Abstract:
OBJECTIVES:to assess reliability and reproducibility of quantitative MRI (7 T) in assessing rat femoro-tibial cartilage volume. METHODS:5 healthy rat knees were scanned in vivo using a 7 T experimental imager. Sagittal high resolution 3D Gradient Echo with fat suppression sequences were performed with a dedicated home-made 2-elements array coil. 3D MRI sets were used to perform manual segmentation of the 3 cartilage compartments (femoral groove, medial and lateral tibial plateaus) by using a tactile screen. To evaluate inter- and intra-observer reproducibilities, the segmentation procedure was done blindly by two trained observers. One observer repeated the operation twice, with a period of 10 months between both readings. RESULTS:the mean duration to manually segment all the slices covering the cartilaginous joint was 4 hours. On the one hand, the inter-observer root mean square of coefficients of variation was 9.1%, 6.2%, 9.6% for the femoral, medial and lateral tibial compartments respectively. On the other hand, the intra-observer reproducibility was 2.1%, 3.2%, 2.5% for these cartilage compartments cited above. CONCLUSION:the image quality obtained at 7 Teslas with our dedicated coil allowed segmentation of the cartilage compartments with good reproducibility. This study demonstrated that MRI is a useful technology to provide a non-invasive and reliable assessment of rat knee cartilage volume.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Goebel JC,Bolbos R,Pinzano A,Schaeffer M,Rengle A,Galois L,Etienne S,Netter P,Loeuille D,Beuf O,Gillet Psubject
Has Abstractpub_date
2008-01-01 00:00:00pages
247-52issue
4-5eissn
0959-2989issn
1878-3619journal_volume
18pub_type
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journal_title:Bio-medical materials and engineering
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journal_title:Bio-medical materials and engineering
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journal_title:Bio-medical materials and engineering
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