Abstract：
:Renal Solutions Allient Sorbent Hemodialysis System utilizes a two-chambered pneumatic pump (Pulsar Blood Pump, Renal Solutions, Inc., Warrendale, PA, USA) to avoid limitations associated with peristaltic pumping systems. Single-needle access is enabled by counter-pulsing the two pump chambers, thereby obviating compliance chambers or blood reservoirs. Each chamber propels 20 cc per pulse of 3 s (dual access) or 6 s (single access) duration, corresponding to a peak Reynolds number of approximately 8000 (based on inlet velocity and chamber diameter). A multimodal series of flow visualization studies (tracer particle, dye washout, and dye erosion) was conducted on a sequence of pump designs with varying port locations and diaphragms to improve the geometry with respect to risk of thrombogenesis. Experiments were conducted in a simplified flow loop using occluders to simulate flow resistance induced by tubing and dialyzer. Tracer visualization revealed flow patterns and qualitatively indicated turbulence intensity. Dye washout identified dwell volume and areas of flow stagnation for each design. Dye erosion results indicated the effectiveness and homogeneity of surface washing. Compared to a centered inlet which resulted in a fluid jet that produced two counter-rotating vortices, a tangential inlet introduced a single vortex, and kept the flow laminar. It also provided better surface washing on the pump inner surface. However, a tangential outlet did not present as much benefit as expected. On the contrary, it created a sharp defection to the flow when transiting from filling to ejection.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Shu F,Parks R,Maholtz J,Ash S,Antaki JFdoi
10.1111/j.1525-1594.2009.00724.xsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
334-45issue
4eissn
0160-564Xissn
1525-1594pii
AOR724journal_volume
33pub_type
杂志文章abstract：:A beta2-microglobulin (beta2M) selective adsorbent (Lixelle) for direct hemoperfusion has been used for the treatment of hemodialysis patients with the long-term complication of dialysis related amyloidosis (DRA), but there is no significant correlation between the serum level of beta2M and the occurrence of DRA. Infl...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.1998.06179.x
更新日期：1998-12-01 00:00:00
abstract：:The major restrictions to the transport of solute and solvent across the peritoneum are the limited peritoneal blood flow, area and permeability. Recent investigations have demonstrated that several vasoactive drugs influence transport parameters. Isoproterenol, nitroprusside, dipyridamole and dopamine exemplify drugs...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1979.tb01052.x
更新日期：1979-08-01 00:00:00
abstract：:In bioartificial pancreatic systems, isolated islets of Langerhans are protected against immune rejection by an artificial membrane, permeable to glucose and insulin, but not to immunoglobulins and lymphocytes. Some of these devices, referred to as vascular systems, are set up to be connected to a vascular site in the...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1990.tb01588.x
更新日期：1990-02-01 00:00:00
abstract：:There are presently no short-term in vitro fatigue tests available that can predict long-term in vivo performance of elastomers in physiological environments. Thus, the introduction of new and better elastomers for cardiovascular applications is hampered in the development stage by lack of data about which materials s...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1983.tb04162.x
更新日期：1983-02-01 00:00:00
abstract：:There is increasing evidence showing that adult stem cells are useful for tissue regeneration. Bone marrow mesenchymal stem cells (MSCs) are self-renewing and are potent in differentiating into multiple cells and tissues. To investigate the practicability of repairing burn wounds with tissue-engineered (TE) skin combi...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2008.00654.x
更新日期：2008-12-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.13503
更新日期：2019-10-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1992.tb00527.x
更新日期：1992-08-01 00:00:00
abstract：:To elucidate the precise mechanism of carpal tunnel syndrome (CTS), serum hyaluronic acid (HA), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were measured in 71 chronic hemodialysis patients with or without CTS and/or shoulder pain. Patients were divided into two gr...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1994.tb02227.x
更新日期：1994-06-01 00:00:00
abstract：:Fibroblast cell culture was performed to evaluate cell adhesion and cell morphology on novel hydrolyzable copolymers composed of poly(D,L-lactic acid) (PDLA) macromonomer, 2-methacryloyloxyethyl phosphorylcholine (MPC), and n-butyl methacrylate. The copolymers were used as cell culture materials for regulating the int...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.2003.07015.x
更新日期：2003-03-01 00:00:00
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journal_title：Artificial organs
pub_type： 临床试验,杂志文章
doi：10.1111/j.1525-1594.1982.tb04146.x
更新日期：1982-11-01 00:00:00
abstract：:The neutralization of bacterial endotoxins (ET) is still an unsolved problem in therapeutic medicine. The efficacy of anti-endotoxin antibodies or receptor antagonists and other substances interfering with the endotoxin-induced pathomechanisms is dependent on an intact cellular degradation system of the host. However,...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1993.tb00630.x
更新日期：1993-09-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章,评审
doi：10.1111/aor.12600
更新日期：2016-06-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12268
更新日期：2014-11-01 00:00:00
abstract：:The Genius is a convenient single-pass batch hemodialysis system. Dialysate is heated during the preparation phase. Once the container is filled at one of the three available starting temperatures, dialysate cools spontaneously. As dialysate temperature plays an important role in hemodynamic stability, knowledge of th...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2009.00981.x
更新日期：2010-12-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.1998.06017.x
更新日期：1998-08-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1997.tb00363.x
更新日期：1997-04-01 00:00:00
abstract：:This article introduces a unique miniaturization process of a magnetically levitated axial flow blood pump from a functional prototype to a pump suitable for animal trials. Through COMSOL three-dimensional finite element analysis and experimental verification, the hybrid magnetic bearings of the pump have been miniatu...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2010.01077.x
更新日期：2010-10-01 00:00:00
abstract：:Spiral/helical forms of blood flow have been observed in large arteries of the cardiovascular system, but their benefits remain underappreciated. Spiral flow has been postulated to improve near-wall washout, promoting anti-atherothrombotic conditions. This research aims to study the washout characteristics of spiral f...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.13520
更新日期：2019-12-01 00:00:00
abstract：:The thrombogenicity of membrane oxygenators as well as clotting parameters profiles, using standard human clotting tests, was analyzed in calves and pigs during 6 h perfusion. Three calves and 3 pigs were connected to extracorporeal circulation with standard heparinization. Blood samples were taken for coagulation var...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.2001.025007579.x
更新日期：2001-07-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1989.tb01561.x
更新日期：1989-10-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.1998.6184r.x
更新日期：1998-09-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12748
更新日期：2017-01-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12678
更新日期：2016-08-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12002
更新日期：2013-05-01 00:00:00
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journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1983.tb04192.x
更新日期：1983-05-01 00:00:00
abstract：:Existing peritoneal dialysis (PD) solutions were formulated for the maintenance of fluid and electrolyte balance, correction of metabolic acidosis, and the removal of metabolic waste products. Solutions currently in development are designed to improve biocompatibility by neutralizing pH and reducing glucose degradatio...
journal_title：Artificial organs
pub_type： 杂志文章,评审
doi：10.1046/j.1525-1594.1998.06022.x
更新日期：1998-01-01 00:00:00
abstract：:Insufficient unloading of the left ventricle with blood stagnation is a main cause of unsuccessful left ventricular (LV) recovery during percutaneous cardiopulmonary support (PCPS). The purpose of this investigation was to evaluate the effectiveness of transaortic catheter venting (TACV) for LV unloading. Six adult mo...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1997.tb03744.x
更新日期：1997-07-01 00:00:00
abstract：:Percutaneous femoral venoarterial (VA) or jugular venovenous (VV) extracorporeal membrane oxygenation (ECMO) can result in delivery of hypoxic blood to the brain, coronaries, and upper extremities. Additionally, VA-ECMO by percutaneous femoral artery cannulation may compromise perfusion to the lower limbs. Use of near...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2012.01496.x
更新日期：2012-08-01 00:00:00
abstract：:One hundred and seventy-two patients at The Methodist Hospital in Houston, Texas, were placed on BioMedicus centrifugal ventricular support. One hundred thirty-nine patients were male and 33 were female with a mean age of 59.7 years. Reasons for support were postcardiotomy cardiac failure (129 patients), cardiac allog...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1995.tb02419.x
更新日期：1995-07-01 00:00:00
abstract：:The purpose of this study was to characterize changes in hepatic venous pressures in patients with chronic hepatitis C. The histology and laboratory data from patients with chronic hepatitis C who underwent a transjugular liver biopsy (TJLB) and hepatic venous pressure gradient measurement were analyzed. Portal hypert...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2009.00925.x
更新日期：2010-07-01 00:00:00
