A computerized model to analyze transcellular fluid shift during hemofiltration.

Abstract:

:Using urea and inulin as markers, we have developed a simple method to calculate intracellular and extracellular fluid volume in patients before and after hemofiltration therapy. During conventional hemofiltration using substitution fluid with a Na+ concentration of 140 mEq/L, a decrease in extracellular fluid volume was noted whereas the intracellular fluid volume was unaltered. Furthermore, we have developed a computerized mathematical model to analyze transcellular fluid shifts during hemofiltration. This model also indicates a decrease in extracellular fluid volume only, the intracellular fluid volume remaining unchanged. High-Na+ hemofiltration using substitution fluid with an Na+ concentration of 160 mEq/L has enabled us to remove fluid from both intracellular and extracellular compartments. Thus, high-Na+ hemofiltration is expected to normalize the intracellular hydration in uremic patients, and to reduce the decrease in extracellular fluid volume during hemofiltration therapy. Our data therefore suggest that high-Na+ hemofiltration could prevent hypotension due to large decreases in extracellular fluid volume by inducing a transcellular fluid shift out of body cells. Our computerized model can be a useful tool in the prescription of the optimal Na+ concentration in substitution fluid for individualized hemofiltration therapy.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Kimura G,Satani M,Kojima S,Kuroda K,Itoh K,Ikeda M

doi

10.1111/j.1525-1594.1982.tb04054.x

subject

Has Abstract

pub_date

1982-02-01 00:00:00

pages

31-6

issue

1

eissn

0160-564X

issn

1525-1594

journal_volume

6

pub_type

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