Comparison of rapid in situ, regular in situ, and ex vivo flushing on hepatic function.

Abstract:

:The efficacy of three flushing techniques on subsequent liver function was assessed using the in vivo isolated liver perfusion model (ILPM). Livers from brain-dead mongrel dogs were flushed with cold Euro-Collins as follows: Group I, rapid in situ flushing (10 min); Group II, regular in situ flushing (45 min); Group III, ex vivo flushing (10 min). All livers were then heterotopically transplanted into recipients, using the ILPM, by anastomosis of the portal vein, vena cava, and hepatic artery to the recipient's portal vein, iliac vein, and iliac artery. Reperfusion followed for 30 min. Laboratory samples collected at 0, 5, 15, and 30 min showed that hepatic function was not altered by ex vivo flushing and was only slightly altered by rapid in situ flushing. Regular in situ flushing proved to be damaging to livers. Histological analysis confirmed these findings. Therefore, either rapid in situ or ex vivo flushing can be safely used by the transplant specialist.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Castellanos J,Toledo-Pereyra LH,Finkelstein I,Kestenberg W,Chapman M,Choudhury S

doi

10.1111/j.1525-1594.1988.tb02760.x

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

222-6

issue

3

eissn

0160-564X

issn

1525-1594

journal_volume

12

pub_type

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