Adverse events of subcutaneous recombinant human erythropoietin therapy: results of a controlled multicenter European study.

Abstract:

:In a controlled European multicenter study, clinical tolerance of subcutaneously administered recombinant human erythropoietin (rh-EPO) therapy and its influence on the course of illness in 362 hemodialyzed patients (162 males, 200 females) from 16 European dialysis centers was studied. Of these, 181 patients served as a control group in the first year and received rh-EPO therapy in the second year. Of the 837 adverse events that occurred, 277 were classified as serious and 560 as nonserious. Thirty-two deaths have been reported for the study population: 18 in the control group and 14 in the therapy group. The individual analysis of the serious adverse events including death demonstrates a protective effect of rh-EPO on the high-risk cardiovascular situation of dialysis patients. Hypertension was no problem, and under rh-EPO therapy an increase in resistance to infection was observed. Subcutaneous rh-EPO treatment might have an even better safety profile than intravenous application.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Klinkmann H,Wieczorek L,Scigalla P

doi

10.1111/j.1525-1594.1993.tb00571.x

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

219-25

issue

4

eissn

0160-564X

issn

1525-1594

journal_volume

17

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • The application of immobilized enzymes in an artificial liver support system.

    abstract::A novel method of extracorporeal support for fulminant liver failure is reported whereby the most important detoxification processes of the liver are reproduced in an enzyme reactor. Most of the endogenous toxins involved in hepatic coma can be deactivated directly by conjugation with a hydrophilic residue such as glu...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1979.tb03801.x

    authors: Brunner G,Holloway CJ,Lösgen H

    更新日期:1979-02-01 00:00:00

  • Physical testing of elastomers for cardiovascular applications.

    abstract::There are presently no short-term in vitro fatigue tests available that can predict long-term in vivo performance of elastomers in physiological environments. Thus, the introduction of new and better elastomers for cardiovascular applications is hampered in the development stage by lack of data about which materials s...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1983.tb04162.x

    authors: McMillin CR

    更新日期:1983-02-01 00:00:00

  • Effect of temporary catheter and late referral on hospitalization and mortality during the first year of hemodialysis treatment.

    abstract::Late referral (LR) to dialysis therapy has been associated with poor outcomes in people with end-stage renal disease. This had been ascribed to the frequent use of temporary vascular catheters (TVCs) in LR patients. The effects of LR and TVC on the outcomes of an incident hemodialysis population (n = 101) were investi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2004.00016.x

    authors: Gonçalves EA,Andreoli MC,Watanabe R,Freitas MC,Pedrosa AC,Manfredi SR,Draibe SA,Cendoroglo M,Canziani ME

    更新日期:2004-11-01 00:00:00

  • Apheresis technologies: an international perspective.

    abstract::The developments in apheresis techniques and their clinical applications world-wide are technologically driven. In the past, apheresis survey statistics have high-lighted both the differences by region in clinical practice and in the types of technologies utilized. Such differences have provided a basis for the scient...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1995.tb02334.x

    authors: Malchesky PS,Bambauer R,Horiuchi T,Kaplan A,Sakurada Y,Samuelsson G

    更新日期:1995-04-01 00:00:00

  • Evaluation of Combined Extracorporeal Life Support and Continuous Renal Replacement Therapy on Hemodynamic Performance and Gaseous Microemboli Handling Ability in a Simulated Neonatal ECLS System.

    abstract::The objective of this study was to evaluate the hemodynamic performance and gaseous microemboli (GME) handling ability of a simulated neonatal extracorporeal life support (ECLS) circuit with an in-line continuous renal replacement therapy (CRRT) device. The circuit consisted of a Maquet RotaFlow centrifugal pump or HL...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12987

    authors: Shank KR,Profeta E,Wang S,O'Connor C,Kunselman AR,Woitas K,Myers JL,Ündar A

    更新日期:2018-04-01 00:00:00

  • Heart Transplant Waiting List Implications of Increased Ventricular Assist Device Use as a Bridge Strategy: A National Analysis.

    abstract:BACKGROUND:The use of ventricular assist devices (VAD) as a bridge to heart transplant (HT) is increasing, while HT volume remains stagnant. This may portend longer waiting times and an otherwise more competitive environment for all patients on the HT waiting list. METHODS:A retrospective analysis of patients who were...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13833

    authors: Han JJ,Elzayn H,Duda MM,Iyengar A,Acker AM,Patrick WL,Helmers M,Birati EY,Atluri P

    更新日期:2020-10-01 00:00:00

  • Correlation between cerebral-renal near-infrared spectroscopy and ipsilateral renal perfusion parameters as clinical outcome predictors after open heart surgery in neonates and infants.

    abstract::The objective of this clinical study is to determine whether correlation exists among cerebral and renal near-infrared spectroscopy (NIRS) measurements, renal Doppler ultrasonography parameters (resistive index, peak systolic velocity), and early postoperative clinical outcomes following cardiac surgery in neonates an...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12455

    authors: Örmeci T,Alkan-Bozkaya T,Özyüksel A,Ersoy C,Ündar A,Akçevin A,Türkoğlu H

    更新日期:2015-01-01 00:00:00

  • Glucose-insulin kinetics of a bioartificial pancreas made of an AN69 hydrogel hollow fiber containing porcine islets and implanted in diabetic mice.

    abstract::The goal of this study was to determine whether porcine islets encapsulated in hollow fibers made of AN69 copolymer can correct hyperglycemia in diabetic mice and provide normal tolerance to a glucose challenge. In vitro perifusion of hollow fibers demonstrated the rapid kinetics of insulin release in response to gluc...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1998.05087.x

    authors: Delaunay C,Darquy S,Honiger J,Capron F,Rouault C,Reach G

    更新日期:1998-04-01 00:00:00

  • An advanced mock circulation loop for in vitro cardiovascular device evaluation.

    abstract::Controlled and repeatable in vitro evaluation of cardiovascular devices using a mock circulation loop (MCL) is essential prior to in vivo or clinical trials. MCLs often consist of only a systemic circulation with no autoregulatory responses and limited validation. This study aimed to develop, and validate against huma...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13636

    authors: Gregory SD,Pauls JP,Wu EL,Stephens A,Steinseifer U,Tansley G,Fraser JF

    更新日期:2020-06-01 00:00:00

  • Pathways for water absorption and physiological role of the lateral interspaces in the kidney tubule.

    abstract::Possible routes for water and salt flow and the most likely theories that describe coupling between water and salt flow across leaky epithelia are presented. The osmotic theories seem the most likely ones. However, several of the theories have weaknesses that render them unsatisfactory, in particular because of the po...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-1594.1987.tb02713.x

    authors: Whittembury G,Carpi-Medina P,González E,Linares H

    更新日期:1987-12-01 00:00:00

  • The compliance problem: a major obstacle in the development of implantable blood pumps.

    abstract::The compliance problem represents a major obstacle in the development of implantable blood pumps. The motor-driven pumps are enclosed in an airtight casing with gas in the motor space. The trapped gas in the motor space either increases the load on the motor during systole or impedes blood sac filling. Potential solut...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1984.tb04248.x

    authors: Lee S,Rosenberg G,Donachy JH,Wisman CB,Pierce WS

    更新日期:1984-02-01 00:00:00

  • The impact of obesity on outcomes in patients receiving extracorporeal life support.

    abstract::Extracorporeal life support (ECLS) has been increasingly utilized to manage cardiac and pulmonary dysfunction. The impact of obesity on outcomes of ECLS is poorly defined. The purpose of the study was to compare in-hospital mortality, resource use, complications, and readmissions in obese versus non-obese patients rec...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13752

    authors: Christian-Miller N,Hadaya J,Nakhla M,Sanaiha Y,Madrigal J,Emami S,Cale M,Sareh S,Benharash P

    更新日期:2020-11-01 00:00:00

  • Hemolysis test of disposable type vibrating flow pump.

    abstract::The vibrating flow pump (VFP) can generate high frequency oscillated blood flow. Because of the high frequency driving with short stroke volume, the pump system can be small. The disposable type VFP (D-VFP) was developed for use for extracorporeal circulation. The electromagnetic actuator was detached from the vibrati...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb03724.x

    authors: Kobayashi S,Nitta S,Yambe T,Sonobe T,Naganuma S,Hashimoto H

    更新日期:1997-07-01 00:00:00

  • Improved retention of endothelial cells seeded on polyurethane small-diameter vascular grafts modified by a recombinant RGD-containing protein.

    abstract::Sponge-type small-diameter vascular grafts were fabricated from a medical-grade polyurethane, Pellethane 2363-80A, by utilization of a salt casting technique. The grafts were compliance matched with a storage modulus of 0.53 +/- 0.08 MPa. The luminal surface of grafts was modified with a thin layer ( approximately 40 ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2003.07141.x

    authors: Hsu SH,Sun SH,Chen DC

    更新日期:2003-12-01 00:00:00

  • Experimental setup to evaluate the performance of percutaneous pulmonary valved stent in different outflow tract morphologies.

    abstract::Percutaneous pulmonary valve implantation is a potential treatment for right ventricular outflow tract (RVOT) dysfunction. However, RVOT implantation site varies among subjects and the success of the procedure depends on RVOT morphology selection. The aim of this study was to use in vitro testing to establish percutan...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2008.00673.x

    authors: Vismara R,Laganà K,Migliavacca F,Schievano S,Coats L,Taylor A,Bonhoeffer P

    更新日期:2009-01-01 00:00:00

  • Stem damage during implantation of modular hip prostheses.

    abstract::Modular hip prostheses are commonly used today. Dedicated surgical auxiliary instrumentation is indispensable. A correct coupling between the prosthesis and the instrument is necessary to avoid damage. Based on a specific commercial design (AnCAFit, Wright Cremascoli Ortho, Toulon, France), the aim of this work was to...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2006.00261.x

    authors: Varini E,Cristofolini L,Viceconti M,Traina F

    更新日期:2006-07-01 00:00:00

  • Is serum albumin a marker of nutritional status in hemodialysis patients without evidence of inflammation?

    abstract::Hypoalbuminemia, a strong predictor of morbidity and mortality in hemodialysis patients, can be a consequence of a combination of malnutrition and inflammatory reactions. The purpose of this study was to analyze serum albumin as a marker of nutritional status in maintenance hemodialysis patients with no signs of infla...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2003.07273.x

    authors: Santos NS,Draibe SA,Kamimura MA,Canziani ME,Cendoroglo M,Júnior AG,Cuppari L

    更新日期:2003-08-01 00:00:00

  • Judicious usage of estrogen/progesterone for angiodysplasia.

    abstract::We recently experienced a case of a female hemodialysis patient with multiple intestinal angiodysplasias. In 2001, she complained of melena, and angiographic embolization halted bleeding from ileum angiodysplasia. In 2002, she again complained of black stool. Abdominal angiography found jejunum angiodysplasia, and pha...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2004.29003.x

    authors: Takenaka T,Kanno Y,Suzuki H

    更新日期:2005-01-01 00:00:00

  • Noninvasive average flow estimation for an implantable rotary blood pump: a new algorithm incorporating the role of blood viscosity.

    abstract::The effect of blood hematocrit (HCT) on a noninvasive flow estimation algorithm was examined in a centrifugal implantable rotary blood pump (iRBP) used for ventricular assistance. An average flow estimator, based on three parameters, input electrical power, pump speed, and HCT, was developed. Data were collected in a ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2007.00339.x

    authors: Malagutti N,Karantonis DM,Cloherty SL,Ayre PJ,Mason DG,Salamonsen RF,Lovell NH

    更新日期:2007-01-01 00:00:00

  • Stent treatment of inferior vena cava compression in an ovine with a total artificial heart.

    abstract::Although current continuous-flow total artificial hearts (CFTAHs) are much smaller than previous models, venous kinking may still occur after device implantation, especially in smaller animals. By inserting a self-expanding stent at the site of venous narrowing in a sheep model implanted with a CFTAH, we were able to ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2011.01233.x

    authors: Tuzun E,Parnis S,Rios J,Winkler JA,Cohn WE

    更新日期:2011-07-01 00:00:00

  • Visually guided performance of simple tasks using simulated prosthetic vision.

    abstract::Loss of photoreceptor cells is one of the major causes of blindness. Several groups are exploring the functional replacement of photoreceptors by a retinal prosthesis. The goal of this study was to simulate the vision levels that recipients of retinal prostheses with 4 x 4, 6 x 10, and 16 x 16 electrode arrays may exp...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2003.07309.x

    authors: Hayes JS,Yin VT,Piyathaisere D,Weiland JD,Humayun MS,Dagnelie G

    更新日期:2003-11-01 00:00:00

  • Miniaturization of a magnetically levitated axial flow blood pump.

    abstract::This article introduces a unique miniaturization process of a magnetically levitated axial flow blood pump from a functional prototype to a pump suitable for animal trials. Through COMSOL three-dimensional finite element analysis and experimental verification, the hybrid magnetic bearings of the pump have been miniatu...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2010.01077.x

    authors: Cheng S,Olles MW,Olsen DB,Joyce LD,Day SW

    更新日期:2010-10-01 00:00:00

  • The response of articular chondrocytes to type II collagen-Au nanocomposites.

    abstract::The nanocomposites (denoted "CII-Au") of porcine type II collagen (CII) with 0.05, 0.1, 0.5, 1, or 2.5% (wt/wt) Au nanoparticles ( approximately 5 nm) were fabricated for potential use in cartilage tissue engineering. Au formed clusters on the surface of all nanocomposites and appeared to distribute along the collagen...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2007.00482.x

    authors: Hsu SH,Yen HJ,Tsai CL

    更新日期:2007-12-01 00:00:00

  • Effects of atrial arrhytmias on the regurgitation of a monoleaflet prosthetic heart valve.

    abstract::Many patients who receive a prosthetic heart valve also have or acquire cardiac arrhythmias. However, most in vitro studies of prosthetic valves examine them under normal rhythms. In this study, a monoleaflet prosthetic heart valve was tested in vitro under conditions that simulated normal sinus rhythm, first degree a...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2005.29101.x

    authors: Zapanta CM

    更新日期:2005-08-01 00:00:00

  • Superior mesenteric artery mycotic aneurysm in patients with left ventricular assist device support and intravenous drug abuse.

    abstract::Mycotic aneurysm of the superior mesenteric artery (SMA) is one of the complications associated with infective endocarditis. However, there are no previous case reports in the literature describing mycotic SMA aneurysm after left ventricular assist device (LVAD) implantation. We describe the case of a 31-year-old male...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2011.01250.x

    authors: Motomura T,Bruckner B,Leon-Becerril J,Anaya-Ayala JE,de Rienzo-Madero B,Bismuth J,Bunge R,Irwin S,Loebe M

    更新日期:2011-07-01 00:00:00

  • In vivo characterization of a decellularized dermis-polymer complex for use in percutaneous devices.

    abstract::To develop a method for making percutaneous devices that have high biocompatibility and do not induce downgrowth of epidermal cells, we prepared a partial decellularized dermis (DD)/poly(methyl methacrylate) (PMMA) complex (PDPC) with a PMMA rod firmly stabilized inside. The porcine decellularized tissue was chosen be...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12330

    authors: Nam K,Matsushima R,Kimura T,Fujisato T,Kishida A

    更新日期:2014-12-01 00:00:00

  • Development of an intravascular pumping oxygenator using a new silicone membrane.

    abstract::A new intravascular pumping oxygenator (IVPO) was developed for intravascular gas exchange and circulatory assistance in critically ill patients with respiratory and circulatory failure. The IVPO utilizes new silicone hollow fibers (diameter, 1 mm; membrane width, 50 microns) and consists of two driving tubes for the ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb00703.x

    authors: Sueda T,Fukunaga S,Morita S,Sueshiro M,Hirai S,Okada K,Orihashi K,Matsuura Y

    更新日期:1997-01-01 00:00:00

  • Angiographic and pathological studies on regression of coronary atherosclerosis of FH patients who received LDL-apheresis treatment.

    abstract::We report on the most recent data confirming the angiographic and pathological efficacy of LDL-apheresis for coronary atherosclerosis of a familial hypercholesterolemia (FH) patient using collected data of a large number of cases and especially of one autopsy case. Changes in coronary artery stenosis have been assesse...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1992.tb00289.x

    authors: Koga N,Iwata Y,Yamamoto A

    更新日期:1992-04-01 00:00:00

  • Sensitivity of the primary stability of a cementless hip stem to its position and orientation.

    abstract::Using computed tomography (CT)-based preoperative planning software, we can define with good accuracy the position of a cementless hip stem inside the host bone, but previous studies suggest that the pose the surgeon achieves during freehand surgery may differ from the planned one even by some millimeters. Advances in...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2008.00577.x

    authors: Reggiani B,Cristofolini L,Taddei F,Viceconti M

    更新日期:2008-07-01 00:00:00

  • Evaluation of double filtration plasmapheresis, thermofiltration, and low-density lipoprotein adsorptive methods by crossover test in the treatment of familial hypercholesterolemia patients.

    abstract::A comparative assessment has been made regarding efficacy and safety of the double filtration plasmapheresis (DFPP), thermofiltration (TFPP), and low-density lipoprotein (LDL) adsorptive (PA) methods by making a crossover test on heterozygous familial hypercholesterolemia patients. Treatments by DFPP, TFPP (secondary ...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1996.tb04448.x

    authors: Suzuki M,Yamane S,Matsugane T,Nobuto T,Azuma N,Nishide T,Shinomiya M,Saito K,Sasaki N,Nosé Y

    更新日期:1996-04-01 00:00:00