Abstract:
:Temporary extracorporeal membrane oxygenation (ECMO) has been established as an essential part of therapy in patients with pulmonary or cardiac failure. As physiological gaseous exchange is artificially altered in this patient group, it is debatable whether a (13) C-breath test can be carried out. In this proof of technical feasibility report, we assess the viability of the (13) C-breath test LiMAx (maximum liver function capacity) in patients on ECMO therapy. All breath probes for the test device were obtained directly via the membrane oxygenator. Data of four patients receiving liver function assessment with the (13) C-breath test LiMAx while having ECMO therapy were analyzed. All results were compared with validated scenarios of the testing procedures. The LiMAx test could successfully be carried out in every case without changing ECMO settings. Clinical course of the patients ranging from multiorgan failure to no sign of liver insufficiency was in accordance with the results of the LiMAx liver function test. The (13) C-breath test is technically feasible in the context of ECMO. Further evaluation of (13) C-breath test in general would be worthwhile. The LiMAx test as a (13) C-breath test accessing liver function might be of particular predictive interest if patients with ECMO therapy develop multiorgan failure.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Bednarsch J,Menk M,Malinowski M,Weber-Carstens S,Pratschke J,Stockmann Mdoi
10.1111/aor.12634subject
Has Abstractpub_date
2016-07-01 00:00:00pages
692-8issue
7eissn
0160-564Xissn
1525-1594journal_volume
40pub_type
杂志文章abstract::Tumor necrosis factor-alpha (TNF-alpha) release has been implicated in a sepsis-like syndrome following cardiopulmonary bypass (CPB). This also may be important in patients who have had a left ventricular assist device (LVAD) implanted. This report investigates the effect of reducing systemic blood flow on hemodynamic...
journal_title:Artificial organs
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journal_title:Artificial organs
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journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
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journal_title:Artificial organs
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pub_type: 杂志文章
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journal_title:Artificial organs
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journal_title:Artificial organs
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journal_title:Artificial organs
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journal_title:Artificial organs
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doi:10.1111/j.1525-1594.2007.00452.x
更新日期:2008-01-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1996.tb04494.x
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pub_type: 杂志文章
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journal_title:Artificial organs
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pub_type: 历史文章,杂志文章,评审
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更新日期:2015-09-01 00:00:00
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journal_title:Artificial organs
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journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00