Hemolysis test of a centrifugal pump in a pulsatile mode: the effect of pulse rate and RPM variance.

Abstract:

:Centrifugal pumps are generally employed as nonpulsatile blood flow pumps; however, these pumps can produce pulsatile flow by periodically alternating the impeller rotation speed. This study investigates blood trauma due to the effect of pulse frequency and various ranges of pump speed. The hemolysis tests were conducted using the Gyro C1E3 pump. The study was divided into the following categories: Group 1 in a nonpulsatile mode; Group 2 operated at 40 bpm with 30% of speed variance; Group 3, 60 bpm with 30% of speed variance; Group 4, 40 bpm with 70% of speed variance; and Group 5, 60 bpm with 70% of speed variance. A flow rate of 3 L/min and a total pressure head of 200 mm Hg were employed in all groups to simulate a percutaneous cardiopulmonary support condition. There were no significant differences in the hemolysis levels among Groups 1, 2, and 3. However, Groups 4 and 5 exhibited a significantly higher hemolysis rate compared to the other groups. These results indicate that a high rate of speed variance increases hemolysis; however, a range of less than 30% does not affect hemolysis. The pulse rate has no significant effect on hemolysis. In conclusion, the higher speed variance increases the hemolysis level when a pulsatile mode is applied with a centrifugal pump at the given test conditions. However, a speed variance of less than 30% or a pulse rate of less than 60 bpm does not affect hemolysis.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Tayama E,Niimi Y,Takami Y,Ohashi Y,Ohtsuka G,Glueck JA,Mueller J,Nosé Y

doi

10.1111/j.1525-1594.1997.tb00489.x

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

1284-7

issue

12

eissn

0160-564X

issn

1525-1594

journal_volume

21

pub_type

杂志文章
  • Effect of heparin, platelets, activated platelets, platelet fragments, and hematocrit on activated clotting time.

    abstract::Activated clotting time (ACT) is the most commonly used laboratory test to control the heparin effect during extracorporeal techniques. The study was undertaken in order to test in vitro the influence of heparin, platelet count, hematocrit, platelet fragmentation, and platelet activation on ACT. Blood was drawn from v...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2000.06552.x

    authors: Girardi L,Sudi K,Muntean W

    更新日期:2000-07-01 00:00:00

  • Surface modification of silicone rubber membrane by plasma induced graft copolymerization as artificial cornea.

    abstract::In this study a highly biocompatible polymer membrane was prepared by surface modification. An artificial cornea was also developed for clinical applications. Silicone rubber (SR) membrane was grafted with hydrophilic monomers such as 2-hydroxyethyl methacrylate (HEMA) and acrylic acid by plasma induced grafted polyme...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1996.tb00661.x

    authors: Hsiue GH,Lee SD,Chang PC

    更新日期:1996-11-01 00:00:00

  • Percutaneous introduction of left atrial cannula for left heart bypass: utility of biplane transesophageal echocardiographic guidance for transseptal puncture.

    abstract::For introduction of a left atrial (LA) cannula by the transseptal puncture technique, we examined the feasibility of using biplane transesophageal echocardiography (B-TEE). A transseptal puncture was performed on 15 patients (3 male; 12 female; mean age, 48.9 +/- 11.2 years) by B-TEE guide during percutaneous transven...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1992.tb00537.x

    authors: Kyo S,Motoyama T,Miyamoto N,Noda H,Dohi Y,Omoto R

    更新日期:1992-08-01 00:00:00

  • Pulse conductance and flow-induced hemolysis during pulsatile cardiopulmonary bypass.

    abstract::In this study, the hypothesis was tested that a low-resistant, high-compliant oxygenator provides better pulse conductance and less hemolysis than a high-resistant, low-compliant oxygenator during pulsatile cardiopulmonary bypass. Forty adults undergoing coronary artery bypass surgery were randomly divided into two gr...

    journal_title:Artificial organs

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1525-1594.2009.00853.x

    authors: Simons AP,Wortel P,van Kan RA,van der Veen FH,Weerwind PW,Maessen JG

    更新日期:2010-04-01 00:00:00

  • Measurement of the closing behavior of the björk-shiley monoleaflet mechanical heart valve with an electrohydraulic total artificial heart.

    abstract::When cavitation occurs near a material surface of a mechanical heart valve (MHV), pits on the surface of the MHV and hemolysis are caused. Therefore, it is very important to investigate the possibility of the occurrence of cavitation in an MHV. To study the possibility of cavitation occurrence in a 25 mm Björk-Shiley ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2003.06981.x

    authors: Lee H,Tsukiya T,Homma A,Taenaka Y,Tatsumi E,Takano H

    更新日期:2003-08-01 00:00:00

  • Performance of baffled bubble blood oxygenators.

    abstract::Bubble blood oxygenators equipped with baffles of various types in the oxygenating column were studied. The rate of hemolysis, the volumetric coefficient for oxygen absorption into blood, and the fractional gas holdup were found to be affected mainly by the superficial gas velocity. When compared with the conventional...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1979.tb01032.x

    authors: Ohshima N,Yoshido F

    更新日期:1979-05-01 00:00:00

  • The status of pacemaker implantations in Japan.

    abstract::It has been over 40 years since the initial clinical application of a cardiac pacemaker. Currently, approximately 300 per million patients in the United States and Europe are kept alive owing to the benefit of implantable pacemakers. Recently, the Japanese Cardiac Pacing Society and the Japanese Society of Artificial ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1994.tb03303.x

    authors: Kojima R

    更新日期:1994-01-01 00:00:00

  • Evaluation of double filtration plasmapheresis, thermofiltration, and low-density lipoprotein adsorptive methods by crossover test in the treatment of familial hypercholesterolemia patients.

    abstract::A comparative assessment has been made regarding efficacy and safety of the double filtration plasmapheresis (DFPP), thermofiltration (TFPP), and low-density lipoprotein (LDL) adsorptive (PA) methods by making a crossover test on heterozygous familial hypercholesterolemia patients. Treatments by DFPP, TFPP (secondary ...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1525-1594.1996.tb04448.x

    authors: Suzuki M,Yamane S,Matsugane T,Nobuto T,Azuma N,Nishide T,Shinomiya M,Saito K,Sasaki N,Nosé Y

    更新日期:1996-04-01 00:00:00

  • A Pseudo-One Compartment Model of Phosphorus Kinetics During Hemodialysis: Further Supporting Evidence.

    abstract::A pseudo-one compartment model has been proposed to describe phosphorus kinetics during hemodialysis and the immediate post-dialysis period. This model assumes that phosphorus mobilization from tissues is proportional to the difference between the pre-dialysis serum concentration (a constant) and the instantaneous ser...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12897

    authors: Leypoldt JK,Agar BU,Cheung AK,Bernardo AA

    更新日期:2017-11-01 00:00:00

  • Doppler ultrasonic detection of particulate release during hemodialysis with cellulose hollow-fiber and sorbent suspension reciprocating dialyzers.

    abstract::Doppler ultrasound is a noninvasive technique for monitoring moving objects such as flowing blood while ignoring stationary objects such as shunt tubing. A Doppler system was investigated to determine its sensitivity in detecting particulate release in blood during hemodialysis. Seven hemodialysis procedures with dogs...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1984.tb04275.x

    authors: Badylak SF,Ash SR,Thornhill JA,Carr DJ

    更新日期:1984-05-01 00:00:00

  • Device exchange versus nonexchange modalities in left ventricular assist device-specific infections: A systematic review and meta-analysis.

    abstract::No standardized treatment algorithm exists for the management of continuous-flow left ventricular assist device (CF-LVAD)-specific infections. The aim of this systematic review and meta-analysis was to compare the outcomes of CF-LVAD-specific infections as managed by device exchange to other treatment modalities not i...

    journal_title:Artificial organs

    pub_type: 杂志文章,meta分析

    doi:10.1111/aor.13378

    authors: Bauer TM,Choi JH,Luc JGY,Weber MP,Moncho Escrivá E,Patel S,Maynes EJ,Boyle AJ,Samuels LE,Entwistle JW,Morris RJ,Massey HT,Tchantchaleishvili V

    更新日期:2019-05-01 00:00:00

  • Modified DALI LDL-apheresis using trisodium citrate anticoagulation plus bicarbonate or lactate-buffered hemofiltration substitution fluids as primers.

    abstract:BACKGROUND:DALI (direct adsorption of lipids) is the first LDL-apheresis technique able to adsorb low-density lipoprotein (LDL) and lipoproteina) directly from whole blood. In the standard procedure, acid citrate dextrose (ACD-A) is used as anticoagulation and the adsorber is rinsed with a specially manufactured primin...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1525-1594.2003.07104.x

    authors: Bosch T,Wendler T,Maschke H

    更新日期:2003-06-01 00:00:00

  • Renal complications of infected ventriculoatrial shunts.

    abstract::Contamination of a ventriculoatrial shunt (VAS) with skin organisms that are usually nonpathogenic may be followed by an immunologically mediated renal injury. The bacteria characteristically involved are coagulase-negative Staphylococci (e.g., Staphylococcus epidermidis), which strongly adhere to the plastic surface ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1993.tb00617.x

    authors: Samtleben W,Bauriedel G,Bosch T,Goetz C,Klare B,Gurland HJ

    更新日期:1993-08-01 00:00:00

  • Microcirculation and artificial heart research.

    abstract::Small blood vessels may play a more important role in artificial heart (AH) recipients than ever suspected before. Observations of elevated total peripheral resistance, low hematocrit, reduced oncotic pressure, high circulating blood volume, and arterial pulsations with nonpulsatile devices require consideration of pe...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1988.tb01529.x

    authors: Lübbe AS

    更新日期:1988-02-01 00:00:00

  • Pretreatment With Inactivated Bacillus Calmette-Guerin Increases CD4+CD25+ Regulatory T Cell Function and Decreases Functional and Structural Effects of Asthma Induction in a Rat Asthma Model.

    abstract::Bacillus Calmette-Guerin (BCG) has been shown to have therapeutic effects on asthma through CD4+CD25+ regulatory T cells (Tregs). We sought to assess pretreatment with inactivated BCG on CD4+CD25+ Tregs and its functional and structural effects in rat asthma model. The rat asthma model was established using ovalbumin ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12566

    authors: Gong P,Li Y,Tan YP,Li H

    更新日期:2016-04-01 00:00:00

  • Oral treatment for jaundice using immobilized bilirubin oxidase.

    abstract::Jaundice is characterized by an excessive accumulation of bilirubin in the blood and tissues. A novel approach to reduce plasma levels of bilirubin by blocking its enterohepatic circulation was investigated. The treatment consisted of oral administration of immobilized bilirubin oxidase, which could oxidize bilirubin ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1992.tb00527.x

    authors: Soltys PJ,Mullon C,Langer R

    更新日期:1992-08-01 00:00:00

  • The roles of vascular smooth muscle cells in the aortic wall thinness under prolonged continuous flow left heart bypass.

    abstract::Aortic wall thinness was one of the most characteristic changes observed in experimental animals under prolonged continuous flow left heart bypass. The goal of this study was to determine the roles of smooth muscle cells in the vascular remodeling process in cases demonstrating aortic wall thinness under prolonged con...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2003.00022.x

    authors: Mizuno T,Nishinaka T,Ohnishi H,Tatsumi E,Tsukiya T,Oshikawa M,Shioya K,Takewa Y,Homma A,Takano H,Kitamura S,Taenaka Y

    更新日期:2003-10-01 00:00:00

  • Selective inhibition of resistance to hemopoietic allografts but not rejection to a natural killer cell sensitive tumor in transgenic mice for granulocyte colony stimulating factor.

    abstract::Transplanted allogeneic marrow grafts often fail to engraft in a lethally irradiated host. Resistance to hemopoietic allograft is a complexed phenomenon involving multiple components. To study the involvement of a hemopoietic cytokine, which was known to play a role for stem cell function, we established lines of mice...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1996.tb04563.x

    authors: Kokai Y,Kimura H,Matsuura A,Fujimoto J

    更新日期:1996-08-01 00:00:00

  • HeartWare Ventricular Assist Device Implantation for Pediatric Heart Failure-A Single Center Approach.

    abstract::While pediatric HeartWare HVAD application has increased, determining candidacy and timing for initiation of pediatric VAD support has remained a challenge. We present our experience with a systematic approach to HVAD implantation as a bridge to pediatric heart transplantation. We performed a retrospective, single cen...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.13344

    authors: Nelson McMillan K,Hibino N,Brown EE,Wadia R,Hunt EA,Marshall C,Alvarez-Machado M,Alejo D,Coulson JD,Ravekes W,Vricella LA

    更新日期:2019-01-01 00:00:00

  • Fluid dynamic characteristics of the VentrAssist rotary blood pump.

    abstract::The VentrAssist pump has no shaft or seal, and the device is unique in design because the rotor is suspended passively by hydrodynamic forces, and urging is accomplished by an integrated direct current motor rotor that also acts as the pump impeller. This device has led to many challenges in its fluidic design, namely...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2000.06584.x

    authors: Tansley G,Vidakovic S,Reizes J

    更新日期:2000-06-01 00:00:00

  • Lipid apheresis: from a heroic treatment to routine clinical practice.

    abstract::Lipid apheresis has developed from a heroic treatment into a routine clinical therapy and currently is the major indication for performing extracorporeal plasma therapy. Whereas it was once reserved for patients with homozygous familial hypercholesterolemia, today it has a place in the secondary prevention of severe c...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-1594.1996.tb04525.x

    authors: Bosch T

    更新日期:1996-05-01 00:00:00

  • Reduction of driveline infections through doubled driveline tunneling of left ventricular assist devices.

    abstract::The durability of ventricular assist device (VAD) therapy improved steadily over the past years. However, driveline infections remain a challenge. To test whether an improved surgical implantation technique may lower the incidence of infections, we analyzed all patients receiving a VAD implantation in the years 2008 a...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12036

    authors: Fleissner F,Avsar M,Malehsa D,Strueber M,Haverich A,Schmitto JD

    更新日期:2013-01-01 00:00:00

  • Cellulose acetate beads activate the complement system but inactivate the anaphylatoxins generated.

    abstract::The generation of anaphylatoxins, particularly C5a, is important in extracorporeal circulation therapies such as granulocyte/monocyte apheresis, which activates the complement system and elevates C5a levels. However, no side effects of granulocyte/monocyte apheresis using cellulose acetate beads have been reported. To...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00995.x

    authors: Takeda Y,Ohba M,Ueno M,Saniabadi AR,Wakabayashi I

    更新日期:2010-12-01 00:00:00

  • Differences in intravenous and subcutaneous application of recombinant human erythropoietin: a multicenter trial.

    abstract::The aims of this clinical study were to compare the maintenance doses for intravenous (i.v.) and subcutaneous (SC) administration of recombinant human erythropoietin (rhEPO) and to investigate whether there is any difference in the increase of the packed cellular volume (PCV) per week under i.v. and SC administration ...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1525-1594.1994.tb03378.x

    authors: Schaller R,Sperschneider H,Thieler H,Dutz W,Hans S,Voigt D,Marx M,Engelmann J,Schöter KH,Scigalla P

    更新日期:1994-08-01 00:00:00

  • Physiologic control of cardiac assist devices.

    abstract::Total artificial hearts (TAHs) and biventricular assist devices (BVADs) have varying levels of acceptance and reliability, and the research on both focuses on their control mechanisms. Efforts generally aim to achieve a response to physiologic demand and left/right output balance, and beneficial cardiac output (CO) an...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1996.tb04438.x

    authors: Hall AW,Soykan O,Harken AH

    更新日期:1996-03-01 00:00:00

  • The accurate control of ultrafiltration.

    abstract::An apparatus has been contructed to regulate ultrafiltration accurately during dialysis. The principle of the apparatus is that, per unit of time, exactly the same amount of dialysate is introduced into the dialyzer as is discharged from it. The apparatus consists of two isovolumetric pumps connected in line. The four...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1978.tb03442.x

    authors: Flendrig JG,Carpay WM,Dekkers WT

    更新日期:1978-05-01 00:00:00

  • Effect of variation in systemic blood flow on plasma TNF-alpha in a pig model with left ventricular assist device.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) release has been implicated in a sepsis-like syndrome following cardiopulmonary bypass (CPB). This also may be important in patients who have had a left ventricular assist device (LVAD) implanted. This report investigates the effect of reducing systemic blood flow on hemodynamic...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2001.025002146.x

    authors: Uozaki Y,Dihmis WC,Yamauchi H,Moczar M,Miyama M,Pasteau F,Tixier D,Bambang SL,Loisance DY

    更新日期:2001-02-01 00:00:00

  • Central Extracorporeal Life Support With Left Ventricular Decompression to Berlin Heart Excor: A Reliable "Bridge to Bridge" Strategy in Crash and Burn Patients.

    abstract::The aim of this study was to compare patients with severe biventricular heart failure who underwent Berlin Heart Excor implantation with (cardiogenic shock [CS] status) or without the need for preoperative extracorporeal life support (ECLS) as a bridge to long-term device. A total of 40 consecutive patients with sever...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12792

    authors: Weymann A,Farag M,Sabashnikov A,Fatullayev J,Zeriouh M,Schmack B,Arif R,Müller F,Alt C,Raake P,Prakash Patil N,Popov AF,Rüdiger Simon A,Karck M,Ruhparwar A,Heidelberg-Cologne-Harefield Cardiothoracic Transplantation & Mecha

    更新日期:2017-06-01 00:00:00

  • Centrifugal pumps and heparin-coated circuits in surgical treatment of giant cerebral aneurysms.

    abstract::Giant cerebral aneurysms may be untreatable by conventional neurosurgical techniques. Early attempts to use circulatory assistance and deep hypothermia were abandoned due to hemorrhagic complications. More recently, interest in circulatory support for complex neurosurgical procedures has been renewed. A consecutive se...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2000.06594.x

    authors: Mesana T,Collart F,Caus T,Pomane C,Graziani N,Bruder N,Dufour H,Grisoli F,Montiès JR

    更新日期:2000-06-01 00:00:00

  • Effect of moisture on and kinetic features of the ultrafiltration rate of dialysis membrane.

    abstract::The kinetic features of ultrafiltration of cellulose dialysis membrane stored under various humidity and temperature conditions were studied to obtain basic information of shelf-life characteristics of dialyzers. The ultrafiltration rate (UFR) decreased with time and the UFR-time curve suggested that the UFR would app...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1981.tb04003.x

    authors: Sato H,Kidaka T

    更新日期:1981-08-01 00:00:00