Abstract:
:The objective of this study is to evaluate whether the accumulation model developed by Zarfl et al. (2008) could be used to predict the minimal inhibitory concentration (MIC) of a group of antibacterial fluoroquinolones (FQs) for Escherichia coli (E. coli). Our model, which is based on the "Fick-Nernst-Planck" equation and the permeability of the neutral and charged species as well as the physicochemical parameters of the FQs, could predict 1/MIC90 using a linear function. It is envisaged that in the drug development projects of new FQs, the accumulation model described in this study could be utilized as an effective tool to enable early assessment of MIC value using physiochemical parameters.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Zhang W,Wang C,Tam KYdoi
10.3233/BME-141203subject
Has Abstractpub_date
2014-01-01 00:00:00pages
3745-51issue
6eissn
0959-2989issn
1878-3619pii
U07565U557027215journal_volume
24pub_type
杂志文章abstract:BACKGROUND:Age is the most important risk factor for primary osteoarthritis (OA). Members of the TGF-β superfamily play a crucial role in chondrocyte differentiation and maintenance of healthy articular cartilage. OBJECTIVE:We have investigated whether age-related changes in TGF-β superfamily signaling components play...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-140976
更新日期:2014-01-01 00:00:00
abstract::The paper presents an application of the FSI technique to determine hemodynamics in the abdominal aorta (AA). To establish boundary conditions for the FSI study, MR anatomical data and 4D MRI velocity-mapping data (in three blood flow velocity directions and time) were collected to acquire realistic geometry of the AA...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151312
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The most common cause of coronary artery disease (CAD) is vascular damage with the cholesterol built-up and other materials on the inner arterial wall, known as atherosclerosis. OBJECTIVE:This paper aims to investigate the effect of stenosis on the hemodynamics in the four suspected coronary artery disease ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-191067
更新日期:2019-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are a group of endogenous noncoding small RNAs characterized by high conservation; furthermore, various studies have shown the capability of miRNAs to impact diseases. For example, a study shows that cell-free miRNAs are stable in bodily fluids, which gives circulating miRNAs the ability to be poten...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章,评审
doi:10.3233/BME-141223
更新日期:2014-01-01 00:00:00
abstract::Previous literatures have indicated that hypothalamic paraventricular nucleus (PVN) neurons are important for regulating the level of sympathetic and vagal nervous activity. Sympathovagal balance is closely related to heart rate variability (HRV). However, it still requires further elucidation regarding the effect of ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151338
更新日期:2015-01-01 00:00:00
abstract::The thrust of the present work is the demonstration of the feasibility of using an enzyme-linked immunosorbent assay (ELISA) for the detection and quantification of a monoclonal antibody human serum. The antibodies used, 7E3 and D3GP3, have been proposed as platelet receptor blockers, being directed specifically again...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::DNA-binding proteins are involved and play a crucial role in a lot of important biological processes. Hence, the identification of the DNA-binding proteins is a challenging and significant problem. In order to reveal the intrinsic information correlated to DNA-binding, nine classes of candidate features based on diffe...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151491
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:We aimed to develop a novel ultrasound system and examine its feasibility for noninvasively detecting thoracic aortic aneurysm (TAA) in clinical settings. METHODS:We developed a novel ultrasound system consisting of a modified console and data analysis algorithm. The exploratory study included 100 patients h...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-191047
更新日期:2019-01-01 00:00:00
abstract::A layer of L-glycine-molecule-imprinted polyaniline (LMIP-PANI) polymer film has been modified on a carbon fiber electrode for the determination of L-glycine standard samples and L-glycine in cerebrospinal fluid of wistar mice. It has been found that a linear relationship exists between current and concentration for t...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-130907
更新日期:2014-01-01 00:00:00
abstract::Age-related macular degeneration (ARMD) and intraocular neovascular diseases have been treated clinically by anti-VEGF antibody drug bevacizumab. However, the use of bevacizumab in the treatment of retinal neovascular diseases has been limited due to the short half-life and frequent injections. In this research, novel...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141003
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Normal pregnancy is associated with profound alterations in the maternal cardiovascular system and PPG represents a sensitive and convenient technique capable of tracking changes in the pulsatile function of arteries. The aim of this study was to investigate the effects of maternal cardiovascular alterations ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-130801
更新日期:2014-01-01 00:00:00
abstract::Recognition of lung cancer cells is very important to the clinical diagnosis of lung cancer. In this paper we present a novel method to extract the structure characteristics of lung cancer cells and automatically recognize their types. Firstly soft mathematical morphology methods are used to enhance the grayscale imag...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Access to peripheral veins is necessary for sample collection, transfusion and infusion of fluids or medications. The peripheral intravenous catheterization (PIVC) procedure is the introduction of a short catheter into a peripheral vein and can be problematic, leading to multiple failed attempts. PURPOSE:To...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章,评审
doi:10.3233/BME-120735
更新日期:2013-01-01 00:00:00
abstract::To evaluate the deterioration in the superelasticity of Ti-coated NiTi orthodontic wires, titanium was coated onto wires to form a 1-microm thick film using radio frequency magnetron sputtering. In superelasticity cycle tests, the sigma5.0 value (the stress at 5.0% strain) of a Ti-coated wire was lower than that of a ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Great potential of cellular therapies has generated extensive research in the field of cells harvesting and culturing. Transplantation of cell cultures has been used in a variety of therapeutic programs but in many cases it appeared that biomaterial scaffold or sheath would enhance cells regenerative potenti...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-140966
更新日期:2014-01-01 00:00:00
abstract::As an injectable scaffold material for bone tissue engineering, calcium phosphate cement (CPC) has good biocompatibility, self-setting, and osteoconduction properties. Alginate-microencapsulated seed cells can pick up the degradation speed and bioactivity of CPC. The aim of this study was to explore the osteogenic abi...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-130875
更新日期:2014-01-01 00:00:00
abstract::This work evaluated the effects of UV irradiation, plasma radiation, steam and 70% ethanol treatments on the sterilization and integrity of auto-crosslinked hyaluronic acid (HA-ACP) scaffolds structured in microparticles and sponges aiming in vivo applications for regenerative medicine of bone tissue. The integrity of...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151558
更新日期:2015-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are a common tool in regenerative medicine. The nanoscale extracellular vesicles (nEVs) secreted by these cells were recently brought up to light thanks to their therapeutic potential. In this study, we assessed the in vitro behaviour of human umbilical vein endothelial cells (HUVECs) exp...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-171626
更新日期:2017-01-01 00:00:00
abstract::Three patterned systems aiming at the control of mammalian cell behavior are presented. The determinant feature common to these systems is the spatial distribution of extracellular matrix (ECM) proteins (mainly collagen) on polymer substrates. This distribution differs from one system to another with respect to the sc...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Stenting has been proposed as an effective treatment to restore blood flow in obstructed arteries by plaques. Although several modified designs for stents have been suggested, most designs have the risk of disturbing blood flow. OBJECTIVE:The main objective is to propose a stent design to attain a uniform l...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-171691
更新日期:2017-01-01 00:00:00
abstract::Microarray data has small samples and high dimension, and it contains a significant amount of irrelevant and redundant genes. This paper proposes a hybrid ensemble method based on double disturbance to improve classification performance. Firstly, original genes are ranked through reliefF algorithm and part of the gene...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151499
更新日期:2015-01-01 00:00:00
abstract::Skilled behavior is difficult or impossible to articulate explicitly by the performers. Likewise biomechanical models of skilled motor actions are often limited by the lack of knowledge of the underlying mechanisms. A 'behavioral cloning' technique is described, based on a trained artificial neural network (ANN), that...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Accelerated hydrothermal aging has long been one of the most widely accepted quality control tests for simulating low-temperature degradation (LTD) in zirconia-containing implants used in total hip arthroplasty (THA). However, it is still unclear how much consistency there is between the experimental predict...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-201083
更新日期:2020-01-01 00:00:00
abstract::Biocompatible metals have been suggested as revolutionary biomaterials for bone-grafting therapies. Although metals and their alloys are widely and successfully used in producing biomedical implants due to their good mechanical properties and corrosion resistance, they have a lack in bioactivity. Therefore coating of ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章,评审
doi:10.3233/BME-161568
更新日期:2016-05-12 00:00:00
abstract::This paper presents the single channel speech enhancement system using subband Kalman filtering by estimating optimal Autoregressive (AR) coefficients and variance for speech and noise, using Weighted Linear Prediction (WLP) and Noise Weighting Function (NWF). The system is applied for normal and Oesophageal speech si...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141183
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Gait analysis, such as portable gait rhythmogram (PGR), provides objective information that helps in the quantitative evaluation of human locomotion. OBJECTIVE:The purpose of this study was to assess the reliability of PGR in post-stroke patients. METHODS:Two raters (A and B) examined 48 post-stroke patien...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-206007
更新日期:2020-01-01 00:00:00
abstract::Bioelectrical impedance phase angle has been recommended as a tool to assess nutrition state, but there are no measuring devices have been specially designed for hospital residents. In this study, a system was established for the measurement of bioelectrical impedance phase angle. The electrical composition, calculati...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141193
更新日期:2014-01-01 00:00:00
abstract::The aim of this work was to investigate the effect of 2.4 MeV proton irradiation on the dielectric property of polyethylene terephthalate (PET) microfibre nondestructively. The dielectric constant εd of single-microfibre has been measured as-such applying laser diffraction technique. Applying this methodology εd is fo...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-130947
更新日期:2014-01-01 00:00:00
abstract::Intraocular lenses (IOL) made of polymethyl methacrylate (PMMA) lack an important yellowish pigment useful as a filter in the visual process and in the protection of the retina from short wavelength light. It was found that the PMMA used for IOL manufacturing can be tinted by dry exposure to mercury near-UV emitting l...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Modeling of thermal-induced mechanical behaviors of soft tissues is of great importance for thermal ablation. This paper presents a method by integrating the heating process with thermal-induced mechanical deformations of soft tissues for simulation and analysis of the thermal ablation process. This method combines bi...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141043
更新日期:2014-01-01 00:00:00