Pulse push/pull hemodialysis: in vitro study on new dialysis modality with higher convective efficiency.

Abstract:

:Midsize molecule retention is related with renal-failure-associated mortality. Here, the authors describe a new dialysis modality, pulse push/pull hemodialysis (PPPHD), which increases convective clearance. Blood and dialysate are circulated by a pulsatile pump, but with pulsatile flow patterns that are 180 degrees out of phase. This causes blood-to-dialysate pressure gradients that oscillate between positive and negative, and which cause consecutive periods of ultrafiltration and backfiltration. The devised PPPHD was compared with conventional high-flux hemodialysis (CHFHD) in terms of solute clearances, albumin loss, and total protein levels. Human plasma containing dissolved uremic marker molecules was used as a blood substitute, and clearances were investigated for blood urea nitrogen, creatinine, vitamin B12, and inulin. Observed clearances were found to be significantly higher for PPPHD by approximately 3-14% for low-molecular-weight solutes, by 47-48% for vitamin B12, and by 38-49% for inulin than for CHFHD. No albumin loss was observed in either of these two study groups. The authors conclude that PPPHD offers a simple straightforward means of enhancing uremic molecule removal by increasing total ultrafiltration volume without the need to infuse replacement fluid.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Lee K,Lee SR,Mun CH,Min BG

doi

10.1111/j.1525-1594.2008.00561.x

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

406-11

issue

5

eissn

0160-564X

issn

1525-1594

pii

AOR561

journal_volume

32

pub_type

杂志文章
  • Effect of age on calcification of poly(hydroxyethyl methacrylate) in animals.

    abstract::The effect of age on the calcification of biomaterials was studied by the subcutaneous implantation of poly(hydroxyethyl methacrylate) hydrogel in rats. The hydrogel sheets were implanted in rats 6, 12, 24, and 52 weeks (1 year) of age. The retrieved implants were compared and the percentage weight increase by mineral...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1985.tb04388.x

    authors: Imai Y

    更新日期:1985-08-01 00:00:00

  • Femoro-femoral versus atrio-aortic extracorporeal membrane oxygenation: selecting the ideal cannulation technique.

    abstract::Veno-arterial extracorporeal membrane oxygenation (ECMO) may be implanted using peripheral ECMO (pECMO) or central ECMO (cECMO) cannulation techniques. The aim of this study was to compare the outcome between these two cannulation techniques. A retrospective study was performed at Düsseldorf University Hospital from O...

    journal_title:Artificial organs

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aor.12245

    authors: Saeed D,Stosik H,Islamovic M,Albert A,Kamiya H,Maxhera B,Lichtenberg A

    更新日期:2014-07-01 00:00:00

  • Pretreatment With Inactivated Bacillus Calmette-Guerin Increases CD4+CD25+ Regulatory T Cell Function and Decreases Functional and Structural Effects of Asthma Induction in a Rat Asthma Model.

    abstract::Bacillus Calmette-Guerin (BCG) has been shown to have therapeutic effects on asthma through CD4+CD25+ regulatory T cells (Tregs). We sought to assess pretreatment with inactivated BCG on CD4+CD25+ Tregs and its functional and structural effects in rat asthma model. The rat asthma model was established using ovalbumin ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12566

    authors: Gong P,Li Y,Tan YP,Li H

    更新日期:2016-04-01 00:00:00

  • Chronic animal experiment with magnetically suspended centrifugal pump.

    abstract::We have been developing a new type of centrifugal pump for long-term use. The magnetically suspended centrifugal pump (MSCP) contains no shaft and seal so that long life expectancy is predicted. Paracorporeal left ventricular (LV) assist circulation between the left atrium and the descending aorta was instituted using...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb03713.x

    authors: Yamada T,Nishimura K,Park CH,Kono S,Yuasa S,Tsukiya T,Akamatsu T,Matsuda K,Ban T

    更新日期:1997-07-01 00:00:00

  • The SlideReactor--a simple hollow fiber based bioreactor suitable for light microscopy.

    abstract::Most bioartificial liver support systems are based on hollow fiber capillaries within modified dialysis cartridges or more sophisticated bioreactor constructions. Due to their design microscopic follow-up of reorganization and growth of tissue between the hollow fibers is not possible. The SlideReactor is a simple hol...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2005.29049.x

    authors: Sauer IM,Schwartlander R,Schmid J,Efimova E,Vondran FW,Kehr D,Pless G,Spinelli A,Brandenburg B,Hildt E,Neuhaus P

    更新日期:2005-03-01 00:00:00

  • Antimicrobial Wound Dressing Containing Silver Sulfadiazine With High Biocompatibility: In Vitro Study.

    abstract::Many patients all over the world suffer from acute wounds caused by traumas or burns. In most crucial cases, skin regeneration cannot be promoted spontaneously, and skin grafts are applied as the main treatment. However, this therapy has some drawbacks which motivate researchers to develop wound dressings. In this stu...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12682

    authors: Mohseni M,Shamloo A,Aghababaei Z,Vossoughi M,Moravvej H

    更新日期:2016-08-01 00:00:00

  • New immunosuppressive proteins (KX-2, -4, and -5) induced by liver transplantation.

    abstract::The presence in rat serum of three novel immunosuppressive proteins is associated with induction of tolerance after liver grafting. One of these, KX-5 (40 kilodalton molecular weight) is present 40-100 days after grafting of DA liver into PVG, a combination in which liver grafts are not rejected; two others, KX-2 (87 ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1996.tb00646.x

    authors: Kamada N

    更新日期:1996-10-01 00:00:00

  • Clinical indications for the use of the "Poisk-IOM" total artificial heart: the experience of 13 implantations in humans.

    abstract::Success of total artificial heart (TAH) implantation as a temporary measure depends on three factors: proper patient selection, adequate surgical technique, and safe cardiac prostheses. From 1986 until March 1990, 237 patients with stagnant heart failure were examined. Sixty-one patients (27%) were put on a waiting li...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1991.tb00745.x

    authors: Shumakov V,Zimin N,Kazakov E,Kormer A,Vorontsov S,Nikolaenko E,Kozlov I,Drobyshev A

    更新日期:1991-10-01 00:00:00

  • A percutaneously accessible pulsatile left ventricular assist device: modified assist device type 5.

    abstract::To provide percutaneous access, a new circulatory assist system was developed. We call this newly developed system the modified assist device (MAD). The system is composed of a sac-type blood pump and cannula. Inflow and outflow valves are mounted in the apex and at the side wall 10 cm from the apex of the cannula, re...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1996.tb00718.x

    authors: Imanishi K,Imachi K,Yoshito H,Isoyama T,Abe Y,Chinzei T,Mabuchi K,Kanda K,Tsutsui N,Suma K,Fujimasa I

    更新日期:1996-02-01 00:00:00

  • A novel, valveless ventricular assist device: the FishTail pump. First experimental in vivo studies.

    abstract::This article presents the first in vivo experiments with a new type of valveless ventricular assist device, a wave-generating pump. Our goal was to evaluate the hemodynamic performance of the pump by comparing it with the Biomedicus BP-80 centrifugal pump and by sustaining a 3 h long left ventricular assistance. We co...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2002.06973.x

    authors: Feier H,Mekkaoui C,Drevet JB,Sérée Y,Richomme C,Rolland PH,Mesana TG

    更新日期:2002-12-01 00:00:00

  • How to comply with the Food and Drug Administration's "Investigational Device Exemption (IDE)" regulations including an application form (revised January 1982).

    abstract::This is a revision of the IDE Application Form, "How to Comply with the Food and Drug Administration's New 'Investigational Device Exemption (IDE)' Regulations, Including an Application Form" originally published in Artificial Organs, Volume 4, Number 4, November 1980. This publication updates the IDE application form...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1982-02-01 00:00:00

  • Significant left ventricular unloading with transaortic catheter venting during venoarterial bypass.

    abstract::Insufficient unloading of the left ventricle with blood stagnation is a main cause of unsuccessful left ventricular (LV) recovery during percutaneous cardiopulmonary support (PCPS). The purpose of this investigation was to evaluate the effectiveness of transaortic catheter venting (TACV) for LV unloading. Six adult mo...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb03744.x

    authors: Shibuya M,Kitamura M,Kurihara H,Kikuchi C,Endo M,Koyanagi H

    更新日期:1997-07-01 00:00:00

  • Arterial pressure: its role in perfusion and as a criterion of extracorporeal circulation adequacy.

    abstract::Thirty-five patients undergoing open-heart surgery are reported. Cardiac index, mean arterial pressure, oxygen consumption, lactate, pyruvate, and lactate excess in the blood were measured. An inverse correlation of arterial pressure with oxygen consumption and lactate excess was found during perfusion. Comparison of ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1982.tb01675.x

    authors: Osipov VP,Khodas MJ,Dementjeva II,Pjatnitskaja GKh

    更新日期:1982-08-01 00:00:00

  • Is low-intensity anticoagulant therapy possible with an open pivot valve?: analysis of its development.

    abstract::In 1976, the authors became the codevelopers of the first successful bileaflet heart valve which has become the standard in valvular surgery. However, there still remains a significant rate of thromboembolism and thrombosis which can be attributed to the inherent design of cavities in the pivot area. These cavities co...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2002.06999.x

    authors: Nicoloff DM,Friedberg HD,Villafaña MA

    更新日期:2002-05-01 00:00:00

  • Quantification of Shear-Induced Platelet Activation: High Shear Stresses for Short Exposure Time.

    abstract::Thrombosis and thromboembolism are the life-threatening clinical complications for patients supported or treated with prosthetic cardiovascular devices. The high mechanical shear stress within these devices is believed to be the major contributing factor to cause platelet activation (PA) and function alteration, leadi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12438

    authors: Ding J,Chen Z,Niu S,Zhang J,Mondal NK,Griffith BP,Wu ZJ

    更新日期:2015-07-01 00:00:00

  • Clinical Use of Centrifugal Pumps and the Roller Pump in Open Heart Surgery: A Comparative Evaluation.

    abstract::Centrifugal pumps have been used widely as the main pump in open heart surgery to reduce damage to blood elements and to reduce the activation of the coagulation system. The purpose of this study was the evaluation and comparison of the effects of two types of centrifugal pumps and of one type of roller pump on blood ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1996.tb04507.x

    authors: Yoshikai M,Hamada M,Takarabe K,Okazaki Y,Yoshika M

    更新日期:1996-05-01 00:00:00

  • Minimally invasive access for central extracorporeal life support: how we do it.

    abstract::Central extracorporeal life support (ECLS) is an effective treatment method of cardiogenic shock patients with or without lung failure. However, complications like infection and bleeding are common. The classical implantation approach requires full sternotomy, mobilization of the heart, with the well-known risks of bl...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12344

    authors: Weymann A,Sabashnikov A,Patil NP,Mohite PN,Zych B,Garcia Saez D,Popov AF,Simon AR

    更新日期:2015-02-01 00:00:00

  • Selective removal of circulating immune complexes from patient plasma.

    abstract::The principle of a patient-specific immunoadsorber (PsIA) is demonstrated. Studies with model systems (HSA/anti-HSA) on immobilization, stability, and leakage form the basis for the presented fast-performance liquid chromatography (FPLC) and batch experiments, which were conducted using two different protein A adsorbe...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2002.06875.x

    authors: Kunkel S,Holtz M,Grossjohann B,Schuett W,Klinkmann H,Kong D,Yamada R,Kimura H,Matic GB,Ramlow W,Boeden HF

    更新日期:2002-02-01 00:00:00

  • Beta-2-microglobulin and main granulocyte components in hemodialysis patients.

    abstract::Plasma levels of granulocyte elastase in complex with alpha 1-proteinase inhibitor (E-alpha 1-PI) increased during hemodialysis from 110 +/- 10 to 506 +/- 66 micrograms/L using dialyzers made of polyamide, from 95 +/- 2.2 to 211 +/- 54 micrograms/ml with hemophane and from 114 +/- 10 to 203 +/- 25 using dialyzers made...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1989.tb02842.x

    authors: Haag-Weber M,Schollmeyer P,Hörl WH

    更新日期:1989-04-01 00:00:00

  • Prevention of right heart failure after left ventricular assist device implantation by phosphodiesterase 5 inhibitor.

    abstract::Right ventricular (RV) function immediately after left ventricular assist device (LVAD) implantation is a crucial prognostic factor. RV failure is linked to increased mortality and worse outcome. A phosphodiesterase 5 inhibitor, sildenafil, was shown to decrease pulmonary vascular resistance and pulmonary artery press...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12277

    authors: Hamdan R,Mansour H,Nassar P,Saab M

    更新日期:2014-11-01 00:00:00

  • The OregonHeart Total Artificial Heart: Design and Performance on a Mock Circulatory Loop.

    abstract::Widespread use of heart transplantation is limited by the scarcity of donor organs. Total artificial heart (TAH) development has been pursued to address this shortage, especially to treat patients who require biventricular support. We have developed a novel TAH that utilizes a continuously spinning rotor that shuttles...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12959

    authors: Glynn J,Song H,Hull B,Withers S,Gelow J,Mudd J,Starr A,Wampler R

    更新日期:2017-10-01 00:00:00

  • Double filtration plasmapheresis for the treatment of rheumatoid arthritis: a study of 21 cases.

    abstract::The treatment of rheumatoid arthritis remains difficult and often controversial. Plasma exchange has been advocated in some cases. In the present study 71 sessions of double filtration plasmapheresis (DFPP) were performed in 21 patients with rheumatoid arthritis in an average of 3.7 +/- 1.1 sessions per patient within...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb00344.x

    authors: Liu JD,Zhang C,Li WS,Lun LD

    更新日期:1997-02-01 00:00:00

  • Influence of flow design on microcirculation in conditions of undulation pump-left ventricle assist device testing.

    abstract::To study the microvessels in bulbar conjunctiva, we conducted an experiment in goat with a pneumatically driven left heart bypass pump, which was replaced with an undulation pump-left ventricle assist device for 9 days. Three flow patterns were tested: complete pulsatile, continuous, and percentage of pulsatile. We st...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2006.00244.x

    authors: Dobsák P,Novakova M,Baba A,Vasku J,Isoyama T,Saito I,Abe Y,Chinzei T,Imachi K

    更新日期:2006-06-01 00:00:00

  • Fluctuations of the hemodynamic derivatives during left ventricular assistance using oscillated blood flow.

    abstract::To analyze the autonomic nervous system during left heart bypass with a vibrating flow pump (VFP), fluctuations in hemodynamic derivatives were evaluated by the spectral analysis method using fast fourier transform methodology. After the left pleural cavity was opened through the fourth intercostal space under general...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:

    authors: Yambe T,Kobayashi S,Nanka S,Naganuma S,Nitta S,Matsuki H,Abe K,Yoshizawa M,Fukuju T,Tabayashi K,Takeda H,Hashimoto H

    更新日期:1996-06-01 00:00:00

  • Oral treatment for jaundice using immobilized bilirubin oxidase.

    abstract::Jaundice is characterized by an excessive accumulation of bilirubin in the blood and tissues. A novel approach to reduce plasma levels of bilirubin by blocking its enterohepatic circulation was investigated. The treatment consisted of oral administration of immobilized bilirubin oxidase, which could oxidize bilirubin ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1992.tb00527.x

    authors: Soltys PJ,Mullon C,Langer R

    更新日期:1992-08-01 00:00:00

  • The application of immobilized enzymes in an artificial liver support system.

    abstract::A novel method of extracorporeal support for fulminant liver failure is reported whereby the most important detoxification processes of the liver are reproduced in an enzyme reactor. Most of the endogenous toxins involved in hepatic coma can be deactivated directly by conjugation with a hydrophilic residue such as glu...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1979.tb03801.x

    authors: Brunner G,Holloway CJ,Lösgen H

    更新日期:1979-02-01 00:00:00

  • Zero-balance ultrafiltration of the priming blood modifies the priming components and improves the clinical outcome in infants undergoing cardiopulmonary bypass: A randomized controlled trial.

    abstract::Cardiopulmonary bypass (CPB) requirement in infants presents a unique challenge because of the large prime volume-to-blood volume ratio. Packed red blood cells (PRBCs) tend to deteriorate with long-term storage owing to their unphysiological composition and osmolality. Given that blood priming is inevitable in neonate...

    journal_title:Artificial organs

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aor.13559

    authors: Gholampour Dehaki M,Niknam S,Bakhshandeh H,Azarfarin R

    更新日期:2020-03-01 00:00:00

  • Biomechanical properties of decellularized porcine pulmonary valve conduits.

    abstract::Tissue-engineered heart valves constructed from a xenogeneic or allogeneic decellularized matrix might overcome the disadvantages of current heart valve substitutes. One major necessity besides effective decellularization is to preserve the biomechanical properties of the valve. Native and decellularized porcine pulmo...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2007.00452.x

    authors: Seebacher G,Grasl C,Stoiber M,Rieder E,Kasimir MT,Dunkler D,Simon P,Weigel G,Schima H

    更新日期:2008-01-01 00:00:00

  • Clinical validation of a predictive modeling equation for sodium.

    abstract::Changes in plasma sodium (Na) concentration during hemodialysis were predicted by changes in Na concentration of the dialysate at equilibrium with the plasma, according to the formula C't = CD - (CD - C'0) [(V0 - QFt)/V0]A/QF, where C'0 and C't are the Na concentration of the dialysate at equilibrium with the plasma a...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1985.tb04365.x

    authors: Man NK,Petitclerc T,Tien NQ,Jehenne G,Funck-Brentano JL

    更新日期:1985-05-01 00:00:00

  • Effect of temporary catheter and late referral on hospitalization and mortality during the first year of hemodialysis treatment.

    abstract::Late referral (LR) to dialysis therapy has been associated with poor outcomes in people with end-stage renal disease. This had been ascribed to the frequent use of temporary vascular catheters (TVCs) in LR patients. The effects of LR and TVC on the outcomes of an incident hemodialysis population (n = 101) were investi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2004.00016.x

    authors: Gonçalves EA,Andreoli MC,Watanabe R,Freitas MC,Pedrosa AC,Manfredi SR,Draibe SA,Cendoroglo M,Canziani ME

    更新日期:2004-11-01 00:00:00