Effects of continuous-flow left ventricular assist devices on cerebral hemodynamics.

Abstract:

:Continuous-flow left ventricular assist devices (LVADs) reduce peak systolic flow, increase diastolic flow, and eliminate pulsatility of circulation. Altered blood flow may lead to a change in end-organ perfusion. Analysis of the flow dynamics of the arteries of end organs, such as the brain, may indicate whether an organ is perfused sufficiently. The aim of this study is to evaluate and identify the flow pattern changes of carotid (CA) and middle cerebral arteries (MCA) in LVAD patients and to compare with heart failure patients and healthy volunteers. Eighty-nine individuals were included in this cross-sectional study. Participants were divided into three groups: LVAD patients (n = 31), heart failure patients (n = 26), and healthy volunteers (n = 27). Carotid and transcranial Doppler ultrasonography were performed for all study groups for peak systolic velocity (PSV), end-diastolic velocity (EDV), pulsatility (PI), and resistive (RI) indices of CA and MCA. Flow dynamics were compared between the groups. Doppler ultrasonographic data were analyzed at a median 12 (3-47) months after LVAD implantation. CA-PSV was lower in LVAD group compared with the other two groups (P < .001), MCA-PSV of LVAD and heart failure groups were similar and lower than healthy volunteers (P < .05). The highest values for CA-EDV were found in the LVAD group (P < .05). MCA-EDV values were found to be lowest in heart failure group (P < .05). For PI and RI, in all CA and MCA, the LVAD group had lower indices compared with the other two groups (P < .001). In addition, MCA flow analysis in patients with LVADs was identified for the first time with this study.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Karahan M,Kocabeyoglu SS,Kervan U,Sert DE,Aygun E,Tola M,Demirkan B,Mungan S,Kursun O,Catav Z,Pac M

doi

10.1111/aor.13616

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

457-464

issue

5

eissn

0160-564X

issn

1525-1594

journal_volume

44

pub_type

杂志文章
  • Plasma administration to defibrinogenated dogs during extracorporeal circulation.

    abstract::Plasma, in an amount corresponding to 0.05 gm fibrinogen/Kg of body weight, was administered during one hour to defibrinogenated dogs subjected to extracorporeal circulation. Four blood filters included in the extracorporeal circuit were removed one by one at 30-minute intervals. The prefilter pressures rose gradually...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1979.tb03809.x

    authors: Berglin E,Hansson HA,William-Olsson G

    更新日期:1979-02-01 00:00:00

  • Microbial and endotoxin contamination in water and dialysate in the central United States.

    abstract::The purified water supplies and randomly selected dialysates of 51 chronic and acute dialysis centers in the central United States were surveyed to assess the relative risks to dialysis patients from microbial and endotoxin contamination. A culture medium more sensitive than those generally employed in routine quality...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1990.tb01601.x

    authors: Klein E,Pass T,Harding GB,Wright R,Million C

    更新日期:1990-04-01 00:00:00

  • Ex vivo evaluation in normal dogs of insulin released by a bioartificial pancreas containing isolated rat islets of Langerhans.

    abstract::In bioartificial pancreatic systems, isolated islets of Langerhans are protected against immune rejection by an artificial membrane, permeable to glucose and insulin, but not to immunoglobulins and lymphocytes. Some of these devices, referred to as vascular systems, are set up to be connected to a vascular site in the...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1990.tb01588.x

    authors: Lepeintre J,Briandet H,Moussy F,Chicheportiche D,Darquy S,Rouchette J,Imbaud P,Duron JJ,Reach G

    更新日期:1990-02-01 00:00:00

  • Pump Speed Waveform Analysis to Detect Aortic Valve Opening in Patients on Ventricular Assist Device Support.

    abstract::As the aortic valve (AV) opens, the pump pressure head remains constant, which is reflected as a "notch/plateau" in pump pressure and flow signals. However, instantaneous flow estimation may be influenced by friction and is particularly difficult in axial pumps. Therefore, a new method to determine the duration of AV ...

    journal_title:Artificial organs

    pub_type: 杂志文章,多中心研究

    doi:10.1111/aor.12570

    authors: Hayward C,Lim CP,Schima H,Macdonald P,Moscato F,Muthiah K,Granegger M

    更新日期:2015-08-01 00:00:00

  • Liposome-encapsulated hemoglobin alleviates brain edema after permanent occlusion of the middle cerebral artery in rats.

    abstract::Liposome-encapsulated hemoglobin (LEH) was proven to be protective in cerebral ischemia/reperfusion injury. The present study evaluated LEH in a rat model of permanent middle cerebral artery (MCA) occlusion to clarify its effect during ischemia and reperfusion. Five minutes after thread occlusion of the MCA, rats were...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2008.00700.x

    authors: Kawaguchi AT,Kurita D,Furuya H,Yamano M,Ogata Y,Haida M

    更新日期:2009-02-01 00:00:00

  • Rate of thrombus accumulation on intravenacaval IVOX devices explanted from human clinical trial patients with acute respiratory failure.

    abstract::The weight gain of IVOX devices removed from the first 49 human clinical trials patients after from 1 to 29 days of implantation into the venae caval blood stream has been assessed. Each patient had received sufficient systemic heparin to maintain activated clotting times between 150 and 200 s while the IVOX device wa...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1994.tb03329.x

    authors: Imai H,Schaap RN,Mortensen JD

    更新日期:1994-11-01 00:00:00

  • A new smartphone-based method for wound area measurement.

    abstract::Proper wound healing can be assessed by monitoring the wound surface area. Its reduction by 10 or 50% should be achieved after 1 or 4 weeks, respectively, from the start of the applied therapy. There are various methods of wound area measurement, which differ in terms of the cost of the devices and their accuracy. Thi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12169

    authors: Foltynski P,Ladyzynski P,Wojcicki JM

    更新日期:2014-04-01 00:00:00

  • The impact of obesity on outcomes in patients receiving extracorporeal life support.

    abstract::Extracorporeal life support (ECLS) has been increasingly utilized to manage cardiac and pulmonary dysfunction. The impact of obesity on outcomes of ECLS is poorly defined. The purpose of the study was to compare in-hospital mortality, resource use, complications, and readmissions in obese versus non-obese patients rec...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13752

    authors: Christian-Miller N,Hadaya J,Nakhla M,Sanaiha Y,Madrigal J,Emami S,Cale M,Sareh S,Benharash P

    更新日期:2020-11-01 00:00:00

  • A Pseudo-One Compartment Model of Phosphorus Kinetics During Hemodialysis: Further Supporting Evidence.

    abstract::A pseudo-one compartment model has been proposed to describe phosphorus kinetics during hemodialysis and the immediate post-dialysis period. This model assumes that phosphorus mobilization from tissues is proportional to the difference between the pre-dialysis serum concentration (a constant) and the instantaneous ser...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12897

    authors: Leypoldt JK,Agar BU,Cheung AK,Bernardo AA

    更新日期:2017-11-01 00:00:00

  • Bulk mass transport limitations during high-flux hemodialysis.

    abstract::Solute clearance during high-flux hemodialysis is determined by the combined effects of solute convection and diffusion in the membrane, blood, and dialysate. Previous studies have focused almost entirely on the membrane transport phenomena, largely ignoring the potential contribution from bulk mass transport across t...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1993.tb00403.x

    authors: Zydney AL

    更新日期:1993-11-01 00:00:00

  • Eccentric roller type total artificial heart creating interatrial shunt.

    abstract::Creating an interatrial shunt to achieve left-right flow balance and modification of the blood chambers to improve the basic performance of the device were performed in developing an eccentric roller type total artificial heart (ERTAH). Smaller blood chambers reduce friction loss and increase durability and energy eff...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2000.06602.x

    authors: Wada H,Fukunaga S,Watari M,Imai K,Sakai H,Shibamura H,Sueda T,Matsuura Y

    更新日期:2000-08-01 00:00:00

  • Effect of temporary catheter and late referral on hospitalization and mortality during the first year of hemodialysis treatment.

    abstract::Late referral (LR) to dialysis therapy has been associated with poor outcomes in people with end-stage renal disease. This had been ascribed to the frequent use of temporary vascular catheters (TVCs) in LR patients. The effects of LR and TVC on the outcomes of an incident hemodialysis population (n = 101) were investi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2004.00016.x

    authors: Gonçalves EA,Andreoli MC,Watanabe R,Freitas MC,Pedrosa AC,Manfredi SR,Draibe SA,Cendoroglo M,Canziani ME

    更新日期:2004-11-01 00:00:00

  • Influence of antihypertensive drugs and steroid hormones on protein adsorption/desorption on polycarbonate.

    abstract::To develop artificial materials for prolonged use in the vascular system, the complicated process of surface-induced thrombosis needs to be better understood. It is documented that certain antihypertensive drugs can inhibit platelet adhesion to an artificial surface; on the other hand, steroid drugs increase platelet ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:

    authors: Chandy T,Sharma CP

    更新日期:1991-06-01 00:00:00

  • Constraint stress, microstructural characteristics, and enhanced mechanical properties of a special fibroblast-embedded collagen construct.

    abstract::Cell-contracted collagen gels could provide rejection-free biomaterials for tissue engineering, but their application is limited by relatively low mechanical strength. We developed a special type I collagen construct (based on embedded fibroblasts) that was formed into a gel thread by using two anchors to constrain ge...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2006.00314.x

    authors: Feng Z,Ishibashi M,Nomura Y,Kitajima T,Nakamura T

    更新日期:2006-11-01 00:00:00

  • Aging adversely impacts biological properties of human bone marrow-derived mesenchymal stem cells: implications for tissue engineering heart valve construction.

    abstract::Our aim was to study the aging effects on the in vitro biological properties of bone marrow-derived mesenchymal stem cells (BMSCs) for construction of tissue-engineered heart valves. BMSCs were taken from teenagers with congenital heart diseases, and middle-aged and elderly patients with valvular diseases. Proliferati...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00824.x

    authors: Xin Y,Wang YM,Zhang H,Li J,Wang W,Wei YJ,Hu SS

    更新日期:2010-03-01 00:00:00

  • Magnevad status of design improvements human blood results and preliminary sheep trial.

    abstract::Magnevad II is an improved version of Magnevad I and both are fourth-generation axial flow left ventricular assist devices. A major simplification has been implemented and tested. Magnevad I used a magnetically suspended rotor requiring active axial control. Magnevad II is completely passive but otherwise similar. A s...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2005.29113.x

    authors: Goldowsky M,Lafaro R,Reed G

    更新日期:2005-10-01 00:00:00

  • Vascular access for continuous arteriovenous hemofiltration in infants and young children.

    abstract::The blood flow through the hemofilter device is the key point for ultrafiltrate production during continuous arteriovenous hemofiltration. It mainly depends on arteriovenous pressure gradient and vascular access, which is the major problem for arteriovenous hemofiltration in infants and small children. In infants, we ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1988.tb01518.x

    authors: Zobel G,Trop M,Beitzke A,Ring E

    更新日期:1988-02-01 00:00:00

  • The PediPump: a new ventricular assist device for children.

    abstract::Options for mechanical circulatory support for the treatment of end-stage heart failure in children are limited. Ventricular assist devices (VADs), which have revolutionized cardiac care in adults, remain largely unavailable for pediatric applications. The PediPump is a new rotary dynamic VAD designed to provide suppo...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2005.29088.x

    authors: Duncan BW,Lorenz M,Kopcak MW,Fukamachi K,Ootaki Y,Chen HM,Chapman PA,Davis SJ,Smith WA

    更新日期:2005-07-01 00:00:00

  • The response of articular chondrocytes to type II collagen-Au nanocomposites.

    abstract::The nanocomposites (denoted "CII-Au") of porcine type II collagen (CII) with 0.05, 0.1, 0.5, 1, or 2.5% (wt/wt) Au nanoparticles ( approximately 5 nm) were fabricated for potential use in cartilage tissue engineering. Au formed clusters on the surface of all nanocomposites and appeared to distribute along the collagen...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2007.00482.x

    authors: Hsu SH,Yen HJ,Tsai CL

    更新日期:2007-12-01 00:00:00

  • A novel method to evaluate thromboresistance of drip chambers with filter used in extracorporeal blood circuits for hemodialysis.

    abstract::We have developed a novel method to simultaneously evaluate thromboresistance of two different types of drip chambers with a filter used in extracorporeal blood circuits for hemodialysis using canine arteriovenous shunt models. Bilateral bypasses between the femoral artery and vein on both sides of the animal were for...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb00354.x

    authors: Yamazaki M,Kobayashi K,Mori Y,Satoh T,Kubota S

    更新日期:1997-02-01 00:00:00

  • The need for standardizing the index of hemolysis.

    abstract::Hemolysis is one of the most important performance parameters of blood pumps. However, comparative in vitro evaluation of the reported hemolysis effect is difficult owing to the lack of uniformity in the test methods used. Currently, three types of formulas are generally accepted and widely used for the index of hemol...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1994.tb03292.x

    authors: Naito K,Mizuguchi K,Nosé Y

    更新日期:1994-01-01 00:00:00

  • Anterior chest wall axillary artery to contralateral axillary vein graft for vascular access in hemodialysis.

    abstract::Patients with end-stage renal failure and peripheral vascular disease pose a difficult management problem in establishing long-term angioaccess for hemodialysis. In 4 patients with access problems, we created axillary artery to contralateral axillary vein Goretex grafts. The grafts were cannulated regularly for period...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1995.tb02291.x

    authors: Ono K,Muto Y,Yano K,Yukizane T

    更新日期:1995-12-01 00:00:00

  • Artificial matrix helps neonatal cardiomyocytes restore injured myocardium in rats.

    abstract::The purpose of this study was to investigate whether an artificial matrix can help neonatal cardiomyocytes restore an injured heart in a rat model of myocardial infarction (MI). The left coronary arteries of female Sprague Dawley (SD) rats were ligated to create MI models. Ventricular cardiomyocytes from 1- to 3-day-o...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2006.00186.x

    authors: Zhang P,Zhang H,Wang H,Wei Y,Hu S

    更新日期:2006-02-01 00:00:00

  • Usefulness of thrombelastography for dosage monitoring of low molecular weight heparin and unfractionated heparin during hemodialysis.

    abstract::Low molecular weight heparin (LMH) acts as an anticoagulation agent mainly through its anti-activated coagulation factor X (Xa) activity. Thrombelastography (TEG) is expected to be useful to monitor the dosage of LMH during hemodialysis because reaction time on TEG (TEG-r) is considered to reflect blood thromboplastin...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1990.tb02996.x

    authors: Shinoda T,Arakura H,Katakura M,Shirota T,Nakagawa S

    更新日期:1990-12-01 00:00:00

  • Respiratory gas exchange through the hydrophilic membrane.

    abstract::To assess the efficiency of respiratory gas exchange in vitro through a dialysis membrane mounted inside a flat plate Kiil dialyzer, the model reactions of hydrogen peroxide reduction by a metal ion and of the carbon dioxide precipitation in the form of a carbonate in the dialysate were used. A comparison of the rates...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1983.tb04189.x

    authors: Zborowski M

    更新日期:1983-05-01 00:00:00

  • Combining novel biomolecules and stimuli-sensitive biomaterials into new recognition-response biomaterial systems.

    abstract::An important present and emerging trend in biomaterials development is the synthesis of polymers which combine capabilities of biologic recognition ("biomimetic") with sensitivity to small environmental changes ("stimuli-responsive"). This short article highlights some of the many opportunities and challenges in this ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1988.tb02813.x

    authors: Hoffman AS

    更新日期:1988-12-01 00:00:00

  • In Vitro Assessment of Electric Currents Increasing the Effectiveness of Vancomycin Against Staphylococcus epidermidis Biofilms.

    abstract::Biofilms are communities of bacteria that can cause infections which are resistant to the immune system and antimicrobial treatments, posing a significant threat for patients with implantable and indwelling medical devices. The purpose of our research was to determine if utilizing specific parameters for electric curr...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12678

    authors: Haddad PA,Mah TF,Mussivand T

    更新日期:2016-08-01 00:00:00

  • Severe meprobamate intoxication treated by hemoperfusion over amberlite resin.

    abstract::A 36-year-old female was treated successfully by hemoperfusion over Amberlite XAD-4 resin after ingestion of 40 gm of meprobamate. Hemoperfusion was started five hours after the ingestion. At that time the patient was in deep coma. The patient was treated by hemoperfusion for five hours, at the end of which time she w...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:

    authors: Freund LG

    更新日期:1981-02-01 00:00:00

  • Electrical pulse train and single pulse stimulation of the small intestine: acute and chronic studies in the dog.

    abstract::In vitro tests have shown that electric currents may lead either to relaxation or contraction of the bowel wall. Because voluntary changes of the intestinal motility could be useful in the treatment of intestinal disorders, we investigated the reactions elicited by electrostimulation of the small intestine in the inta...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1989.tb02846.x

    authors: Moritz A,Grundfest-Broniatowski S,Ilyes L,Kasick J,Jacobs G,Olsen E,Nosé Y

    更新日期:1989-04-01 00:00:00

  • Preservation of human saphenous vein against reactive oxygen species-induced oxidative stress by green tea polyphenol pretreatment.

    abstract::The injurious effects of reactive oxygen species on venous tissues and the potential protective role played by green tea polyphenol (GTPP) on human saphenous veins were investigated. Oxidative stress was induced exogenously in the vein segments, either by adding 0.8 or 1.6 M of H2O2, or by using 80 or 160 U/L of xanth...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2003.07163.x

    authors: Han DW,Suh H,Park YH,Cho BK,Hyon SH,Park JC

    更新日期:2003-12-01 00:00:00