Improved mechanism for capturing muscle power for circulatory support.

Abstract:

:Although it is now understood that trained skeletal muscle can generate enough steady-state power to provide significant circulatory support, there are currently no means by which to tap this endogenous energy source to aid the failing heart. To that end, an implantable muscle energy converter (MEC) has been constructed and its function has been improved to optimize durability, anatomic fit, and mechanical efficiency. Bench tests show that MEC transmission losses average less than 10% of total work input and that about 85% of this muscle power is successfully transferred to the working fluid of the pump. Results from canine implant trials confirm excellent biocompatibility and demonstrate that contractile work of the latissimus dorsi muscle-measured to 290 mJ/stroke in one dog-can be transmitted within the body at levels consistent with cardiac assist requirements. These findings suggest that muscle-powered cardiac assist devices are feasible and that efforts to further develop this technology are warranted.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Trumble DR,Melvin DB,Byrne MT,Magovern JA

doi

10.1111/j.1525-1594.2005.29108.x

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

691-700

issue

9

eissn

0160-564X

issn

1525-1594

pii

AOR29108

journal_volume

29

pub_type

杂志文章,评审
  • Techniques for optimization of pulsatile ventricular assist device support.

    abstract::For some time now researchers have argued the efficacy of pulsatile versus nonpulsatile hemodynamic support. Pulsatile systems, while providing a more physiological pumping source, are burdened with a multiparametric output function that can greatly affect the utility of such ventricular assist device (VAD) support. A...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1992.tb00299.x

    authors: Mills TC,Ott RA

    更新日期:1992-04-01 00:00:00

  • Recharging the battery of implantable biomedical devices by light.

    abstract::This article describes a new powering system for implantable medical devices that could significantly increase their lifetime. The idea is based on the substitution of the usual implantable device battery for an electric accumulator (rechargeable battery), which is fed by the electric power generated by a photovoltaic...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00803.x

    authors: Algora C,Peña R

    更新日期:2009-10-01 00:00:00

  • The monomeric formulation optimization of dental composite: mechanical and kinetic studies.

    abstract::The optimization of the monomer composition, using a polymerization kinetic study and the mechanical behavior study of the composites, was the principal objective of this work. The monomeric mixture analyzed is a part of the composite that has been in development at the University of Campinas, Brazil. Parameters such ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2003.07250.x

    authors: López Palacio RE,de Carvalho Zavaglia CA

    更新日期:2003-05-01 00:00:00

  • Simple evaluation method of biocompatibility of artificial oxygenator hollow fiber.

    abstract::We made miniature modules filled with artificial oxygenator hollow fibers and conducted a simple experiment to study the effect of different membrane structures on the blood. Three types of modules were made: one filled with polyolefin, one filled with polypropylene, and a blank module. The 3 modules were connected th...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1996.tb00677.x

    authors: Nishida H,Shibuya M,Endo M,Koyanagi H

    更新日期:1996-12-01 00:00:00

  • Hemodynamic Evaluation of a Biological and Mechanical Aortic Valve Prosthesis Using Patient-Specific MRI-Based CFD.

    abstract::Modeling different treatment options before a procedure is performed is a promising approach for surgical decision making and patient care in heart valve disease. This study investigated the hemodynamic impact of different prostheses through patient-specific MRI-based CFD simulations. Ten time-resolved MRI data sets w...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12955

    authors: Hellmeier F,Nordmeyer S,Yevtushenko P,Bruening J,Berger F,Kuehne T,Goubergrits L,Kelm M

    更新日期:2018-01-01 00:00:00

  • The Effect of Diode Laser With Different Parameters on Root Fracture During Irrigation Procedure.

    abstract::The aim of this study is to compare the effect of a single diode laser application and agitation of EDTA with diode laser with different parameters at different time intervals on root fracture. Ninety mandibular incisors were instrumented except the negative control group. The specimens were divided randomly into 10 g...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12608

    authors: Karataş E,Arslan H,Topçuoğlu HS,Yılmaz CB,Yeter KY,Ayrancı LB

    更新日期:2016-06-01 00:00:00

  • Selective inhibition of resistance to hemopoietic allografts but not rejection to a natural killer cell sensitive tumor in transgenic mice for granulocyte colony stimulating factor.

    abstract::Transplanted allogeneic marrow grafts often fail to engraft in a lethally irradiated host. Resistance to hemopoietic allograft is a complexed phenomenon involving multiple components. To study the involvement of a hemopoietic cytokine, which was known to play a role for stem cell function, we established lines of mice...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1996.tb04563.x

    authors: Kokai Y,Kimura H,Matsuura A,Fujimoto J

    更新日期:1996-08-01 00:00:00

  • Clinical experience with BioMedicus centrifugal ventricular support in 172 patients.

    abstract::One hundred and seventy-two patients at The Methodist Hospital in Houston, Texas, were placed on BioMedicus centrifugal ventricular support. One hundred thirty-nine patients were male and 33 were female with a mean age of 59.7 years. Reasons for support were postcardiotomy cardiac failure (129 patients), cardiac allog...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1995.tb02419.x

    authors: Noon GP,Ball JW Jr,Papaconstantinou HT

    更新日期:1995-07-01 00:00:00

  • Computational fluid dynamics prediction of blood damage in a centrifugal pump.

    abstract::This study explores a quantitative evaluation of blood damage that occurs in a continuous flow left ventricular assist device due to fluid stress. Computational fluid dynamics (CFD) analysis is used to track the shear stress history of 388 particle streaklines. The accumulation of shear and exposure time is integrated...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2003.00026.x

    authors: Song X,Throckmorton AL,Wood HG,Antaki JF,Olsen DB

    更新日期:2003-10-01 00:00:00

  • Phosphorylcholine and poly(D,L-lactic acid) containing copolymers as substrates for cell adhesion.

    abstract::Fibroblast cell culture was performed to evaluate cell adhesion and cell morphology on novel hydrolyzable copolymers composed of poly(D,L-lactic acid) (PDLA) macromonomer, 2-methacryloyloxyethyl phosphorylcholine (MPC), and n-butyl methacrylate. The copolymers were used as cell culture materials for regulating the int...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2003.07015.x

    authors: Watanabe J,Ishihara K

    更新日期:2003-03-01 00:00:00

  • Electrotactile stimulator for artificial proprioception.

    abstract::With the goal of investigating artificial proprioception elicited by electrical stimulation, we have developed a tactile phi phenomenon-based stimulator. This two-channel microprocessed pulse amplitude modulation system generates two different envelope waveforms (triangular and elliptical) and allows programming and v...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1995.tb02318.x

    authors: Nohama P,Lopes AV,Cliquet Júnior A

    更新日期:1995-03-01 00:00:00

  • The compliance problem: a major obstacle in the development of implantable blood pumps.

    abstract::The compliance problem represents a major obstacle in the development of implantable blood pumps. The motor-driven pumps are enclosed in an airtight casing with gas in the motor space. The trapped gas in the motor space either increases the load on the motor during systole or impedes blood sac filling. Potential solut...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1984.tb04248.x

    authors: Lee S,Rosenberg G,Donachy JH,Wisman CB,Pierce WS

    更新日期:1984-02-01 00:00:00

  • Stent treatment of inferior vena cava compression in an ovine with a total artificial heart.

    abstract::Although current continuous-flow total artificial hearts (CFTAHs) are much smaller than previous models, venous kinking may still occur after device implantation, especially in smaller animals. By inserting a self-expanding stent at the site of venous narrowing in a sheep model implanted with a CFTAH, we were able to ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2011.01233.x

    authors: Tuzun E,Parnis S,Rios J,Winkler JA,Cohn WE

    更新日期:2011-07-01 00:00:00

  • In vitro generation of atrioventricular heart valve neoscaffolds.

    abstract::Tissue engineering of cardiovascular structures represents a novel approach to improve clinical strategies in heart valve disease treatment. The aim of this study was to engineer decellularized atrioventricular heart valve neoscaffolds with an intact ultrastructure and to reseed them with umbilical cord-derived endoth...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12321

    authors: Weymann A,Radovits T,Schmack B,Li S,Korkmaz S,Soós P,Istók R,Veres G,Chaimow N,Karck M,Szabó G

    更新日期:2014-07-01 00:00:00

  • Double filtration plasmapheresis for the treatment of rheumatoid arthritis: a study of 21 cases.

    abstract::The treatment of rheumatoid arthritis remains difficult and often controversial. Plasma exchange has been advocated in some cases. In the present study 71 sessions of double filtration plasmapheresis (DFPP) were performed in 21 patients with rheumatoid arthritis in an average of 3.7 +/- 1.1 sessions per patient within...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb00344.x

    authors: Liu JD,Zhang C,Li WS,Lun LD

    更新日期:1997-02-01 00:00:00

  • An In Vitro Feasibility Study of the Influence of Configurations and Leaflet Thickness on the Hydrodynamics of Deformed Transcatheter Aortic Valve.

    abstract::Clinically, the percutaneous transcatheter aortic valve (TAV) has been reported to be deformed in a noncircular configuration after its implant. The deformation is universal and various, and it leads to serious leakage and durability problems. Even in the same deformation, the leaflets made in different tissue thickne...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12833

    authors: Feng W,Yang X,Liu Y,Fan Y

    更新日期:2017-08-01 00:00:00

  • Development of integrated electronics unit for drive and control of undulation pump-left ventricular assist device.

    abstract::In this study, we have developed an implantable electronics unit (IEU) for driving an undulation pump-left ventricular assist device (UP-LVAD). The IEU consists of a pump driver, three series-connected lithium ion batteries (1800 mAh), a charger, and a transcutaneous information transmission system. These electronic s...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2006.00233.x

    authors: Okamoto E,Makino T,Inoue Y,Tanaka S,Yasuda T,Nakamura M,Saito I,Abe Y,Chinzei T,Isoyama T,Mochiizuki S,Imachi K,Mitamura Y

    更新日期:2006-05-01 00:00:00

  • Microencapsulation of crystalline insulin or islets of Langerhans: an insulin diffusion study.

    abstract::Microcapsules containing insulin crystals or islets of Langerhans were made by extruding a mixture of insulin crystals or islets and sodium alginate into a calcium chloride solution, and then coating it with poly-l-lysine. When these microcapsules were incubated at 37 degrees C, insulin could be detected readily in th...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1983.tb04187.x

    authors: Leung YF,O'Shea GM,Goosen MF,Sun AM

    更新日期:1983-05-01 00:00:00

  • Effect of electrolyzed water on wound healing.

    abstract::Electrolyzed water accelerated the healing of full-thickness cutaneous wounds in rats, but only anode chamber water (acid pH or neutralized) was effective. Hypochlorous acid (HOCl), also produced by electrolysis, was ineffective, suggesting that these types of electrolyzed water enhance wound healing by a mechanism un...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2000.06557-3.x

    authors: Yahagi N,Kono M,Kitahara M,Ohmura A,Sumita O,Hashimoto T,Hori K,Ning-Juan C,Woodson P,Kubota S,Murakami A,Takamoto S

    更新日期:2000-12-01 00:00:00

  • Prevention of right heart failure after left ventricular assist device implantation by phosphodiesterase 5 inhibitor.

    abstract::Right ventricular (RV) function immediately after left ventricular assist device (LVAD) implantation is a crucial prognostic factor. RV failure is linked to increased mortality and worse outcome. A phosphodiesterase 5 inhibitor, sildenafil, was shown to decrease pulmonary vascular resistance and pulmonary artery press...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12277

    authors: Hamdan R,Mansour H,Nassar P,Saab M

    更新日期:2014-11-01 00:00:00

  • Extracorporeal life support during and after bilateral sequential lung transplantation in patients with pulmonary artery hypertension.

    abstract::The use of extracorporeal membrane oxygenator instead of standard cardiopulmonary bypass during lung transplantation is debatable. Moreover, recently, the concept of prolonged postoperative extracorporeal membrane oxygenator (ECMO) support has been introduced in many transplant centers to prevent primary graft dysfunc...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13628

    authors: Dell'Amore A,Campisi A,Congiu S,Mazzarra S,Pastore S,Dolci G,Baiocchi M,Frascaroli G

    更新日期:2020-06-01 00:00:00

  • Low-intensity ultrasound stimulation enhances chondrogenic differentiation in alginate culture of mesenchymal stem cells.

    abstract::Mesenchymal stem cells (MSCs) are regarded as a potential autologous source for cartilage repair, because they can differentiate into chondrocytes by transforming growth factor-beta (TGF-beta) treatment under the 3-dimensional (3-D) culture condition. However, more efficient and versatile methods for chondrogenic diff...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2006.00288.x

    authors: Lee HJ,Choi BH,Min BH,Son YS,Park SR

    更新日期:2006-09-01 00:00:00

  • A computerized model to analyze transcellular fluid shift during hemofiltration.

    abstract::Using urea and inulin as markers, we have developed a simple method to calculate intracellular and extracellular fluid volume in patients before and after hemofiltration therapy. During conventional hemofiltration using substitution fluid with a Na+ concentration of 140 mEq/L, a decrease in extracellular fluid volume ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1982.tb04054.x

    authors: Kimura G,Satani M,Kojima S,Kuroda K,Itoh K,Ikeda M

    更新日期:1982-02-01 00:00:00

  • Systemic consequences of ventricular assist devices: alterations of coagulation, immune function, inflammation, and the neuroendocrine system.

    abstract::Implantable ventricular assist devices have proven efficacious as a bridge to transplantation and as a bridge to recovery. Although current indications for use of assist devices are somewhat limited, they are likely to expand in the upcoming years, including their use as destination therapy for end-stage heart failure...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审

    doi:10.1046/j.1525-1594.2002.07122.x

    authors: Hampton CR,Verrier ED

    更新日期:2002-11-01 00:00:00

  • Implantable volume monitor and miniaturized stimulator dedicated to bladder control.

    abstract::This paper describes a new miniaturized implantable bladder controller that is composed of 4 main parts: a volume monitoring device based on the tomography approach, a fully programmable miniaturized central processor and stimulator, a bidirectional data and power link, and an external controller. The proposed system ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:

    authors: Sawan M,Arabi K,Provost B

    更新日期:1997-03-01 00:00:00

  • An implantable two channel drop foot stimulator: initial clinical results.

    abstract::This article reports preliminary results of pilot studies of a new implantable two channel drop foot stimulator. The stimulator consists of an externally worn transmitter inductively coupled to an implanted receiver unit located in the lower leg, lateral and distal to the knee. The receiver is connected to electrodes ...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1525-1594.2002.06949.x

    authors: Kenney L,Bultstra G,Buschman R,Taylor P,Mann G,Hermens H,Holsheimer J,Nene A,Tenniglo M,van der Aa H,Hobby J

    更新日期:2002-03-01 00:00:00

  • Dialysate and blood temperature during hemodialysis: comparing isothermic dialysis with a single-pass batch system.

    abstract::The Genius is a convenient single-pass batch hemodialysis system. Dialysate is heated during the preparation phase. Once the container is filled at one of the three available starting temperatures, dialysate cools spontaneously. As dialysate temperature plays an important role in hemodynamic stability, knowledge of th...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00981.x

    authors: Dhondt A,Eloot S,Verbeke F,Vanholder R

    更新日期:2010-12-01 00:00:00

  • Multimodal flow visualization and optimization of pneumatic blood pump for sorbent hemodialysis system.

    abstract::Renal Solutions Allient Sorbent Hemodialysis System utilizes a two-chambered pneumatic pump (Pulsar Blood Pump, Renal Solutions, Inc., Warrendale, PA, USA) to avoid limitations associated with peristaltic pumping systems. Single-needle access is enabled by counter-pulsing the two pump chambers, thereby obviating compl...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00724.x

    authors: Shu F,Parks R,Maholtz J,Ash S,Antaki JF

    更新日期:2009-04-01 00:00:00

  • Hemolysis test of a centrifugal pump in a pulsatile mode: the effect of pulse rate and RPM variance.

    abstract::Centrifugal pumps are generally employed as nonpulsatile blood flow pumps; however, these pumps can produce pulsatile flow by periodically alternating the impeller rotation speed. This study investigates blood trauma due to the effect of pulse frequency and various ranges of pump speed. The hemolysis tests were conduc...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb00489.x

    authors: Tayama E,Niimi Y,Takami Y,Ohashi Y,Ohtsuka G,Glueck JA,Mueller J,Nosé Y

    更新日期:1997-12-01 00:00:00

  • Tissue-engineered skin containing mesenchymal stem cells improves burn wounds.

    abstract::There is increasing evidence showing that adult stem cells are useful for tissue regeneration. Bone marrow mesenchymal stem cells (MSCs) are self-renewing and are potent in differentiating into multiple cells and tissues. To investigate the practicability of repairing burn wounds with tissue-engineered (TE) skin combi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2008.00654.x

    authors: Liu P,Deng Z,Han S,Liu T,Wen N,Lu W,Geng X,Huang S,Jin Y

    更新日期:2008-12-01 00:00:00