Use of enzyme-linked immunosorbent assay (ELISA) for detection and quantification of monoclonal antibodies.

Abstract:

:The thrust of the present work is the demonstration of the feasibility of using an enzyme-linked immunosorbent assay (ELISA) for the detection and quantification of a monoclonal antibody human serum. The antibodies used, 7E3 and D3GP3, have been proposed as platelet receptor blockers, being directed specifically against the platelet membrane receptors (glycoprotein IIb/IIIa) and thus of significance in the management of patients at a very hgih risk of thrombotic occlusion. It is shown that 7E3 is more easily adsorbed than D3GP3 and hence has a higher potential for the stated application.

journal_name

Biomed Mater Eng

authors

Lewis G

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

363-7

issue

5

eissn

0959-2989

issn

1878-3619

journal_volume

4

pub_type

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