Abstract:
:The major restrictions to the transport of solute and solvent across the peritoneum are the limited peritoneal blood flow, area and permeability. Recent investigations have demonstrated that several vasoactive drugs influence transport parameters. Isoproterenol, nitroprusside, dipyridamole and dopamine exemplify drugs that dilate the splanchnic vasculature, thereby augmenting transport, whereas vasoconstriction induced by l-norepinephrine decreases clearances. The tissue prostaglandins affect peritoneal mass transport in accord with their known vasoactive effects, suggesting a role in modulating peritoneal blood flow. The gastrointestinal hormones vasodilate the splanchnic circulation. Exposure of the endothelial surface to glucagon markedly increases peritoneal mass transport, while secretin increases the ultrafiltration rate significantly. These preliminary studies suggest the possible future clinical use of drugs and hormones to augment the efficiency of peritoneal dialysis.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Maher JFdoi
10.1111/j.1525-1594.1979.tb01052.xsubject
Has Abstractpub_date
1979-08-01 00:00:00pages
224-7issue
3eissn
0160-564Xissn
1525-1594journal_volume
3pub_type
杂志文章abstract::The Symbion Acute Ventricular Assist Device (AVAD) System is an experimental paracorporeal pulsatile ventricular assist device (VAD) for single or biventricular assist. Eleven patients were implanted but 2 died within 24 h and were excluded from the study. Nine patients, four with left ventricular assist devices (LVAD...
journal_title:Artificial organs
pub_type: 临床试验,杂志文章
doi:10.1111/j.1525-1594.1989.tb01575.x
更新日期:1989-12-01 00:00:00
abstract::Infusion into rats of the polycation hexadimethrine (HDM) leads to onset of massive proteinuria, which recovers when the infusion is stopped. Several lines of evidence indicate that the proteinuria results from binding of HDM to polyanions of the glomerular filter, with neutralization of shielding of their charges. To...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1987.tb02712.x
更新日期:1987-12-01 00:00:00
abstract::The aims of this study were to investigate whether introducing an interphase interval (IPI) to biphasic pulses during stimulation of the dorsiflexor muscles would affect force production and to determine whether the IPI effect is dependent on electrode position. Twelve healthy volunteers participated in the study. Eac...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.12346
更新日期:2014-11-01 00:00:00
abstract::Five typical mechanical heart valves (Starr-Edwards, Björk-Shiley convexo-concave (c-c), Björk-Shiley monostrut, Bicer-Val, and St. Jude Medical) were tested in the mitral position under the pulsatile flow condition. The test program included measurements of velocity and turbulent stresses at 5 downstream locations. T...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1997.tb00451.x
更新日期:1997-10-01 00:00:00
abstract::We have been developing some types of microcapsule suspensions with polyurethane membranes to evaluate the absolute hemolytic characteristics of the centrifugal blood pumps used in circulatory support devices such as artificial hearts. In order to facilitate/realize hemolysis testing on centrifugal blood pumps that ha...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.2007.00503.x
更新日期:2008-02-01 00:00:00
abstract::A method of creating multifocal ischemia in animals leading to left ventricular (LV) functional impairment is described. In a series of 10 mongrel dogs, electrodes were implanted in multiple branches of the coronary arteries. Subsequently, in seven animals, an 800-microA anodal current was applied for 3 h repeatedly o...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1984.tb04321.x
更新日期:1984-11-01 00:00:00
abstract::Aortic wall thinness was one of the most characteristic changes observed in experimental animals under prolonged continuous flow left heart bypass. The goal of this study was to determine the roles of smooth muscle cells in the vascular remodeling process in cases demonstrating aortic wall thinness under prolonged con...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1046/j.1525-1594.2003.00022.x
更新日期:2003-10-01 00:00:00
abstract::A comparative study of the thrombogenicity of several microporous membranes was performed using an ex vivo system simulating the conditions in an artificial lung. A study of platelet adhesion and adsorbed protein layer indicated that the membranes separated into three groups. Copolyurethane membranes adsorbed very few...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1985.tb04343.x
更新日期:1985-02-01 00:00:00
abstract::The polymer poly(ε-caprolactone) (PCL) has been used in the biomaterial field for its relatively inexpensive price and suitability for modification. Also, its chemical and biological properties are desirable for biomedical applications. The electrospinning process has been used for producing polymer fibers of PCL due ...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.13713
更新日期:2020-08-01 00:00:00
abstract::The effect of age on the calcification of biomaterials was studied by the subcutaneous implantation of poly(hydroxyethyl methacrylate) hydrogel in rats. The hydrogel sheets were implanted in rats 6, 12, 24, and 52 weeks (1 year) of age. The retrieved implants were compared and the percentage weight increase by mineral...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1985.tb04388.x
更新日期:1985-08-01 00:00:00
abstract::The thrombogenicity of membrane oxygenators as well as clotting parameters profiles, using standard human clotting tests, was analyzed in calves and pigs during 6 h perfusion. Three calves and 3 pigs were connected to extracorporeal circulation with standard heparinization. Blood samples were taken for coagulation var...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1046/j.1525-1594.2001.025007579.x
更新日期:2001-07-01 00:00:00
abstract::In chronic cardiomyopathy, mechanical circulatory support (MCS) plays an increasingly important role for children as the shortage of suitable donor hearts increases waiting time on the transplant list. We report our experience with the paracorporal Berlin Heart EXCOR System (Berlin Heart AG, Berlin, Germany) used as a...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.12062
更新日期:2013-08-01 00:00:00
abstract::In bioartificial pancreatic systems, isolated islets of Langerhans are protected against immune rejection by an artificial membrane, permeable to glucose and insulin, but not to immunoglobulins and lymphocytes. Some of these devices, referred to as vascular systems, are set up to be connected to a vascular site in the...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1990.tb01588.x
更新日期:1990-02-01 00:00:00
abstract::Recently, the use of electrolyzed solutions has attracted considerable interest in Japan. This study investigates the efficiency of electrolyzed solutions as disinfecting agents (DA) in the reuse of dialyzers and compares their efficiency to that of other disinfectants currently in use. The following 3 methods were em...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1046/j.1525-1594.2000.06611.x
更新日期:2000-12-01 00:00:00
abstract::To develop an effective hybrid bioartificial liver (BAL) device, the material of the scaffold is very important to support hepatocytes that have both growth ability and hepatic differentiated functions. In this study we used paper (Kimwipe, Kimberly-Clark Corp., Roswell, GA, U.S.A.) as a scaffold. Primary hepatocytes ...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1046/j.1525-1594.2000.06506.x
更新日期:2000-04-01 00:00:00
abstract::Tubular polymer scaffolds based on tissue engineering techniques have been studied as potential alternatives for vascular regeneration implants. The blood vessels of the cardiovascular system are mainly fibrous, composed of collagen (Col) and elastin (El), and its inner layer consists of endothelial cells. In this wor...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.13857
更新日期:2020-11-10 00:00:00
abstract::Cardiac monitoring of ventricular assist devices (VADs) is important for detecting heart failure risks, such as critical arrhythmia and ventricular fibrillation, and for supplying data that are useful for hemodynamic control. Specifically, impedance cardiograms (ICGs) are especially beneficial because they have no eff...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.2011.01381.x
更新日期:2012-05-01 00:00:00
abstract::The rotational axis of the centrifugal pump has some associated problems such as blood destruction and sealing between the axis and pump housing. To improve upon these deficits we have developed a new type of blood pump, the magnetic rotary pump (MRP). The MRP has an original design with no rotational axis and no impe...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1997.tb03734.x
更新日期:1997-07-01 00:00:00
abstract::Progress in the techniques for surgical implantation of the artificial heart has progressed in parallel with the technology and design of the prosthesis. In the author's first experience with total artificial heart (TAH) implantation (1968) a trans-sternal split was used opening the sixth intercostal space on the righ...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1977.tb00984.x
更新日期:1977-11-01 00:00:00
abstract::Different from the existing tissue engineering strategies, rapid prototyping (RP) techniques aim to automatically produce complex organs directly from computer-aided design freeform models with high resolution and sophistication. Analogous to building a nuclear power plant, cell biology (especially, renewable stem cel...
journal_title:Artificial organs
pub_type: 杂志文章,评审
doi:10.1111/j.1525-1594.2012.01499.x
更新日期:2012-11-01 00:00:00
abstract::Myristoyl gelatin (MG) retains its gel structure at temperatures above body temperature without any crosslinking. As a coating material, MG adheres well to polyester fibers, and the outermost layers of the sealant that are in contact with blood or surrounding tissue become hydrophilic. We produced MG-impregnated knitt...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1997.tb00363.x
更新日期:1997-04-01 00:00:00
abstract::Patients with end-stage renal disease have a very high prevalence and extent of arterial calcification. A number of studies suggest that similar pathophysiologic mechanisms are responsible for development and progression of calcification of atherosclerotic plaque and bone formation. Fetuin-A is a potent calcification ...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.2009.00814.x
更新日期:2009-10-01 00:00:00
abstract::One hundred and seventy-two patients at The Methodist Hospital in Houston, Texas, were placed on BioMedicus centrifugal ventricular support. One hundred thirty-nine patients were male and 33 were female with a mean age of 59.7 years. Reasons for support were postcardiotomy cardiac failure (129 patients), cardiac allog...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1995.tb02419.x
更新日期:1995-07-01 00:00:00
abstract::The specific timing for discontinuing renal replacement therapy (RRT) in acute kidney injury (AKI) patients is debatable. The predictive abilities of variables at the time of discontinuation of RRT for the long-term prognoses of patients have not been explored. This study aimed to explore the prognostic factors upon d...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.12927
更新日期:2017-12-01 00:00:00
abstract::Cardiac surgery with cardiopulmonary bypass is associated with a systemic inflammatory response syndrome. The major clinical features of this include a reduction of pulmonary compliance and increased extracellular fluids, with increased pulmonary shunt fraction similar to acute respiratory distress syndrome, thus resu...
journal_title:Artificial organs
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1525-1594.2009.00777.x
更新日期:2009-08-01 00:00:00
abstract::Bicarbonate balance is usually calculated from the Henderson-Hasselbalch equation under the assumption that pK is constant. To evaluate the pK variability and its effects on bicarbonate computed with autoanalyzers in dialysis patients, we studied 44 patients on maintenance hemodialysis. The pH, PCO2, total CO2, and pK...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1987.tb02715.x
更新日期:1987-12-01 00:00:00
abstract::Hemolysis is one of the most important performance parameters of blood pumps. However, comparative in vitro evaluation of the reported hemolysis effect is difficult owing to the lack of uniformity in the test methods used. Currently, three types of formulas are generally accepted and widely used for the index of hemol...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1994.tb03292.x
更新日期:1994-01-01 00:00:00
abstract::Rotary blood pumps are emerging as a viable technology for total artificial hearts, and the development of physiological control algorithms is accelerated with new evaluation environments. In this article, we present a novel hybrid mock circulation loop (HMCL) designed specifically for evaluation of rotary total artif...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.12380
更新日期:2014-09-01 00:00:00
abstract::The limited success of cardiac stem cell therapy has lately generated discussion regarding its effectiveness. We hypothesized that immediate cell loss after intramyocardial injection significantly obscures the regenerative potential of stem cell therapy. Therefore, our aim was to assess the distribution and quantity o...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.12268
更新日期:2014-11-01 00:00:00
abstract::Extracorporeal human lymphatic organs are expected to be excellent tools in the study of human molecular and cellular bases of the immunologic balance and tissue harmony. A rational approach and process to design a device and a procedure to recreate the human lymph node environment in vitro is described with emphasis ...
journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.2006.00303.x
更新日期:2006-10-01 00:00:00