weighing less than 8 kg. The Infant Jarvik 2015 left ventricular assist device (LVAD) was tested in a hybrid simulator of the cardiovascular system reproducing specific patients' hemodynamics for different patient weights (2-7 kg). For each weight, the sensitivity of the pump to different circulatory parameters (peripheral resistance, left ventricular elastance, right ventricular elastance, heart rate, and heart filling characteristics) has been tested repeating for each experiment a pump ramp (10 000-18 000 rpm). The increase in the pump speed causes a decrease (increase) in the left (right) atrial pressure, an increase (decrease) in the arterial systemic (pulmonary) pressure, an increase in the right ventricular pressure, a decrease (increase) in the left (right) ventricular volume, a decrease in the left ventricular cardiac output, an increase in the LVAD output and an increase in the right ventricular cardiac output (total cardiac output). Suction was observed for lower weight patients and for higher pump speed in the case of vasodilation, left ventricular recovery, bradycardia, right ventricular failure, and left ventricular hypertrophy. Backflow was observed in the case of left ventricular recovery at lower pump speed. In the hybrid simulator, the Infant Jarvik 2015 could be suitable for the implantation in patients lower than 8 kg because of the stability of the device respect to the cardio/circulatory changes (low frequency of suction and backflow) and because of the capability of the device to maintain adequate patient hemodynamics.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Di Molfetta A,Zielinski K,Ferrari G,Kozarski M,Okrzeja P,Iacobelli R,Filippelli S,Perri G,Darowski M,Massetti M,Jarvik R,Amodeo A

doi

10.1111/aor.13302

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

E1-E8

issue

1

eissn

0160-564X

issn

1525-1594

journal_volume

43

pub_type

杂志文章
  • Intravenous prostacyclin mitigates inhaled nitric oxide rebound effect: A case control study.

    abstract::Although extracorporeal membrane oxygenation (ECMO) improves oxygenation, pulmonary vascular resistance may be increased due to endothelial function impairment. Inhaled nitric oxide (iNO) is increasingly used for treatment of pulmonary hypertension after surgical repair of congenital heart defects, with or without ECM...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1999.06448.x

    authors: Hermon M,Golej J,Burda G,Marx M,Trittenwein G,Pollak A

    更新日期:1999-11-01 00:00:00

  • Effects of scaling on centrifugal blood pumps.

    abstract::Experimental studies on the effects of scaling on the performance of centrifugal blood pumps were conducted in a closed-loop test rig. For the prototype, eight different impellers of the same outer diameter of 25 mm were tested at 1,500, 2,000, and 2,500 revolutions per minute (rpm) using blood analog as fluid medium....

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2002.07119.x

    authors: Wong YW,Chan WK,Yu SC,Chua LP

    更新日期:2002-11-01 00:00:00

  • Is the dog a useful model for accelerated calcification study of cardiovascular bioprostheses?

    abstract::Chitosan posttreatment has been shown to be effective in prevention of calcification of the glutaraldehyde treated bovine pericardium when implanted subdermally in rats for 12 weeks. The efficacy of chitosan posttreatment in complete calcium mitigation of the glutaraldehyde treated porcine aortic valves implanted in t...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb00735.x

    authors: Chanda J,Kuribayashi R,Abe T,Sekine S,Shibata Y,Yamagishi I

    更新日期:1997-05-01 00:00:00

  • Application of a pressure-relieving air compliance chamber in a single-pulsatile extracorporeal life support system: an experimental study.

    abstract::Nonpulsatile blood pumps are mainly used in extracorporeal life support systems. Although pulsating blood flow is known to be physiological, a pulsatile pump is not commonly applied in a circuit with a membrane oxygenator because of damage to the blood cells. The hypothesis that the placement of a pressure-relieving c...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2004.07341.x

    authors: Kim TS,Sun K,Lee KB,Lee HW,Baek KJ,Park SY,Son HS,Kim KT,Kim HM

    更新日期:2004-12-01 00:00:00

  • Artificial matrix helps neonatal cardiomyocytes restore injured myocardium in rats.

    abstract::The purpose of this study was to investigate whether an artificial matrix can help neonatal cardiomyocytes restore an injured heart in a rat model of myocardial infarction (MI). The left coronary arteries of female Sprague Dawley (SD) rats were ligated to create MI models. Ventricular cardiomyocytes from 1- to 3-day-o...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2006.00186.x

    authors: Zhang P,Zhang H,Wang H,Wei Y,Hu S

    更新日期:2006-02-01 00:00:00

  • Central Extracorporeal Life Support With Left Ventricular Decompression to Berlin Heart Excor: A Reliable "Bridge to Bridge" Strategy in Crash and Burn Patients.

    abstract::The aim of this study was to compare patients with severe biventricular heart failure who underwent Berlin Heart Excor implantation with (cardiogenic shock [CS] status) or without the need for preoperative extracorporeal life support (ECLS) as a bridge to long-term device. A total of 40 consecutive patients with sever...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12792

    authors: Weymann A,Farag M,Sabashnikov A,Fatullayev J,Zeriouh M,Schmack B,Arif R,Müller F,Alt C,Raake P,Prakash Patil N,Popov AF,Rüdiger Simon A,Karck M,Ruhparwar A,Heidelberg-Cologne-Harefield Cardiothoracic Transplantation & Mecha

    更新日期:2017-06-01 00:00:00

  • Usability and safety of ventricular assist devices: human factors and design aspects.

    abstract::The purpose of this study was the investigation of the usability and ergonomics of ventricular assist devices (VADs) in everyday usage. Patients with four different VAD types were observed. After implantation, instruction, and discharge from the hospital, the patients returned on a regular basis to the outpatient clin...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00844.x

    authors: Geidl L,Zrunek P,Deckert Z,Zimpfer D,Sandner S,Wieselthaler G,Schima H

    更新日期:2009-09-01 00:00:00

  • Oxidative Stress Increases Erythrocyte Sensitivity to Shear-Mediated Damage.

    abstract::Patients receiving mechanical circulatory support often present with heightened inflammation and free radical production associated with pre-existing conditions in addition to that which is due to blood interactions with nonbiological surfaces. The aim of this experimental laboratory study was to assess the deformabil...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12997

    authors: McNamee AP,Horobin JT,Tansley GD,Simmonds MJ

    更新日期:2018-02-01 00:00:00

  • A novel technique to produce tubular scaffolds based on collagen and elastin.

    abstract::Tubular polymer scaffolds based on tissue engineering techniques have been studied as potential alternatives for vascular regeneration implants. The blood vessels of the cardiovascular system are mainly fibrous, composed of collagen (Col) and elastin (El), and its inner layer consists of endothelial cells. In this wor...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13857

    authors: Rodrigues ICP,Pereira KD,Woigt LF,Jardini AL,Luchessi AD,Lopes ÉSN,Webster TJ,Gabriel LP

    更新日期:2020-11-10 00:00:00

  • Use of clinical guidelines for treatment of anemia among hemodialysis patients.

    abstract::Changing financial incentives have strongly influenced dosing patterns of recombinant human erythropoietin (rHuEPO) since its introduction in 1989. Although guidelines for prescribing rHuEPO exist, the extent to which they are adhered to is unknown. Using a retrospective cohort observational study design, the factors ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2000.06495.x

    authors: Thamer M,Richard CM,Klinkmann J,Ivanovich P,Lang G,Cotter DJ

    更新日期:2000-02-01 00:00:00

  • Elective decompression of the left ventricle in pediatric patients may reduce the duration of venoarterial extracorporeal membrane oxygenation.

    abstract::We aimed to determine the effect of elective left heart decompression at the time of initiation of central venoarterial extracorporeal membrane oxygenation (VA ECMO) on VA ECMO duration and clinical outcomes in children in a single tertiary ECMO referral center with a large pediatric population from a national referra...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12390

    authors: Hacking DF,Best D,d'Udekem Y,Brizard CP,Konstantinov IE,Millar J,Butt W

    更新日期:2015-04-01 00:00:00

  • Cadaver fitting study of the DexAide right ventricular assist device.

    abstract::The DexAide right ventricular assist device (RVAD) has been developed to provide an implantable RVAD option to surgeons. The aim of this study was to determine the optimal cannula design and optimal implantation location of the DexAide RVAD in preparation for its clinical use. Separately, a HeartMate XVE left ventricu...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2007.00438.x

    authors: Ootaki Y,Ootaki C,Kamohara K,Akiyama M,Cingoz F,Kopcak MW Jr,Dessoffy R,Liu J,Massiello A,Horvath D,Chen JF,Zhou Q,Benefit S,Golding LA,Fukamachi K

    更新日期:2007-08-01 00:00:00

  • Standing up with denervated muscles in humans using functional electrical stimulation.

    abstract::The use of electrical stimulation for denervated muscles is still considered to be a controversial issue by many rehabilitation facilities and medical professionals because prior clinical experience has shown that treating denervated muscle tissue using exponential current over a long time period constitutes an imposs...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1999.06376.x

    authors: Kern H,Hofer C,Strohhofer M,Mayr W,Richter W,Stöhr H

    更新日期:1999-05-01 00:00:00

  • Cooling device for bradycardia based on Peltier element for accurate anastomosis of off-pump coronary artery bypass grafting.

    abstract::Upon introducing off-pump coronary artery bypass grafting (CABG), the indications for CABG were expanded to include patients who previously had no operative indications. For accurate anastomosis, various devices and methods have been developed. Bradycardia is easily induced by drug administration. However, this method...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2002.07087.x

    authors: Kuniyoshi Y,Koja K,Miyagi K,Shimoji M,Uezu T,Arakaki K,Yamashiro S,Mabuni K,Senaha S

    更新日期:2002-10-01 00:00:00

  • From wooden limbs to biomaterial organs: the ethics of organ replacement and artificial organs.

    abstract::This paper discussed issues of ethical assessment and moral concern associated with organ replacement and physical enhancement: research, allocation, organ donation, artificial organs, xenografts, biomaterials, and neuromaterials. While emphasizing the medical and moral benefits over associated risks, it calls for a b...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1995.tb02362.x

    authors: Kielstein R,Sass HM

    更新日期:1995-05-01 00:00:00

  • Artificial cells with emphasis on cell encapsulation of genetically engineered cells.

    abstract::Artificial cells are prepared in the laboratory for medical and biotechnological applications. Encapsulated cells are being studied for the treatment of diabetes, liver failure, and other conditions. More recently, there have been extensive studies into the use of encapsulated genetically engineered cells for gene the...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1998.06243.x

    authors: Chang TM

    更新日期:1998-11-01 00:00:00

  • Implantation of the total artificial heart by lateral thoracotomy.

    abstract::Progress in the techniques for surgical implantation of the artificial heart has progressed in parallel with the technology and design of the prosthesis. In the author's first experience with total artificial heart (TAH) implantation (1968) a trans-sternal split was used opening the sixth intercostal space on the righ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1977.tb00984.x

    authors: Olsen DB,Fukumasu H,Kolff J,Nakagaki M,Finch LR,Kolff WJ

    更新日期:1977-11-01 00:00:00

  • Balloon Dilatation for Removal of an Irretrievable Permanent Hemodialysis Catheter: The Safest Approach.

    abstract::Long-term hemodialysis catheter dwell time in the central vein predisposes to fibrin sheath development, which subsequently causes catheter malfunction or occlusion. In very rare cases, the catheter can be overgrown with fibrin and rigidly connected with the vein or heart structures. This makes its removal almost impo...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12643

    authors: Garcarek J,Gołębiowski T,Letachowicz K,Kusztal M,Szymczak M,Madziarska K,Jakuszko K,Zmonarski S,Guziński M,Weyde W,Klinger M

    更新日期:2016-05-01 00:00:00

  • The microsystems based visual prosthesis for optic nerve stimulation.

    abstract::The microsystems based visual prosthesis (MiViP) visual prosthesis generates visual perceptions well below safety and stimulator saturation limits. These perceptions, called phosphenes, are of reasonably small size and are broadly distributed in the visual field. They can thus be used to convey useful visual informati...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2002.06939.x

    authors: Delbeke J,Wanet-Defalque MC,Gérard B,Troosters M,Michaux G,Veraart C

    更新日期:2002-03-01 00:00:00

  • Paracorporeal artificial heart in postoperative heart failure.

    abstract::A pneumatically driven artificial heart with a tubular silicone rubber membrane and disc valves was used for functional heart replacement in the paracorporeal mode. A fluidic drive system allows adjustment of the heart rate, positive and negative pressures and systole/diastole ratio. Since August, 1977, the artificial...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1978.tb03465.x

    authors: Turina MT,Bosio R,Senning A

    更新日期:1978-08-01 00:00:00

  • Pseudoendothelium formation in expanded polytetrafluoroethylene grafts implanted in the inferior vena cava of normal and defibrinogenated dogs.

    abstract::The outgrowth of endothelial cells in an expanded polytetrafluoroethylene graft implanted in the canine inferior vena cava was studied by scanning electron microscopy. The adjacent endothelial cells of the vena cava started to invade the anastomotic area three days after the implantation and reached approximately the ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1981.tb04020.x

    authors: Ishimaru S,Berglin E,Hansson HA,Teger-Nilsson AC,William-Olsson G

    更新日期:1981-11-01 00:00:00

  • Device exchange versus nonexchange modalities in left ventricular assist device-specific infections: A systematic review and meta-analysis.

    abstract::No standardized treatment algorithm exists for the management of continuous-flow left ventricular assist device (CF-LVAD)-specific infections. The aim of this systematic review and meta-analysis was to compare the outcomes of CF-LVAD-specific infections as managed by device exchange to other treatment modalities not i...

    journal_title:Artificial organs

    pub_type: 杂志文章,meta分析

    doi:10.1111/aor.13378

    authors: Bauer TM,Choi JH,Luc JGY,Weber MP,Moncho Escrivá E,Patel S,Maynes EJ,Boyle AJ,Samuels LE,Entwistle JW,Morris RJ,Massey HT,Tchantchaleishvili V

    更新日期:2019-05-01 00:00:00

  • The compliance problem: a major obstacle in the development of implantable blood pumps.

    abstract::The compliance problem represents a major obstacle in the development of implantable blood pumps. The motor-driven pumps are enclosed in an airtight casing with gas in the motor space. The trapped gas in the motor space either increases the load on the motor during systole or impedes blood sac filling. Potential solut...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1984.tb04248.x

    authors: Lee S,Rosenberg G,Donachy JH,Wisman CB,Pierce WS

    更新日期:1984-02-01 00:00:00

  • Estimation of phosphene spatial variability for visual prosthesis applications.

    abstract::Visual prostheses are the focus of intensive research efforts to restore some measure of useful vision to blind or near-blind patients. The development of such technology is being guided to an extent by tools that simulate prosthesis behavior for healthy sighted subjects in order to assess system requirements and conf...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00878.x

    authors: Obeid I,Veraart C,Delbeke J

    更新日期:2010-05-01 00:00:00

  • Use of an integrated sideport for diagnosis and management of decreased flow rates in a programmable implanted insulin delivery system. Implantable Insulin Pump Trial Study Group.

    abstract::The aim of this study was to develop procedures for the diagnosis and nonsurgical management of decreased insulin flow in an implantable programmable pump for long-term intraperitoneal or intravenous insulin delivery featuring a sideport. Patency of the catheter lumen was tested by measuring the time needed for sidepo...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1996.tb04586.x

    authors: Scavini M,Reich S,Eaton RP,Charles MA,Dunn FL

    更新日期:1996-09-01 00:00:00

  • The roles of vascular smooth muscle cells in the aortic wall thinness under prolonged continuous flow left heart bypass.

    abstract::Aortic wall thinness was one of the most characteristic changes observed in experimental animals under prolonged continuous flow left heart bypass. The goal of this study was to determine the roles of smooth muscle cells in the vascular remodeling process in cases demonstrating aortic wall thinness under prolonged con...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2003.00022.x

    authors: Mizuno T,Nishinaka T,Ohnishi H,Tatsumi E,Tsukiya T,Oshikawa M,Shioya K,Takewa Y,Homma A,Takano H,Kitamura S,Taenaka Y

    更新日期:2003-10-01 00:00:00

  • Effect of age on calcification of poly(hydroxyethyl methacrylate) in animals.

    abstract::The effect of age on the calcification of biomaterials was studied by the subcutaneous implantation of poly(hydroxyethyl methacrylate) hydrogel in rats. The hydrogel sheets were implanted in rats 6, 12, 24, and 52 weeks (1 year) of age. The retrieved implants were compared and the percentage weight increase by mineral...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1985.tb04388.x

    authors: Imai Y

    更新日期:1985-08-01 00:00:00

  • Extracorporeal Life Support in Out-of-Hospital Refractory Cardiac Arrest.

    abstract::Out-of-Hospital refractory Cardiac Arrest (OHrCA) has a mortality rate between 90 and 95%. Since 2009, French medical academic societies have recommended the use of extracorporeal life support (ECLS) for OHrCA. According to these guidelines, patients were eligible for ECLS support if vital signs were still present dur...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12655

    authors: Rousse N,Robin E,Juthier F,Hysi I,Banfi C,Al Ibrahim M,Coadou H,Goldstein P,Wiel E,Vincentelli A

    更新日期:2016-09-01 00:00:00

  • Hemolytic evaluation using polyurethane microcapsule suspensions in circulatory support devices: normalized index of hemolysis comparisons of commercial centrifugal blood pumps.

    abstract::We have been developing some types of microcapsule suspensions with polyurethane membranes to evaluate the absolute hemolytic characteristics of the centrifugal blood pumps used in circulatory support devices such as artificial hearts. In order to facilitate/realize hemolysis testing on centrifugal blood pumps that ha...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2007.00503.x

    authors: Maruyama O,Yamaguchi K,Nishida M,Onoguchi T,Tsutsui T,Jikuya T,Yamane T

    更新日期:2008-02-01 00:00:00

  • Experimental study of a new method for early detection of vascular access stenoses: pulse pressure analysis at hemodialysis needle.

    abstract::Hemodialysis vascular access (VA) stenosis remains a frequent complication. However, early detection is challenging and costly. The aim of this in vitro study was to assess a new detection method based on pulse pressure analysis at the hemodialysis needle. A silicon model of a radiocephalic arteriovenous fistula was b...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00772.x

    authors: Van Canneyt K,Planken RN,Eloot S,Segers P,Verdonck P

    更新日期:2010-02-01 00:00:00