(13) C Breath Tests Are Feasible in Patients With Extracorporeal Membrane Oxygenation Devices.

Abstract:

:Temporary extracorporeal membrane oxygenation (ECMO) has been established as an essential part of therapy in patients with pulmonary or cardiac failure. As physiological gaseous exchange is artificially altered in this patient group, it is debatable whether a (13) C-breath test can be carried out. In this proof of technical feasibility report, we assess the viability of the (13) C-breath test LiMAx (maximum liver function capacity) in patients on ECMO therapy. All breath probes for the test device were obtained directly via the membrane oxygenator. Data of four patients receiving liver function assessment with the (13) C-breath test LiMAx while having ECMO therapy were analyzed. All results were compared with validated scenarios of the testing procedures. The LiMAx test could successfully be carried out in every case without changing ECMO settings. Clinical course of the patients ranging from multiorgan failure to no sign of liver insufficiency was in accordance with the results of the LiMAx liver function test. The (13) C-breath test is technically feasible in the context of ECMO. Further evaluation of (13) C-breath test in general would be worthwhile. The LiMAx test as a (13) C-breath test accessing liver function might be of particular predictive interest if patients with ECMO therapy develop multiorgan failure.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Bednarsch J,Menk M,Malinowski M,Weber-Carstens S,Pratschke J,Stockmann M

doi

10.1111/aor.12634

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

692-8

issue

7

eissn

0160-564X

issn

1525-1594

journal_volume

40

pub_type

杂志文章
  • Effect of variation in systemic blood flow on plasma TNF-alpha in a pig model with left ventricular assist device.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) release has been implicated in a sepsis-like syndrome following cardiopulmonary bypass (CPB). This also may be important in patients who have had a left ventricular assist device (LVAD) implanted. This report investigates the effect of reducing systemic blood flow on hemodynamic...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2001.025002146.x

    authors: Uozaki Y,Dihmis WC,Yamauchi H,Moczar M,Miyama M,Pasteau F,Tixier D,Bambang SL,Loisance DY

    更新日期:2001-02-01 00:00:00

  • Myocardial protection in pediatric cardiac surgery.

    abstract::The combination of hypothermia and potassium cardioplegic arrest has become the most common method of myocardial protection in the evolution of myocardial protection. This review focuses on myocardial protection in pediatric cardiac surgery. In the 1980s, blood was added to cardioplegia solution in order to supply the...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审

    doi:10.1111/aor.12029

    authors: Turkoz R

    更新日期:2013-01-01 00:00:00

  • Can the human lumbar posterior columns be stimulated by transcutaneous spinal cord stimulation? A modeling study.

    abstract::Stimulation of different spinal cord segments in humans is a widely developed clinical practice for modification of pain, altered sensation, and movement. The human lumbar cord has become a target for modification of motor control by epidural and, more recently, by transcutaneous spinal cord stimulation. Posterior col...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2011.01213.x

    authors: Danner SM,Hofstoetter US,Ladenbauer J,Rattay F,Minassian K

    更新日期:2011-03-01 00:00:00

  • The BiVACOR rotary biventricular assist device: concept and in vitro investigation.

    abstract::The BiVACOR is a novel rotary Biventricular Assist Device (BiVAD) undergoing development to treat global end-stage heart failure. The design includes left and right vanes positioned on a shared rotating hub to form a double-sided magnetically and hydrodynamically suspended centrifugal impeller. The performance of the ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2008.00633.x

    authors: Timms D,Fraser J,Hayne M,Dunning J,McNeil K,Pearcy M

    更新日期:2008-10-01 00:00:00

  • Gaseous micro-emboli activity during cardiopulmonary bypass in adults: pulsatile flow versus nonpulsatile flow.

    abstract::Cardiopulmonary bypass (CPB) has a risk of cerebral injury, with an important role of gaseous micro-emboli (GME) coming from the CPB circuit. Pulsatile perfusion is supposed to perform specific conditions for supplementary GME activity. We aimed to determine whether pulsatile CPB augments production and delivery of GM...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12000

    authors: Dodonov M,Milano A,Onorati F,Dal Corso B,Menon T,Ferrarini D,Tessari M,Faggian G,Mazzucco A

    更新日期:2013-04-01 00:00:00

  • Promigratory activity of oxytocin on umbilical cord blood-derived mesenchymal stem cells.

    abstract::Recent studies show that oxytocin has various effects on cellular behaviors. Oxytocin is reported to stimulate cardiomyogenesis of embryonic stem cells and endothelial cell proliferation. Mesenchymal stem cells (MSCs) are widely used for cardiac repair, and we elucidated the effect of oxytocin on umbilical cord derive...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00894.x

    authors: Kim YS,Kwon JS,Hong MH,Kim J,Song CH,Jeong MH,Cho JG,Park JC,Kang JC,Ahn Y

    更新日期:2010-06-01 00:00:00

  • Gas-exchange function of a preprimed pediatric oxygenator stored for one year for emergency cardiopulmonary bypass.

    abstract::To save priming time and perform more rapid initiation of emergency cardiopulmonary bypass for acute cardiopulmonary failure, an extracorporeal circuit with a hollow-fiber oxygenator (EL-2000 for pediatric use; Kurary Co. Ltd., Osaka, Japan) was preprimed, and the gas-exchange function was evaluated after 1 year of st...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1992.tb00331.x

    authors: Otsu T,Terasaki H,Choi H,Tajiri A,Okamoto T,Matsuyama K,Morioka T

    更新日期:1992-10-01 00:00:00

  • Hemolysis test of disposable type vibrating flow pump.

    abstract::The vibrating flow pump (VFP) can generate high frequency oscillated blood flow. Because of the high frequency driving with short stroke volume, the pump system can be small. The disposable type VFP (D-VFP) was developed for use for extracorporeal circulation. The electromagnetic actuator was detached from the vibrati...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb03724.x

    authors: Kobayashi S,Nitta S,Yambe T,Sonobe T,Naganuma S,Hashimoto H

    更新日期:1997-07-01 00:00:00

  • Plasma middle molecules in asymptomatic and "sick" uremic patients.

    abstract::By using high speed gel filtration combined with ion exchange gradient elution chromatography, the concentrations of plasma (p) middle molecules (MM) were determined in 126 samples from 90 non-dialyzed azotemic patients and in 210 pre-dialysis samples from 53 regular hemodialysis and 24 intermittent peritoneal dialysi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:

    authors: Asaba H,Bergström J,Fürst P,Johnson C,Yahiel V

    更新日期:1981-01-01 00:00:00

  • Bulk mass transport limitations during high-flux hemodialysis.

    abstract::Solute clearance during high-flux hemodialysis is determined by the combined effects of solute convection and diffusion in the membrane, blood, and dialysate. Previous studies have focused almost entirely on the membrane transport phenomena, largely ignoring the potential contribution from bulk mass transport across t...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1993.tb00403.x

    authors: Zydney AL

    更新日期:1993-11-01 00:00:00

  • The PediPump: a new ventricular assist device for children.

    abstract::Options for mechanical circulatory support for the treatment of end-stage heart failure in children are limited. Ventricular assist devices (VADs), which have revolutionized cardiac care in adults, remain largely unavailable for pediatric applications. The PediPump is a new rotary dynamic VAD designed to provide suppo...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2005.29088.x

    authors: Duncan BW,Lorenz M,Kopcak MW,Fukamachi K,Ootaki Y,Chen HM,Chapman PA,Davis SJ,Smith WA

    更新日期:2005-07-01 00:00:00

  • Nonsymmetric leaflet motion of St. Jude Medical mitral valves simulated with a computer-controlled hydraulic mock circulator.

    abstract::Since the introduction of high-performance prosthetic heart valves, particularly bileaflet valves and monoleaflet valves with larger opening angles, we have observed in vivo complex leaflet motion which has not been experimentally confirmed yet. We developed a computer-controlled hydraulic mock circulator to study the...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb00373.x

    authors: Ohta Y,Okamoto K,Sonderegger M,Dohi T,Matsumoto H,Horiuchi T

    更新日期:1997-04-01 00:00:00

  • Isoelastic polyurethane prosthesis for segmental trachea replacement in beagle dogs.

    abstract::Porous polyurethane (nonwoven) was used for the development of tracheal prosthesis, which--in a special testing design--was adapted to shape and biomechanic properties of the natural organ. This prosthesis was implanted into 19 beagle dogs using inverted, everted, and end-to-end anastomosis. Insufficiency of the anast...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1989.tb02866.x

    authors: Schauwecker HH,Gerlach J,Planck H,Bücherl ES

    更新日期:1989-06-01 00:00:00

  • Influence of flow design on microcirculation in conditions of undulation pump-left ventricle assist device testing.

    abstract::To study the microvessels in bulbar conjunctiva, we conducted an experiment in goat with a pneumatically driven left heart bypass pump, which was replaced with an undulation pump-left ventricle assist device for 9 days. Three flow patterns were tested: complete pulsatile, continuous, and percentage of pulsatile. We st...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2006.00244.x

    authors: Dobsák P,Novakova M,Baba A,Vasku J,Isoyama T,Saito I,Abe Y,Chinzei T,Imachi K

    更新日期:2006-06-01 00:00:00

  • Cadaver fitting study of the DexAide right ventricular assist device.

    abstract::The DexAide right ventricular assist device (RVAD) has been developed to provide an implantable RVAD option to surgeons. The aim of this study was to determine the optimal cannula design and optimal implantation location of the DexAide RVAD in preparation for its clinical use. Separately, a HeartMate XVE left ventricu...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2007.00438.x

    authors: Ootaki Y,Ootaki C,Kamohara K,Akiyama M,Cingoz F,Kopcak MW Jr,Dessoffy R,Liu J,Massiello A,Horvath D,Chen JF,Zhou Q,Benefit S,Golding LA,Fukamachi K

    更新日期:2007-08-01 00:00:00

  • Biomechanical properties of decellularized porcine pulmonary valve conduits.

    abstract::Tissue-engineered heart valves constructed from a xenogeneic or allogeneic decellularized matrix might overcome the disadvantages of current heart valve substitutes. One major necessity besides effective decellularization is to preserve the biomechanical properties of the valve. Native and decellularized porcine pulmo...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2007.00452.x

    authors: Seebacher G,Grasl C,Stoiber M,Rieder E,Kasimir MT,Dunkler D,Simon P,Weigel G,Schima H

    更新日期:2008-01-01 00:00:00

  • Numerical Simulation of Nonpulsatile Left Ventricular Bypass.

    abstract::A computer simulation was carried out to investigate the influence of nonpulsatile left ventricular assistance on hemodynamics. A simulation circuit was constructed to represent the circulatory system. A source of current was added to denote the nonpulsatile blood pump. The left and right ventricles were replaced by v...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1996.tb04494.x

    authors: Mitsui N,Fukunaga S,Koura Y,Morita S,Hotei H,Sueshiro M,Sueda T,Matsuura Y

    更新日期:1996-05-01 00:00:00

  • Comparison between standard single chamber versus dual chamber low glucose degradation product peritoneal dialysis fluids.

    abstract::Dual chamber (DC) peritoneal dialysis (PD) dialysates contain fewer glucose degradation products (GDPs), so potentially reducing advanced glycosylation end products (AGEs), which have been reported to increase inflammation and cardiovascular risk. We wished to determine whether use of DC dialysates resulted in demonst...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13768

    authors: Vareesangthip K,Vongsanim S,Fan S,Davenport A

    更新日期:2020-07-09 00:00:00

  • Motor control in the human spinal cord.

    abstract::Features of the human spinal cord motor control are described using two spinal cord injury models: (i) the spinal cord completely separated from brain motor structures by accidental injury; (ii) the spinal cord receiving reduced and altered supraspinal input due to an incomplete lesion. Systematic studies using surfac...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2005.29038.x

    authors: Dimitrijevic MR,Persy I,Forstner C,Kern H,Dimitrijevic MM

    更新日期:2005-03-01 00:00:00

  • Microencapsulation of crystalline insulin or islets of Langerhans: an insulin diffusion study.

    abstract::Microcapsules containing insulin crystals or islets of Langerhans were made by extruding a mixture of insulin crystals or islets and sodium alginate into a calcium chloride solution, and then coating it with poly-l-lysine. When these microcapsules were incubated at 37 degrees C, insulin could be detected readily in th...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1983.tb04187.x

    authors: Leung YF,O'Shea GM,Goosen MF,Sun AM

    更新日期:1983-05-01 00:00:00

  • Controlled delivery of low-dose bone morphogenetic protein-2 using heparin-conjugated fibrin in the posterolateral lumbar fusion of rabbits.

    abstract::The heparin-conjugated fibrin (HCF) system has been developed to deliver bone morphogenetic proteins (BMPs) for a long-term period and thus enhance bone regeneration. In the present study, we tested the effectiveness of the delivery system for spinal fusion with a very low dose of BMP-2. A total of 15 rabbits underwen...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2012.01578.x

    authors: Koo KH,Lee JM,Ahn JM,Kim BS,La WG,Kim CS,Im GI

    更新日期:2013-05-01 00:00:00

  • Significance of percutaneous cardiopulmonary bypass support for volume reduction surgery with severe hypercapnia.

    abstract::In patients with reduced respiratory function, lung resection is associated with high risk because separate ventilation is generally needed for safe management. For patients with end-stage emphysema, intraoperative respiratory management is important and particularly difficult because neither incomplete oxygenation no...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2000.06339.x

    authors: Tsunezuka Y,Sato H,Tsubota M,Seki M

    更新日期:2000-01-01 00:00:00

  • Ferritin: a reliable indicator of iron supplementation in patients on chronic hemodialysis/hemofiltration treatment?

    abstract::Four hundred and forty-two serum ferritin determinations were performed in 144 patients on chronic intermittent hemodialysis treatment with intravenous iron substitution and/or oral iron substitution. Iron substitution should be done individually according to regular serum ferritin determinations. Intravenous iron sub...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1981.tb03980.x

    authors: Müller HA,Schneider H,Hövelborn U,Streicher E

    更新日期:1981-05-01 00:00:00

  • Stent treatment of inferior vena cava compression in an ovine with a total artificial heart.

    abstract::Although current continuous-flow total artificial hearts (CFTAHs) are much smaller than previous models, venous kinking may still occur after device implantation, especially in smaller animals. By inserting a self-expanding stent at the site of venous narrowing in a sheep model implanted with a CFTAH, we were able to ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2011.01233.x

    authors: Tuzun E,Parnis S,Rios J,Winkler JA,Cohn WE

    更新日期:2011-07-01 00:00:00

  • Intensive Home Hemodialysis: An Eye at the Past Looking for the Hemodialysis of the Future.

    abstract::Multiple observational studies along with a limited number of randomized clinical trials suggest that intensive hemodialysis (IHD) not only improves outcomes for uremic patients undergoing chronic dialysis but does so with a more favorable cost/benefit ratio compared with conventional hemodialysis. As a result of this...

    journal_title:Artificial organs

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/aor.12458

    authors: Naso A,Scaparrotta G,Naso E,Calò LA

    更新日期:2015-09-01 00:00:00

  • Pulsatile culture of a poly(DL-lactic-co-glycolic acid) sandwiched cell/hydrogel construct fabricated using a step-by-step mold/extraction method.

    abstract::To overcome the weak mechanical properties of cell/hydrogel composites, a poly(DL-lactic-co-glycolic acid) sandwiched adipose-derived stem cell (ADSC)/fibrin construct was fabricated using a step-by-step mold/extraction method to generate the middle smooth muscle layer of natural blood vessels. A pulse bioreactor with...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2010.01137.x

    authors: Wang X,Sui S

    更新日期:2011-06-01 00:00:00

  • Selective Cerebro-Myocardial Perfusion in Complex Neonatal Aortic Arch Pathology: Midterm Results.

    abstract::Aortic arch repair in newborns and infants has traditionally been accomplished using a period of deep hypothermic circulatory arrest. To reduce neurologic and cardiac dysfunction related to circulatory arrest and myocardial ischemia during complex aortic arch surgery, an alternative and novel strategy for cerebro-myoc...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13128

    authors: Hoxha S,Abbasciano RG,Sandrini C,Rossetti L,Menon T,Barozzi L,Linardi D,Rungatscher A,Faggian G,Luciani GB

    更新日期:2018-04-01 00:00:00

  • Hemoperfusion and DNA synthesis in the rat liver. Part I: the effect of hemoperfusion on the rate of DNA synthesis.

    abstract::An investigation has been made into whether charcoal hemoperfusion stimulates a hyperplastic response in the liver of the normal rat. Animals underwent hemoperfusion over Norit RBX1 (Strathclyde, Glasgow, U.K.) charcoal granules using a technique which allowed perfusion in the unrestrained and conscious state. Control...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1982.tb04080.x

    authors: Ryan CJ,Courtney JM,Wood CB,Blumgart LH

    更新日期:1982-05-01 00:00:00

  • Computational simulation of a non-newtonian model of the blood separation process.

    abstract::The aim of this work is to construct a computational fluid dynamics model capable of simulating the transient non-Newtonian process of apheresis. A Lagrangian-Eulerian model has been developed which tracks the blood particles within a two-dimensional flow configuration. Within the Eulerian method, the fluid mass and m...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2005.00164.x

    authors: De Gruttola S,Boomsma K,Poulikakos D

    更新日期:2005-12-01 00:00:00

  • Delivery of the bioactive gas hydrogen sulfide during cold preservation of rat liver: effects on hepatic function in an ex vivo model.

    abstract::The insults sustained by transplanted livers (hepatectomy, hypothermic preservation, and normothermic reperfusion) could compromise hepatic function. Hydrogen sulfide (H₂S) is a physiologic gaseous signaling molecule, like nitric oxide (NO) and carbon monoxide (CO). We examined the effect of diallyl disulfide as a H₂S...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2011.01256.x

    authors: Balaban CL,Rodriguez JV,Guibert EE

    更新日期:2011-05-01 00:00:00