Abstract：
BACKGROUND:Scallop shell powder is called bioshell calcium oxide (BiSCaO), which is known to possess deodorizing properties and broad antimicrobial activity against various pathogenic microbes, including viruses, bacteria, spores, and fungi. OBJECTIVE:This study aims to investigate the applications of BiSCaO suspension cleansing in clinical situations, for instance for the prevention and treatment of infections in chronic wounds in healing-impaired patients, without delaying wound healing. METHODS:The bactericidal activities of 1000 ppm BiSCaO suspension; 500 ppm hypochlorous acid; 1000 ppm povidone iodine; and saline were compared to evaluate in vivo disinfection and healing of Pseudomonas aeruginosa-infected wounds in hairless rats. RESULTS:Cleansing of the infected wounds with BiSCaO suspension daily for 3 days significantly enhanced wound healing and reduced the in vivo bacterial counts, in comparison to hypochlorous acid, povidone iodine, and saline. Furthermore, histological examinations showed significantly advanced granulation tissue and capillary formation in the wounds cleansed with BiSCaO suspension than in those cleansed with the other solutions. CONCLUSIONS:This study suggested that the possibility of using BiSCaO suspension as a disinfectant for infected wounds and limiting disinfection to 3 days may be sufficient to avoid the negative effects on wound repair.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Takayama T,Ishihara M,Sato Y,Nakamura S,Fukuda K,Murakami K,Yokoe Hdoi
10.3233/BME-201082subject
Has Abstractpub_date
2020-01-01 00:00:00pages
95-105issue
2eissn
0959-2989issn
1878-3619pii
BME201082journal_volume
31pub_type
杂志文章abstract：:One goal of functional tissue engineering is to manufacture scaffolds infiltrated with chondrocytes which are suitable for transplantation into the lesion areas of articular cartilage. Various research strategies are used to fabricate cartilage transplants which would have the correct phenotype, contain enough extrace...
journal_title：Bio-medical materials and engineering
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abstract：:Motor imagery EEG-based BCI has advantages in the assistance of human control of peripheral devices, such as the mobile robot or wheelchair, because the subject is not exposed to any stimulation and suffers no risk of fatigue. However, the intensive training necessary to recognize the numerous classes of data makes it...
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pub_type： 临床试验,杂志文章
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journal_title：Bio-medical materials and engineering
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journal_title：Bio-medical materials and engineering
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journal_title：Bio-medical materials and engineering
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journal_title：Bio-medical materials and engineering
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更新日期：1993-04-01 00:00:00
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journal_title：Bio-medical materials and engineering
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journal_title：Bio-medical materials and engineering
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更新日期：2005-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
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doi：
更新日期：2007-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
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doi：
更新日期：2004-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
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journal_title：Bio-medical materials and engineering
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journal_title：Bio-medical materials and engineering
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journal_title：Bio-medical materials and engineering
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