A human lymph node in vitro--challenges and progress.

Abstract:

:Extracorporeal human lymphatic organs are expected to be excellent tools in the study of human molecular and cellular bases of the immunologic balance and tissue harmony. A rational approach and process to design a device and a procedure to recreate the human lymph node environment in vitro is described with emphasis on T-cell activation. Based on this approach, a bioreactor and a process supporting self-assembly of human lymphatic tissues due to proper emulation of human architecture and homeostasis could be developed.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Giese C,Demmler CD,Ammer R,Hartmann S,Lubitz A,Miller L,Müller R,Marx U

doi

10.1111/j.1525-1594.2006.00303.x

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

803-8

issue

10

eissn

0160-564X

issn

1525-1594

pii

AOR303

journal_volume

30

pub_type

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