Differences in intravenous and subcutaneous application of recombinant human erythropoietin: a multicenter trial.

Abstract:

:The aims of this clinical study were to compare the maintenance doses for intravenous (i.v.) and subcutaneous (SC) administration of recombinant human erythropoietin (rhEPO) and to investigate whether there is any difference in the increase of the packed cellular volume (PCV) per week under i.v. and SC administration of rhEPO from two production sites (Genetics Institute, Cambridge, USA; and Boehringer Mannheim, Penzberg, Germany). A total of 90 patients suffering from end-stage renal disease were included in the study. All patients had already been treated for at least 6 months with chronic hemodialysis. The study was carried out as a randomized, multicenter parallel group comparison study with a 1-week pretreatment phase, a subsequent 8-week double-blind phase, and a final open phase. The final open phase consisted of a correction phase and a maintenance phase. The production site had no influence on the PCV increase per week, and there were no differences with respect to tolerability. The median rhEPO dose required to maintain the target PCV of 30 to 35 vol.% was 33 U/kg body weight three times a week in the i.v. group compared with 22 U/kg in the SC group (i.e., an average of 30% less with SC administration). Development or aggravation of hypertension under rhEPO therapy was observed, especially during the correction phase and more frequently in the SC group than in the i.v. group. During the maintenance phase, there was no essential difference between the two groups.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Schaller R,Sperschneider H,Thieler H,Dutz W,Hans S,Voigt D,Marx M,Engelmann J,Schöter KH,Scigalla P

doi

10.1111/j.1525-1594.1994.tb03378.x

subject

Has Abstract,Author List Incomplete

pub_date

1994-08-01 00:00:00

pages

552-8

issue

8

eissn

0160-564X

issn

1525-1594

journal_volume

18

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Hemolysis and heat generation in six different types of centrifugal blood pumps.

    abstract::What the most causative factor affecting hemolysis is still controversial. To resolve this problem, we investigated the relationship between hemolysis and heat generation in six types of centrifugal blood pumps (Bio-Pump, Delphin, Capiox, Nikkiso, Isoflow, and Toyobo). The analyzed parameters were index of hemolysis i...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1995.tb02453.x

    authors: Araki K,Taenaka Y,Masuzawa T,Tatsumi E,Wakisaka Y,Watari M,Nakatani T,Akagi H,Baba Y,Anai H

    更新日期:1995-09-01 00:00:00

  • Estimation of theophylline clearance during continuous arteriovenous hemofiltration.

    abstract::Pharmacologic agents and other non-protein-bound compounds smaller than 5,000 daltons have the potential to be removed by continuous arteriovenous hemofiltration (CAVH). A proposed method for estimating drug clearance by CAVH (ClCAVH) equates ultrafiltrate clearance to the product of the sieving coefficient and the av...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1990.tb02997.x

    authors: Horton MW,Godley PJ,Moore ES,Fineg J,Gillespie WR

    更新日期:1990-12-01 00:00:00

  • Hantaan virus infection with acute renal failure.

    abstract::We report on 10 patients with acute renal involvement in Hantaan virus infection observed at the Department of Nephrology, Faculty of Medicine, Skopje, Republic of Macedonia, during a period of 3 years (October 1987-July 1990). Eight patients were male and 2 were female, aged 37.5 +/- 4.8 years. The diagnosis of Hanta...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1995.tb02432.x

    authors: Polenaković M,Grcevska L,Gerasimovska-Tanevska V,Oncevski A,Dzikova S,Cakalaroski K,Masin G

    更新日期:1995-08-01 00:00:00

  • Heart Transplant Waiting List Implications of Increased Ventricular Assist Device Use as a Bridge Strategy: A National Analysis.

    abstract:BACKGROUND:The use of ventricular assist devices (VAD) as a bridge to heart transplant (HT) is increasing, while HT volume remains stagnant. This may portend longer waiting times and an otherwise more competitive environment for all patients on the HT waiting list. METHODS:A retrospective analysis of patients who were...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13833

    authors: Han JJ,Elzayn H,Duda MM,Iyengar A,Acker AM,Patrick WL,Helmers M,Birati EY,Atluri P

    更新日期:2020-10-01 00:00:00

  • The E4T electric powered total artificial heart (TAH).

    abstract::The E4T is a totally implantable total artificial heart (TAH) resulting from many years of research work at the Cleveland Clinic Foundation (CCF) and Nimbus, Inc. It consists of four implanted subsystems: the pumping unit, the variable volume device, the transcutaneous transformer, and the internal battery. The pumpin...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1988.tb02795.x

    authors: Smith WA,Hete BF,Kiraly RJ,Fujimoto LK,Jacobs GB,Ishikawa M,Butler K,Nosé Y

    更新日期:1988-10-01 00:00:00

  • The ethics of technology introduction.

    abstract::The rapid acceleration of technology development is outpacing our ability to assess it objectively and competently. Our challenge is to develop new assessment methods that take into account the fast moving nature of technology development while still protecting the patients' and the public interest. ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1998.06020.x

    authors: Abele JE

    更新日期:1998-01-01 00:00:00

  • Thromboembolic complications of the Symbion AVAD System.

    abstract::The Symbion Acute Ventricular Assist Device (AVAD) System is an experimental paracorporeal pulsatile ventricular assist device (VAD) for single or biventricular assist. Eleven patients were implanted but 2 died within 24 h and were excluded from the study. Nine patients, four with left ventricular assist devices (LVAD...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1989.tb01575.x

    authors: Icenogle TB,Smith RG,Cleavinger M,Vasu MA,Williams RJ,Sethi GK,Copeland JG

    更新日期:1989-12-01 00:00:00

  • Influence of different heparin concentrations on the results of in vitro investigations in plasmaseparation technology using capillary membrane filters.

    abstract::Capillary membrane filters are devices commonly used for plasmapheresis and recirculating detoxification systems, including plasmaseparation units. Besides clinical trials and case reports, research on plasmafiltration techniques is carried out using in vitro systems. Notably, such hemoperfused in vitro systems requir...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2003.07132.x

    authors: Unger JK,Haltern C,Dohmen B,Rossaint R

    更新日期:2003-07-01 00:00:00

  • Demand for and use of functional electrical stimulation systems and conventional orthoses in the spinal lesioned community of the UK.

    abstract::The use of and demand for functional electrical stimulation (FES) systems and conventional orthoses in the spinal cord lesioned population was assessed. The assessment was conducted by a postal survey of the members of the spinal injury associations in the U.K. Out of all the respondents, only 2% had used an FES syste...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1999.06361.x

    authors: Maxwell DJ,Granat MH,Baardman G,Hermens HJ

    更新日期:1999-05-01 00:00:00

  • A percutaneously accessible pulsatile left ventricular assist device: modified assist device type 5.

    abstract::To provide percutaneous access, a new circulatory assist system was developed. We call this newly developed system the modified assist device (MAD). The system is composed of a sac-type blood pump and cannula. Inflow and outflow valves are mounted in the apex and at the side wall 10 cm from the apex of the cannula, re...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1996.tb00718.x

    authors: Imanishi K,Imachi K,Yoshito H,Isoyama T,Abe Y,Chinzei T,Mabuchi K,Kanda K,Tsutsui N,Suma K,Fujimasa I

    更新日期:1996-02-01 00:00:00

  • Effects of scaling on centrifugal blood pumps.

    abstract::Experimental studies on the effects of scaling on the performance of centrifugal blood pumps were conducted in a closed-loop test rig. For the prototype, eight different impellers of the same outer diameter of 25 mm were tested at 1,500, 2,000, and 2,500 revolutions per minute (rpm) using blood analog as fluid medium....

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2002.07119.x

    authors: Wong YW,Chan WK,Yu SC,Chua LP

    更新日期:2002-11-01 00:00:00

  • Investigation of parameter estimator and adaptive controller for assist pump by computer simulation.

    abstract::The multi-output adaptive controller of a left ventricular assist device (LVAD) was studied by computer simulation. The controller regulated two outputs--mean aortic pressure (mAoP) and mean atrial pressure (mLAP)--by regulating vacuum pressure (input). The autoregressive models were used to describe the circulatory s...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1991.tb00769.x

    authors: Shimooka T,Mitamura Y,Yuhta T

    更新日期:1991-04-01 00:00:00

  • Sensitivity of the primary stability of a cementless hip stem to its position and orientation.

    abstract::Using computed tomography (CT)-based preoperative planning software, we can define with good accuracy the position of a cementless hip stem inside the host bone, but previous studies suggest that the pose the surgeon achieves during freehand surgery may differ from the planned one even by some millimeters. Advances in...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2008.00577.x

    authors: Reggiani B,Cristofolini L,Taddei F,Viceconti M

    更新日期:2008-07-01 00:00:00

  • Effect of age on calcification of poly(hydroxyethyl methacrylate) in animals.

    abstract::The effect of age on the calcification of biomaterials was studied by the subcutaneous implantation of poly(hydroxyethyl methacrylate) hydrogel in rats. The hydrogel sheets were implanted in rats 6, 12, 24, and 52 weeks (1 year) of age. The retrieved implants were compared and the percentage weight increase by mineral...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1985.tb04388.x

    authors: Imai Y

    更新日期:1985-08-01 00:00:00

  • Use of tactile stiffness to detect fatigue in the latissimus dorsi muscle.

    abstract::In clinical settings, no method has been established to examine the fatigue of a latissimus dorsi muscle (LDM) preconditioned for cardiomyoplasty. We examined the feasibility of measuring muscle stiffness (tactile stiffness) to evaluate muscle fatigue in situ using our tactile sensor. We stimulated canine LDM with bur...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2000.06551.x

    authors: Inaba H,Miyaji K,Kaneko Y,Ohtsuka T,Ezure M,Tambara K,Takamoto S,Omata S

    更新日期:2000-10-01 00:00:00

  • Effect of hemodialysis on T lymphocyte subsets, con-A-activated suppressor cell activity, and interleukin-2 receptor expression on lymphocytes in chronic uremic patients.

    abstract::Effect of hemodialysis (HD) on some indices of immune response was studied in nine chronic uremics. Total lymphocyte, OKT4+, and OKT8+ cell numbers significantly decreased during the first 20 min of HD, and they were decreased till the third hour of the procedure, whereas the OKT4+/OKT8+ cell number ratio did not chan...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1989.tb02861.x

    authors: Tchórzewski H,Luciak M,Trznadel K,Majewska E,Pokoca L

    更新日期:1989-06-01 00:00:00

  • Intraarterial perfusion of the hindlimb with pyridoxalated hemoglobin polyoxyethylene conjugate solution in anesthetized dogs.

    abstract::To evaluate the potential clinical usefulness of a modified hemoglobin, pyridoxalated hemoglobin polyoxyethylene conjugate (PHP), the hindlimb vascular bed was perfused with PHP solution while monitoring tissue oxygen tension (PtO2) in anesthetized dogs. The hindlimb region was perfused through the external iliac arte...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1995.tb02371.x

    authors: Kida Y,Yamakawa T,Iwasaki S,Furusho N,Kadowaki Y,Iwata S,Iwashita Y,Nishi K

    更新日期:1995-06-01 00:00:00

  • Influence of antihypertensive drugs and steroid hormones on protein adsorption/desorption on polycarbonate.

    abstract::To develop artificial materials for prolonged use in the vascular system, the complicated process of surface-induced thrombosis needs to be better understood. It is documented that certain antihypertensive drugs can inhibit platelet adhesion to an artificial surface; on the other hand, steroid drugs increase platelet ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:

    authors: Chandy T,Sharma CP

    更新日期:1991-06-01 00:00:00

  • LDL apheresis: a novel technique (LIPOCOLLECT 200).

    abstract::Therapeutic means to lower Lp(a) are limited. The most effective method to reduce plasma Lp(a) concentration significantly is therapeutic apheresis, namely, low-density lipoprotein (LDL) lipoprotein(a) (Lp(a)) apheresis. A novel technique based on reusable LDL adsorber called Lipocollect 200 (Medicollect, Rimbach, Ger...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00959.x

    authors: Stefanutti C,Di Giacomo S,Mazzarella B,Castelli A

    更新日期:2009-12-01 00:00:00

  • Pulsatile flow and simple flow control method during weaning period in centrifugal pump: toward more expanded usage in open heart surgery.

    abstract::To expand the usage of the centrifugal pump (CP) in open heart surgery, we performed two studies. In the first, we evaluated pulsatile flow in the CP. In vitro pump performance of the Terumo Capiox pump (TCP) and the Sarns Delphin pump (SDP) and increase of free hemoglobin (mg/dl) after driving 6 h were investigated u...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1994.tb03393.x

    authors: Nishida H,Koyanagi H,Endo M,Suzuki S,Oshiyama H,Nojiri C,Fukasawa H,Akutsu T

    更新日期:1994-09-01 00:00:00

  • Ex vivo evaluation in normal dogs of insulin released by a bioartificial pancreas containing isolated rat islets of Langerhans.

    abstract::In bioartificial pancreatic systems, isolated islets of Langerhans are protected against immune rejection by an artificial membrane, permeable to glucose and insulin, but not to immunoglobulins and lymphocytes. Some of these devices, referred to as vascular systems, are set up to be connected to a vascular site in the...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1990.tb01588.x

    authors: Lepeintre J,Briandet H,Moussy F,Chicheportiche D,Darquy S,Rouchette J,Imbaud P,Duron JJ,Reach G

    更新日期:1990-02-01 00:00:00

  • Performance of baffled bubble blood oxygenators.

    abstract::Bubble blood oxygenators equipped with baffles of various types in the oxygenating column were studied. The rate of hemolysis, the volumetric coefficient for oxygen absorption into blood, and the fractional gas holdup were found to be affected mainly by the superficial gas velocity. When compared with the conventional...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1979.tb01032.x

    authors: Ohshima N,Yoshido F

    更新日期:1979-05-01 00:00:00

  • Influence of middle molecules on the anemia of uremic patients.

    abstract::To evaluate their toxicity at the cellular level, middle molecules from uremic serum were incubated with erythrocytes from healthy subjects and the activity of the enzyme Delta-aminolevulinic acid dehydrase (D-ALA-D) and peroxidative hemolysis were investigated. Uremic middle molecules caused a significant decrease of...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1978.tb01626.x

    authors: Leber HW,Spiegelhalter R,Ulm A,Goubeaud G,Rawer P

    更新日期:1978-11-01 00:00:00

  • The bradykinin response and early hypotension at the introduction of continuous renal replacement therapy in the intensive care unit.

    abstract::We assessed the relationship of certain clinical variables (including bradykinin [BK] release and dialysis membrane) to initial mean arterial pressure (MAP) reduction in 47 patients requiring continuous renal replacement therapy (CRRT) in an intensive care unit. The pretreatment MAP was 84 +/- 14 mm Hg for the group a...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2001.06703.x

    authors: Stoves J,Goode NP,Visvanathan R,Jones CH,Shires M,Will EJ,Davison AM

    更新日期:2001-12-01 00:00:00

  • Renal osteodystrophy in dialysis patients: diagnosis and treatment.

    abstract::This article reviews the clinical, biological, radiological, and pathological procedures and their respective indications for the practical diagnosis of the following various histological patterns of renal osteodystrophy: osteitis fibrosa due to parathyroid hormone (PTH) hypersecretion: osteomalacia or rickets due to ...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审

    doi:10.1046/j.1525-1594.1998.06198.x

    authors: Fournier A,Oprisiu R,Hottelart C,Yverneau PH,Ghazali A,Atik A,Hedri H,Said S,Sechet A,Rasolombololona M,Abighanem O,Sarraj A,El Esper N,Moriniere P,Boudailliez B,Westeel PF,Achard JM,Pruna A

    更新日期:1998-07-01 00:00:00

  • Hemolytic evaluation using polyurethane microcapsule suspensions in circulatory support devices: normalized index of hemolysis comparisons of commercial centrifugal blood pumps.

    abstract::We have been developing some types of microcapsule suspensions with polyurethane membranes to evaluate the absolute hemolytic characteristics of the centrifugal blood pumps used in circulatory support devices such as artificial hearts. In order to facilitate/realize hemolysis testing on centrifugal blood pumps that ha...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2007.00503.x

    authors: Maruyama O,Yamaguchi K,Nishida M,Onoguchi T,Tsutsui T,Jikuya T,Yamane T

    更新日期:2008-02-01 00:00:00

  • Biodegradation and biocompatibility of polyorganophosphazene.

    abstract::We investigated biodegradation and biocompatibility of poly(organophosphazenes). We prepared poly(organophosphazenes) having different side chain groups. The blood compatibility of poly(organophosphazenes) containing fluorinated side groups, poly(bis[trifluoroethoxy]phosphazene) (PbFP) and poly([trifluoroethoxy][ethyl...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2002.07029.x

    authors: Kawakami H,Kanezaki S,Sudo M,Kanno M,Nagaoka S,Kubota S

    更新日期:2002-10-01 00:00:00

  • Relation between echinocytosis and erythrocyte calcium content in hemodialyzed uremic patients.

    abstract::A rise in intracellular calcium concentration in erythrocytes has multiple effects on these cells. The purpose of this study was to determine the changes of calcium content in red blood cells (RBCs) and of echinocyte percentages in uremic patients during hemodialysis sessions. In 30 uremic patients under hemodialysis,...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2001.025006486.x

    authors: Agroyannis B,Kopelias I,Fourtounas C,Paraskevopoulos A,Tzanatos H,Dalamangas A,Mallas E

    更新日期:2001-06-01 00:00:00

  • Doppler ultrasonic detection of particulate release during hemodialysis with cellulose hollow-fiber and sorbent suspension reciprocating dialyzers.

    abstract::Doppler ultrasound is a noninvasive technique for monitoring moving objects such as flowing blood while ignoring stationary objects such as shunt tubing. A Doppler system was investigated to determine its sensitivity in detecting particulate release in blood during hemodialysis. Seven hemodialysis procedures with dogs...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1984.tb04275.x

    authors: Badylak SF,Ash SR,Thornhill JA,Carr DJ

    更新日期:1984-05-01 00:00:00

  • Acquired Von Willebrand Syndrome and Blood Pump Design.

    abstract::The existence of acquired von Willebrand syndrome (AVWS) in patients with continuous flow left ventricular assist devices (LVADs) is well documented and has been verified by numerous investigators. AVWS has not been observed to occur in pulsatile devices such as the SynCardia total artificial heart (TAH), the HeartMat...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审

    doi:10.1111/aor.13291

    authors: Rosenberg G,Siedlecki CA,Jhun CS,Weiss WJ,Manning K,Deutsch S,Pierce W

    更新日期:2018-12-01 00:00:00