Glucose-insulin kinetics of a bioartificial pancreas made of an AN69 hydrogel hollow fiber containing porcine islets and implanted in diabetic mice.

abstract：:The ventricular assist device inflow cannulation site is the primary interface between the device and the patient. Connecting these cannulae to either atria or ventricles induces major changes in flow dynamics; however, there are little data available on precise quantification of these changes. The objective of this i...

journal_title：Artificial organs

authors： Timms D,Gregory S,Hsu PL,Thomson B,Pearcy M,McNeil K,Fraser J,Steinseifer U

更新日期：2010-09-01 00:00:00

abstract：:In a controlled European multicenter study, clinical tolerance of subcutaneously administered recombinant human erythropoietin (rh-EPO) therapy and its influence on the course of illness in 362 hemodialyzed patients (162 males, 200 females) from 16 European dialysis centers was studied. Of these, 181 patients served a...

journal_title：Artificial organs

authors： Klinkmann H,Wieczorek L,Scigalla P

更新日期：1993-04-01 00:00:00

abstract：:Experimental studies on the effects of scaling on the performance of centrifugal blood pumps were conducted in a closed-loop test rig. For the prototype, eight different impellers of the same outer diameter of 25 mm were tested at 1,500, 2,000, and 2,500 revolutions per minute (rpm) using blood analog as fluid medium....

journal_title：Artificial organs

authors： Wong YW,Chan WK,Yu SC,Chua LP

更新日期：2002-11-01 00:00:00

abstract：:We developed a new left ventricular (LV) assist catheter (transaortic valve from LV to femoral artery) that is implemented percutaneously and exerted as a synchronous pulsatile partial LV flow support with conventional intraaortic balloon pump (IABP) driving system and centrifugal pump system. We investigated whether ...

journal_title：Artificial organs

authors： Ide H,Yamaguchi A,Ino T,Matsumoto H,Fujimasa I

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Ventricular assist devices are gaining ground in the therapeutic treatment of chronic heart failure. These devices are sometimes used as a bridge to recovery by unloading the left ventricle (LV) and restoring its function. It is therefore important to preserve the heart muscle and apply less invasive implant...

journal_title：Artificial organs

authors： Vandenberghe S,Nishida T,Segers P,Meyns B,Verdonck P

更新日期：2004-07-01 00:00:00

abstract：:Five hundred and eighty homograft valves have been inserted into the aortic position as isolated valve replacements, and followed up for 7--14 years. After ten years 90% of frozen homografts, 80% of autografts and 70% of freeze-dried homografts were free of valve-related death. There was only one embolism reported giv...

journal_title：Artificial organs

authors： Bodnar E,Wain WH,Martelli V,Ross DN

更新日期：1980-02-01 00:00:00

abstract：:The use of extracorporeal membrane oxygenator instead of standard cardiopulmonary bypass during lung transplantation is debatable. Moreover, recently, the concept of prolonged postoperative extracorporeal membrane oxygenator (ECMO) support has been introduced in many transplant centers to prevent primary graft dysfunc...

journal_title：Artificial organs

authors： Dell'Amore A,Campisi A,Congiu S,Mazzarra S,Pastore S,Dolci G,Baiocchi M,Frascaroli G

更新日期：2020-06-01 00:00:00

abstract：:Polynitroxylated pegylated hemoglobin (PNPH) as a multifunctional therapeutic takes advantage of the ability of hemoglobin (Hb) to transport oxygen, the antioxidative stress activities from the redox coupling of nitroxide and heme iron, and the hypercolloid properties of pegylation. The published preclinical data demo...

journal_title：Artificial organs

authors： Hsia CJ,Ma L

更新日期：2012-02-01 00:00:00

abstract：:Polyvinyl chloride (PVC) is one of the most frequently used polymers for the manufacturing of medical devices. Limitations for its usage are based upon unfavorable surface properties of the polymer including its hydrophobicity and lack of functionalities in order to increase its versatility. To address this issue, wet...

journal_title：Artificial organs

authors： Gabriel M,Strand D,Vahl CF

更新日期：2012-09-01 00:00:00

abstract：:The therapy of terminal heart failure with left ventricular assist devices has become a standard in cardiac surgery. Yet the surgical implantation technique is not standardized and differs from center to center. Complications associated with left ventricular assist device (LVAD) inflow cannula placement are thrombosis...

journal_title：Artificial organs

authors： Hanke JS,Krabatsch T,Rojas SV,Deniz E,Ismail I,Martens A,Shrestha M,Haverich A,Netuka I,Schmitto JD

更新日期：2017-03-01 00:00:00

abstract：:Artificial cells are prepared in the laboratory for medical and biotechnological applications. Encapsulated cells are being studied for the treatment of diabetes, liver failure, and other conditions. More recently, there have been extensive studies into the use of encapsulated genetically engineered cells for gene the...

journal_title：Artificial organs

authors： Chang TM

更新日期：1998-11-01 00:00:00

abstract：:A method of creating multifocal ischemia in animals leading to left ventricular (LV) functional impairment is described. In a series of 10 mongrel dogs, electrodes were implanted in multiple branches of the coronary arteries. Subsequently, in seven animals, an 800-microA anodal current was applied for 3 h repeatedly o...

journal_title：Artificial organs

authors： Polanski J,Mandell G,Wasfie T,Freed PS,Yoshizu H,Stein PD,Sabbah HN,Kantrowitz A

更新日期：1984-11-01 00:00:00

abstract：:Continuous and intermittent high shear were loaded to red blood cells in a cone and a plate rheoscope. The mechanical damage to red cells was compared for continuous and intermittent shear. The intermittent shear was achieved by alternately starting and stopping shear repeatedly. In the case of intermittent shear load...

journal_title：Artificial organs

authors： Mizunuma H,Sakai S

更新日期：2007-06-01 00:00:00

abstract：:The aim of this study was to develop procedures for the diagnosis and nonsurgical management of decreased insulin flow in an implantable programmable pump for long-term intraperitoneal or intravenous insulin delivery featuring a sideport. Patency of the catheter lumen was tested by measuring the time needed for sidepo...

journal_title：Artificial organs

authors： Scavini M,Reich S,Eaton RP,Charles MA,Dunn FL

更新日期：1996-09-01 00:00:00

abstract：:Midsize molecule retention is related with renal-failure-associated mortality. Here, the authors describe a new dialysis modality, pulse push/pull hemodialysis (PPPHD), which increases convective clearance. Blood and dialysate are circulated by a pulsatile pump, but with pulsatile flow patterns that are 180 degrees ou...

journal_title：Artificial organs

authors： Lee K,Lee SR,Mun CH,Min BG

更新日期：2008-05-01 00:00:00

abstract：:Cardiopulmonary bypass (CPB) requirement in infants presents a unique challenge because of the large prime volume-to-blood volume ratio. Packed red blood cells (PRBCs) tend to deteriorate with long-term storage owing to their unphysiological composition and osmolality. Given that blood priming is inevitable in neonate...

journal_title：Artificial organs

authors： Gholampour Dehaki M,Niknam S,Bakhshandeh H,Azarfarin R

更新日期：2020-03-01 00:00:00

abstract：:To develop an effective hybrid bioartificial liver (BAL) device, the material of the scaffold is very important to support hepatocytes that have both growth ability and hepatic differentiated functions. In this study we used paper (Kimwipe, Kimberly-Clark Corp., Roswell, GA, U.S.A.) as a scaffold. Primary hepatocytes ...

journal_title：Artificial organs

authors： Mizuguchi T,Mitaka T,Sato F,Mochizuki Y,Hirata K

更新日期：2000-04-01 00:00:00

abstract：:In a preliminary experiment, 38% of the spent dialysis fluid water was reclaimed by a forward osmosis process through a cellulose triacetate membrane. The simplicity of forward osmosis and its minimal external energy requirements may allow the construction of a small bulk device that can reclaim a considerable portion...

journal_title：Artificial organs

authors： Talaat KM

更新日期：2009-12-01 00:00:00

abstract：:Options for mechanical circulatory support for the treatment of end-stage heart failure in children are limited. Ventricular assist devices (VADs), which have revolutionized cardiac care in adults, remain largely unavailable for pediatric applications. The PediPump is a new rotary dynamic VAD designed to provide suppo...

journal_title：Artificial organs

authors： Duncan BW,Lorenz M,Kopcak MW,Fukamachi K,Ootaki Y,Chen HM,Chapman PA,Davis SJ,Smith WA

更新日期：2005-07-01 00:00:00

abstract：:The new Advanced ventricular assist device (Advanced VAD) has many features such as improving pulsatility and preventing regurgitant flow during pump stoppage. The purpose of this study was to evaluate the effects of design modifications of the Advanced VAD on these features in vitro. Bench testing of four versions of...

journal_title：Artificial organs

authors： Miyamoto T,Byram N,Karimov JH,Adams J,Dessoffy R,Kuban BD,Gao S,Horvath DJ,Fukamachi K

更新日期：2019-10-01 00:00:00

abstract：:A computer simulation was carried out to investigate the influence of nonpulsatile left ventricular assistance on hemodynamics. A simulation circuit was constructed to represent the circulatory system. A source of current was added to denote the nonpulsatile blood pump. The left and right ventricles were replaced by v...

journal_title：Artificial organs

authors： Mitsui N,Fukunaga S,Koura Y,Morita S,Hotei H,Sueshiro M,Sueda T,Matsuura Y

更新日期：1996-05-01 00:00:00

abstract：:Nonpulsatile blood pumps are mainly used in extracorporeal life support systems. Although pulsating blood flow is known to be physiological, a pulsatile pump is not commonly applied in a circuit with a membrane oxygenator because of damage to the blood cells. The hypothesis that the placement of a pressure-relieving c...

journal_title：Artificial organs

authors： Kim TS,Sun K,Lee KB,Lee HW,Baek KJ,Park SY,Son HS,Kim KT,Kim HM

更新日期：2004-12-01 00:00:00

abstract：:Tissue engineering utilizes an interdisciplinary approach to generate constructs for the treatment and repair of diseased organs. Generation of small vessels as vascular grafts or as envisioned central vessel for vascularized constructs is still a challenge. Here, the decellularization of porcine vessels by a non-dete...

journal_title：Artificial organs

authors： Eyre K,Samper E,Haverich A,Hilfiker A,Andrée B

更新日期：2020-10-01 00:00:00

abstract：:The effects of Fluosol-DA 20% on circulating blood cells, hemodynamic parameters, blood gases, and organs are described and compared with the results of phase I human studies and animal experiments. Bleeding of preoperative anemia and/or surgical bleeding, Fluosol-DA 20% was administered to 7 of 10 Jehovah's Witness p...

journal_title：Artificial organs

authors： Ohyanagi H,Nakaya S,Okumura S,Saitoh Y

更新日期：1984-02-01 00:00:00

abstract：:Lipid apheresis has developed from a heroic treatment into a routine clinical therapy and currently is the major indication for performing extracorporeal plasma therapy. Whereas it was once reserved for patients with homozygous familial hypercholesterolemia, today it has a place in the secondary prevention of severe c...

journal_title：Artificial organs

authors： Bosch T

更新日期：1996-05-01 00:00:00

abstract：:A review and analysis of 5,001 neonatal venoarterial (VA) extracorporeal membrane oxygenation (ECMO) cases showed that bacterial and fungal infection occurred in 147 (2.9%) and 26 (0.6%) patients, respectively, with an overall incidence of 3.5%. Bivariate analysis was used to compare infected infants with controls, ba...

journal_title：Artificial organs

authors： Douglass BH,Keenan AL,Purohit DM

更新日期：1996-03-01 00:00:00

abstract：:The abdominal left ventricular assist device (ALVAD) is an order of magnitude more effective than conventional intra-aortic balloon pumping (IABP) in unloading and providing circulatory support to the failing left ventricle. This is a report of a unique case which demonstrates that in the absence of pulmonary vascular...

journal_title：Artificial organs

authors： Norman JC,Dacso CC,Reul GJ,Massin EK,Klima T,Kahan BD,Keiser JT,Cooley DA

更新日期：1978-11-01 00:00:00

abstract：:Although it is now understood that trained skeletal muscle can generate enough steady-state power to provide significant circulatory support, there are currently no means by which to tap this endogenous energy source to aid the failing heart. To that end, an implantable muscle energy converter (MEC) has been construct...

journal_title：Artificial organs

authors： Trumble DR,Melvin DB,Byrne MT,Magovern JA

更新日期：2005-09-01 00:00:00

abstract：:Aortic arch repair in newborns and infants has traditionally been accomplished using a period of deep hypothermic circulatory arrest. To reduce neurologic and cardiac dysfunction related to circulatory arrest and myocardial ischemia during complex aortic arch surgery, an alternative and novel strategy for cerebro-myoc...

journal_title：Artificial organs

authors： Hoxha S,Abbasciano RG,Sandrini C,Rossetti L,Menon T,Barozzi L,Linardi D,Rungatscher A,Faggian G,Luciani GB

更新日期：2018-04-01 00:00:00

abstract：:Cardiomyoplasty has been proposed as an alternative surgical treatment for congestive heart failure. The girdling effect of the muscle wrap is believed to reduce diastolic wall stress. We tested the hypothesis that nonstimulated or passive cardiomyoplasty (CDM) would reduce hemodynamic deficits in rats with experiment...

journal_title：Artificial organs

authors： De Angelis K,Leirner AA,Irigoyen MC,Cestari IA

更新日期：2001-11-01 00:00:00