Abstract:
:In 1993, the development began of a small axial flow blood pump, the DeBakey ventricular assist device (VAD). The material was recently converted to a titanium alloy, and a waterproof pump package was incorporated for long-term intracorporeal circulation. Thirteen intrathoracic implantations in calves were achieved. Nine animals survived the 2 week perioperative period and were supported for a range of 26-93 days. The first study had low flow due to poor anatomical fit of the straight cannula. In contrast, a curved cannula used subsequently provided a good anatomical fit with sufficient flow. Mean flow of 4.4 L/min was sustained with 9,900 rpm and required power was an average of 8.8 W. No thromboembolic evidences were observed in any case, and the plasma free hemoglobin level was maintained lower than 5 mg/dl, except in the early postoperative period. Three animals were terminated because of bleeding due to anticoagulant mismanagement. Electric interference (n = 1) and drive line breakage/fault (n = 2) were observed as device-related failures. Minor modifications were made to the drive line. In conclusion, the DeBakey VAD demonstrated adequate basic performance and biocompatibility. The highly reliable mechanical components and improved electrical parts are promising for a long-term implantable cardiac prosthesis.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Tayama E,Olsen DB,Ohashi Y,Benkowski R,Morley D,Noon GP,Nosé Y,Debakey MEdoi
10.1046/j.1525-1594.1999.06300.xsubject
Has Abstractpub_date
1999-12-01 00:00:00pages
1113-6issue
12eissn
0160-564Xissn
1525-1594pii
aor6300journal_volume
23pub_type
临床试验,杂志文章abstract::Central extracorporeal life support (ECLS) is an effective treatment method of cardiogenic shock patients with or without lung failure. However, complications like infection and bleeding are common. The classical implantation approach requires full sternotomy, mobilization of the heart, with the well-known risks of bl...
journal_title:Artificial organs
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journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章,评审
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更新日期:1996-08-01 00:00:00
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journal_title:Artificial organs
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journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1982.tb01675.x
更新日期:1982-08-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.12062
更新日期:2013-08-01 00:00:00
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更新日期:1994-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-10-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1046/j.1525-1594.2000.06496.x
更新日期:2000-05-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1978.tb01002.x
更新日期:1978-02-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1996.tb00661.x
更新日期:1996-11-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1990.tb01588.x
更新日期:1990-02-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.13503
更新日期:2019-10-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1046/j.1525-1594.1999.06376.x
更新日期:1999-05-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1987.tb02622.x
更新日期:1987-02-01 00:00:00
abstract::A pseudo-one compartment model has been proposed to describe phosphorus kinetics during hemodialysis and the immediate post-dialysis period. This model assumes that phosphorus mobilization from tissues is proportional to the difference between the pre-dialysis serum concentration (a constant) and the instantaneous ser...
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pub_type: 杂志文章
doi:10.1111/aor.12897
更新日期:2017-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00
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journal_title:Artificial organs
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更新日期:2006-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1979-05-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00
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更新日期:2004-04-01 00:00:00
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journal_title:Artificial organs
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doi:10.1046/j.1525-1594.2000.06432.x
更新日期:2000-01-01 00:00:00
abstract::A galactosamine-induced fulminant hepatic failure (FHF) rat model was used to study the effects of homologous cross-circulation and in situ liver perfusion. Cross-circulation with homologous donors did not significantly improve the survival time or recovery rate of grade II hepatic coma rats. Homologous in situ liver ...
journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:1980-08-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:1985-08-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:1999-02-01 00:00:00
abstract::Cybernetics-based concepts can allow for complete independence for paralyzed individuals, including sensory motor recovery. Spinal cord injuries are responsible for a huge stress on health and a financial burden to society. This article focuses on novel procedures such as functional diagnosis for paraplegics and tetra...
journal_title:Artificial organs
pub_type: 杂志文章,评审
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更新日期:2015-10-01 00:00:00