From wooden limbs to biomaterial organs: the ethics of organ replacement and artificial organs.

abstract：:Cardiomyoplasty has been proposed as an alternative surgical treatment for congestive heart failure. The girdling effect of the muscle wrap is believed to reduce diastolic wall stress. We tested the hypothesis that nonstimulated or passive cardiomyoplasty (CDM) would reduce hemodynamic deficits in rats with experiment...

journal_title：Artificial organs

authors： De Angelis K,Leirner AA,Irigoyen MC,Cestari IA

更新日期：2001-11-01 00:00:00

abstract：:Thirteen percent of 99 patients undergoing maintenance hemodialysis showed an increased predialysis peripheral blood eosinophil count (mean value of 828 cells/mm3, range 410-2,710). Patients with eosinophilia were predominantly male and evidenced more frequent elevation of total plasma IgE levels. Otherwise, no differ...

journal_title：Artificial organs

authors： Friedberg M,Joffe P,Nielsen B,Nielsen LP

更新日期：1987-04-01 00:00:00

abstract：:The outgrowth of endothelial cells in an expanded polytetrafluoroethylene graft implanted in the canine inferior vena cava was studied by scanning electron microscopy. The adjacent endothelial cells of the vena cava started to invade the anastomotic area three days after the implantation and reached approximately the ...

journal_title：Artificial organs

authors： Ishimaru S,Berglin E,Hansson HA,Teger-Nilsson AC,William-Olsson G

更新日期：1981-11-01 00:00:00

abstract：:The effects of Fluosol-DA 20% on circulating blood cells, hemodynamic parameters, blood gases, and organs are described and compared with the results of phase I human studies and animal experiments. Bleeding of preoperative anemia and/or surgical bleeding, Fluosol-DA 20% was administered to 7 of 10 Jehovah's Witness p...

journal_title：Artificial organs

authors： Ohyanagi H,Nakaya S,Okumura S,Saitoh Y

更新日期：1984-02-01 00:00:00

abstract：:A computer simulation was carried out to investigate the influence of nonpulsatile left ventricular assistance on hemodynamics. A simulation circuit was constructed to represent the circulatory system. A source of current was added to denote the nonpulsatile blood pump. The left and right ventricles were replaced by v...

journal_title：Artificial organs

authors： Mitsui N,Fukunaga S,Koura Y,Morita S,Hotei H,Sueshiro M,Sueda T,Matsuura Y

更新日期：1996-05-01 00:00:00

abstract：:Present-day computational fluid dynamics (CFD) techniques can be used to analyze the behavior of fluid flow in a variety of pumps. CFD can be a powerful tool during the design stage for rapid virtual prototyping of different designs, analyzing performance parameters, and making design improvements. Computational flow ...

journal_title：Artificial organs

authors： Sukumar R,Athavale MM,Makhijani VB,Przekwas AJ

更新日期：1996-06-01 00:00:00

abstract：:Nonpulsatile blood pumps are mainly used in extracorporeal life support systems. Although pulsating blood flow is known to be physiological, a pulsatile pump is not commonly applied in a circuit with a membrane oxygenator because of damage to the blood cells. The hypothesis that the placement of a pressure-relieving c...

journal_title：Artificial organs

authors： Kim TS,Sun K,Lee KB,Lee HW,Baek KJ,Park SY,Son HS,Kim KT,Kim HM

更新日期：2004-12-01 00:00:00

abstract：:Polyvinyl chloride (PVC) is one of the most frequently used polymers for the manufacturing of medical devices. Limitations for its usage are based upon unfavorable surface properties of the polymer including its hydrophobicity and lack of functionalities in order to increase its versatility. To address this issue, wet...

journal_title：Artificial organs

authors： Gabriel M,Strand D,Vahl CF

更新日期：2012-09-01 00:00:00

abstract：:The accurate representation of rotary blood pumps in a numerical environment is important for meaningful investigation of pump-cardiovascular system interactions. Although numerous models for ventricular assist devices (VADs) have been developed, modeling methods for rotary total artificial hearts (rTAHs) are still re...

journal_title：Artificial organs

authors： Nestler F,Bradley AP,Wilson SJ,Timms DL

更新日期：2014-03-01 00:00:00

abstract：:Continuous hemodiafiltration (CHDF) has been performed for the treatment of severe acute pancreatitis. Phospholipase A2 (PLA2) is one of the important mediators which exacerbate acute pancreatitis, but whether PLA2 can be removed by CHDF is unclear. In this study, the kinetics of group IB and group IIA PLA2 was examin...

journal_title：Artificial organs

authors： Suzuki M,Okahisa T,Sogabe M,Iwaki H,Okita Y,Ohnishi Y,Ito S

更新日期：2007-05-01 00:00:00

abstract：:No standardized treatment algorithm exists for the management of continuous-flow left ventricular assist device (CF-LVAD)-specific infections. The aim of this systematic review and meta-analysis was to compare the outcomes of CF-LVAD-specific infections as managed by device exchange to other treatment modalities not i...

journal_title：Artificial organs

authors： Bauer TM,Choi JH,Luc JGY,Weber MP,Moncho Escrivá E,Patel S,Maynes EJ,Boyle AJ,Samuels LE,Entwistle JW,Morris RJ,Massey HT,Tchantchaleishvili V

更新日期：2019-05-01 00:00:00

abstract：:Current hemodialysis treatment is insufficient because of intermittent treatment and loss of tubular function. In order to overcome the loss of tubular function, a bioartificial kidney has been developed consisting of continuous hemofiltration (CHF) with 10 L/day of filtrate and a bioartificial tubule device using pro...

journal_title：Artificial organs

authors： Saito A

更新日期：2004-01-01 00:00:00

abstract：:We report on 10 patients with acute renal involvement in Hantaan virus infection observed at the Department of Nephrology, Faculty of Medicine, Skopje, Republic of Macedonia, during a period of 3 years (October 1987-July 1990). Eight patients were male and 2 were female, aged 37.5 +/- 4.8 years. The diagnosis of Hanta...

journal_title：Artificial organs

authors： Polenaković M,Grcevska L,Gerasimovska-Tanevska V,Oncevski A,Dzikova S,Cakalaroski K,Masin G

更新日期：1995-08-01 00:00:00

abstract：:The heparin-conjugated fibrin (HCF) system has been developed to deliver bone morphogenetic proteins (BMPs) for a long-term period and thus enhance bone regeneration. In the present study, we tested the effectiveness of the delivery system for spinal fusion with a very low dose of BMP-2. A total of 15 rabbits underwen...

journal_title：Artificial organs

authors： Koo KH,Lee JM,Ahn JM,Kim BS,La WG,Kim CS,Im GI

更新日期：2013-05-01 00:00:00

abstract：:The in vitro development of a vascular stroma might be a solution for the engineering of vascularized tissues, however, in vitro stability of capillary-like structures is limited. In order to test the influence on maintenance of capillary-like structures, human growth hormone (hGH) was added in concentrations of 0.5, ...

journal_title：Artificial organs

authors： Frerich B,Kurtz-Hoffmann J,Lindemann N

更新日期：2005-04-01 00:00:00

abstract：:The purpose of this study was to investigate whether an artificial matrix can help neonatal cardiomyocytes restore an injured heart in a rat model of myocardial infarction (MI). The left coronary arteries of female Sprague Dawley (SD) rats were ligated to create MI models. Ventricular cardiomyocytes from 1- to 3-day-o...

journal_title：Artificial organs

authors： Zhang P,Zhang H,Wang H,Wei Y,Hu S

更新日期：2006-02-01 00:00:00

abstract：:In transplantation surgery, extending the criteria for organ donation to include organs that may have otherwise been previously discarded has provided the impetus to improve organ preservation. The traditional method of cold static storage (CS) has been tried and tested and is suitable for organs meeting standard crit...

journal_title：Artificial organs

authors： Kumar R,Chung WY,Dennison AR,Garcea G

更新日期：2017-09-01 00:00:00

abstract：:Infusion into rats of the polycation hexadimethrine (HDM) leads to onset of massive proteinuria, which recovers when the infusion is stopped. Several lines of evidence indicate that the proteinuria results from binding of HDM to polyanions of the glomerular filter, with neutralization of shielding of their charges. To...

journal_title：Artificial organs

authors： Hunsicker LG,Bertolatus JA

更新日期：1987-12-01 00:00:00

abstract：:This study assessed the efficacy of multiarterial bypass in coronary artery bypass grafting (CABG) in dialysis patients. Eighty dialysis patients who underwent CABG were divided into 2 groups. Group A consisted of 38 patients in whom the left internal thoracic artery and additional saphenous vein graft (SVG) had been ...

journal_title：Artificial organs

authors： Nakayama Y,Sakata R,Ura M

更新日期：2001-04-01 00:00:00

abstract：:Loss of photoreceptor cells is one of the major causes of blindness. Several groups are exploring the functional replacement of photoreceptors by a retinal prosthesis. The goal of this study was to simulate the vision levels that recipients of retinal prostheses with 4 x 4, 6 x 10, and 16 x 16 electrode arrays may exp...

journal_title：Artificial organs

authors： Hayes JS,Yin VT,Piyathaisere D,Weiland JD,Humayun MS,Dagnelie G

更新日期：2003-11-01 00:00:00

abstract：:A beta2-microglobulin (beta2M) selective adsorbent (Lixelle) for direct hemoperfusion has been used for the treatment of hemodialysis patients with the long-term complication of dialysis related amyloidosis (DRA), but there is no significant correlation between the serum level of beta2M and the occurrence of DRA. Infl...

journal_title：Artificial organs

authors： Tsuchida K,Takemoto Y,Nakamura T,Fu O,Okada C,Yamagami S,Kishimoto T

更新日期：1998-12-01 00:00:00

abstract：:The insults sustained by transplanted livers (hepatectomy, hypothermic preservation, and normothermic reperfusion) could compromise hepatic function. Hydrogen sulfide (H₂S) is a physiologic gaseous signaling molecule, like nitric oxide (NO) and carbon monoxide (CO). We examined the effect of diallyl disulfide as a H₂S...

journal_title：Artificial organs

authors： Balaban CL,Rodriguez JV,Guibert EE

更新日期：2011-05-01 00:00:00

abstract：:Monoclonal antibodies for targeting cytotoxic conjugates to tumor cells are currently being evaluated together with extracorporeal affinity adsorption. The aim of the adsorption was to reduce undesired side effects in normal organs and to increase the tumor-to-normal tissue ratios. This technique is also applicable to...

journal_title：Artificial organs

authors： Mårtensson L,Nilsson R,Sjögren HO,Strand SE,Tennvall J

更新日期：2007-04-01 00:00:00

abstract：:Percutaneous pulmonary valve implantation is a potential treatment for right ventricular outflow tract (RVOT) dysfunction. However, RVOT implantation site varies among subjects and the success of the procedure depends on RVOT morphology selection. The aim of this study was to use in vitro testing to establish percutan...

journal_title：Artificial organs

authors： Vismara R,Laganà K,Migliavacca F,Schievano S,Coats L,Taylor A,Bonhoeffer P

更新日期：2009-01-01 00:00:00

abstract：:Growth factors and morphogens secreted by bone marrow mesenchymal stem cells (BMSCs) of bone marrow fluid may promote tooth regeneration. Accordingly, a tissue engineering approach was utilized to develop an economical strategy for obtaining the growth factors and morphogens from BMSCs. Unerupted second molar tooth bu...

journal_title：Artificial organs

authors： Kuo TF,Lin HC,Yang KC,Lin FH,Chen MH,Wu CC,Chang HH

更新日期：2011-02-01 00:00:00

abstract：:Secondary flow in the centrifugal blood pump helps to enhance the washout effect and to minimize thrombus formation. On the other hand, it has an adverse effect on pump efficiency. Excessive secondary flow may induce hemolytic effects. Understanding the secondary flow is thus important to the design of a compact, effi...

journal_title：Artificial organs

authors： Watanabe N,Masuda T,Iida T,Kataoka H,Fujimoto T,Takatani S

更新日期：2005-01-01 00:00:00

abstract：:Aortic wall thinness was one of the most characteristic changes observed in experimental animals under prolonged continuous flow left heart bypass. The goal of this study was to determine the roles of smooth muscle cells in the vascular remodeling process in cases demonstrating aortic wall thinness under prolonged con...

journal_title：Artificial organs

authors： Mizuno T,Nishinaka T,Ohnishi H,Tatsumi E,Tsukiya T,Oshikawa M,Shioya K,Takewa Y,Homma A,Takano H,Kitamura S,Taenaka Y

更新日期：2003-10-01 00:00:00

abstract：:Using urea and inulin as markers, we have developed a simple method to calculate intracellular and extracellular fluid volume in patients before and after hemofiltration therapy. During conventional hemofiltration using substitution fluid with a Na+ concentration of 140 mEq/L, a decrease in extracellular fluid volume ...

journal_title：Artificial organs

authors： Kimura G,Satani M,Kojima S,Kuroda K,Itoh K,Ikeda M

更新日期：1982-02-01 00:00:00

abstract：:Plasma levels of granulocyte elastase in complex with alpha 1-proteinase inhibitor (E-alpha 1-PI) increased during hemodialysis from 110 +/- 10 to 506 +/- 66 micrograms/L using dialyzers made of polyamide, from 95 +/- 2.2 to 211 +/- 54 micrograms/ml with hemophane and from 114 +/- 10 to 203 +/- 25 using dialyzers made...

journal_title：Artificial organs

authors： Haag-Weber M,Schollmeyer P,Hörl WH

更新日期：1989-04-01 00:00:00

abstract：:Temporary extracorporeal membrane oxygenation (ECMO) has been established as an essential part of therapy in patients with pulmonary or cardiac failure. As physiological gaseous exchange is artificially altered in this patient group, it is debatable whether a (13) C-breath test can be carried out. In this proof of tec...

journal_title：Artificial organs

authors： Bednarsch J,Menk M,Malinowski M,Weber-Carstens S,Pratschke J,Stockmann M

更新日期：2016-07-01 00:00:00