Hemolytic evaluation using polyurethane microcapsule suspensions in circulatory support devices: normalized index of hemolysis comparisons of commercial centrifugal blood pumps.

Abstract:

:We have been developing some types of microcapsule suspensions with polyurethane membranes to evaluate the absolute hemolytic characteristics of the centrifugal blood pumps used in circulatory support devices such as artificial hearts. In order to facilitate/realize hemolysis testing on centrifugal blood pumps that have hemolysis levels as low as those of commercial centrifugal blood pumps, we eliminated capsules with diameters less than 72.2 microm, amounting to 15.4% of all capsules in the conventional suspension (crude suspension [CS]), and adjusted the capsule volume ratio to correspond to a hematocrit of 40%. In this way we succeeded in enhancing the sensitivity of the suspension to microcapsule destruction 61 fold. We used this new suspension (fine suspension [FS]) to perform hemolysis tests on four types of commercial pump with mock circulation systems. Under conditions of 500 mm Hg and 11.2 L/min, we successfully determined the hemolytic characteristics (normalized index of hemolysis [NIH]) of some of the centrifugal blood pumps; the results showed some correlation with those of hemolysis tests on bovine blood and suggest that microcapsule suspensions with polyurethane membranes are useful as standard test solutions for the absolute evaluation of centrifugal blood pumps.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Maruyama O,Yamaguchi K,Nishida M,Onoguchi T,Tsutsui T,Jikuya T,Yamane T

doi

10.1111/j.1525-1594.2007.00503.x

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

146-56

issue

2

eissn

0160-564X

issn

1525-1594

pii

AOR503

journal_volume

32

pub_type

杂志文章
  • Significant left ventricular unloading with transaortic catheter venting during venoarterial bypass.

    abstract::Insufficient unloading of the left ventricle with blood stagnation is a main cause of unsuccessful left ventricular (LV) recovery during percutaneous cardiopulmonary support (PCPS). The purpose of this investigation was to evaluate the effectiveness of transaortic catheter venting (TACV) for LV unloading. Six adult mo...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb03744.x

    authors: Shibuya M,Kitamura M,Kurihara H,Kikuchi C,Endo M,Koyanagi H

    更新日期:1997-07-01 00:00:00

  • Hemolysis Related to Turbulent Eddy Size Distributions Using Comparisons of Experiments to Computations.

    abstract::Turbulent blood flow in medical devices contributes to blood trauma, yet the exact mechanism(s) have not been fully elucidated. Local turbulent stresses, viscous stresses, and the rate of dissipation of the turbulent kinetic energy have been proffered as hypotheses to describe and predict blood damage. In this work, s...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12572

    authors: Ozturk M,O'Rear EA,Papavassiliou DV

    更新日期:2015-12-01 00:00:00

  • Dialysis reduces portal pressure in patients with chronic hepatitis C.

    abstract::The purpose of this study was to characterize changes in hepatic venous pressures in patients with chronic hepatitis C. The histology and laboratory data from patients with chronic hepatitis C who underwent a transjugular liver biopsy (TJLB) and hepatic venous pressure gradient measurement were analyzed. Portal hypert...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00925.x

    authors: Khurana S,Simcox T,Twaddell W,Drachenberg C,Flasar M

    更新日期:2010-07-01 00:00:00

  • Cell adhesive and antifouling polyvinyl chloride surfaces via wet chemical modification.

    abstract::Polyvinyl chloride (PVC) is one of the most frequently used polymers for the manufacturing of medical devices. Limitations for its usage are based upon unfavorable surface properties of the polymer including its hydrophobicity and lack of functionalities in order to increase its versatility. To address this issue, wet...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2012.01462.x

    authors: Gabriel M,Strand D,Vahl CF

    更新日期:2012-09-01 00:00:00

  • Forward osmosis process for dialysis fluid regeneration.

    abstract::In a preliminary experiment, 38% of the spent dialysis fluid water was reclaimed by a forward osmosis process through a cellulose triacetate membrane. The simplicity of forward osmosis and its minimal external energy requirements may allow the construction of a small bulk device that can reclaim a considerable portion...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00816.x

    authors: Talaat KM

    更新日期:2009-12-01 00:00:00

  • Effect of temporary catheter and late referral on hospitalization and mortality during the first year of hemodialysis treatment.

    abstract::Late referral (LR) to dialysis therapy has been associated with poor outcomes in people with end-stage renal disease. This had been ascribed to the frequent use of temporary vascular catheters (TVCs) in LR patients. The effects of LR and TVC on the outcomes of an incident hemodialysis population (n = 101) were investi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2004.00016.x

    authors: Gonçalves EA,Andreoli MC,Watanabe R,Freitas MC,Pedrosa AC,Manfredi SR,Draibe SA,Cendoroglo M,Canziani ME

    更新日期:2004-11-01 00:00:00

  • Totally Endoscopic Robotic-Assisted Cardiac Surgery in Children.

    abstract::Robotic surgery for intracardiac pathologies in children is relatively uncommon. This study presents our initial experience with robotic-assisted cardiac surgery in children. We also present the feasibility and safety of robotic surgery in children. From May 2013 to June 2018, 30 children underwent totally endoscopic ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13357

    authors: Onan B,Aydin U,Kadirogullari E,Onan IS,Sen O

    更新日期:2019-04-01 00:00:00

  • Clinical validation of a predictive modeling equation for sodium.

    abstract::Changes in plasma sodium (Na) concentration during hemodialysis were predicted by changes in Na concentration of the dialysate at equilibrium with the plasma, according to the formula C't = CD - (CD - C'0) [(V0 - QFt)/V0]A/QF, where C'0 and C't are the Na concentration of the dialysate at equilibrium with the plasma a...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1985.tb04365.x

    authors: Man NK,Petitclerc T,Tien NQ,Jehenne G,Funck-Brentano JL

    更新日期:1985-05-01 00:00:00

  • Automatic Control of Veno-Venous Extracorporeal Lung Assist.

    abstract::Veno-venous extracorporeal lung assist (ECLA) can provide sufficient gas exchange even in most severe cases of acute respiratory distress syndrome. Commercially available systems are manually controlled, although an automatically controlled ECLA could allow individualized and continuous adaption to clinical requiremen...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12664

    authors: Kopp R,Bensberg R,Stollenwerk A,Arens J,Grottke O,Walter M,Rossaint R

    更新日期:2016-10-01 00:00:00

  • Influence of Instruments Used in Root Canal Preparation on Amount of Apically Extruded Debris.

    abstract::The aim of the present study was to compare the effects of ProTaper Gold, WaveOne Gold, ProTaper Universal, and WaveOne instruments on the amount of apically extruded debris. Eighty mandibular premolar teeth with straight root canals were selected and assigned to four groups (n = 20). The root canals were instrumented...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12675

    authors: Karataş E,Ersoy İ,Gündüz HA,Uygun AD,Kol E,Çakıcı F

    更新日期:2016-08-01 00:00:00

  • Promigratory activity of oxytocin on umbilical cord blood-derived mesenchymal stem cells.

    abstract::Recent studies show that oxytocin has various effects on cellular behaviors. Oxytocin is reported to stimulate cardiomyogenesis of embryonic stem cells and endothelial cell proliferation. Mesenchymal stem cells (MSCs) are widely used for cardiac repair, and we elucidated the effect of oxytocin on umbilical cord derive...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00894.x

    authors: Kim YS,Kwon JS,Hong MH,Kim J,Song CH,Jeong MH,Cho JG,Park JC,Kang JC,Ahn Y

    更新日期:2010-06-01 00:00:00

  • Cellulose acetate beads activate the complement system but inactivate the anaphylatoxins generated.

    abstract::The generation of anaphylatoxins, particularly C5a, is important in extracorporeal circulation therapies such as granulocyte/monocyte apheresis, which activates the complement system and elevates C5a levels. However, no side effects of granulocyte/monocyte apheresis using cellulose acetate beads have been reported. To...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00995.x

    authors: Takeda Y,Ohba M,Ueno M,Saniabadi AR,Wakabayashi I

    更新日期:2010-12-01 00:00:00

  • Low-intensity ultrasound stimulation enhances chondrogenic differentiation in alginate culture of mesenchymal stem cells.

    abstract::Mesenchymal stem cells (MSCs) are regarded as a potential autologous source for cartilage repair, because they can differentiate into chondrocytes by transforming growth factor-beta (TGF-beta) treatment under the 3-dimensional (3-D) culture condition. However, more efficient and versatile methods for chondrogenic diff...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2006.00288.x

    authors: Lee HJ,Choi BH,Min BH,Son YS,Park SR

    更新日期:2006-09-01 00:00:00

  • Oral treatment for jaundice using immobilized bilirubin oxidase.

    abstract::Jaundice is characterized by an excessive accumulation of bilirubin in the blood and tissues. A novel approach to reduce plasma levels of bilirubin by blocking its enterohepatic circulation was investigated. The treatment consisted of oral administration of immobilized bilirubin oxidase, which could oxidize bilirubin ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1992.tb00527.x

    authors: Soltys PJ,Mullon C,Langer R

    更新日期:1992-08-01 00:00:00

  • Thromboembolic complications of the Symbion AVAD System.

    abstract::The Symbion Acute Ventricular Assist Device (AVAD) System is an experimental paracorporeal pulsatile ventricular assist device (VAD) for single or biventricular assist. Eleven patients were implanted but 2 died within 24 h and were excluded from the study. Nine patients, four with left ventricular assist devices (LVAD...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1989.tb01575.x

    authors: Icenogle TB,Smith RG,Cleavinger M,Vasu MA,Williams RJ,Sethi GK,Copeland JG

    更新日期:1989-12-01 00:00:00

  • Comparison of rapid in situ, regular in situ, and ex vivo flushing on hepatic function.

    abstract::The efficacy of three flushing techniques on subsequent liver function was assessed using the in vivo isolated liver perfusion model (ILPM). Livers from brain-dead mongrel dogs were flushed with cold Euro-Collins as follows: Group I, rapid in situ flushing (10 min); Group II, regular in situ flushing (45 min); Group I...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1988.tb02760.x

    authors: Castellanos J,Toledo-Pereyra LH,Finkelstein I,Kestenberg W,Chapman M,Choudhury S

    更新日期:1988-06-01 00:00:00

  • Hantaan virus infection with acute renal failure.

    abstract::We report on 10 patients with acute renal involvement in Hantaan virus infection observed at the Department of Nephrology, Faculty of Medicine, Skopje, Republic of Macedonia, during a period of 3 years (October 1987-July 1990). Eight patients were male and 2 were female, aged 37.5 +/- 4.8 years. The diagnosis of Hanta...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1995.tb02432.x

    authors: Polenaković M,Grcevska L,Gerasimovska-Tanevska V,Oncevski A,Dzikova S,Cakalaroski K,Masin G

    更新日期:1995-08-01 00:00:00

  • A comparative study between flow visualization and computational fluid dynamic analysis for the sun medical centrifugal blood pump.

    abstract::Flow visualization experiments and computational fluid dynamic (CFD) analyses were performed and the results were compared to clarify the detailed fluid dynamic characteristics for the prototype design of a centrifugal pump, namely, an implantable ventricular assist system from Sun Medical, whose hemocompatibility was...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2004.07161.x

    authors: Yamane T,Miyamoto Y,Tajima K,Yamazaki K

    更新日期:2004-05-01 00:00:00

  • Pretreatment With Inactivated Bacillus Calmette-Guerin Increases CD4+CD25+ Regulatory T Cell Function and Decreases Functional and Structural Effects of Asthma Induction in a Rat Asthma Model.

    abstract::Bacillus Calmette-Guerin (BCG) has been shown to have therapeutic effects on asthma through CD4+CD25+ regulatory T cells (Tregs). We sought to assess pretreatment with inactivated BCG on CD4+CD25+ Tregs and its functional and structural effects in rat asthma model. The rat asthma model was established using ovalbumin ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12566

    authors: Gong P,Li Y,Tan YP,Li H

    更新日期:2016-04-01 00:00:00

  • The PediPump: a new ventricular assist device for children.

    abstract::Options for mechanical circulatory support for the treatment of end-stage heart failure in children are limited. Ventricular assist devices (VADs), which have revolutionized cardiac care in adults, remain largely unavailable for pediatric applications. The PediPump is a new rotary dynamic VAD designed to provide suppo...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2005.29088.x

    authors: Duncan BW,Lorenz M,Kopcak MW,Fukamachi K,Ootaki Y,Chen HM,Chapman PA,Davis SJ,Smith WA

    更新日期:2005-07-01 00:00:00

  • Device exchange versus nonexchange modalities in left ventricular assist device-specific infections: A systematic review and meta-analysis.

    abstract::No standardized treatment algorithm exists for the management of continuous-flow left ventricular assist device (CF-LVAD)-specific infections. The aim of this systematic review and meta-analysis was to compare the outcomes of CF-LVAD-specific infections as managed by device exchange to other treatment modalities not i...

    journal_title:Artificial organs

    pub_type: 杂志文章,meta分析

    doi:10.1111/aor.13378

    authors: Bauer TM,Choi JH,Luc JGY,Weber MP,Moncho Escrivá E,Patel S,Maynes EJ,Boyle AJ,Samuels LE,Entwistle JW,Morris RJ,Massey HT,Tchantchaleishvili V

    更新日期:2019-05-01 00:00:00

  • A hemoglobin-based multifunctional therapeutic: polynitroxylated pegylated hemoglobin.

    abstract::Polynitroxylated pegylated hemoglobin (PNPH) as a multifunctional therapeutic takes advantage of the ability of hemoglobin (Hb) to transport oxygen, the antioxidative stress activities from the redox coupling of nitroxide and heme iron, and the hypercolloid properties of pegylation. The published preclinical data demo...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2011.01307.x

    authors: Hsia CJ,Ma L

    更新日期:2012-02-01 00:00:00

  • Low molecular weight heparin versus unfractioned heparin for anticoagulation during perioperative extracorporeal membrane oxygenation: A single center experience in 102 lung transplant patients.

    abstract::Extracorporeal membrane oxygenation (ECMO) is gaining importance in the perioperative management of lung transplant patients. To date, the ideal substance for anticoagulation of ECMO patients is still a matter of debate. In this study, we describe our experience with the use of low molecular weight heparin (LMWH) in c...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13642

    authors: Gratz J,Pausch A,Schaden E,Baierl A,Jaksch P,Erhart F,Hoetzenecker K,Wiegele M

    更新日期:2020-06-01 00:00:00

  • Outcomes with ventricular assist device versus extracorporeal membrane oxygenation as a bridge to pediatric heart transplantation.

    abstract::Extracorporeal membrane oxygenation (ECMO) has long been the sole means of mechanical support for pediatric patients with end-stage cardiac failure, but has a high waitlist mortality and a reported survival to hospital discharge of less than 50%. The purpose of this study was to compare waitlist mortality and survival...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00969.x

    authors: Jeewa A,Manlhiot C,McCrindle BW,Van Arsdell G,Humpl T,Dipchand AI

    更新日期:2010-12-01 00:00:00

  • Microencapsulation of crystalline insulin or islets of Langerhans: an insulin diffusion study.

    abstract::Microcapsules containing insulin crystals or islets of Langerhans were made by extruding a mixture of insulin crystals or islets and sodium alginate into a calcium chloride solution, and then coating it with poly-l-lysine. When these microcapsules were incubated at 37 degrees C, insulin could be detected readily in th...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1983.tb04187.x

    authors: Leung YF,O'Shea GM,Goosen MF,Sun AM

    更新日期:1983-05-01 00:00:00

  • The analysis of driving mode influence on energy dissipation in pneumatic artificial heart chambers.

    abstract::The energy dissipated in blood or on a total artificial heart (TAH) chamber's elements directly or indirectly decreases the biological or technical safety of the TAH's work. The energetic analysis of the Polish total artificial heart (POLTAH) external work with the objective of estimating the valve and membrane roles ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1998.05074.x

    authors: Nawrat Z,Malota Z

    更新日期:1998-10-01 00:00:00

  • Pre- and postoperative magnetic resonance imaging in neonatal arterial switch operation using warm perfusion.

    abstract::Neurological morbidity is a major concern in pediatric cardiac surgery. Cardiopulmonary bypass is one of the few modifiable factors affecting neurodevelopmental outcome. This study aimed to measure the incidence of abnormalities apparent by magnetic resonance imaging (MRI) after neonatal arterial switch operation usin...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2011.01325.x

    authors: Durandy Y,Rubatti M,Couturier R,Rohnean A

    更新日期:2011-11-01 00:00:00

  • Intra-Aortic Balloon Pump Support in the Isolated Beating Porcine Heart in Nonischemic and Ischemic Pump Failure.

    abstract::The blood pressure changes induced by the intra-aortic balloon pump (IABP) are expected to create clinical improvement in terms of coronary perfusion and myocardial oxygen consumption. However, the measured effects reported in literature are inconsistent. The aim of this study was to investigate the influence of ische...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12470

    authors: Schampaert S,van Nunen LX,Pijls NH,Rutten MC,van Tuijl S,van de Vosse FN,van 't Veer M

    更新日期:2015-11-01 00:00:00

  • Demand for and use of functional electrical stimulation systems and conventional orthoses in the spinal lesioned community of the UK.

    abstract::The use of and demand for functional electrical stimulation (FES) systems and conventional orthoses in the spinal cord lesioned population was assessed. The assessment was conducted by a postal survey of the members of the spinal injury associations in the U.K. Out of all the respondents, only 2% had used an FES syste...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1999.06361.x

    authors: Maxwell DJ,Granat MH,Baardman G,Hermens HJ

    更新日期:1999-05-01 00:00:00

  • A computerized model to analyze transcellular fluid shift during hemofiltration.

    abstract::Using urea and inulin as markers, we have developed a simple method to calculate intracellular and extracellular fluid volume in patients before and after hemofiltration therapy. During conventional hemofiltration using substitution fluid with a Na+ concentration of 140 mEq/L, a decrease in extracellular fluid volume ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1982.tb04054.x

    authors: Kimura G,Satani M,Kojima S,Kuroda K,Itoh K,Ikeda M

    更新日期:1982-02-01 00:00:00