Abstract:
BACKGROUND:Physical activity plays a tremendous role in determining bone mechanical behavior, which is superimposed to gravidity. OBJECTIVE:Compare the geometric and material responses of the rat femur to a high intensity treadmill running training of a relatively short duration, as assessed by 3-point mechanical test. METHODS:Mature male rats (180.0 ± 30 g) were assigned (7 rats/group) to no exercise (NE) or treadmill exercise (EX). After a preconditioning period, the running speed was set at 45 cm.seg-1 during 2 wks, frequency 5 d/wk, 2-hour sessions/day. Body weight and weight of the crural quadriceps were registered at euthanasia. The right femur was mechanically tested through 3-point bending. The left femur was ashed to estimate bone mineral content. Geometric and material bone properties were estimated directly or calculated by appropriate equations. RESULTS:1) Final body weight was 14% reduced in EX rats, while the crural quadriceps was 47% increased. Yield and fracture loads, and structural stiffness were significantly higher in the EX rats, as were the apparent elastic modulus, the bone mineral content and the degree of mineralization. Geometric properties were not affected. CONCLUSIONS:High intensity treadmill running training increases bone strength and stiffness by increasing material stiffness and mineralization, without affecting geometric bone parameters.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Bozzini C,Viscor G,Kristjánsson JCR,Picasso E,Champin G,Alippi RM,Bozzini CEdoi
10.3233/BME-171684subject
Has Abstractpub_date
2017-01-01 00:00:00pages
431-441issue
4eissn
0959-2989issn
1878-3619pii
BME1684journal_volume
28pub_type
杂志文章abstract::The interaction between implant materials and bone cells or oral epithelial (OE) cells contributes to the clinical success of dental implants. The functional activity of cells in contact with an implant is determined by its surface properties. Before cells attach, extracellular matrix (ECM) in the serum deposits on th...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章,评审
doi:
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To characterize the structure and to evaluate the cytotoxicity of cellulose nanowhiskers (CNW) prepared from cotton linters. METHODS:A series of CNW dispersions was prepared by hydrolyzing cotton linters with sulfuric acid. The structure of CNW was characterized by scanning electron microscopy (SEM), transmi...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-2012-0697
更新日期:2012-01-01 00:00:00
abstract::This study presents a novel spatial registration method of Image-guided neurosurgery system (IGNS) based on stereo-vision. Images of the patient's head are captured by a video camera, which is calibrated and tracked by an optical tracking system. Then, a set of sparse facial data points are reconstructed from them by ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151391
更新日期:2015-01-01 00:00:00
abstract::We previously reported a simple method for the preparation of size-controlled spherical silver nanoparticles (Ag NPs) generated by autoclaving a mixture of silver-containing glass powder and glucose. The particle size is regulated by the glucose concentration, with concentrations of 0.25, 1.0 and 4.0 wt% glucose provi...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-130772
更新日期:2013-01-01 00:00:00
abstract::Synthetic grafting materials, such as calcium phosphates (hydroxyapatite, HA; tricalcium phosphate, TCP), polymers, or composites thereof, can be used as osteoconductive scaffolds and delivery vehicles for osteoinductive growth factors. Carrier materials must be engineered to deliver these factors in a controlled fash...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The periodontal ligament (PDL), which maintains homeostasis in the periodontium, is a group of specialized connective tissue fibers attached to both the cementum and alveolar bone. Regeneration of periodontium with PDL cells has been investigated, and the chemical and molecular structures of scaffolds contro...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-171709
更新日期:2018-01-01 00:00:00
abstract::Based upon previous research on the relation between hip prosthesis designs and strain distributions in a proximal femur model, a prototype of a "physiological" hip prosthesis was designed and manufactured. Strain gauge measurements on a dry femur before and after implantation of this prosthesis were made in different...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Surface replication is a nondestructive evaluation technique applied in examining surface wear by recording surface irregularities, especially in conditions when surfaces of interest cannot be further manipulated to fit directly under a microscope to be examined. Enamel is the outermost protective layer of t...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-206006
更新日期:2020-01-01 00:00:00
abstract::Skilled behavior is difficult or impossible to articulate explicitly by the performers. Likewise biomechanical models of skilled motor actions are often limited by the lack of knowledge of the underlying mechanisms. A 'behavioral cloning' technique is described, based on a trained artificial neural network (ANN), that...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::To evaluate the deterioration in the superelasticity of Ti-coated NiTi orthodontic wires, titanium was coated onto wires to form a 1-microm thick film using radio frequency magnetron sputtering. In superelasticity cycle tests, the sigma5.0 value (the stress at 5.0% strain) of a Ti-coated wire was lower than that of a ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Gabexate mesilate is a non-peptide protease inhibitor, developed in Japan, which is used in the treatment of acute pancreatitis and disseminated intravascular coagulation. This compound is readily hydrolyzed as it has ester bonds in its structure. It is now out of patent in Japan and there are many generic versions on...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-2010-0611
更新日期:2010-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141252
更新日期:2015-01-01 00:00:00
abstract::Poly(N-substituted alpha/beta-asparagine) was evaluated as a thermoresponsible and an injectable scaffold for cartilage regeneration. Solutions of this polymer are liquid state below 25 degrees C and nonfluid hydrogel above 35 degrees C, allowing an aqueous solution containing cells at room temperature to form a hydro...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The use of helmets was considered to be one of the important prevention strategies employed on construction sites. The shock absorption performance of a construction (or industrial) helmet is its most important performance parameter. Industrial helmets will experience cumulative structural damage when being ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-201132
更新日期:2021-01-01 00:00:00
abstract::Hydroxyapatite is widely utilized as a component in dental hygiene agents. The ability to adsorb and remove dental plaque adhering to tooth surfaces is recognized as an important property of hydroxyapatite particles. In this study, the adsorptive ability of hydroxyapatite was evaluated based on its adsorptive amount a...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::The thrust of the present work is the demonstration of the feasibility of using an enzyme-linked immunosorbent assay (ELISA) for the detection and quantification of a monoclonal antibody human serum. The antibodies used, 7E3 and D3GP3, have been proposed as platelet receptor blockers, being directed specifically again...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Using a wet method, we have synthesized octacalcium phosphate carbonate, in which HPO42- in octacalcium phosphate is replaced with CO32-. The physical, crystal, and chemical properties of this new material were compared to octacalcium phosphate, Ca-deficient hydroxyapatite, and Ca-deficient carbonate apatite using X-r...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-171651
更新日期:2017-01-01 00:00:00
abstract::The finite element (FE) method has been widely used to investigate the mechanism of traumatic brain injuries (TBIs), because it is technically difficult to quantify the responses of the brain tissues to the impact in experiments. One of technical challenges to build a FE model of a human head is the modeling of the ce...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-171666
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The most common cause of coronary artery disease (CAD) is vascular damage with the cholesterol built-up and other materials on the inner arterial wall, known as atherosclerosis. OBJECTIVE:This paper aims to investigate the effect of stenosis on the hemodynamics in the four suspected coronary artery disease ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-191067
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Adhesive resin composite, which is used to bond orthodontic bracket to tooth surface is exposed to the influence of wear by tooth brushing and wear may influence loosening of the bracket. OBJECTIVE:The aim of this study was to evaluate in vitro the effect of tooth brushing on the adhesion strength of orthod...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-161592
更新日期:2016-09-28 00:00:00
abstract::The effect of carbonate in reducing the crystal size of precipitated hydroxyapatite by approximately an order of magnitude has not been used previously in the preparation of gel monoliths for the fabrication of carbonate hydroxyapatite ceramics. The aim of this study was to devise a method whereby gel monoliths of car...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::In this second part of the series of reviews, attention focuses on analytical and numerical methods that have been used to estimate the magnitude of the contact stress in: models of articular joints; models of total joint replacements, without and with the associated joint; or models of simple physical systems that ar...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract::In the organism epithelia perform perfect barrier functions. Strong rheological and mechanical influences constitute the normal environment of this tissue throughout life. Most epithelia are exposed to different fluids at the luminal and basal sides. To obtain realistic information about tissue development in modern b...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Experimental results on the platelet adhesion, and CHO cell adhesion and growth onto nonionic surfactant which is composed of a long alkyl chain (n = 12-18) as the hydrophobic part, and a polyethyleneoxide (PEO) segment (n = 10-23) as the hydrophilic part coated and air-plasma treated PSf surfaces are presented in ter...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::The method of formation of bioactive calcium-phosphate coating on medical titanium alloy Ti-6Al-4V (3.5-5.3% V; 5.3-6.8% Al; balance -Ti) by plasma electrolytic oxidation (PEO) has been developed. Evaluation of osteogenerating properties of the coating at fractures of the shaft of the femur on Wistar line laboratory r...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-161608
更新日期:2016-01-01 00:00:00
abstract::A number of materials have been considered as sources of grafts to repair bone defects. Here, we examined the possibility of creating in situ-forming gels from sodium carboxymethylcellulose (CMC) and poly(ethyleneimine) (PEI) for use as an in vivo carrier of demineralized bone matrix (DBM). The interaction between ani...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-2009-0603
更新日期:2009-01-01 00:00:00
abstract::Chimerism analysis has become an important tool to manage patients in the peri-transplant period of allogenic stem cell transplantation. During this period, cells of donor and host origin can coexist and increasing proportion of cells of host origin is considered as a recurrence of the underlying disease. We currently...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::The objective of this study is to evaluate whether the accumulation model developed by Zarfl et al. (2008) could be used to predict the minimal inhibitory concentration (MIC) of a group of antibacterial fluoroquinolones (FQs) for Escherichia coli (E. coli). Our model, which is based on the "Fick-Nernst-Planck" equatio...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141203
更新日期:2014-01-01 00:00:00
abstract::To investigate the inhibition effect of oxymatrine induces human lung cancer A549 cells apoptosis. The A549 cells were cultured for 24 h, than the various concentration of oxymatrine (2 mmol/L, 4 mmol/L, 8 mmol/L, 15 mmol/L) were added into different experimental group cells, and 5-fluorouracil were added into the pos...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151302
更新日期:2015-01-01 00:00:00
abstract::This study aimed to determine the optimal starting material for the development of an acellular osteochondral graft. Osteochondral tissues from three different species were characterised; pig (6 months), cow (18 months) and two ages of sheep (8-12 months and >4 year old). Tissues from the acetabulum and femoral head o...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151533
更新日期:2015-01-01 00:00:00